The discovery was wonderful for the kids but imagine how the parents must have felt? Probably one of the greatest days of their lives. Imagine the dread they must have felt knowing their kid had what was basically a death sentence
2 years ago, at 24 years old, being 1.80 m tall weighing ca. 75 kg, I was diagnosed with Diabetes. Docs said basically since I'm not fat or old it's most likely type 1 Diabetes. About 1 week before the diagnosis, I weighed ca. 80 kg. In just one week I dropped 5 kg all the while eating like crazy, especially sugar (which was weird for me, since I wasn't that much of a sweets snacker), getting up every night to drink about 2 litres of water and piss about 6 times. Only at night, imagine the days. Also, I normally sleep through the night "in one sitting". I felt incredibly weak and weirdly hungry, my eyesight was extremely blurry and I was constantly in a daze. Sure, those parents probably had the greatest day of their lives, but those kids must have been through hell and beyond. Finally feeling energized, not having the urge to stuff yourself or drink water like you went through a desert for 3 days straight. Having hope not to die with your 10 years of age. I only felt symptoms for a couple of weeks, they suffered months or even years AND most likely felt responsible for their parents sadness. It's kind of macabre to say, but.. you "may always" have another kid, but these kids would never have another life (I know it's far more complex, hence quotation marks). I know what you wanna say and I'm not challenging you think otherwise, but getting handed back a chance at life as a "healthy human" is far more than just wonderful. Or at least, what I wanna say is, of course one shouldn't forget the parents, but I think those kids were the happiest on the days of their first injections. Then again, you might be a parent, I'm a guy with Diabetes, so no wonder I feel the kids should be the focus and not the parents. In the end, there's nothing wrong with your comment, this text is only a justification as to why I feel in disagreement with it. Guess it's too personal for me lol I'm just grateful I may live on, I can't imagine how utterly thankful those kids must have been. Have a nice day everyone!
This is always inspiring to think about. They closed in on something and have saved thousands of thousands of lives. Shame about it's price in the modern pharmacy.
@@DomyTheMad420 hahahahaha, yeah we totaaaaally dont want free healthcare and the ability to get help without being in debt the rest of our live but neither goverment party will give us that. Yeah we want to be in debt, its our fault
There is something very heartwarming about hearing that they rushed to the diabetic ward and injected the children with insulin that clearly saved their lives. It reminds me of a CBS Sunday Morning episode that's just all of a sudden tearing at your heart.
If you this that's admirable (as you should), then you'd be the most despicable sort of hypocrite if you support the FDA preventing people from getting access to medicine they want.
@@ShankarSivarajan Um, no, that doesn't follow. The FDA prevents drugs that don't work or that have catastrophic side effects from going onto the market. Thalidomide is the classic example. Did you mean the Patent Office?
I can only imagine how Banting would feel seeing countless pharmaceutical companies benefit from something he felt was so essential to save human lives that he wouldn't patent it
Go ham on them like he went on Collip. Probably be proud of Canada for not succumbing to greed and ensuring everyone who needs it can get it for free/cheap.
Good for Banting. I'd have knocked out that guy too for suggesting he would patent the purification process. For something that was discovered almost a hundred years ago and was not patented, insulin sure is way too expensive today in my home country (0 points for guessing where). Imagine how bad it could be if it had been patented from the start.
Insulin is also expensive in other places. In Poland my father's stock of insulin for 8 months costs around 200 dollars. Thankfully Glucometers are free with prescription for strips (I sent one to a friend in US) and strips with prescription cost only about a dollar for 50 (without prescription price is about 10 times). The reason partially is that companies use their own refined methods of mass producing insulin. By that I mean artificial insulin. Of course it should be cheaper, but that is only part of problems your country is facing. Without Universal Healthcare system - every insurance company negotiates for themselves. In Poland government speaks for 38 million people, so they can bring the prices down.
Private profiting is a two edged sword. In the hands of someone less trustworthy it would make it worse. But someone who asserted themselves as wanting to control it only because they distrusted other organizations but trying genuinely to make it cheaper for people can probably do more for people than the government. It's like the risk of a bad king vs wanting a good king to be powerful making it hard to figure out if monarchy is a better system or not. In the end really neither system is better: individual people will either use the systems in good faith, or they won't. A good person can make do with any system.
Nicolae Paulescu also made significant contributions to the discovery of insulin. He made a similar extract, and by the time Banting and Best isolated insulin in February 1922, he was already awaiting the patent confirmation for his 'pancreine'. Roif Luft, president of the International Diabetes Federation in 1971 and chairman of the Nobel Prize Committee for Physiology and Medicine, stated that "One fact remains, namely that the earlier discovery made by Paulescu was misinterpreted by Banting and Best for reasons which we cannot know anything about today … In my opinion, the [Nobel] prize should-without any doubt-have been shared between Paulescu, Banting and Best." Please at least make a note in the 'Lies' episode
I'm curious if Paulescu the ultra nationalistic antisemitism who administrated the insulin extract rectally instead, had same opinion about the medicine most be cheap and access for everyone have right and afford to buy it?
