Motor Neuron Disease, Animation
ฝัง
- เผยแพร่เมื่อ 30 ส.ค. 2021
- Upper and lower motor neuron diseases: Amyotrophic lateral sclerosis (ALS), Progressive bulbar palsy (PBP), Primary lateral sclerosis (PLS), Spinal muscular atrophy (SMA) - Werdnig-Hoffmann disease, Kugelberg-Welander disease, Spinobulbar muscular atrophy (SBMA) - Kennedy’s disease, Post-polio syndrome (PPS). Symptoms, diagnosis, progression, expected lifespan.
This video is available for instant download licensing here: www.alilamedicalmedia.com/-/g...
©Alila Medical Media. All rights reserved.
Voice by : Marty Henne
Support us on Patreon and get early access to videos and free image downloads: patreon.com/AlilaMedicalMedia
All images/videos by Alila Medical Media are for information purposes ONLY and are NOT intended to replace professional medical advice, diagnosis or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition.
Motor neuron disease is a group of rare neurological conditions in which motor neurons - the nerve cells that control skeletal muscle movement - are progressively degenerated. Loss of motor neurons results in muscle weakness that gradually worsens over time, impairing the body’s ability to move, eat, speak, or even breathe.
Usually, motor instructions from the brain are transmitted to the muscles via 2 neurons: an upper motor neuron starts in the primary motor cortex of the cerebrum; and a lower motor neuron continues from the brainstem or spinal cord, forming the corticobulbar and corticospinal tracts, respectively. The corticobulbar tracts control muscles of the face, head, and neck and are responsible for facial expression, speech, swallowing, among others. The corticospinal tracts control muscles of the torso and limbs.
Lesions of upper and lower motor neurons affect the muscles in different ways. A loss of upper motor neuron function often leads to increased muscle tone, muscle stiffness, known as spasticity, and overresponsive reflexes. On the other hand, lower motor neuron lesions often result in reduced muscle tone, flaccid paralysis, and muscle wasting and twitching.
The many forms of motor neuron disease are classified according to whether the loss of neuron function is inherited or sporadic, and whether the condition affects upper or lower motor neurons.
The most common form is amyotrophic lateral sclerosis, ALS, which affects both upper and lower motor neurons. Patients typically present with spastic paralysis and overactive reflexes in the lower limbs; and flaccid paralysis and reduced responses in the upper limbs, along with tongue twitching. In the later stage, symptoms may also include slurred speech, and difficulty swallowing and breathing. Most people with ALS die from respiratory failure, typically within a few years from diagnosis, although a small number of patients may survive for a much longer time. ALS usually strikes in midlife, but it can occur in people of any age. Most ALS cases are sporadic, only about 10% are inherited, with at least a dozen of genes involved.
Progressive bulbar palsy, PBP, affects the lower motor neurons that originate from the brainstem, also known as the bulbar region. Symptoms include difficulty chewing, swallowing, and speaking. PBP is sometimes considered a subtype of ALS, because most PBP patients eventually also develop widespread muscle weakness.
Primary lateral sclerosis, PLS, affects only upper motor neurons. PLS progresses much more slowly than ALS and is not usually fatal. However, because a number of ALS cases start out as PLS, a PLS diagnosis is considered definitive only after at least 4 years.
Spinal muscular atrophy, SMA, is a group of genetic disorders affecting lower motor neurons. There are many different forms of SMA, caused by mutations in different genes, with different modes of inheritance. The three main forms are due to defects in the same SMN1 gene (autosomal recessive), but differ in age of onset, severity.
Spinobulbar muscular atrophy, or Kennedy’s disease, is a form of SMA caused by mutations in the androgen receptor gene on the X chromosome. This disease typically strikes in adulthood and affects mostly men (X-linked inheritance). Early symptoms include tremor, lower limb weakness, and tongue twitching. Late symptoms include widespread muscle weakness and wasting. The disease however progresses very slowly, with most patients having a normal lifespan.
Post-polio syndrome, PPS, is a condition that affects polio survivors, sometimes decades after the initial illness. Symptoms include muscle and joint weakness and pain, twitches, muscle wasting, and intolerance to cold. Some patients may also have difficulty breathing and swallowing. PPS is usually not fatal.
There is no cure for motor neuron disease, but supportive treatments can relieve symptoms and may help maintain quality of life.
