IMMUNE SYSTEM MADE EASY- IMMUNOLOGY INNATE AND ADAPTIVE IMMUNITY SIMPLE ANIMATION
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- เผยแพร่เมื่อ 3 พ.ค. 2024
- The immune system is the basic defence system of the body that protects us from harmful pathogens and diseases.
GERM INFECTED PLACES YOU TOUCH EVERY DAY : • Top 10 GERM INFECTED A...
The immune system consists of various types of cells and different proteins that kill the harmful invading micro-organisms and protect our body from disease.
In this video we will discuss about the human immune system. What is the basic structure of the Human Immune system and how it functions
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Pathogens can rapidly evolve and adapt, and thereby avoid detection and neutralization by the immune system; however, multiple defense mechanisms have also evolved to recognize and neutralize pathogens. Even simple unicellular organisms such as bacteria possess a rudimentary immune system in the form of enzymes that protect against bacteriophage infections. Other basic immune mechanisms evolved in ancient eukaryotes and remain in their modern descendants, such as plants and invertebrates. These mechanisms include phagocytosis, antimicrobial peptides called defensins, and the complement system. Jawed vertebrates, including humans, have even more sophisticated defense mechanisms,[1including the ability to adapt over time to recognize specific pathogens more efficiently. Adaptive (or acquired) immunity creates immunological memory after an initial response to a specific pathogen, leading to an enhanced response to subsequent encounters with that same pathogen. This process of acquired immunity is the basis of vaccination.
The immune system protects organisms from infection with layered defenses of increasing specificity. In simple terms, physical barriers prevent pathogens such as bacteria and viruses from entering the organism. If a pathogen breaches these barriers, the innate immune system provides an immediate, but non-specific response. Innate immune systems are found in all plants and animals. If pathogens successfully evade the innate response, vertebrates possess a second layer of protection, the adaptive immune system, which is activated by the innate response. Here, the immune system adapts its response during an infection to improve its recognition of the pathogen. This improved response is then retained after the pathogen has been eliminated, in the form of an immunological memory, and allows the adaptive immune system to mount faster and stronger attacks each time this pathogen is encountered.
The complement system is a biochemical cascade that attacks the surfaces of foreign cells. It contains over 20 different proteins and is named for its ability to "complement" the killing of pathogens by antibodies. Complement is the major humoral component of the innate immune response. Many species have complement systems, including non-mammals like plants, fish, and some invertebrates.[33]
In humans, this response is activated by complement binding to antibodies that have attached to these microbes or the binding of complement proteins to carbohydrates on the surfaces of microbes. This recognition signal triggers a rapid killing response.[55] The speed of the response is a result of signal amplification that occurs after sequential proteolytic activation of complement molecules, which are also proteases. After complement proteins initially bind to the microbe, they activate their protease activity, which in turn activates other complement proteases, and so on. This produces a catalytic cascade that amplifies the initial signal by controlled positive feedback.[56] The cascade results in the production of peptides that attract immune cells, increase vascular permeability, and opsonize (coat) the surface of a pathogen, marking it for destruction. This deposition of complement can also kill cells directly by disrupting their plasma membrane
2:22 Barrier
5:16 Innate
7:03 Cells of innate
15:12 Complement
16:36 Adaptive
22:21 Innate vs Adaptive
Thanks 👍
Thank you
2:22 Barrier
5:16 Innate
7:03 Cells of innate
15:12 Complement
16:36 Adaptive
22:21 Innate vs Adaptive
25:09 THE END
Thanx brother may God help u always
Fantastic lectures
I can only imagine the hard work and time invested in each video by this dude. Those who disliked this video have no morality I think.
He is good, try Dr. Najeeb he has at lest 10 lectures each one is 60 minutes, explaining the immune system of a human being, but these lectures for MD doctors.
no, no don't take it personaly. If youtube suggests you a video you are not interested in, by disliking you help the algorithm understand what you prefer to have suggested.
@@apostolismoschopoulos1876 when TH-cam suggests videos you can tick, not interested. Depends if you are on an app or browser.
