Venki Ramakrishnan: The most promising ways to stop ageing
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- เผยแพร่เมื่อ 20 ก.ค. 2024
- Anti-aging is big business. From books encouraging diets such as intermittent fasting to cosmetic creams to combat wrinkles, a multibillion-dollar industry has been built on promises to make us live longer and look younger. But how close are we really to extending our lifespan in a way that gives us extra years of healthy life?
Nobel prizewinner Venki Ramakrishnan, a molecular biologist and former president of the UK’s Royal Society, is the latest to tackle this question. He has spent 25 years studying the ribosome, which is where our cells make proteins using the information encoded in our genes, at the MRC Laboratory of Molecular Biology in Cambridge, UK.
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Great interview! It’s fantastic to see a Nobel-Prize-winning biologist getting into this field, and coming to the conclusion that we know enough about the hallmarks of ageing to begin to intervene. I don’t have a Nobel but I came to the same conclusion when I started studying ageing biology!
Unfortunately his comments on the ethics of targeting aging biology are very disappointing. He calls it a first-world problem, even though average global life expectancy is 72 years. And he states population growth would be a problem, which you made an excellent video rebuttal on.
@@SirTenenbaum Yes, I was disappointed by those comments… When referring to it as a ‘first-world problem’, he says ‘as someone who grew up in India’-a country where almost 70% of deaths are caused by ageing! And that number is of course growing all the time as India develops. And thanks, glad you enjoyed my video!
We're not even close to any valuable conclusions!! We're in a "total mess" (and "that's all about business-driven science"!)
@@alexanderchikunov7593 Sorry to hear you’re so pessimistic. You might enjoy my book, where I go through what we do and don’t know about ageing, and where we’re close to some exciting breakthroughs. Despite some trying to cash in on the excitement around longevity, it’s definitely not all ‘business-driven’!
@@alexanderchikunov7593 At this point, with the sudden emergence of AI as a tool that is growing at an incredible rate, we really have no idea how close we are or not. AI drug discovery programs like AlphaFold 3 and ESM3 are immensely powerful and are far beyond anything we have ever seen, and will rapidly accelerate the entire R&D chain.
It’s not just living longer but being healthy longer. Many humans in world who lived over 100 but very few with good quality of life to be functional mind and body.
The last 5 minutes - Thank you!!!
Agree but not just climate change but global pollution, loss of land and fresh water to commercial mass prod’n for convenience and consumerism and need for more effective ways to cope with growing tonns of garbage and chemicals. What happened to push for recycling and reusing?
On close caption they misspelled the name of Prof. Matt Kaeberlein at the University of Washington - Healthy Aging and Longevity Research Institute.
I would take 10 years of extra healthy life but not have a longer life. I am now 76. I hope for another 10 years. I dont want any more. Ive never been afraid of death. Even at times wished for it. Have no problem accepting my own mortality.
Have great time..
Thankyou Venki,,for sharing your knowledge
True!not even a fraction of the trillions of $ poured into material sciences(non-living) is spent into understanding the living " cell",the neuron whose functions and characteristics are jealously guarded by nature and remain an enigma to modern neurology !
Great conclusive interview !! Brain storming.
Say something that makes you think. Typical Indian! So unlike real Asians.
1. Yang Chen-Ning (1922-Oct-01) is 102 years old
2. Robert Kuok (1923-Oct-06) is 101 years old
3. Jimmy Carter (1924-Oct-01) is 100 years old
4. Mahathir Mohamad (1925-Jul-10) is 99 years old
5. David Attenborough (1926-May-08) is 98 years old
6. Desmond Morris (1928-Jan-24) is 96 years old
7. James Watson (1928-Apr-06) is 96 years old
8. Li Ka-shing (1928-Jun-13) is 96 years old
9. Noam Chomsky (1928-Dec-07) is 96 years old
10. James Hong (1929-Feb-22) is 95 years old
Even Stephen Hawking lived 76.
This gentleman is a scientiest and a philosopher.