My take might be kind of hot here, but it sounds like Banting wouldn't have liked anyone who wanted to patent, and maybe he let that straight up prejudice him?
I'd love to see a series like this or a one off on the development of the pacemaker. I got my degree in biomedical engineering from the University of Minnesota and it's kinda just a common legend there. And, WOW, is it a good example of why having regulations are good.
My 86 year old grandmother whom I am very close to had to get one. She got CoVid-19 and had no primary symptoms whatsoever. Then almost as soon as she recovered she developed major arrhythmias. She had a profoundly healthy heart for her age before then and no cardiac family history. The doctors said it was most likely the far more pernicious Post-Acute Sequillae. They were able to put it in with pin-hole laprascopy in twilight sedation, but she goes in about once every 30-60 days because of remote monitoring issues now for medication adjustments or defribullation.
Matt, James, Rob, Dan.... Thank you for posting this. Thank you for making this series. I had no idea the toll diabities takes on a person both Type 1 and Type 2 until I heard the story from my girlfriend. She has had T1D since she was five and ever since I found out about her condition I've been looking for videos that advocate for information to be shared that's factual like I know your channel strives for. The price of any disease is so high and showing the emotional toll is so critical. I cant wait for the rest of these videos to come out. I've supported you for years and you continue to surpize me constantly with the critical information you share with the TH-cam community. I also am so happy to see the Medicaid link and the advocacy. Together through information we can cure the world. I would be interested to see more coverage of rare diseases on this channel. Thanks again!
Funny is that MOSTE of them generally agreed to forfeit the fortune part, from what was said in the video, the fights seemed to be mostly boiled down to fame and recognition.
Alcohol doesn't necessarily lower blood sugar, it's different for every person. I'm diabetic and my blood sugar may either get really high or really low whenever I get wasted even if I am carefully controlling it. And coffee is probably one of the worst things to give to someone with hyperglicemia: your heart may simply not withstand pumping thicker blood real fast (my heartrate when I have high blood sugar gets high even without coffee).
"They resolved not to profit of this discovery". A noble goal. Too bad that others did not share this conviction. In case the price-hiking of insulin over the past decade wasn't enraging enough on its own.
This one really hits me where I live. I am Type 1 diabetic, and only discovered when I was brought to Accident & Emergency (what we call ER). I had been feeling rundown with a terrible thirst for a few weeks. Then the vomiting and cramps started. And then the vomit turned black... When the nurses examined me, it turned out I was suffering from diabetic ketoacidosis, which happens when a person's blood sugar is far too high for far too long. Needless to say, I was in the High Dependency Unit and then a general diabetes ward for about a week. Without insulin, I literally would not be alive today.
When I was a toddler , I was rushed to the hospital and later diagnosed with type 1 diabetes. Every day since, I use insulin to keep myself alive. And I’m so incredibly grateful, you guys are telling this story! 100 years ago, I would have been Pronounced dead as soon as I got diagnosed. Now? I can live my life, I just need a small injection once in a while and a machine that has insulin inside it to act as my pancreas. your telling the story to the people who have never heard it, who need to hear it! And to that? I am so incredibly grateful. Love you guys, You keep up the amazing videos and your great ♥️
My boyfriend is a type 1 diabetic and I'm eternally grateful to those men for creating insulin to save countless lives. I just wish here in the states it was cheaper
My son was diagnosed with diabetes two weeks ago so he is alive only thanks to insulin now. So really looking forward to watching this after he will be sleeping in half an hour hopefully :-)
The discovery of Recombinant Insulin also was huge in making life better for people with diabetes. As stated in the video, the 14 year old had an allergic reaction to the beef insulin. Recombinant Insulin was created by using bacteria to create human insulin by biomedical engineering in the 70s. This greatly reduced the risk of an allergic reaction due to impurities and the foreign elements in boar and cadaver insulin, which were used since its first discovery. Science!
@@kestrels-in-the-sky Luckily we are in Czech republic so we are not paying anything. Got insulin pump for free, sensors for free, insulin for free, education about it all, glucose meter which also measures ketone levels and all the testing strips for it (just both one set of ketone strips with my own money), all the infusion sets for the insuline pump and also disinfectant and such for the changing of them. And also the emergency syringe for hypoglycemic shock was for free. So glad we live in developed country with universal healthcare as quick sum of all the stuff is around 130 000 CZK so around 6 000 USD.
I'm gonna ruin you moment of 69 likes. Here's a like to you and your son. Give him a hug from me. I may not have diabetes but I at least know that emotional support is very important in trying times. I've had a lot of trying times but rarely got the support I needed. I wish him well. 😁
Imagine the euphoria in the room with the six comatose kids, with the first starting to wake up within a short period of time. The knowledge that it worked and wasn't a fluke and that it will change the world.
As a Type 1 diabetes myself, I'm literally with teary eyes to see something so meaningful for me in one of my favorite channels. Thank you. Thank you. Thank you.