Disliking a video will directly impact the channel
@@wolfduranti8735 thanks dear! Anyone with a brain who puts in the work can learn and understand! It saved my life as doctors would have killed me by now with their alleged medicines!
It's just a thought, from somebody who doesn't feel this way but can see how others could.
Firstly he portrays images of what could mainly be seen as biblical angels, at around 19:40. Maybe people dislike religion, or are not from a religion that recognises those type of images, or just don't like religion being crossed with science.
Secondly, he can't help where he's from or his accent, but due to a lot of scammer videos from people like kitboga and scammer payback etc, people associate the indian accent with bad things, and there may be far less "good" associations, that's just how people work when they're exposed to one-sided feelings like that.
Thirdly, there will always be trolls who dislike videos no matter what - I saw the most beautifully created video with over 100k likes, but it still had 3 dislikes, three. There was no way a humane person would have a single reason to dislike it, but somehow three single people out of millions of views, disliked it.
Now personally, I liked the video and gave it a thumbs up because it really helped me further understand the subject when I needed it, I'm just giving a few reasons as to why people may have disliked the video
I've watched dozens of videos that explain the immune system but I would say this is my favorite. Very good explanations of how all this works. Thanks so much!
Perfect explanation!! This helped me a lot. Please keep up the good work. You explain everything in detail and it makes understanding much more easier. Thank you so much. Really appreciate your hard work!!
Just watched this for the second time and I have to say thanks again for a lovely clear, well structured, visual introduction to this difficult to absorb subject.
Thank you so much for this wonderful explanation and the graphics and the effort you did to make this video. I was diagnosed just few days ago of missing antibodies. So this is very helpful. God bless and thanks again. ♥️
Stay Blessed Man... This is helping out a lot in these difficult times..
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For a 70 years old physician, you could make what I already know much more succinct. Thank you very much.
yo you commenting similar praises on all the immunology videos on yt
@@raahul1303 he's happy, dude. we love a positive commenter
@@isabellavazquez-muniz9250 exactlu
This guy is 70? He sounds like he's 20-30
❤I appreciate your work and dedication to detail simplified and interactive and engaging
THANK YOU SO MUCH for making this so easy and simple to understand!
For a complete layman on this topic, the amount of knowledge transfer that happened in 25 minutes was amazing!!!! Thank you from my heart.....!!!
How well u have encapsulated every point of a whole chapter from my Immunology note!!! Thank u so Much
An amazing video. Thanks for clarifying the immune system in easy to follow explanations. I thank you for creating this video to help all of us understand the immune system.
Thank you so much, this has been a huge help! Your work in this video is incredible!
Just within 20 mins, whole Immune system explained in a very Simple way...simply the Great Sir..Thanks
You made it all so simple! Seriously Ive got to appreciate your hardwork.
all credits to you my brother. Your time and hard work are appreciated.
The video covered my entire syllabus of Immunology. Just Active and Pssive immunity remained.
Thank You So Much Sir 💖
Watching in 2021. I can't imagine why even one person would dislike this insightful presentation.
lol dislike is no more
watching in 2022! Lets goooo
Thank you very much for this! I have volunteered as an EMT. Emergency Medicine. As such, we don't learn this stuff. This is very enlightening!
Thank you for making this. I appreciate it, much needed during these times.🙏💗
I love the fact he explains short but precise and clear thank you sir!
Loved this lecture.. ❤️
Happy to be a round. Got exposure to a lot of topics that i missed during classes. Please do share more important videos and restart the channel ☺️✨️
Your style keeps one interested. Time moves quickly when one presents things in such a good style.
I am only 7 minutes into the video and I already believe it is the best I've seen. I would like to point out that the very first thing that should be discussed in immunology is the fact that its defense MUST know what is "self" and what is not. Anything that is not "self", that is that it does not belong, must be destroyed. So an understanding on how the immune system decides, figures out, what is not self must be explained.
you made it easier to understand...Thank you this helped me a lot..