Love our videos? Check out our new courses made entirely with videos like this (without watermark): www.alilaacademy.com/
I have Motor Neurone Disease/ALS and this is one of the best videos around. Most talks/videos ignore mentioning spasticity which is a major symptom. Thanks so much🙏🏼
I've seen your videos. So nice. My first girlfriend had this. I don't know what else to say except I care.
@@michaelbelsky5435 thankyou so much Michael, that means a lot to me 🙏🏼I am really sorry to hear that your first girlfriend had this disease. Take care
9315984906
❤
Great video had so much information.. Especially PLS and SMA seems most amazing to me.
My mother have this disease... We tried to get treated for her condition but we are helpless no medicine for this disease...she is still alive ...have difficulty in speeching, sollowing , muscle twitching ...I pray to god no one should not affected by this disease.....I requested all researchers pls find a cure for this deadly slow killing disease ...
This is a horrible disease,,, I lost my mom ,
@@shilpashivigupta527 I am so sorry for your loss, may she RIP
My father has the same disease and his condition is rapidly deteriorating.. He has pneumonia and is only breathing through artificial respiration. I contacted an Indian doctor who has a sanatorium in India. He told me that if he is in the early stages before he gets pneumonia, I can treat him, but if he reaches pneumonia, I cannot do anything. Him.. If your mother did not have pneumonia, I will give you his number, email and health card, and contact him, and I hope you treat her quickly because it is a malignant disease.
My mom too. The depression is worse. May God heal them.
My mom also suffering from this disease since an year it horrible not understanding what to do and where to take her for better treatment condition is getting worst day by day infront my eyes but not able to do anything...
Exactly useful information thanks alot
Most useful information
My father had Amyotrophic lateral sclerosis (ALS) . He survived only for 1 year after the diagnosis of disease. 😢
Symptoms pls?
Sorry for that 😮💨🙏
@@factsinshorts9653 full paralysis,
Im sorry for your loss 😔 hopefully you don't inherit it 🙏
@@JahoSelamaj Aameen.. Hopefully..plzz pray for us.
My uncle just diagnosed this disease, his muscles become weak, both of his hands are affected. The dr told me, no cure for this disease, He can’t even hold utensils. Really sad for him, no one look after my uncle his condition is getting worse. Good thing i have lot of time to accompany him for chek up.
Sorry to hear mate my good friend also just had this said to him 2days ago which country are u inn?
Ami nije ei pesent lala jhore all taim likuid chamoch kore khai haph bar hoi majhe golai atke jai kosto hoi dom nite।kotha joriye jai।phijiyo theraphi kori।valo hobar medisin ache।jodi Janan to gretful hoi।
What happened is your uncle ok now ?????
@@mohtesibhe is dead
ALS is commonly known as Lou Gehrig’s disease, after the baseball player whose diagnosis and eventual death brought wide public attention to the illness.
Good information
Thank you
You are wonderful
Have you looked into the Deanna Protocol? The father (surgeon) came up with the supplements to help his daughter, who has ALS
My first dear girl friend died from this. It's so depressing!
I suggest making a video about polio
Make a video on height growing
I have mmn. And my treatment dedicated help me to lead a normal life. I've been diagnosis 12 yrs ago
How did you manage it ,thank God you survived
How did you managed it please reply my husband also suffered MNd problem please reply
@@Parvathi6876I hope your husband heals
May we know ,how to survived the MND my friend diagnosed. Please can u tell us , 🙏🥺🥺
My father in law is also suffering from this disease now after three years he is unable to move muscles and speech properly.
Good video. However, along with physiotherapy, it is important to consider the root cause of Motor Neuron Diseases. Various studies have revealed that during motor neuron disease due to progressive degeneration of brain cells; a person gradually loses his ability to coordinate, walk, eat and maintain the right posture balance. Along with physiotherapy, it has been suggested that stem cell therapy can be an effective solution to promote brain cells in the body, delay the loss of functional cells, and initiate an anti-inflammatory response to manage functional attributes of the muscles.
My wife is suffering the MND,she was suffering speaking and swallowing the food in its first stage itself,but she is frequently demanding food,and eating several time a day itself.All treatment has completed,but no result.Her health is losing everyday even after such hug food.
Pls call Jesus Christ this is the only way to survive
Have you tried ayurveda...
Patanjali has claimed they have cured patients with motor neuron disease
Cảm ơn bạn đã chia sẻ thông tin, rất vui được kết nối với bạn😍😍😍💥💥💥💥💥💥🔥🔥🔥
Maintain quality of life? You got to be kidding me
My husband cure from this disease thank you God
How mam..can you please tell me
Please tell us what you did for him .... Radhey radhey 🙏🏼
Pray for my grandfather pls 🙏
Unfortunately there is no cure at the moment 😢 its a long painful journey all one can do is mange the disease as far and as long as possible and make the patient comfortable.
