This is the best video on complement I have seen. I'm not an immunologist or even a student. Just a librarian who is fascinated by the immune system. Thanks!
@@fidelkipkoech5555 I've always said, I'll stop learning maybe, just maybe three days after I'm dead. ;) No reason to not study various things, as knowledge is power. Back when I was in the Army (retired in 2010), I ran into not one, but two cases of pheochromocytoma. One was recognized late, the soldier was to begin treatment after field training, but expired from a ruptured AAA. The other, I pieced together what was going on, asked doctor to do me a favor and run a couple extra tests and there it was, he had pheochromocytoma. His problem was quickly addressed and he returned to duty. So, that trivia can and does save lives. Diagnosing things, just Boolean flow really. I do Boolean algebra and regular expressions in my head as part of my job. :) Annoyingly, basic math tends to give me trouble, but that's what calculators or if I had to, fall back to a slide rule is for.
couldn't agree more- coming from a physician/scientist who's heard many (attempted) explanations of complement systems. this is pure gold. never heard such a clear cut explanation
This and similar courses makes things a lot easier to recognize hydrophobic parts and lipophilic parts of some carbon chains. That helps me understand some odd points in the pharmacology of some medications.
Hey, really like your videos, especially the ones where you debunk conspiracy theories. I recently saw something about Tesla's radiance energy curcuit. It is suggestet that this would be able to supply everybody with free energy but companies dont want us to know about it because we should pay for their energy. Maybe that could be a video idea. Keep on the great work!
The fact that analogues to the complement system are found in mosquitos suggests that it predates the protostome-deuterostome split, about 600 million years ago. Yeah, that's old.
I think he'd have to hire an editor fulltime to do that. TH-cam stopped submitted captions from being a thing for some reason, too, so it's not like us fans can help out.
Dave ! Help me there is this community that does "reality shifting" and I want to know what are they experiencing ? Why people say that they "shifted of reality" ?
Professor Dave, I am an MS1(first year medical student) and my first block includes immunology. I wanted to say your videos including this complement protein video are more concise than the lectures from my immunology professor. Thank you!
I'm so glad that you're making these lectures. I considered months ago that the US population (from high school and up) needs to learn how the immune system works. If we know how the immune system works then we will all understand and agree on something like a vaccine. Thank you for spreading this information.
Indeed, the problems with COVID seems to be that leukocytes are being infected, interfering with their response, while innate responses are also being blunted. By the time the immune system notices that the infection was unaddressed, it went into scorched earth mode (to oversimplify it by a lot) and that's the cytokine storm of COVID-19 and the Spanish Flu.
you don't know how much you helped me understand this topic. i was on the verge of crying going through our readings but this video really clarified a lot of things (for some reason it seemed like our lecturers were also speaking a whole different language while teaching this). thank you so much!
Hey professor dave, I’m having some problems with family members of mine believing flat earth. I think It would be really helpful for a lot of people if you could make a video explaining the most obvious rebuttals without using condescending language. Anyone who thinks the earth is flat would immediately click off any of your past video’s when you call flat earthers stupid. Obviously they are, but they don’t know that, i feel that if you really want to change peoples minds on it you should make a video targeting that demographic, ie people who struggle with thinking logically. I’d love to have a video to send to my family that is dumbed down enough for them to understand and actually tries to get through to them without calling them stupid. Just pretend a 9 year old asked you if the earth was round or flat and how do we know.
With a couple of hundred bucks, you can get a microwave antenna and receiver and receive the GOES satellite feeds directly. There are videos on youtube on what all you need to do and it's not all that difficult if you can turn a screwdriver. Then, ask how the satellite is hanging up there in precisely the same way that a brick won't and they're a hell of a lot heavier than a brick.
This is really excellent. Also the speed at which you speak is perfect for people who are trying to understand something, other videos I have to pause and re listen because they’re talking too fast, but this is perfect!
This was the best video I have ever watched about Complement system. Only someone who have left a few minutes left to cover this topic knows how fantastic this work is. Thank you Prof Dave.