Your voice is so amazing! & Explanation is on point ! So helpful video! Love to listen your voice💯
voice is d reason 😂That's y I watched the whole video
Explanations are very clear cut and easy to understand. Thank you so much sir.
Much needed topic. Thank you for your great work.
I love the way you use etymology for mnemonics. It's something I wish every teacher did, knowing why a thing is called what it is called often helps with retention of its function/characteristics!
Agree entirely, excellent presentation.
I strongly agree
this is a fantastic explanation! thank you!
I am learning biology which I never liked due to complicated names and instead opted for PCM with a measure in Chemistry. Very hard work of the presenter. Keep it up.
Without a doubt, this is the best immunology video I've seen and it will be the best forever
This is an amazing video. Even for a commercial professional like me it was so easy to understand. I was jumbled in my mind with all the immunity system types and cells. After watching this video, the structure is quite clear now
Very informative and understandable. Love all the drawings to support the dialogue
Sir,
You are a natural teacher. I enjoyed your lessons and I have no biology background
So much information in one video. Has all my exam questions, thank you so much.
Nicely Explaind, Keep Going, Awesome Videos and Explanations! Thanks
since 4 days I was trying to learn this chapter ..& I found this channel on TH-cam ..first of all thank you so much for making this type of conceptual videos it helps me a lot❤
literally read hundreds of slides (and yet still don't understand) before finding this gem, thank you so much!
Thank you! I’ve watched several videos and this one was the easiest to understand!
Amazing video! Great job! And thankyou so much!
Thank you for this video! You really helped me understand each cells and its job!
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who on earth can give a thumb down to such a beautiful presentation...... best and most simplified i have ever seen
Systematic and totally non-confusing , clear presentation of the topic of innate and aquairef immunity. Thanks for brushing up of memories of very old practitioners like me.
Awesome explanation. Thank you. A person with non- medicine background could understand things really well
Ooooo
I wish you did the lectures for my Bio classes, you make it easy and clear to understand. Thank you.
Ow my god.. I'm just amazed with this great video.. I just can't believe how much this video makes the topic easier to understand.. I'm so greatful to the person making the video ❤❤❤❤❤ thank you so much.. It's tooooo good brother
Thanks so much for this thorough explanation and the dynamic animations.
An excellent explanation of the Immune System
By watching for the first time ur channel .... I was really impressed with ur lectures so that I subscribed ur channel
Thank you so much for this wonderful and helpful video!
U deserve a true standing ovation!! Salute...u made my investing in biotech immuno companies super easier :) great work! Respect!
Thank you so much for sharing ... I don’t have to open again may book to refresh myself.
*Herpes is a serious and recurring disease which can't be cured through drugs or injections by the American doctors but the best way to deal with Herpes is by taking natural herbs medicine for it and is only few American doctors that know about this herbal medicine from Dr odion.. I have read about Dr odion the great herbalist doctor from African who can cure Herpeewith his powerful herbal medicine. for the people suffering from the following diseases Hiv, Herpes, Cancer, Als,Herpatitis, Diabetes, Hpv,Infections ETC should contact him for his herbal medicine because i am a living testimony and i was cured of Herpes. Although, i sent him what he requested and he sent me his medicine which i took for two weeks and today when i went for test i was tested Herpes negative and he can also cure herpes etc you can reach him through his WhatsApp number:+2349019421176 he will help you out or email drodionherbalhome12@gmial.com.....
Youu made it super easy for me!!! after watching the entire thing i was like accha ye itta easy tha 😂 I have been ignoring these basics from a long time, I wish I had watched it earlier!! Your explanations are amazing
Awesome 😎, I’m a clinical immunologist and this video is so awesome 👏🏻 very simple and informative
The simplest way to summarise immunology 🔥 📛. Much grateful from Kenya 🇰🇪
Immune system: our body's specific response, ability to protect ourselves from any antigen foreign Invader.
-barrier immunity
-innate immunity
-adaptive immunity.
