Acid Base Extraction Explained: how to preform an acid base extraction on plant alkaloids
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- เผยแพร่เมื่อ 21 ต.ค. 2024
- Also make sure your solvents won’t mix, and preferably have very different densities so they easily separate.
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Note: alkaloids in their non polar (free base) form may be oils and liquid at room temperature. So if you want to filter them out it’s better to filter out from the polar (salted) state.
some of the best high as fuck in the kitchen at 2am discourse
This has been a trip, such a succinct explanation delivered in the most hilarious way.
I'm glad you liked it : )
wow dude! you just took a weeks worth of research and nailed it down in 13 min. good job! and THANK YOU cause this made sense and is applicable. I appreciate you posting- hope you will consider doing more videos
I’m glad you liked it and it helped, feel free to make recommendations for videos : )
@ILiveInWackyTown Haha thanks and I don’t know or care what’s in style. I’m still growing my hair out though. Despite being super simple hopefully if anyone intends to do an acid base extraction this is just the foundation of their knowledge on it and they learn more after watching the video. Pretty simple to not cause an explosion though, just don’t have fire near your flammable solvent
@lincolnschoolpreservation3574I am gonna try it. Any tips that might help me not to blow myself up? Thanks
Salsa, secret sauce of the universe.. great video in so many great ways
I’m glad you liked it!
Lol that was hilarious. Totally correct and a nice explanation. Perhaps you should make a part 2 and add something about safe solvents to use and how you can wash a solution multiple times to achieve an arbitrary level of purity. Don't want people accidentally harming themselves with salsa extract that's contaminated with say benzine etc ;)
Perhaps. I just didn’t want to make a video where I literally do all the work for someone but I could give some extra tips. As for solvent. I actually think it would be pretty much fine to use gasoline although I haven’t used it yet, so long as it’s not your final solvent your stuff is in, and you clean your product properly. Of course it’s not ideal though, but I thought about it when thinking of how to save money. It seems like you know some of this stuff already and don’t personally need another video, do you?
Of course I’m not saying I would use gasoline, unless I had to
This should be the most viewed on this subject - love it brother!
Will be completing this soon:)
I’m really glad you think so and love it. Feel free to make recommendations
How did it go?
Feels like I just had a bro learn me some shit, good video man
Wonderful words of wisdom ❤️
Best explanation hands down ❤
Dammit, stir the mixture after hcl. Was looking for mistakes as im well aware of the chemistry but lacking experience. Thanks! I hope this will help to succeed
300th like, thank you
Thank you for this video sir,it's really helped me understand this process
If your source is oily do a nonpolar pull of the oils while it's acidic. Then when you go basic the free bases will pull without forming an emulsion. ❤
thank you, id like to extract the alkaloids in kratom to remove the fiber etc as im its natural form it causes a LOT of digestive issues. thank you for showing mee the rabbitholes entrance heh.
You’re welcome : )
6:32 Most plants do not have alkaloids, least not in amounts detectable by current science methods, but when they do, indeed they most often have more than a single one.
8:14 "pie-path" 🤣
Salsa having Tomatoes probably has a very minute amount of alkaloids too - interesting intuitive choice.
Also, whoever tells me the guy's not stoned as f@¢k has had way too much alkaloids for the day.
Regardless his explanation is very easy to understand and helpful, and I am honored that an online hippie assumed I know what protonation and amines are, to name a few things.
Cheers!
I’m glad you liked the video. You’re right about what you said
Dude thanks so much between you and Hamilton's content I got the scoop
In glad it helped!
@@aryanprivilege9651 I’m glad you liked it and thanks for the stories
Hamilton's content?? And link please?
th-cam.com/video/qipKKBmY_LQ/w-d-xo.html@@L7pusher
The guy who can intellectually and physically beat you down all while looking good 🗿
MY Friend (hope u are ok with my Friend) i just want say YOU ARE THE BEST COOL NICE EFFECTIVE TEACHER OF THE WORLD. So Thank u full much y from France. Since 2 years i learn as self made man the Alkaloid Chem to get the most safe smoking (foggy smokey forbidden withe stuff);
Today you give me a big big knowledge about that.