I am a licensed medical technologist and I'm studying for my second license this coming October. Complement system always ALWAYS aggravate the shit out of me. This lecture gave me atleast an idea what to remember 😅
@Professor Dave Explains, I have come to purchase your book through my enjoyment of your TH-cam content. I must say that I find it very insightful, succint and a refreshing read overall. I look forward to more from you, as you definitely posess great talent. P.S.: on page 18 there is a helium atom representation with the subtext implying that it is in colour, when in fact at least my edition is grayscale. Just a (hopefully) helpful note.
Thank you so much for this. In my role as a medical writer, I have been doing some programs on paroxysmal nocturnal hematoglobinuria, which is a disease of the complement cascade. This clearly explained a lot of the things I was confused about.
Protectin prevents C9 penetrating the membrane and eliminating host cells. This is good, however would this not prevent the elimination of virus-infected host cells?
I have a question… Are you anti religion? Since quite a few religious stories contradict science, Do you think religion is stupid and/or are you against it? I’m not trying to accuse you of anything, I’m just asking
This has been really helpful. I've been struggling to understand the complement cascade but with how you've laid everything out, I'm subliming.. .. Thank you so much
Professor dave I learned a lot from this video, but I have just one question. I know that there are a variety of proteins that regulate the complement system. Some of these proteins like C1 inhibitors displace and inactivate many proteins. however, Do any bacteria produce these proteins as a defense mechanism
This is the best video on complement I have seen. I'm not an immunologist or even a student. Just a librarian who is fascinated by the immune system. Thanks!
Wow! You've inspired me...I'm a medical student and find this stuff boring yet you're not even a student but study immunology voluntarily, congrats
@@fidelkipkoech5555 I've always said, I'll stop learning maybe, just maybe three days after I'm dead. ;)
No reason to not study various things, as knowledge is power.
Back when I was in the Army (retired in 2010), I ran into not one, but two cases of pheochromocytoma. One was recognized late, the soldier was to begin treatment after field training, but expired from a ruptured AAA. The other, I pieced together what was going on, asked doctor to do me a favor and run a couple extra tests and there it was, he had pheochromocytoma. His problem was quickly addressed and he returned to duty. So, that trivia can and does save lives. Diagnosing things, just Boolean flow really.
I do Boolean algebra and regular expressions in my head as part of my job. :)
Annoyingly, basic math tends to give me trouble, but that's what calculators or if I had to, fall back to a slide rule is for.
@@fidelkipkoech5555 same this is the class I’m hating the most so far but I think it’s mostly bc my prof is absolutely awful
Beautiful ❤
couldn't agree more- coming from a physician/scientist who's heard many (attempted) explanations of complement systems. this is pure gold. never heard such a clear cut explanation
Just on time for my quiz on this topic!
I have an immunology test next week for my first year of grad school--this has been SO much more helpful than anything my professor has said!
This makes re-reading my immunology textbook nearly painless. Lovely stuff you have.
This and similar courses makes things a lot easier to recognize hydrophobic parts and lipophilic parts of some carbon chains. That helps me understand some odd points in the pharmacology of some medications.
Saw so many videos.. But finally got clarity in this one
Excellent explanation, sir..
You're a God send
Just the best I heard about the compliment system , long live
Hey, really like your videos, especially the ones where you debunk conspiracy theories. I recently saw something about Tesla's radiance energy curcuit. It is suggestet that this would be able to supply everybody with free energy but companies dont want us to know about it because we should pay for their energy. Maybe that could be a video idea. Keep on the great work!
This is amazing. Thank youuuu 😍❤❤
Can't thank you enough..🙏🏼
Thanks
better than my uni lectures!!
Awesome video 👌
thank you
Thank you so much for the explanation!
So currently, 12/10/2022 has C4b2b been officially adopted and is now officially used or is C4b2a debatable?? Prof please?🙏🙏
How can I answer a question asking ,describe the compliment system cascade
Best video ever
Regarding the history - they knew about bacteria before Pasteur and Koch? That timeline didn’t sound right
Thank you sir🙏
I have exam next week
But now I feel like it's so easy for me
Thank you so much professor Dave 🙏🏻🥲
Thank you❤
TL;DR - "... It's complicated." And not at all helped by historic naming conventions.
When do we get to C3d, though?
great job!!!