Barrier immunity 1) skin 2) respiratory system 3) gastrointestinal 4) nose and pharynx
Innate immunity: *cellular *complement
Cellular include- PMNL : neutrophils, basophil, eosinophils.
•mast cells •monocyte •dendritic / Langerhans cell (antigen presenting cells ) •natural killer cells
Adaptive immunity: cell mediated (T lymphocytes are of 2 types t-helper CD4 and cytotoxic t cell/ killer cell/ CD8 cell ) optimization: it's like a sugar coat to make it more tasty, antibodies stick to the antigen and release chemotoxins that alert nearby neutrophils and these neutrophils phagocytose the entire antigen.
Humoral immunity (B lymphocytes)
Какие продукты человек должны употреблять чтобы на организм человека больше антител CD4 и CD8 вырабатывался?
@@GRAZHDANIN.SSSR. those are not antibodies, they are simply markers associated with helper T’s vs CTL’s.
One of the best made vedio on immunology 👌
this is the best video on youtube explaining this..you are so talented thank you so much
Thanks for your great effort. it helps a lots and I love the way you explain through this video.
Thank you very much for your clear explanation..
the explanations are very clear. all terms are explain very well. good job. thanks for sharing
Thanks alot for your time and effort explaining the topic and uploading the video. Regards from Germany.
Thanks for making such a informative clip to summarize the whole immunology
This is amazing! Thank you so much!
There’s no one on hematopoiesis😭
Amazing Amazing.. The 25 minutes video is complete syllabus for many. Highly appreciated, Thank you for sharing this. Just a request, Do you have any video on autoimmune disorders.? Would be really thankful for the help
Hey I speak with a medical doctor about ways to support your system during all of this. You should check it out on my channel: FredricksonHealthSolutions
The interview is called boosting the immune system!
@@DrRobertFredrickson l just took my quercetin with zinc and ascorbic acid and took vitamin D,K2 and will take magnesium to absorb the D. I took B vitamins and eat antioxidant rich plant foods. Prevention is best!
@@shantinaturechild6385 love your healthy habits!
TH1 & TH2 Balance and Autoimmunity
“It is dangerously misleading to say that vaccines make us "immune" or protect against disease, when in fact that is the exact opposite of the truth. Vaccines only drive disease deeper and cause us to harbor it chronically (causing autoimmune disease).” - Dr. Richard Moscowitz, MD
A balance of Th1/Th2 cells in the body is defined as immunostasis (or immune balance) and is required for optimum health and wellness. Vaccines promote a failure in immunostasis by making the Th2-type cells dominant.
In Natural Immunity, for example exposure Measles; Th1 response externalises the infection and provides permanent immunity.
In Vaccine-Induced Immunity, Th2 response internalises the infection because the Immune System was forced into an emergency -based Th2 response and results in poor immune memory. Thus regular vaccine boosters are required throughout life.
T cells (thymus cells) are the major cell in the immune system; they direct and control all immune responses as well as immune memory. Subsets of T cells are the T-helper cells (Th). T-helper cells coordinate and direct the safest and most effective immune response. Using Moskowitz’s measles example, we know that, when infected with the measles virus naturally via the nasopharyngeal route, the body produces a Th1 response that externalizes the infection and provides permanent immunity. Fever, rash, coughing, sneezing, etc are signs of the body ridding itself of this infection. Bypassing the normal body lines of defense by injecting a vaccine forces the immune system into an emergency-based Th2 response which serves to internalize the infection. You don’t get the disease but are susceptible to the disease later since the Th2 response results in poor immune memory. So, if a natural, viral (measles) infection results in a Th1 response, why don’t we make vaccines that could elicit the same response.
Adjuvants are often employed to enhance the development of an efficacious specific response. The problem lies within what type of immune response is happening. TH1 is the cell-mediated immune response that happens after naturally acquiring an infection, and then TH2 humoral kicks in with antibodies and ensures immunity, but, they work in tandom. Vaccination uses adjuvants to stimulate a TH2 response, bypassing the TH1, which puts the immune system into a perpetual state of confusion. This can kick in Autoimmunity for predisposed individuals (See the medical textbook “Vaccines and Autoimmunity” by world renowned immunologist Dr. Yehuda Shoenfeld MD).