Very rude (but common!) mistake. We're NOT "living twice longer than our ancestors". Our "MEDIAN (average) lifespan" increased for the last 200 years up to 80 years - instead of 40 years in 1800s. But 90% of this increase is a result of a huge decrease of a KIDS mortality!! So, today MORE people (more %% of Population!) live up to 50 years, 60, 70, 80 and 90! They don't die in their childhood! BUT that DOESN't mean that "people live longer" today!
Does anyone know how to contact Dr. Venki Ramakrishnan? I met him in NYC recently but forgot to ask him something. TY!
Hi, did you manage to contact him? I’m searching for an email address to ask a question as well. I hope so.. Thank you in advance
Vanki, you make no mention here, or in your book of the emerging Artificial General Intelligence, and its affect on biotech and pharmaceutical developments emerging and the possible ramifications of such exponentially self evaluating and "visualizing" capabilties. You do not utter one word about it or its possible affects? Why is that? May I ask?
He did say that AlphaFold 2 was "decades ahead" of when we expected such potential to arise. But even then he just couldn't bring himself to extrapolate that out to mean enhanced human longevity within our own lifetimes.
He has yet to comment on AlphaFold 3, which is a huge improvement on AlphaFold 2, and was just released not even two weeks ago. And then there's the effect of generative AI on drug discovery as well. And AlphaFold 2 is in use by every biology lab in the world. Basically, unless you are in your 70s or 80s today and in good health, you are going to profit enormously from the changes in the field, which Venki downplays.
He was obviously blindsided by AlphaFold 2, as were most biologists. But he is still sticking to his "no increased longevity for anyone alive today" guns.
I think he's just another addition to the discussion and doesn't have any special insights over someone like, for instance, the actual head of DeepMind that invented AlphaFold, Demis Hassabis. I trust HIS analysis, which is still sober and not hyped up, a lot more than Venki's, who is saying nothing new.
You might appreciate this interview with Demis about AlphaFold 3, which is so good it can predict which drugs are going to work better than others, which AlphaFold 2 could not do: th-cam.com/video/RIrnMVDM_N8/w-d-xo.html
Because it's bullshit which will never improve upon the advice to practice moderation in all things while taking care to avoid ingesting crap in the place of real food.
M K Stalin felicitated Nobel Laureate Venkataraman Ramakrishnan. Stalin hosted a grand ceremony on the scale of celebrating Ilaya Raja, Leonel, or a politician like Velu because he had never celebrated a Nobel Laureate. Nevertheless, he wanted to appreciate science in a way never attempted in Tamil Nadu by anybody or the more knowledgeable, English-speaking J Jayalalitha.
How did Venkataraman Ramakrishnan feel when a great and popular politician whose father is Kalainar or an artist in literature or litterateur par excellence felicitated him? What was the atmosphere like? What was it like being in the august and imposing presence of one of the walking colossi of Tamil Nadu politics ever since the Dravidian revolution? Was it a proud and glorious moment when a great litterateur par excellence's son himself felicitated him? How would the Hindu newspaper describe such an electrifying moment and atmosphere? Can the Hindu newspaper tell us what hung in the air? Interestingly and intriguingly, what was the audience like? What was it like being at the center of attraction of such a unique audience who were in awe of a scientist even though they have known and seen only celebrities like Illaya Raja, Lionel, or politician Velu?
Was it a God's Gift?
I am a psychotraumatologist, in our research we see that DNA repair is highly significantly correlated to successful trauma focused psychotherapy with methods such as Narrative Exposure Therapy NET. If I were researching DNA repair, I would pull out Vincent Felitti’s ACE scale, modern version is Martin Teicher’s (Harvard) MACE scale And do a checklist intake on adversity and trauma in childhood before I research any markers that have to do with gene’s or biology. Then I would run a controlled randomised trial, comparing those that have received trauma- focussed Psychotherapy with those who haven’t. What do you think? Why suicidal ideation is related for exactly the same reason. Early childhood trauma and adversity especially changes your immune system etc… but we know that this can be reversed with successful trauma-focussed treatment, even if the body is already affected by cancer, heart disease, or other diseases such as auto-immune diseases , cancer, for example. Just let the medical world is ignorant of the impact of trauma and life stressors. many people would benefit from effective psychotherapy rather than medication
You can mimic fasting with avoiding methionine in diet
Can humanity survive the next ice age? If we cannot, then does a healthy human lifespan really matter?