The fact that analogues to the complement system are found in mosquitos suggests that it predates the protostome-deuterostome split, about 600 million years ago. Yeah, that's old.
Can you make your videos available for subtitles in all languages?
Unfortunately one must input the subtitles manually.
I think he'd have to hire an editor fulltime to do that. TH-cam stopped submitted captions from being a thing for some reason, too, so it's not like us fans can help out.
Autotranslated subtitles work fine for me.
Sir, ppt available?
Thank you Science Jesus, very cool
Dave ! Help me there is this community that does "reality shifting" and I want to know what are they experiencing ? Why people say that they "shifted of reality" ?
1:50 Sea squirts aren't invertebrates, they're chordates. Just saying.
Sorry, chordates aren't necessarily vertebrates. Posted too quick.
Where do you see a vertebral column in a sea squirt ?
I have exam tomorrow, and idk why I can't memorize shit
I am from Hindi medium 😳🤔
hehe, he said cleavage. funi.
happy teachers day from the philippines hahaha
How am I supposed to memorize all of this?
it’s FAR better than those long azz med school lectures… mine is literally 100 slides
Professor Dave, I am an MS1(first year medical student) and my first block includes immunology. I wanted to say your videos including this complement protein video are more concise than the lectures from my immunology professor. Thank you!
nibba you didn't have to say anything other than 'first year med'. MS1😵💫
Same
It's strange how Years of crazy cramming could be resolved one simple vedio.. you did a great job here.
I'm so glad that you're making these lectures. I considered months ago that the US population (from high school and up) needs to learn how the immune system works. If we know how the immune system works then we will all understand and agree on something like a vaccine. Thank you for spreading this information.
Indeed, the problems with COVID seems to be that leukocytes are being infected, interfering with their response, while innate responses are also being blunted. By the time the immune system notices that the infection was unaddressed, it went into scorched earth mode (to oversimplify it by a lot) and that's the cytokine storm of COVID-19 and the Spanish Flu.
You are so spot on! If more people understood immunology, we would haver far fewer ridiculous conspiracy lies circulating about vaccines!
I really don't know how my Med School would be without you sir 😭🙏❤️🔥. A Big thanks to you for making my life easy
شرح جميل لدرس معقد جدا
Hey Professor, I understand almost everything you explain so please start makin videos about music theory and all. You're the best teacher ever.
He knows alot about the SCIENCE stuff, unfortunately music theory is not a science.
you don't know how much you helped me understand this topic. i was on the verge of crying going through our readings but this video really clarified a lot of things (for some reason it seemed like our lecturers were also speaking a whole different language while teaching this). thank you so much!
Hey professor dave, I’m having some problems with family members of mine believing flat earth. I think It would be really helpful for a lot of people if you could make a video explaining the most obvious rebuttals without using condescending language. Anyone who thinks the earth is flat would immediately click off any of your past video’s when you call flat earthers stupid. Obviously they are, but they don’t know that, i feel that if you really want to change peoples minds on it you should make a video targeting that demographic, ie people who struggle with thinking logically. I’d love to have a video to send to my family that is dumbed down enough for them to understand and actually tries to get through to them without calling them stupid. Just pretend a 9 year old asked you if the earth was round or flat and how do we know.
With a couple of hundred bucks, you can get a microwave antenna and receiver and receive the GOES satellite feeds directly. There are videos on youtube on what all you need to do and it's not all that difficult if you can turn a screwdriver.
Then, ask how the satellite is hanging up there in precisely the same way that a brick won't and they're a hell of a lot heavier than a brick.
I feel like there's no convincing flat earthers - their view point is so irrational you can't easily convince them with logic
This is really excellent. Also the speed at which you speak is perfect for people who are trying to understand something, other videos I have to pause and re listen because they’re talking too fast, but this is perfect!
Your videos are so helpful to me, thank you🙏🏻
This was the best video I have ever watched about Complement system. Only someone who have left a few minutes left to cover this topic knows how fantastic this work is. Thank you Prof Dave.
Thank you so so so much! Amazing explanation and illustration! Thank you for your effort.