The vaccination process itself destroys immune capacity by overstimulating the humoral TH2 immune response while never engaging the cell-mediated TH1 immune response. The immune system then stays in a state of agitation, which leads to all sorts of chronic health problems, injury and death. And, never confers immunity (e.g., booster shots are required to create more antibodies - the only measurement of "vaccine effectiveness"). On the other hand, when a child naturally gets an infection a proper TH1 immune response occurs, and then TH2 kicks in, tags the antigens with antibodies and we now have immunity. No need for booster shots.
"What people don't know about vaccines - what most doctors don't know - but well demonstrated in medical literature, is that vaccines shift your immune system to an immune suppression type of state called the "TH2 shift." That's what most vaccines do. They shift your immune system to a weaker, antibody type immune system... If you're injecting people with so many vaccines that your keeping them in this constant state - that now your switching everyone to this TH2 immune suppression - then everyone becomes more susceptible [to infectious diseases]... and no one is talking about that. Now, a lot of scientists know that, but they are afraid to speak out because their careers would be ruined." - Dr. Russell Blaylock M.D. Neurosurgeon
The Th1/Th2 balance in autoimmunity.
www.ncbi.nlm.nih.gov/m/pubmed/8679122/
Th1 and Th2 lymphocytes in autoimmune disease.
www.ncbi.nlm.nih.gov/m/pubmed/15952931/
Another explanation:
"Bypassing the mucosal aspect of the immune system by directly injecting organisms into the body leads to a corruption in the immune system itself where IgA (Immunoglobulin A) is transmitted into IgE (Immunoglobulin E), and/or the B cells are hyperactivated to produce pathological amounts of self-tracking antibody as well as suppression of cytotoxic T cells ‘stealth adapted.’ These are formed when vaccine viruses combine with viruses from tissues used to culture them, or when bacteria lose their cell walls when a person takes antibiotics and transform them into ‘L forms,’ leading to a lack of some critical antigens normally recognized by the cellular immune system.
The mechanism by which the immune system is corrupted can best be realized when you understand that the two poles of the immune system (the cellular and humoral mechanisms) have a reciprocal relationship in that when the activity of one pole is increased, the other must decrease. Thus, when one is stimulated, the other is inhibited. Since vaccines activate the B cells to secret antibody, the cytotoxic (killer) T cells are subsequently suppressed. In fact, the ‘prevention’ of a disease via vaccination is, in reality, an inability to expel organisms due to the suppression of the cell-mediated response.
Thus, rather than preventing disease, the disease is actually prevented from ever being resolved. Thus, the autoimmune disease you develop is determined by which tissues in the body are attacked by auto-antibodies. If the inside lining of the gastrointestinal tract (the mucosa) is attacked by auto-antibodies, you can develop leaky gut syndrome. Crohn’s disease and colitis are also caused by auto-antibody attack of the GI tract itself. If the islet (insulin producing) cells of the pancreas are attacked by auto-antibodies, you develop insulin dependent (juvenile) diabetes.
If the respiratory mucosa is attacked by auto-antibodies, you develop ‘leaky lung’ syndrome where, just as with leaky gut, antigens recognized as foreign to the body which are inhaled are unable to traverse the lining of the respiratory tract, causing the creation of antibodies against those antigens (usually dust, mold, pet or pollen antigens). If the components of the articular surface of the joints are attacked by auto-antibodies, you develop rheumatoid (or juvenile) arthritis. If the kidney tissue is attacked by auto-antibodies, you develop one of the many types of nephritis.
If you develop auto-antibodies against the very DNA in the nucleus of all cells, you develop systemic Lupus (thus, the autoimmune potential of DNA vaccines being developed now is self-evident: worse yet, DNA components from these vaccines can be incorporated into your DNA, leading to actual genetic changes which could cause extinction of all vaccinated life on the Earth). And on and on and on.
