Multidrug-Resistant Tuberculosis (MDR-TB): Mycobacterium tuberculosis
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- เผยแพร่เมื่อ 5 ก.ค. 2024
- What is tuberculosis? Just like the rest of these diseases, it's caused by a bacterium, specifically Mycobacterium tuberculosis. This one is tricky because there are strains that are becoming increasingly resistant to antibiotics, so let's learn what we can about these fellas, so that we can be on our toes!
Script by Kellie Vinal
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I'm studying biochemistry and actually did my bachelor thesis about isoniazid resistance in tuberculosis. It might actually get published soon! :D
That's awesome! I am familiar with isoniazid as a serendipitous (as all the pathbreaking discoveries were until recently) discovery in psychopharmacology. IIRC, it was abandoned in favor of iproniazid, which was, in turn, abandoned in favor of isocarboxazid. Unfortunately, I only ever took one chemistry course in high school, so I don't understand much about the physicochemical aspects of all of this. Have you ever read a detailed account of the discovery of its antidepressant efficacy? It's an interesting story. I was wondering if you could briefly explain what it is about these drugs antibiotic effect especially effective for Tuberculosis, as I have never understood it. Hydrazine drugs are interesting to me because they have so many different effects. You can use phenelzine for many different conditions; it is also an inhibitor of SSAO, and its major metabolite, phenethylhydrazine, is a potent inhibitor of GABA-T and could be used as a GABAnergic drug in its own right. It probably should be, actually, as it is so much less toxic than vigabatrin. But I digress. Cheers!
@@bsadewitz isoniazid is able to block An enzyme that is necessary for mycolic acids synthesis. These are special long fatty acids used in the membrane of these bacteria. First isoniazid needs to get activated by KatG (a Sort of catalase that oxidizes it) and then it'll go on and inhibit InhA which plays a role in the mycolic acid synthesis
Sir how to get diagnosis for multidrug
@@ashiammi33351 Hi, i'm assuming you mean how this gets tested in the lab? They basically take a swab and try to grow it in a culture where multiple drugs at certain concentrations are added. There are defined thresholds set by WHO. If the sample manages to grow, it means it is multidrug resistant. They are also working on using genetic screening to predict the resistance level of a certain strain, but the culture method remains the golden standard for now.
Best of luck.. you're future of world sir..may god accomplished you're every desire. 💓
Keep up with the good work Dave. This is the sort of knowledge that saves lives. And that is a good thing.
This video is quite accurate, good job on it. I would add, because I think its important to why TB remains such a problem even to this day, that the current drug regimin the antibiotic course is 6-9 months long AND the drugs make you nauseous. This can obviously cause major issues with compliance. It is difficult enough to get someone in a developed nation to take just a full course of 7 days of antibiotics....imagine trying to get people in poor areas or underdeveloped areas of the world to commit to 9 months of a 2-4 drug cocktail (4 drugs for 2 months, then 2 of those for 4-7 additional months) that makes them feel terrible and lethargic.
I have a four thousand word paper due in three weeks in this topic, working through articles has been awful for my adhd brain so thank you so much for making the concept so much easier to understand
I would be happy to read it if your willing to share I have been acutely infected and misdiagnosed for 2 years suffering slowly wasting away
Great video as always, one correction though, sputum and saliva are not the same thing, sputum is the mucus that develops in the lungs.
@ Professor Dave I would have wished for a bit more in depth explanation of the causes for the symptoms - like the infamous caverns in the lungs.
One of Grandfather Nurgle's many blessings upon mankind.
You never said how drtb is treated, can you talk about that please
what is it means if the result in xpert is MTB not detected..
love the hair cut!
Thanks Dave for the awesome work, are there any outcoming videos on current and passed Cancer meds?
maybe at some point in the pharmacology series!
i was susected to have a mycobacterium, but my sputum test are all negative of tb.
Thank you. 🙏🏽
So dying of consumption does not mean eating or drinking yourself to death?
Thanks!
Mdr tb can be fine then sir ?
I like his explanation.
Yeah it's very good
I had this as a child & tested positive on my first th skin test that we all take before school . No one knew I had even come in contact with it. I have latent tb variety.
Can someone explain (2:22) me please that by sharing food together , kissing or toothbrush doesn't spread the bacteria?? How this cannot be true
I also didn't get it...
