hii mam this is manikanta kolasani did my Integrated MSc in systems biology from University of Hyderabad India mam I was watching ur video b cell devolopment this is phenomenal
I think that the delta loci is directly downstream and adjacent to the mu loci for the b-cell heavy chain. That's why the two can be produced from splicing variants. In your drawing, it had delta at the opposite end from mu, which I thought was a little confusing. Also, when class switching occurs, it is entirely possible that any other constant region isotype loci downstream of what the cell is switching to stays intact meaning that it is possible for the cell to type switch again. That being said, it is impossible for the cell to switch back to a previous isotype as that dna was excised from the genome.
I have a polyclonal Vdj TCR with seronegative celiac disease. I have now high hemoglobulin (18),high hematocrit (52) with high mcv and mch (most likely due to my chronic gastritis). I have read that kidney can also be damaged ( Berger disease) by Iga. How do I know if my kidney is damaged if I do have the seronegative type ( IgA/Ema and fecis). Is Cd4 produced in the bone marrow?
oof sorry man, but that is not one I excelled at. If you want them toward a micro slant I recommend armando hasudungan. I have found his pretty helpful to me in the past!
Errors bring diversity! So, so, so quotable. Thank you for your videos! I love your conversational but content focused style!
You explain everything in such a fun and understandable way.
Thank you so so much for this immuno video series!
i like thinking for IgD, its coexpressed with IgM because you cant get your M w/out the D. to become an MD
Excellent video, very helpful
This video is really helpful. Thanks for the video
hii mam this is manikanta kolasani did my Integrated MSc in systems biology from University of Hyderabad India
mam I was watching ur video b cell devolopment
this is phenomenal
I love your teaching style I was literally cracking up when you said ‘wait a minute just kidding’😂😂😭 16:31
Hey you’re great. This was soo helpful I wish you were doing my lectures 😭
I think that the delta loci is directly downstream and adjacent to the mu loci for the b-cell heavy chain. That's why the two can be produced from splicing variants. In your drawing, it had delta at the opposite end from mu, which I thought was a little confusing. Also, when class switching occurs, it is entirely possible that any other constant region isotype loci downstream of what the cell is switching to stays intact meaning that it is possible for the cell to type switch again. That being said, it is impossible for the cell to switch back to a previous isotype as that dna was excised from the genome.
Are you 100% sure about this? I’m studying for a test and this seems to be very high yield information
I have a polyclonal Vdj TCR with seronegative celiac disease.
I have now high hemoglobulin (18),high hematocrit (52) with high mcv and mch (most likely due to my chronic gastritis).
I have read that kidney can also be damaged ( Berger disease) by Iga.
How do I know if my kidney is damaged if I do have the seronegative type ( IgA/Ema and fecis).
Is Cd4 produced in the bone marrow?
i love you, so well explained
Great explanation
STEP makes me sad
Thank you!
My hero!!
I wish you could make videos on molecular biology
oof sorry man, but that is not one I excelled at. If you want them toward a micro slant I recommend armando hasudungan. I have found his pretty helpful to me in the past!
THank you for this video!
can you by any chance help me answer my exam questions during my exam since its online?
Sadly no - but you will do just fine!