The brain and spinal chord can also be attacked with auto-antibodies (vaccine induced encephalitis), leading to a variety of neurological diseases. The most severe of these, leading to death, are sudden infant death syndrome (SIDS) and most cases of ‘shaken baby syndrome.’
If components of the myelin sheath (the insulating covering of nerve fibers which allows proper nerve conduction) or the actual neurofilaments themselves are attacked by auto-antibodies, the resultant condition is determined solely by the location of the damage done. Such neurological conditions include but are not limited to minimal brain dysfunction, ADD/ADHD, learning disabilities, mental retardation, criminal behavior, the spectrum of pervasive developmental disorders (including autism), multiple sclerosis, Parkinson’s disease, Lou Gehrig’s disease, Guillain-Barré, and seizure disorders." - Rebecca Carley, MD
@@thor4164 Wow. Most grateful for this elaborate explanation. Very relevant in the current context.
Can't thank you enough!! Your one video is enough for me to learn concepts...even mugging up is not needed after watching your explanations!!!!!
You explained it really well. Thanks a lot.
You can always and literally always count on Indian teachers for explaining complicated topics to be way easier than ever thanks you you and every indian teacher and all teachers who work hard just to show the ease of learning ❤❤
Thanks a ton. Glad u liked it
Very cute animations :) Learned more about the cells in our innate system today~
Thankk you so much
Best explanation ever!!! I finally understood this topic.
Very detailed and easy to understand. Very helpful ❤️ I also appreciate your drawing and hand written its beautiful 🌸
Cell Of duty : Immunity Warface
Can't get over how beautiful the artist drawing.
bro sorry to break it to you but he didnt draw it, it says animated in the title
It is whiteboard animation
This was the best explanation. Thank you!
You are so good at explaining how thank you🙏🏽
The best and the easy explanation anybody can give on this issue
Hello, I believe teaching is an art and you are artist for sure!
Thank you,
Excellent. Good job and thank you so much for the beautiful video
You do a lot of hardwork that should be appreciated thanks ❤
Excellent explanation - thanks! Where can the handouts you mentioned be found?
A little late but in the description!
@@kxkxsxi6305 It's not clearly marked but I think you have to click on the Patreon link: "Join our Community at Patreon and get Awesome Rewards : www.patreon.com/medsimplfied". To get the handouts you have to pay a monthly subscription - definitely worth it if you can afford it!
4:35 SH*T
Pssst keep up the good work your doing great
Thank you so much sir!!!
This lecture was of great help to me 🙏
you saved my life omgggg
thank you so much!!!!
This channel is like life saver😅👍
BASICS.🤗
Good and inormative for the basics and till 10th class(though basics r for evry1).
Dnt watch it if u came for deep knowledge of immune like markers activation blah blah blah.Still I loved every bit of it good for BASICS
You have saved me today, you have made me ready for physiology tutorials about body immune system
this was amazing. Thank u a million brother
Thank you so much sir...👍
You are welcome😃😃
Wow, detailed and entertainin.
I can not thank you enough for your increndible opsonization explaining, in addition to your clear accent and fluent English
So glad i was able to help
This is fantastic & equally fantastic presentation Sir. Thankyou so very much. Liked & Subscribed! GOD bless you
thank you, spectacular lectute
That's really helpful 🌹🌹🌹🌹🌹🌹🌹 thank you so much
You are welcome
very clear. thank you. you guys making youtube a real strength.
Wow!! Thank you for an incredible lecture and video. It’s true to its name MEDSIMPLIFIED!! I will buy a T-shirt of medsimplified to support it and advertise it. Thank you!!
That unhappy microbe at 4:36 minutes made me smile 😁
lmao fax
You know how gollum felt after finding the ring...my exact feelings about your channel ( in a non- psycho way)...this channel and the narrator is precious😅😍
Omgg. That made my day.😁
Great job. Thank you for this lecture
Thank you for sharing information. It was so easy to understand.