Very useful! Thank you, sir. Doubt: We are choosing the active/binding site of whatever ligand was already there but what if our ligand which we will subsequently use for docking binds to a different region?
Thank you very much sir, your explanation is very good, I have learnt lot of things regarding docking. I have one doubt sir how can we perform docking studies for metal complexes. Is it applicable for metal complexes also?
A nice understandable video. thank you for the same. As I am new to this work please let me know what should be done as this message is seen in the right hand corner "Enable additional feature". Is is free or purchasable.
Thank you sir for your feedback. I have a question. During preparation of proteins for docking.. How do you determine the coordinates for the ligand binding if the downloaded protein doesn't have a ligand attached to it?
Hello, Sir. Thank you very much for an informative video. I have a question, Sir. If you dont mind. I did a preparation using Discovery Studio Visualizer and validation using AutoDock 4.2. (pdb id 3v99) but the rmsd was too high. Could you, please, suggest any solution for my validation, Sir? I tried to change a couple of the steps but the rmsd always too high. I dont know what to do anymore..
Thanks for your valuable feedback. I think this will help you. www.sigmaaldrich.com/technical-documents/articles/biology/protein-expression-systems.html
Sir I need to do docking on this enzyme using MOE software there is difference as it consider hem as a ligand not receptor and it’s a big issue for me I also tried with all protocol and no results found there is any help for that ?!
I prepared the protein as described in this video. Sir, can u please share with us if you have ever faced a python error while autodocking the macro molecule in PyRx?
Thanks Sir Molecular docking is fantastic
Sir please make a full playlist series of videos in molecular docking
actually I never seen better than ur explain >>>keep going
Yess, this was so helpful. thank you!!
Very useful! Thank you, sir. Doubt: We are choosing the active/binding site of whatever ligand was already there but what if our ligand which we will subsequently use for docking binds to a different region?
Can we avoid defining binding site?
i do not have the details of the protein - active sites or ligands in the discovery studio visualizer. how can I remove the ligand ?
Amazing Job. Congrats!!!
Thankyou so much, nice video
Sir preparation to keep li protein ki next docking kasy krni ha
@Dr. RAVIKUMAR CHANDRASEKARAN; Sir I am unable to see dock ligands tab in discovery studio visualiser.
Thank you very much sir, your explanation is very good, I have learnt lot of things regarding docking. I have one doubt sir how can we perform docking studies for metal complexes. Is it applicable for metal complexes also?
Yes. U can do. Thanks for your valuable feedback and support.
Thank you very much
Next video of docking?
A nice understandable video.
thank you for the same. As I am new to this work please let me know what should be done as this message is seen in the right hand corner "Enable additional feature". Is is free or purchasable.
hi sir, how to get the docking software in discovery studio?
Thank you sir for your feedback. I have a question. During preparation of proteins for docking.. How do you determine the coordinates for the ligand binding if the downloaded protein doesn't have a ligand attached to it?
Thanks for the video I meant.
Thanks for your support. In such cases u can select the active site residues using ASP tools or go for blind docking.
How to calculate binding energy of protein ligand docked structure from ds. Kindly upload tutorial for that
I have a similar question too
sir I have a query.
Good day to you sir. What is to be done if ligand profiles are not seen in the downloaded material from PDB.
Please provide me link to download a discovery studio visualizer for 32 bit Windows 7....I am requesting..
Thank you sir.why do we add polar hydrogen to the protein?
thank your very much for this information , if i want to prepare my protein but the protein has 10 ligand witch i choose and how i do it
Thank a lot !
Sir i am unable to download the pdb file of prepared protein in my laptop. Kindly clear why?
Thank you very much.
sir what is the cost of this software. I want to purchase it.
sir where u put radius value in auto dock or vina.or what about x, y and z size.
Sir I can't see dock ligands tab in discovery studio visualiser
Please make a video how to enable advance features in discovery studio
By purchasing license.
Hello, Sir. Thank you very much for an informative video. I have a question, Sir. If you dont mind. I did a preparation using Discovery Studio Visualizer and validation using AutoDock 4.2. (pdb id 3v99) but the rmsd was too high. Could you, please, suggest any solution for my validation, Sir? I tried to change a couple of the steps but the rmsd always too high. I dont know what to do anymore..
What about Kollman charges
sir why cant i see a docking option in my discovery studio App
Sir in PDB their is a line Expression system: Escherichia Coli
ehat does this means ??
Thanks for your valuable feedback. I think this will help you. www.sigmaaldrich.com/technical-documents/articles/biology/protein-expression-systems.html
Sir I need to do docking on this enzyme using MOE software there is difference as it consider hem as a ligand not receptor and it’s a big issue for me I also tried with all protocol and no results found there is any help for that ?!
sir is it free software or paid software? I can't find this client software
Sir I want to learn drug design. Can you suggest me any course?
I prepared the protein as described in this video. Sir, can u please share with us if you have ever faced a python error while autodocking the macro molecule in PyRx?
yes it arises generally
Sir, I cant see the docking tab in my discovery studio visualiser ??
Only in paid version it will be available
its very nice Dr...can u send u r mail...Thank u.