As a Type 1 Diabetic, I am very thankful that this discovery was made with an express desire against profit. I have lived with this condition for the better part of a decade now and in this age of modern medicine, it's just an inconvenience rather than a death sentence. I look forward to seeing more of this series.
As a diabetic, this brings me great joy that you are dedicating a mini series to this. The history is very interesting and your guys videos are ones that I have been watching for years. So thank you.
Wow, how amazing. I can't imagine what it felt like to be a diabetic who thought you had a death sentence to find out that there was something that could save your life. Save countless lives. That's wonderful.
It's strange. My father had type 1 diabetes his entire life and I have a strong genetic disposition to developing diabetes. But I never thought to look up the history of Insulin. Thanks Extra Credits for once again broadening our minds and teaching us new stories.
As someone who was just recently diagnosed with diabetes. This series has taken on a whole new perspective for me. Im so greatful that this discovery was made, and right here in my own country too.
When thinking about island riches, we think of spices, sugar, exotic fruits and the like. But perhaps, the most important of all island riches are the ones in us all. (Islets of Langerhans)
I claim those islets in the name of the Spanish Crown and our Beloved King Ferdinand II of Aragon and our Queen Isabella I of Castile! **plants flag into my own pancreas**
I deeply appreciate that you haven´t hidden the fact that this life changing achievement of modern science and medicine was made thanks to animal research (without the repeated experiments it would have took way longer to save those children and many others after them... and we have seen that time is never on the side of science). Even today that is a fundamental part of basic research, and the laws about animal welfare in place and the advanced technology allow us to avoid such cruel experiments. Many newspapers avoid reporting the part of a research that was done on animals and this is a type of misinformation we need to avoid. I understand that it is a difficult topic but we also need to say things how they are, we need to face reality.
You should create a “Extra Medicine” channel. I really like learning about the discovery of vaccines, the history of diseases, and other general medical knowledge.
I'd like to see it expanded into an "Extra Science" channel. Interesting things occur in the other branches of science too, and its history thereof. Stuff like the life of Antoine Lavoisier (discovered oxygen, invented medical cross-ventilation, revolutionized tobacco farming, Mrs. Lavoisier translating scientific papers from English to French for him and his papers from French into English for publication, rewarded by being sent to the guillotine during the French Revolution), Erastothenes's technique in ancient Greece for measuring the circumference of the Earth to an error of less than 3% (they knew the world was spherical, and Aristotle could prove it in five different ways), the Stanford Prison Experiment (which had to be called off after less than halfway through due to the madness the people undergoing it were experiencing), and, while this is still ongoing, a rundown of the atomic elements discovered by Yuri Oganessian (who discovered or helped discover twelve elements--bohrium, meitnerium, hassium, darmstadtium, roentgenium, copernicium, nihonium, flerovium, moscovium, livermorium, tennessine, and oganesson, the last of which was named in his honor by his team--the most of any one person, and is still alive and still looking for more). Speaking of chemical elements, polonium has quite the rich history, used for both good and evil. Marie Curie named it to bring awareness of her home country of Poland, and it is extremely radioactive, so much that it was used by Russian spies to discreetly poison KGB defector Alexander Litvinenko...and was radioactive enough that the taxi he rode had to be decommissioned for being too radioactive to use simply because he sat in it for half an hour after ingesting a grain of polonium.
What I enjoyed was both the heartwarming medical miracle story mixed with the acknowledgement of the deeply flawed people involved in it. *lays a wreath for the doggos*
Type-1 and Type-2 diabetes aren't different because of the age of the person they inflict. Type-1 diabetes is when your body loses the ability to produce insulin. Type 2 diabetes is when your body becomes resistant to insulin. Type-2 diabetics still produce insulin.
I was scrolling through my recommend when I saw this video, me and my brother have had type 1 diabetes for a while and I’ve really wanted to learn about the discovery of the thing that is keeping me alive, thank you guys for doing this!
Thank you for doing a series on this- some aspects of history are easily drowned out by talk of kings and generals, yet have had a stunning impact on people’s lives- like this. Had I been diagnosed with T1 Diabetes a century earlier than I did, I would’ve certainly been dead by age 6, but with modern medicine life expectancy for T1 diabetics is approaching parity with non-diabetics. Truly revolutionary.
This was one of the most important scientific discoveries in history and they decided to make this life saving thing cost extremely high amounts of money that most people can't afford to spend
this video dropped right as I got my first continuous glucose monitor prescribed. Remembering my 2 weeks of this made it almost too hard to finish the video, those poor children :/ Thanks Extra Credits team for being so wonderful.