I Suffered from this 10 yrs back....but I still don't share food..or drink from same bottle...I keep my things seperate...it's now in my habit. My doc said it won't spread at all...but still don't want to take any risk😅😅
sick video bro
Thank u
Hello sir I am from India 🇮🇳 nice explanation I easily understand thank you
Hi can anyone help me please, I have lymph node and after 1 year 1st line drug it didn't go, no other symptoms at all, no problem, doctor saying might be mdr tb I am about to get married please tell if I can make physical contact with my partner or not ? Pls reply my question all the std test reports are negative
Mdr tb might transmit to people around you while talking,coughing, laughing etc. I hope you'd take great care. Wear a mask around people and stay in a well ventilated room. Also,have a healthy diet. It would help you to recover soon and will help your body to response to the medicine.
I hope you get well soon.
Take care.
How can it be spread by singing but not kissing? Frankly, I find that pretty unbelieveable. I'll buy the singing part but not that something spread by singing isn't also spread by kissing.
I have latent tb ...please suggetion to me for treatment ....please sir ...
Hows ur symptoms
My wife has been suffering from a long time in her lower abdominal TB. After cesarean section operation my wife get affected with TB. Abdominal wall get affected beside the ovary , reproductive system get affected. Fast time by DNC used collection came out . Finally her overy and reproductive system have been operation because of long injury . TV drags continued more than 8 months . Now after operation some collection remains in lower abdominal area collection is going through the vagina. I don't know what will happen in her life at last. Please help me in this regard. I am from Bangladesh. Here most of the doctors are not good at treatment. I have spent much money but no result I get.
I was *eating water* when watching this video
I then started *drinking water*
Im 14 and found a ventilator in my room. I asked my parents about it and asked why i had it and why i used it as a 3 year old. Apparently I had TB and decided to do some research on it and im pretty surprised.
What age u had tb?
@@dinesandinesan9812 3 months old, last time I remember using the ventilator I was 3, but loooong time ago, I'm about to be 15 thus Sunday, Jan 30
Ohh u had tb by birth?
if Tb spreads by talking why it can't spread by shaking, kissing?
I had MDR-TB, few years back, around May 2020. At first i thought i was getting Covid but the doctor said it was TB. Spent a lot of money and 2 years of treatment but i pull through. Got it from my uncle, god rest his soul.
I am also currently undergoing MDR-TB treatment, I got it from my mother who was also a victim of this disease😞
@@AyushiRose are u alright?
Can a person suffered from Tb twice??? Is that curable second time????
Yes, just like every other disease. Even vaccine still have about 10% to fail in preventing and they only last 15 years.
Yes a person can be reinfected by the tb bacteria.
And also it is curable if treated properly.
Can mdr tb completely cured? Pls ans if possible.
Yes it can completely cured if you take the medication correctly as your doctor ordered you. It takes 18 months or 12 months to be completed to be cured based on which country you are. I used to work in MDR TB hospital as a Pharmacy manager.
@@bemnetmehari5776 thanks..wife suffering from this.dr told her to take medicine over 2 yrs.
@@kunalandshoryaoh sorry , I wish her full recovery.
@@bemnetmehari5776 she's in her 14th month...what are the chances that all tb bacteria are finished now?
@@kunalandshorya I can't say anything now. But one thing to tell is that always consultant you doctor.
I don't get it, it can spread by talking and not by kissing??
Ok, you caught my attention. I want to learn more. You are my portal. Will you invite me to learn more?
Kim.
yes subscribe and watch!
Damn tuberculosis took Arthur Morgan away from us he was a good man
I’m writing on this tomorrow, how’s that for timing 😂
medical pathology!
Hi to my future self in med school looking at this stuff
Pdf indo
I don't understand how can you get infected by breathing next to an ill person but not by kissing, do you mean that it's not transmited through saliva?
@@kingt.hawkings32 But then why don't kissing transmit it too. Saliva is exchanged, is it that you can only absorb it through the breathing?
@@kingt.hawkings32 Thank you.
Because you have to INHALE the droplets into your lungs - which you usually don´t do during kissing.
@@kingt.hawkings32 No, the people in the latent stage cannot spread the disease at all, as their immune system suppresses the bacteria.
Dave, I'm sorry. recently saw your haircut and couldn't help but notice that you were brutally dumped by your wife, Karen. You don't suck, you'll get through this dave. Love you
Who the shit is Karen?
relevant especially with the current epidemic
I had tuberculosis long ago and i survived it
At what age u had it bro?
Dave, may you debunk the antivaxxers please?
Do you need help?
Message on whatsapp for help
@@lauramorgan3074 nop
First!
Who does share toothbrush? It's weird hahahaa
First!!!
Edit: for once
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