Glutamate Receptor mGluR5 and Behavior Deficits in Autism - Adrien Eshraghi PhD - Synchrony 2023

Adrien Eshraghi PhD is a Professor in the Departments of Neurological Surgery and Biomedical Engineering. His team is actively developing experimental models of ASD and central auditory processing disorders (CAPD) to provide insights into the pathophysiology of these neurological disorders and guide the development of novel treatment modalities.
Presently he and his team are utilizing genome editing techniques such as CRISPR/Cas9 as well as neurons derived from induced pluripotent stem cells (iPSC) from ASD patients to understand the molecular mechanisms underlying this neurodevelopmental disorder.
In this talk Dr. Eshraghi presents their latest findings on the relevance of metabotropic glutamate receptor 5 (mGluR5) in ASD. Although various genes have been implicated in predisposition to ASD, mGluR5 is one of the most common downstream targets, which may be involved in autism. mGluR5 signaling has been shown to play a crucial role in neurodevelopment and neural transmission making it a very attractive target for understanding the pathogenesis of ASD. mGluR5 animal models demonstrate an ASD-like phenotype, specifically impaired social interaction as well as repetitive and anxiety-like behavior, which are correlates of behavior symptoms observed in individuals with ASD.
🎥 This talk was part of Synchrony 2023 Online Symposium - 'From Bench to Biopharma', organised by the The BRAIN Foundation
🎥 Synchrony 2023 playlist: • Synchrony Symposium 2023
Synchrony brainfoundatio... is the first and only international symposium on translational research in #autism, that brings together academia, #biotech, #pharmaceuticalcompanies and venture partners from around the world with the mission to improve health and quality of life of people with #autismspectrumdisorder.
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The BRAIN Foundation brainfoundatio... is a 501c(3) non-profit. The founders of BRAIN envision a world where every child and adult on the autism spectrum is healthy, participates fully in education and employment, and has a better quality of life. It aims to catalyze research that results in evidence-based interventions for the disabilities associated with autism, and also results in better medical standard of care. To accomplish this, it funds impactful research through #philanthropy and our network of partners in the venture, corporate, and grassroots community.