TBP is a placeholder to direct the polymerase recruitment by associating with TAFs. It seems like evolution decided - for unknown reason - to incorporate TBP for cooperative binding and promoter recognition in SL1 without using its TATA affinity. Great question but there is no proper answer to your question 😅
In a way yes - if you argue that both Core and UPE are necessary. But some articles argue that UPE is not always necessary - so that means it is not necessarily always a bipartite promoter.
This is such a good video, thank you so much!!
Sir, I am a great fan of your videos .
I have request. Can you please make a video on rRNA processing including ETS and ITS removal and other details
thank you!!!
Holy mother of space cows!!! This was awesome!!!
A great video...
Where is video for polymerase iii initiation?
On my list of videos to make :) I will get to it soon.
The video on RNA Pol III is live now :)
What is the point of SL1 having TBPs if RNA Pol I doesn't utilize a TATA box?
TBP is a placeholder to direct the polymerase recruitment by associating with TAFs. It seems like evolution decided - for unknown reason - to incorporate TBP for cooperative binding and promoter recognition in SL1 without using its TATA affinity. Great question but there is no proper answer to your question 😅
Is poly 1 promoter is bipartite???
In a way yes - if you argue that both Core and UPE are necessary. But some articles argue that UPE is not always necessary - so that means it is not necessarily always a bipartite promoter.
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