I’m glad : ) which special white stuff? Can you give any hints? Does it start with a D and end with a T?
@@DrAndrewHutchings yo DOC, thank to read me. I work with HCl Cc you now.
Really nice explained bro,i got that whoale topic in just 13 mins, well done, colleague ! But next time you´ll might demonstrate an simple a/b extraction and precipation (in lets say petrol ehter or hexane), with lets say piperine out of pepper. this is way more educating than just explaining the theoretical background. keep in mind that most of your vievers aren't chemists and doesnt really care about the theory, they expect precipates! best regards from (Exzelenz)-Universität Hamburg, Department Chemistry, signed a german chemist
PS: You really are in good shape bro, keep it up
Thanks. I hope Germany is doing well
what meathod is better acid extraction method or this one? just wanted to know.
@@SCP_Foundation_EditSSR Im not sure what they acid extraction method is so I can’t say. This is a traditional acid base extraction
Thank you, *brah.*
Im trying to isolate M from P and am lost. I did a alcohol extraction from the organic matter and got very good separation. I siphon off top aqueous layer and discarded the bottom gunky sludge away now....im lost??? How to precipitate M from this black syrup??? Im no chemistry guy by far either
Does it matter which polar/non polar solvent/acid you use?
@@fluffypuppy720 for the most part, no
@@DrAndrewHutchingsthank you for your reply. One question: if the alkaloids are basic or neutral, what makes them go into the non polar solvent. As I am currently understanding I would dissolve the crude plant material in a polar solvent such as water but would need to acidify the water to solubilize the alkaloids, then add a non polar solvent, the alkaloids go into that, then I discard the aqueous layer, add back the polar solvent(water), then add an acid to protonate the alkaloids and they now go into the polar solvent (water) and I discard the non polar layer. Then I am able to crystallize the alkaloids in water by evaporation? Or by cooling here’s where Im sort of hung up. Any help much appreciated.
Best video
When I make drugs if I get caught I’m sending the cops your direction 😂
@@GalaxyNewsRadio_ what country do you live in? Probably not the same as me!
@@DrAndrewHutchings true, but they do be extraditing mfs. 🤣You got big as fuck dude, I understand that’s cause steroids but it’s also hella hard work. You seem happy unlike most dudes on steroids. Gs live that good life
@@GalaxyNewsRadio_ I live in a country that doesn’t extradite lol, I live in Belarus. I’m also not doing any illegal drug making anywhere so there is no reason to extradite. I will however have a completely legal biotech lab soon.
I am not 100% natural, which is part of why I’m bigger, but a lot of it is also that soon after the acid base video I started eating waaay more than I used to eat and that allowed me to grow much more.
To clarify the natural thing, I’m not 100% natural but I’m a lot more natural than most fitness people on social media or amateur bodybuilders
@@DrAndrewHutchings that’s really cool dude.
Groovy
Hi, i hope i dont react too late, but i would like to know how would you do for an already polar molecule for instance mushroms
If you want a consultation please message me on Instagram at AndreyHutch
Just use everclear then decant off the water
@@alanomofo water will pull psylocibine but not psylocine
I haven't watched , I'm downloading soon. would this work for any type of psychedlic plants?
Yeah pretty much
Not weed
Is there any defatting required with San Pedro?
That's pretty much what you do during the acid base extraction with the non polar solvent
I'm about to isolate something this is cool stuff
Can you give any hints as to what it is? : )
It sure is fun to isolate molecules from plants
Any recommendations for videos?
@@DrAndrewHutchings There are lots of food safe mescaline extractions online but no pictures or videos. Perhaps you could do a video on that. Wether you use the actual cactus or not shouldnt matter but it would be nice to see someone like you walk through it.
nice. very informative 👍
Your first A/B extraction will make you feel like a real chemist when you figure it out.