To think that without four people constantly fighting with each other to achieve the same goal, I wouldn’t be here without them. That’s truly amazing, and I’m glad they could do this
Being a type 1 diabetic, there discovery really saved my life and allowed me to grow to an age to have children and make memories with my family. However, there is still cost to it that is causing me great harm. From the high cost of the drug that keeps me alive day to day that has driven me into thousand of dollars in debt to the constant testing of my blood to keep track of my blood sugar levels and the hardness of trying to find nutrition information that I need to take the right amount of insulin. With these things still prevalent, it feels like there is no cure yet to the type 1 diabetes at least not until an artificial pancreas is made which I hope is soon. 🙏🙏
You can buy handheld testers for a few tens of $. You need the test strips and those little snap pin things (don't know the technical term) but those will give you enough information about where your blood sugar is. Places like aliexpress or ebay or even Amazon if you want to buy Bezos more yachts. I'm guessing you are in the US - and Dr's will connive with the companies to reel you in for unnecessary lab tests that can be done on this sort of unit at home. Ex partner had it amongst other people. Test in the morning first thing and at night - if yours tends to go on the low side keep chocolate or something similar available at all times.
brilliant, a series on exactly how my life was saved! not living under the deadly healthcare system of the U.S that withholds live saving treatments behind a paywall only surmountable with one's life savings and getting insulin nearly for free (as these great men intended) I am very interested in how they not only came up with the treatment, but how doctors in the 1920s managed to stay in agreement to not profit off of the literal lifeline of thousands of people.
I’m not usually one for tears but thank you guys. I really hope you can bring some more attention to this with your special touch. A 3 month supply of just one type of insulin can cost 1700 without insurance here in the US Type 1 since 2018
they sold it for a $1. one Canadian dollar. because no one should profit from it. but the recent changes to insulin prices is leaving me in tears the whole video. and that is the fault of no one at Extra Credits. This channel is doing a great job
I love seeing more being informed about this, as I got Diabetes type 1 at age four. In recent years awareness has grown a lot more but when I was younger I've often gotten either bullied or confused by others that I didn't exercise or diet good enough etc. etc., often stemming from a confusion between type 1 and type 2. The big difference between the two is that type 2 is more becoming resistant to insulin, not having as big of an effect while type 1 is a lack of production of insulin in the body, having to inject it manually. Having more people be aware of this disease others often dismissed as just a joke on obesity, makes me happy that others won't have to endure what I did mentally, while still having to struggle with a chronic disease on top of that.
It has been said that insulin was the last medical advancement not motivated by profit. Additionally, the development of insulin is a point of great pride among Canadians.
My grandmother has type 2 diabetes. My family’s grateful that we can afford the healthcare necessary for her to buy insulin. It’s terrible that companies are forcing people to pay for this life saving medicine. Healthcare is a right not a privilege
A whole series of medical discoveries would be interesting. Some interesting ones would be the first successful surgery of any organ i.e. kidney and heart. Or the discovery of certain medications that revolutionized the way we treat patients today. Excellent video.
I'm now not only looking forward to part two, but to the future medical breakthrough episodes Really helps young people nowadays to watch something entertaining, but also educational So from the bottom of my heart, thank you Extra Credits for making History fun for me and my family
So happy you guys are doing a story on this my whole family on my dads side struggles with type 2 diabetes and high glucose I've personally been borderline diabetic for 5 or 6 years and have to watch my sugar intake my dad b4 he died though i remember his doctor telling him and me the story about the insanity of insulins creation on a regular visit i took him 2 but nowhere near in depth like this so i find it fascinating can't wait for part 2
Wow this is a great start to the series. In BC we have high schools named after Banting and Best, and I didn't know they were the doctors behind the discovery of Insulin!
How upsetting to learn that insulin was developed with the intention of being free to anyone who needs it. Pharmaceutical companies charge 25x the cost to produce insulin, and our government just sits back and says nothing while taking "donations" from those same companies.
I have to thank these men for my existence as without their discovery my mother would have most likely died as a child from type 1 diabetes. From the bottom of my heart, I thank them.
Scientists and Doctors: "Insulin is such a required substance that we've made it literally cheaper than dirt so everyone that requires it to survive can get it when they need it!" Unbridled murrikan ancap phama corps: "Hhehe literally captive customers have to pay ransom or die." Well-trained apologists: "Ah-ah-ah! Saying that's wrong mean you're a communist!"
I doubt evryone who don't agree with American pharma looting it's people are communist like the capitalist pharma companies of india and china would like very much of there cheaper product would get access to American markets and break the monopolies.
As a Type 1 Diabetic, it’s sobering to think that I would have perished in middle school before the 1920’s. If not for the work of these four men, I would not be alive today.
Alright guys listen. I’ve been here since the first Punic war but this was the first time since Flanders fields that an episode of EC has brought me to tears. Those poor children.
I avoided watching this series for 6 months. I was pre-diabetic at my last doctor's appointment. But I JUST got my bloodwork back in the last half hour, and I am not even pre-diabetic anymore! There's other stuff to do to improve my health, but this is such a weight off.
![[MV] A leap of faith...ความเชื่อใจครั้งสุดท้าย (From "Petrichor the series")](http://i.ytimg.com/vi/U1piZH2CNXA/mqdefault.jpg)
If you live in Minnesota, learn more at U21checkups.com. If you don’t, check here: www.medicaid.gov/medicaid/benefits/epsdt/index.html
wait how is this post 2 days old?