Correction: cortico bulbar and cortico spinal are the umn's and not the lmn's 0:42
Those are names of tracts, which include both upper and lower neurons
What the solution please tell me
My grandpa had this disease and he passed away because of it
0:25,1:08,1:30,1:36,2:32,2:58,3:28,4:27
My Father Have also MND an year
My mother passed away two days before ...her suffering came to an end ..she was 28 to 30 kg while passed away ..what kind of disease is this ? Beg all researchers pls find at least medicine for this mnd ...deadly disease....may her soul rest and peace ...,😭😭😭😭
Sorry to hear about your loss brother.
Sorry for your loss brother.
Why there is spasticity of lower limbs muscles while flaccid paralysis of UL muscles in ALS??
Because both lower and upper neurons are damaged in ALS, each set of symptoms is characteristic of either upper or lower neuron disease. See at 1:08
My father was also suffering from this disease but i lost him in January 😭😭😭
My mother is affected in this disease.her left lef should not working
Plz help is there any treatment for this disease
My sister is also suffering from this disease her legs are not working
We are treating her from patanjali wellness centre they have claimed that they have cured motor neuron disease patients
My father passed away with this disease its awful may Allah forgive us
Why would Allah forgive?
Allah yr7mo
allah 😂 grow up
Stephen Hawking 😔
I want to medicine of this disies
Im 47 yr old. I have too. What should ido? Pls help me
I have motor neuron disease it's not fun it hurts it's even hard to sleep
I'm so sorry.Where do u hurt?
My mom's sick with that.
Is there no cure for this disease? 😭
Apparently a cure hasn’t yet been found
People have reversed ms on an all meat diet. Haven’t found any stories yet about mn but still searching.
@@MG-dr5mf We hope they will reach the drug asap
@@annastyles5783 We hope they will reach the drug asap
Where r u from ,?
Just want to say I lost my mum 😢 to mnd
🙏🙏🙏🙏🌹💕
😂😊
Any reference where we can get supportive treatment for this disease?
MND is a vata disease, we have got very good results from Nadi Chikitsa. This is a cheap and effective therapy, changes have to be made in the diet and routine of the patient, many patients are cured here, please consult a qualified Marm medical expert, if you want, you can also mail me, there is no charge, My aim is that my advice may improve someone's life
@@dhanwantarineurocare9189 hi can you please share with me details
Mail your query with complete symptoms
@@dhanwantarineurocare9189 can I please have your mail id
@@dhanwantarineurocare9189 hi please send me your contact
We lost our dad 18 years this month. Only seems like yesterday 😢 if there is a God then why does he take good people...................
Why is it when famous people get it then its top of the engender. My dad worked all his life. Then one day he started tripping over his own feet. He eas gone after 18 months 😢
My full body muscle twitching. It's MND disease s iam 39 years . .my right side waist pain and back side a pain one type of burn.
. Gastric problems also.pls reply me
Hello my brother has been suffering this disease for an year he became weak day by day,as doctor said there is no medicine for these disease😢😢😢😢😢😢
MND is a vata disease, we have got very good results from Nadi Chikitsa. This is a cheap and effective therapy, changes have to be made in the diet and routine of the patient, many patients are cured here, please consult a qualified Marm medical expert, if you want, you can also mail me, there is no charge, My aim is that my advice may improve someone's life
@@dhanwantarineurocare9189 how can I contact u bro plz
You can also check for patanjali and some ayurvedic centres of Kerala
For mnd
My sister is suffering from mnd we are treating her at patanjali
@@dhanwantarineurocare9189 please share me the details pls
just a question (also its pretty dumb cuz im very bad at this stuff) can we technically donate motor neurons?
Not as of yet, the technology isn't there.
My father died bcoz of this disease 😭😭😭😭
So That’s what Stephen Hawking had Diagnosed
এই রোগের চিকিৎসা কি?
এই রোগের কোন চিকিৎসা নাই
Jesus Christ is only way to escape MND disease pls go and prayer to Jesus Christ Amen
I m also playing for my mom
And all mdn patients
I believe Jesus Christ give back my mom
Raj
Who else is thinking of Stephen Hawking?
V knl
OMG, this is horrible.
medicine is a joke in most conditions.