Mass Spectrometry Fragmentation Part 2

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[@vinitamaharaj5738]

Your videos on spectroscopy have been SO helpful! I really appreciate the time and effort it has taken to put these videos together. It is clear, concise, and extremely well arranged.

[@johannatampogao3922]

I just wanna say thank u for being my professor in this online learning.

[@13ironmike]

Extremely helpful videos. Thank you for breaking it down slowly and in detail!

[@brisadelabarrera2371]

This is the best explanation I could find. Thank you so much!

[@raliyaaliyu2604]

You have the best videos on spectroscopy thanks alot

[@skyingswift]

Thank you so much, sir. You will be remembered 😭

[@esmeralda_jenn]

My favorite channel for now!

[@Knowbee]

Great! Glad I could help

[@chamodikasenarath3956]

Thank You sir, very helpful..Comments solve the confusion.

[@nagwahamada2002]

Really, it a very good explanation, good effort . Thanks

[@elizabethruiz8046]

Thank you so much! I finally could understand fragmentation patterns.

[@faisalus313]

Can you help me about that, please ?

[@olaak3454]

it's really really helpful, thank you so much for this 🖤

[@sammanimiurangana1842]

Extremely helpful videos. Thank you

[@dinukabandara1523]

Great One Sir. Hats off to you. Only concern is with the definition of alpha C.

[@dinaws1440]

Thank you so much, this video really helpful!

[@stephenqueen6946]

saving my butt when I'm expected to write a practical report on a bunch of stuff that was not taught in the class

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This so amazing it has really helped me

[@jo-jokids9445]

thank you sir, Very informative class

[@mominaan36]

Thank you sir. It was really helpful.

[@omarel-nemr6506]

The alpha carbon is not the carbon that is bonded to the functional group but the next carbon after it

[@JayaSaputra]

it's really helpful, but it's confusing how you define the α-carbon, in the beginning you define α-carbon as carbonyl-C, but when you explain about McLafferty rearrangement you take "real" α-carbon (the carbon next to carbonyl-C) as α-carbon. But, overall it's really helpful. thanks

[@Knowbee]

Sorry for the confusion. You are right. I misspoke. A true alpha carbon is the carbon directly next the the carbonyl carbon. Thank you!

[@JRockTT]

I had the same question. Thank you for clearing that up!

[@chemistrylover7940]

Thank u sooo muchh sir... It is very helpful....

[@sekarayuni6281]

Thanks for the explanation sir!

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[@usamanasir110]

Very awesome lecture

[@john.the.beloved]

God bless you!

[@weizhang6375]

That is perfect teaching video I had ever. At 6:24, why the CH3CH2CHCH2CH2 is + ? Is due to loss of elections from the bond of gamma carbon? I am really confused for the step Where the gamma carbon become radical, and alpha carbon become +. Thanks for your answer!

[@silverskater558]

Do you have any idea how easy your video is. THANK YOU FOR DONATION TO SOCIETY BY POSTING THIS AND PART 1

[@Knowbee]

You're welcome. Thank you!

[@nfzb]

Thats very helpful! Thank you. But does anyone know how can i find more explanation about fragmentation of ester?

[@miguelfernandezgarcia163]

Gamma cleavage and McLaffery rearrangment are best remembered if for the former one thinks about the stability of 5-atom ring-like conformations (OH, 3xC and H = 5) and for the latter of 6-atom ring-like conformations (O, 4xC and H = 6)

[@anishkumarsharma9952]

Very well!!! All the concepts related to the fragmentation are clear. That was totally awsm. But i have a doubt....
In mass spectrometry, we generally deal with soft ionization technique like ESI and APCI where a hydrogen atom is added to the molecule . Does this addition will change the fragmentation pattern Or how does that addition of hydrogen will effect the fragmentation. Could you just explain this.?

[@jumanareda8810]

Thank you ♥️♥️

[@lamrisaid4067]

But ,how about aromatic compound fragmentation ?

[@davidjrn8013]

for McLafferty rearrangements, isn't final structures of -OH will have a single bond and C alpha have double bond?
Thank you.

[@mustafaalhayali5506]

thanks alot sir

[@aissabym2762]

THANK YOU

[@rachidatair702]

it would be great if you made an exemple xith acid COOH cause we have C=0( cétone) and Hydroxile (OH)

[@songohan393]

Thank you

[@dayanashaytou8437]

hello why alpha carbon was attached directly in the first ketone while it is not the same in the second ketone using Mc method ?

[@hmshehzad4814]

Thank u so much

[@katana7533]

thank you so much, now I get it :)

[@Knowbee]

Glad you got it! Thank you!

[@kastogeorge7141]

Good explaination, but how could say Carbon from the functional group is the alpha carbon, while what I know is, the alpha carbon is the one attach direct to functional group ,and the functional group there is the carbonly group(C=O),

[@Alchemist_171]

Exactly.

[@rikaanapi4816]

Thank you for this sir!

[@arshadarshad-zk8fk]

During gamma cleavage why carbon -hudrogen bond breaks firstly than Carbon-carbon bond . C-C is weaker than C-H Bond???????

[@uathrhsalim]

Thank you so much TT TT

[@chemistrylover7940]

Plzzzz tell about aromatic alcohol

[@VaishnaviDevi316]

i dont understand how could the carbonyl carbon be alpha carbon..the carbon next to the carbonyl carbon is the alpha carbon isn't it? usually the carbon next to any functional group is termed as alpha carbon right?

[@Knowbee]

You are correct. I may have misspoke. The carbon next to the carbonyl carbon is the alpha carbon. Sorry for the confusion and thanks for the clarification.

[@VaishnaviDevi316]

Thank u know bee!! keep up the great work and its very useful for us!! :) and i would like to ask one more thing..can you pls upload video lectures for solid state chemistry..Packing model in solids..i feel it would be more helpful for us!! thank u!!

[@Knowbee]

Thanks Devi, Unfortunately I won't be making any solid state chem. videos. I stick mostly to the life-sciences chemistry. Please let me know if there is anything else I can do for you.

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