@@thepoglin8479 it was privated
WASNT NICOLAE PAULESCU WHO DISCOVERD THE INSULIN
Wait you still didn’t finish the takeover of India series
A STORY ABOUT A CANADIAN LETS GOOO
The discovery was wonderful for the kids but imagine how the parents must have felt? Probably one of the greatest days of their lives. Imagine the dread they must have felt knowing their kid had what was basically a death sentence
Exactly.
I kinda choked up a bit at that part honestly.
Hello. Again.
2 years ago, at 24 years old, being 1.80 m tall weighing ca. 75 kg, I was diagnosed with Diabetes. Docs said basically since I'm not fat or old it's most likely type 1 Diabetes.
About 1 week before the diagnosis, I weighed ca. 80 kg. In just one week I dropped 5 kg all the while eating like crazy, especially sugar (which was weird for me, since I wasn't that much of a sweets snacker), getting up every night to drink about 2 litres of water and piss about 6 times. Only at night, imagine the days. Also, I normally sleep through the night "in one sitting". I felt incredibly weak and weirdly hungry, my eyesight was extremely blurry and I was constantly in a daze. Sure, those parents probably had the greatest day of their lives, but those kids must have been through hell and beyond. Finally feeling energized, not having the urge to stuff yourself or drink water like you went through a desert for 3 days straight. Having hope not to die with your 10 years of age. I only felt symptoms for a couple of weeks, they suffered months or even years AND most likely felt responsible for their parents sadness. It's kind of macabre to say, but.. you "may always" have another kid, but these kids would never have another life (I know it's far more complex, hence quotation marks).
I know what you wanna say and I'm not challenging you think otherwise, but getting handed back a chance at life as a "healthy human" is far more than just wonderful. Or at least, what I wanna say is, of course one shouldn't forget the parents, but I think those kids were the happiest on the days of their first injections. Then again, you might be a parent, I'm a guy with Diabetes, so no wonder I feel the kids should be the focus and not the parents. In the end, there's nothing wrong with your comment, this text is only a justification as to why I feel in disagreement with it. Guess it's too personal for me lol I'm just grateful I may live on, I can't imagine how utterly thankful those kids must have been. Have a nice day everyone!
Yeah
This is always inspiring to think about. They closed in on something and have saved thousands of thousands of lives. Shame about it's price in the modern pharmacy.
Millions of lives and counting, myself included.
aaaaaaaaaaaaaaaaaaaaaaaaaaaahahahahahahaha
you AMERICANS crack me up.
@@DomyTheMad420 hahahahaha, yeah we totaaaaally dont want free healthcare and the ability to get help without being in debt the rest of our live but neither goverment party will give us that. Yeah we want to be in debt, its our fault
@@DomyTheMad420 indeed, laugh at our suffering
Empathy and care made it possible.
Capitalism made it inaccessible.
There is something very heartwarming about hearing that they rushed to the diabetic ward and injected the children with insulin that clearly saved their lives. It reminds me of a CBS Sunday Morning episode that's just all of a sudden tearing at your heart.
I admire Banting's response to the standard practices of the modern pharmaceutical industry. We could use a few more guys like him.
@@Lazarus1095 it wasn’t only Banting though he had a humongous part in it
@@Iceglorp I think they’re talking about his anti-greed stance, not his overall contributions to the project.
If you this that's admirable (as you should), then you'd be the most despicable sort of hypocrite if you support the FDA preventing people from getting access to medicine they want.
@@ShankarSivarajan Um, no, that doesn't follow. The FDA prevents drugs that don't work or that have catastrophic side effects from going onto the market. Thalidomide is the classic example.
Did you mean the Patent Office?
I can only imagine how Banting would feel seeing countless pharmaceutical companies benefit from something he felt was so essential to save human lives that he wouldn't patent it
Open source wasn't a thing back then. Think one of the first thing I would do is to hand him a Apache 3.0 license and a lawyer
maybe we should take notes as to how he convinced collip not to profit off it
Go ham on them like he went on Collip. Probably be proud of Canada for not succumbing to greed and ensuring everyone who needs it can get it for free/cheap.
My man would have gone to big pharma personally and beat someone’s ass.
Type 1, I don't know if I feel anything is simultaneously as evil and prevalent as charging people money for life sustaining medicine.
Good for Banting. I'd have knocked out that guy too for suggesting he would patent the purification process. For something that was discovered almost a hundred years ago and was not patented, insulin sure is way too expensive today in my home country (0 points for guessing where). Imagine how bad it could be if it had been patented from the start.
I think we need Banting to come back and beat up the for profit medical system we currently have
@@millersam07 amen
Insulin is also expensive in other places. In Poland my father's stock of insulin for 8 months costs around 200 dollars. Thankfully Glucometers are free with prescription for strips (I sent one to a friend in US) and strips with prescription cost only about a dollar for 50 (without prescription price is about 10 times).