I am a licensed medical technologist and I'm studying for my second license this coming October. Complement system always ALWAYS aggravate the shit out of me. This lecture gave me atleast an idea what to remember 😅
@Professor Dave Explains, I have come to purchase your book through my enjoyment of your TH-cam content. I must say that I find it very insightful, succint and a refreshing read overall. I look forward to more from you, as you definitely posess great talent.
P.S.: on page 18 there is a helium atom representation with the subtext implying that it is in colour, when in fact at least my edition is grayscale. Just a (hopefully) helpful note.
Very detailed and direct illustration and description. Learn more from these lectures. Thanks a lot.
in class and on our powerpoints, it says Cb4 and C2b joins together to make C4b2b (in lectin and classical)... did it change or...?
Very comprehensive with just enough detail for competence but not too overwhelming!
Save my life!!! Thank you!!!
Animal immune system are really well made... Amazing presentation!
Professor Dave.... This video is great. It helped me understand the video much better.
I really appreciate the evolutionary context. Really outs things into better perspective!
dude you just cleared the evolutionary aspect of the complement system, great job👍🏻
Hey one teeny tiny mistake that caught my eyes :- C3 convertase = C4b2a ryt? It shows 2b ( 4:37). Great video. Keep posting!!❤❤
Thank you so much for this. In my role as a medical writer, I have been doing some programs on paroxysmal nocturnal hematoglobinuria, which is a disease of the complement cascade. This clearly explained a lot of the things I was confused about.
Wow loved it
Protectin prevents C9 penetrating the membrane and eliminating host cells. This is good, however would this not prevent the elimination of virus-infected host cells?
great video
Let's play a game called "Open This Email Right Now"-you win!
Thanks, but my biology exam was a few months ago.
This 16 mins class is better than my 2hr immunologist professors lecture..👀💩
Great video but you're really fast. Maybe slow down in the next one for ease in assimilation. Again, great video
It is very helpful. thank you so much
Is there any way you can explain a bit about alzheimer and things in that way, i have it in school but i don’t really get it
WOOOO YEAAAH, BABY THAT'S WHAT I'VE BEEN WAITING FOOOOR WOOOO!
Your videoes better than faradars immunology course
Love your teaching skills to visual learners. You make studying easier 🥳🥳
I had to learn all this a long time ago. Thanks for the update.
I have a question…
Are you anti religion?
Since quite a few religious stories contradict science,
Do you think religion is stupid and/or are you against it?
I’m not trying to accuse you of anything, I’m just asking
Thanks professor Dave!
Very explicit and comprehensive.✌️👍👍
This has been really helpful. I've been struggling to understand the complement cascade but with how you've laid everything out, I'm subliming..
.. Thank you so much
really made such an intimidating topic so easy to understand! thank you Professor Dave :))
Really good!
داسوي ملخص عليك حبيبي خوش تشرح 😂💔💔
no words. simplistic way to teach complex theory with best illustrations. thank you. Best video on this topic.
Thanks...Great knowledge..
Thanks for saving me 2 hours of reading
Excellent video!! I have a better understanding of the Complement system now. I'll recommend this to my classmates to watch. 👏👏👏👏👏👏👏👏👏👏
Well done Dave! 👏🏽
Great video. I am a pharmacist trying to help my patients with Long Covid and appreciate the excellent education here.
Damn
Man just explained the gibberish in my Professor's slide perfectly.
Ready for this exam now.
Thank you so much!
Your videos are amazing, makes immunology easier, making my day😊 Thanks Professor wish u all success.
Professor dave I learned a lot from this video, but I have just one question.
I know that there are a variety of proteins that regulate the complement system. Some of these proteins like C1 inhibitors displace and inactivate many proteins.
however,
Do any bacteria produce these proteins as a defense mechanism
DIA 60 DA GREVE UFC MED TURMA 132
Can't be explained better ❤❤❤❤
I've been a subscriber since 2016. It's amazing how easy you make things seem easy for us❤❤❤ Lots of love Professor!!❤️
Thankyou thankyou sooo muchh !!!
Wow!
Very well explained. Thank you!
Really great job, thanks a lot!
Buda unatuokolea manze
Great explanation , thanks 💕
THE BEST!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!