Did you figure it out?
@@DrAndrewHutchings my first was on Mucinex DM pills in high school. Empty orange juice bottle, used sodium carbonate as my alkali instead of ammonia or NaOH. (Put baking soda in the oven to produce it). Crushed the pills up with a hammer in some foil to contain ir(it poked holes tho so had to use layers and get creative).
Then I added the crushed pills to the sodium carbonate water that is alkaline. Shake the shit out of it for a while, then I used naptha to pull the freebased dxm. Used ziplock bag to seperate from the aqueous layer.
Then I used country time lemonade mix as my acid hahahahaa. Made super strong lemonade mix to shake with the naphtha containing freebase dxm. This formed dxm citrate which stays in aqueous lemonade layer. Use ziplock bag as a sep funnel again by cutting a corner off, capturing the lemonade fraction. Then I boiled that down extra concentrated and drank it. Hard to know exact amount of citric acid in it so it would come out pretty sour and I had to add more sodium carbonate to my final product sometimes to bring up the pH slightly too avoid stomach irritation.
Pretty ghetto but it worked! Modified the ammonia and naptha tek from érowid with things I had on hand and it worked! That's what made me feel like a real chemist! Plus, when jt feels like you're doing something wrong it's more fun :)
(Don't do DXM kids)
@@DrAndrewHutchings yes ;) I had to get creative but I knew the concept intuitively by the end. And that's the feeling that makes tou feel like a real chemist. When you can conceptualisé the reactions in your head, and modify procedures because you know what's similar, that's a good feeling. Just following instructions doesn't cut it! When you can modify things with success, that proves you really understood the concept!
@@Dude8718 awesome and I agree
great explanation u should teach
Thanks. I used to teach chemistry. I think this video was a bit long but people seem to like it
👍
If an alkaloid in the plant is a salt doesn't that mean it's water soluble without the addition of acid?
It should but I like to be extra sure. I don't know if there are any studies on it but I know that there are oily components of most plants and just in case some of the alkaloids are in oil form in those oily components I would prefer to add some acid.
A little late but thank you
Hello, I am a moron first and foremost. What school or university level of Chemistry would a basic procedure like this be taught at? Thanks, sincerely -a moron.
Basic organic chemistry. Typically people take a class on it in university if they are studying chemistry. A 14 old can do it though
Great video thank you
I’m glad you liked it and hope it helps you extract some nice chemicals!
@@DrAndrewHutchings AHO (:
W guy
Do you have a web site?
Yes I do : ) AndrewHutchings.org and you can also contact me over Instagram @natural_true_fitness
shit will disappear on you trying to cheat on this test..
If only we had more tests like this to prevent people from cheating. I hate cheating. I have never cheated threw out all my time in school and university while everybody around me she did constantly and sometimes got better grades than me because if their cheating
You have a good understanding of this topic, but you could really improve your presentation. I mean it’s quite blatant that you set aside zero preparation for this discussion. Diagrams, a white board, some kind of visual depiction helps your audience understand to a better degree.
I agree but I don’t own a white board or anything and I don’t plan out any videos. Chemistry isn’t the main topic of my channel and I just randomly decided to make this video late one night
I think that presentation was on the money. Adds to the charm of deemt
Shut up nerd
Did you used to wear a gladiator costume?
No why?
I need a tutor big money lol
Contact me at andrew.747474@gmail.com
Probably the worst explanation of acid to base extraction I've ever seen...😂
Are you putting some of that dmt on those delicious muscles??
Haha nope. But a day long mescaline trip would essentially be a day of fasting, which could perhaps do a physique some good, a good way to diet down extra hard.
Hippies 🤦♂️
If they watch enough of my videos maybe they will be buff hippies : )
@@DrAndrewHutchings if they can sit through this maybe a scientist
not hippies, psychonaut nerds is more correct.
Hi Richard Simmons