The reason partially is that companies use their own refined methods of mass producing insulin. By that I mean artificial insulin.
Of course it should be cheaper, but that is only part of problems your country is facing. Without Universal Healthcare system - every insurance company negotiates for themselves. In Poland government speaks for 38 million people, so they can bring the prices down.
It’s expensive because Canada sold the patent for it to the USA
Private profiting is a two edged sword. In the hands of someone less trustworthy it would make it worse. But someone who asserted themselves as wanting to control it only because they distrusted other organizations but trying genuinely to make it cheaper for people can probably do more for people than the government. It's like the risk of a bad king vs wanting a good king to be powerful making it hard to figure out if monarchy is a better system or not.
In the end really neither system is better: individual people will either use the systems in good faith, or they won't. A good person can make do with any system.
Anybody with the loved one who's suffering from the effects of diabetes, this sort of stuff can actually make you emotional.
Nicolae Paulescu also made significant contributions to the discovery of insulin. He made a similar extract, and by the time Banting and Best isolated insulin in February 1922, he was already awaiting the patent confirmation for his 'pancreine'. Roif Luft, president of the International Diabetes Federation in 1971 and chairman of the Nobel Prize Committee for Physiology and Medicine, stated that "One fact remains, namely that the earlier discovery made by Paulescu was misinterpreted by Banting and Best for reasons which we cannot know anything about today … In my opinion, the [Nobel] prize should-without any doubt-have been shared between Paulescu, Banting and Best."
Please at least make a note in the 'Lies' episode
Thank you! It's pretty sad that he dosen't really get recognition if at all.
I'm curious if Paulescu the ultra nationalistic antisemitism who administrated the insulin extract rectally instead, had same opinion about the medicine most be cheap and access for everyone have right and afford to buy it?
My take might be kind of hot here, but it sounds like Banting wouldn't have liked anyone who wanted to patent, and maybe he let that straight up prejudice him?
@@donaldduck9884what does any of that have to do with this 🤷 ford was an absolute ahole u still learn abt him and the founding fathers owned slaves
@@mattmathematics3591
Founding father? I'm totally confused what you are talking about so pls explain better what you talking about?
I'd love to see a series like this or a one off on the development of the pacemaker. I got my degree in biomedical engineering from the University of Minnesota and it's kinda just a common legend there. And, WOW, is it a good example of why having regulations are good.
I second this.
My 86 year old grandmother whom I am very close to had to get one. She got CoVid-19 and had no primary symptoms whatsoever.
Then almost as soon as she recovered she developed major arrhythmias. She had a profoundly healthy heart for her age before then and no cardiac family history. The doctors said it was most likely the far more pernicious Post-Acute Sequillae.
They were able to put it in with pin-hole laprascopy in twilight sedation, but she goes in about once every 30-60 days because of remote monitoring issues now for medication adjustments or defribullation.
Jarvik artificial heart would be cool too
Yeah that would be cool
The end of this comment makes me worry about the test subject involved in the project, but my grandma's had a pacemaker for years sooo...
"They resolved not to profit off this discovery"
US pharmaceutical companies: I'll pretend I didn't hear that
@@scottanno8861 ok antisemite
if anything, I blame insurance not covering enough
It's not just insulin, but other drugs, too.
@@GiordanDiodato nope it’s pharma, and government refusal to advance along with the rest of the developed world with free healthcare.
Right now one vile of insulin costs about $100
Nothing like a good fist fight to dissuade greed.
Someone needs to tell Banting about the drug market today, he'd probably physically manifest as the Doom Slayer
@@notme8232 Nah, we'd suddenly get treated to a real life vigilante, only known as Bantman.
often I feel tempted
these days greed is maximized
sir you have an option tell me or lets say broken bones will be made and you've got a lot of bones
I owe these men my life. I was diagnosed at 8 months old, and nearly died. 20 years later, and I'm still here. I'm super excited for this series!
Matt, James, Rob, Dan.... Thank you for posting this. Thank you for making this series. I had no idea the toll diabities takes on a person both Type 1 and Type 2 until I heard the story from my girlfriend. She has had T1D since she was five and ever since I found out about her condition I've been looking for videos that advocate for information to be shared that's factual like I know your channel strives for. The price of any disease is so high and showing the emotional toll is so critical. I cant wait for the rest of these videos to come out. I've supported you for years and you continue to surpize me constantly with the critical information you share with the TH-cam community. I also am so happy to see the Medicaid link and the advocacy. Together through information we can cure the world. I would be interested to see more coverage of rare diseases on this channel. Thanks again!
Is she doing better now?
Fame, Recognition, and Fortune.
Some of many reasons why humanity may never know progress among its good and talented men and women… 😔
Wealth, fame, power. The world had it all won by one man: the Pirate King, Gold Roger!
Funny is that MOSTE of them generally agreed to forfeit the fortune part, from what was said in the video, the fights seemed to be mostly boiled down to fame and recognition.