The ending is about psychological ageing which is a socio cultural creation and thus can be debunked otherwise Vvvenky is fine with his Statins. Age is just a number which you can decide. My mantra is always be careful of what you put inside and give less work to your stomach and spend what you collect. Right Venky.
He really should have stayed away from the moralizing, as we already have about 3,000 years of that and don't need any more. And yes, just because he owns the fact that he is a hypocrite by taking a statin doesn't make him less of a hypocrite!
Just tell us about the science, leave your personal philosophy out of it.
@25min: I've observed the same - people are not wiser at 70 than at 40. Good discussion, but title is hype.
Most titles on social media incl YT are similar now.
Depends greatly on the person, I've observed.
If this is the only problem we're concerned about..a la bonne heure...😮🤣🙄
Here i am broke and jobless looking for ways to self epstein..
to go soon and painlessly.. make that possible.
Alas, the afterlife and the ghosts exist, they say the bad karma one accrues for self Epstein-ing takes a long time to erode.
And so, i am stuck here, i dont fear ageing, i laughed at it, now i smile. Everything is as it should be.
Dont do it mate.
Don't give up please. You write beautifully. There is positivity in you. May you be happier and healthier.
A very narrow-minded and biased view of ageing. Glad I saw that interview as I was considering buying his book. No need to.
The same stuff we've already heard a thousand times from other people. Including the inevitable moralizing.
I want to buy the product you sell. It should be more effective in stopping aging
@@utpalsa That's the point. We're not selling anything, but he is. His book. But it just appears to be a reiteration of things we already know, and his interviews are just a reiteration of things we already know.
Products that slow or stop aging will only come from well-funded R&D departments. Nobody is claiming otherwise.
So I don't need to hear the 100th person say "eat well, exercise, be social, have a positive attitude" and then go into moral issues, also for the 100th time.
Go ahead Venki 😂
I cancelled my order for his latest book when, at nearly the end of the interview, he revealed his allegiance to woke ideology. What a shame.
Sorry but you cant stop aging. You can take steps to wsrd off the worst ravages like healthy eating and exercise but then a car knocks you flying off your bicycle and hey presto 20 yrs later a tilted pelvis and arthritis.
Its ok if you are wealthy enough to pay for physio. (Ive never yet met an alternative practitioner that does any more than basic physio. They just charge twice as much.)
Exactly and this waffler isn't helping himself by necking statins.😐
Frankly speaking, Venki Ramakrishnan DID NOT really deserve the Nobel Prize on the Ribosome. I consider the following scientists had ENORMOUS contributions, much more than Venki, in the field :
Harry F. Noller, University of California at Santa Cruz, Peter B. Moore of Yale University. Yusupov et al (2001), from UC Santa Cruz and Ogle et al (2001), from Venki's MRC group in Cambridge, were both printed in the same issue of Science, May 4, 2001, back-to-back. However, Noller's life-long contributions on Ribosomes makes Venki look like a pigmy in the field, really. Also, way back in 1976, James A. Lake of UCLA had published a paper titled 'Ribosome Structure Determined by Electron Microscopy...' for small & large subunits and monomeric ribosomes, all verified by crystallography. Richard Brimacombe's group at Berlin also had published their Cryo-electron Microscopic study in 2000. Possibly, it was Venki's political support from his past mentor Thomas Steitz of Yale and the US clout, that resulted in Venki being chosen against more deserving candidates. Actually, Debi Prasad Burma et al (1985) Archives of Biochemistry and Biophysics had first showed in their seminal paper from BHU that in the ribosomes, it was the RNA and NOT any of the associated proteins that carries out the catalytic function.