I think that when people are desperate, they honestly will let go of these temptations. Everyone is naturally tempted, but most want to overcome it.
@@bungalo50
*Pirate King, Atomsk; not Gold Roger.
@@bungalo50 Actually, it's Gol D. Roger.
"The child is dying!" "Quick! Get him coffee and booze!"
Alcohol doesn't necessarily lower blood sugar, it's different for every person. I'm diabetic and my blood sugar may either get really high or really low whenever I get wasted even if I am carefully controlling it.
And coffee is probably one of the worst things to give to someone with hyperglicemia: your heart may simply not withstand pumping thicker blood real fast (my heartrate when I have high blood sugar gets high even without coffee).
Booze
I mean what I want on my death bed. Lol
@@לירוןטל-ז4ר I would have thought the opposite for alcohol, since alcohol breaks down in to sugar.
@@Docwilson91 alcohol makes your blood sugar raise first, and then drop dangerously.
"They resolved not to profit of this discovery". A noble goal. Too bad that others did not share this conviction.
In case the price-hiking of insulin over the past decade wasn't enraging enough on its own.
This one really hits me where I live.
I am Type 1 diabetic, and only discovered when I was brought to Accident & Emergency (what we call ER). I had been feeling rundown with a terrible thirst for a few weeks. Then the vomiting and cramps started. And then the vomit turned black...
When the nurses examined me, it turned out I was suffering from diabetic ketoacidosis, which happens when a person's blood sugar is far too high for far too long. Needless to say, I was in the High Dependency Unit and then a general diabetes ward for about a week. Without insulin, I literally would not be alive today.
When I was a toddler , I was rushed to the hospital and later diagnosed with type 1 diabetes. Every day since, I use insulin to keep myself alive. And I’m so incredibly grateful, you guys are telling this story! 100 years ago, I would have been Pronounced dead as soon as I got diagnosed. Now? I can live my life, I just need a small injection once in a while and a machine that has insulin inside it to act as my pancreas. your telling the story to the people who have never heard it, who need to hear it! And to that? I am so incredibly grateful. Love you guys, You keep up the amazing videos and your great ♥️
Always makes me feel pride as a Canadian that someone from my country developed this treatment. And was selfless about distributing
From a type 1 diabetic, thank u Canada
@@zakariaraqiq Romania did it first
My boyfriend is a type 1 diabetic and I'm eternally grateful to those men for creating insulin to save countless lives. I just wish here in the states it was cheaper
My son was diagnosed with diabetes two weeks ago so he is alive only thanks to insulin now. So really looking forward to watching this after he will be sleeping in half an hour hopefully :-)
Sending good thoughts for your son. 🙏🏻🙏🏻🙏🏻
The discovery of Recombinant Insulin also was huge in making life better for people with diabetes. As stated in the video, the 14 year old had an allergic reaction to the beef insulin. Recombinant Insulin was created by using bacteria to create human insulin by biomedical engineering in the 70s. This greatly reduced the risk of an allergic reaction due to impurities and the foreign elements in boar and cadaver insulin, which were used since its first discovery. Science!
How much is his insulin costing you
If your in the us
@@kestrels-in-the-sky Luckily we are in Czech republic so we are not paying anything. Got insulin pump for free, sensors for free, insulin for free, education about it all, glucose meter which also measures ketone levels and all the testing strips for it (just both one set of ketone strips with my own money), all the infusion sets for the insuline pump and also disinfectant and such for the changing of them. And also the emergency syringe for hypoglycemic shock was for free.
So glad we live in developed country with universal healthcare as quick sum of all the stuff is around 130 000 CZK so around 6 000 USD.
I'm gonna ruin you moment of 69 likes. Here's a like to you and your son. Give him a hug from me. I may not have diabetes but I at least know that emotional support is very important in trying times. I've had a lot of trying times but rarely got the support I needed. I wish him well. 😁
Humans: simultaneously the most amazing and most horrifying thing.
As sir Terry Pratchett put it; “ where the falling angel meets the rising ape”
*Terry Pratchett voted best author ever*
Imagine the euphoria in the room with the six comatose kids, with the first starting to wake up within a short period of time. The knowledge that it worked and wasn't a fluke and that it will change the world.
As a Type 1 diabetes myself, I'm literally with teary eyes to see something so meaningful for me in one of my favorite channels. Thank you. Thank you. Thank you.
I have had diabetes for almost 7 years now, very glad medicine has progressed enough to keep me alive 👍🏻
thx for your username and god bless you
Best of luck managing your condition!
As a Type 1 Diabetic, I am very thankful that this discovery was made with an express desire against profit. I have lived with this condition for the better part of a decade now and in this age of modern medicine, it's just an inconvenience rather than a death sentence. I look forward to seeing more of this series.
As a diabetic, this brings me great joy that you are dedicating a mini series to this. The history is very interesting and your guys videos are ones that I have been watching for years. So thank you.
Wow, how amazing. I can't imagine what it felt like to be a diabetic who thought you had a death sentence to find out that there was something that could save your life. Save countless lives. That's wonderful.
I love that you’re doing this. My girlfriend is a type 1 diabetic and it’s awesome to learn the history of what keeps her alive
I am disappointed to see that there is no mention of Nicolae Paulescu or any other scientist before them.
Yeah extra history.
It's strange. My father had type 1 diabetes his entire life and I have a strong genetic disposition to developing diabetes. But I never thought to look up the history of Insulin.
Thanks Extra Credits for once again broadening our minds and teaching us new stories.
As someone who was just recently diagnosed with diabetes. This series has taken on a whole new perspective for me. Im so greatful that this discovery was made, and right here in my own country too.
When thinking about island riches, we think of spices, sugar, exotic fruits and the like.
But perhaps, the most important of all island riches are the ones in us all. (Islets of Langerhans)
Let's plunder those islands for corporate profit.
I claim those islets in the name of the Spanish Crown and our Beloved King Ferdinand II of Aragon and our Queen Isabella I of Castile!
**plants flag into my own pancreas**
@@espio87 you can have mine :/ they're not functional anyway
Well time to colonize my body britain and France eat your HEART out
Nice man.
I deeply appreciate that you haven´t hidden the fact that this life changing achievement of modern science and medicine was made thanks to animal research (without the repeated experiments it would have took way longer to save those children and many others after them... and we have seen that time is never on the side of science). Even today that is a fundamental part of basic research, and the laws about animal welfare in place and the advanced technology allow us to avoid such cruel experiments. Many newspapers avoid reporting the part of a research that was done on animals and this is a type of misinformation we need to avoid. I understand that it is a difficult topic but we also need to say things how they are, we need to face reality.
You should create a “Extra Medicine” channel. I really like learning about the discovery of vaccines, the history of diseases, and other general medical knowledge.
I'd watch that
I'd like to see it expanded into an "Extra Science" channel. Interesting things occur in the other branches of science too, and its history thereof. Stuff like the life of Antoine Lavoisier (discovered oxygen, invented medical cross-ventilation, revolutionized tobacco farming, Mrs. Lavoisier translating scientific papers from English to French for him and his papers from French into English for publication, rewarded by being sent to the guillotine during the French Revolution), Erastothenes's technique in ancient Greece for measuring the circumference of the Earth to an error of less than 3% (they knew the world was spherical, and Aristotle could prove it in five different ways), the Stanford Prison Experiment (which had to be called off after less than halfway through due to the madness the people undergoing it were experiencing), and, while this is still ongoing, a rundown of the atomic elements discovered by Yuri Oganessian (who discovered or helped discover twelve elements--bohrium, meitnerium, hassium, darmstadtium, roentgenium, copernicium, nihonium, flerovium, moscovium, livermorium, tennessine, and oganesson, the last of which was named in his honor by his team--the most of any one person, and is still alive and still looking for more).
Speaking of chemical elements, polonium has quite the rich history, used for both good and evil. Marie Curie named it to bring awareness of her home country of Poland, and it is extremely radioactive, so much that it was used by Russian spies to discreetly poison KGB defector Alexander Litvinenko...and was radioactive enough that the taxi he rode had to be decommissioned for being too radioactive to use simply because he sat in it for half an hour after ingesting a grain of polonium.
We already have too many extras. Extra SCIFI, Extra Credits and Extra history.
@@history-jovianextra mythology
What I enjoyed was both the heartwarming medical miracle story mixed with the acknowledgement of the deeply flawed people involved in it.
*lays a wreath for the doggos*
Ah! My university, really cool to see some Canadian history. We don't get much coverage and this is a perfect topic!
Type-1 and Type-2 diabetes aren't different because of the age of the person they inflict. Type-1 diabetes is when your body loses the ability to produce insulin. Type 2 diabetes is when your body becomes resistant to insulin. Type-2 diabetics still produce insulin.
I was scrolling through my recommend when I saw this video, me and my brother have had type 1 diabetes for a while and I’ve really wanted to learn about the discovery of the thing that is keeping me alive, thank you guys for doing this!
My brother is diabetic, this is a series i look forward to watching.
My grandfather is also diabetic
I've been a Type 1 for 12+ years now. Amazing to see how far we've come in 100 years.
Thank you for doing a series on this- some aspects of history are easily drowned out by talk of kings and generals, yet have had a stunning impact on people’s lives- like this. Had I been diagnosed with T1 Diabetes a century earlier than I did, I would’ve certainly been dead by age 6, but with modern medicine life expectancy for T1 diabetics is approaching parity with non-diabetics. Truly revolutionary.
We need Banting to come back as a ghost and haunt the pharmaceutical executives and shareholders day in and day out.
Ghost of medicine past
+
This was one of the most important scientific discoveries in history and they decided to make this life saving thing cost extremely high amounts of money that most people can't afford to spend
Wow. This episode is amazing. That moment when the parent cried is wonderfully written and delivered. I love this series already
Man, I know life is hard, but damn, to hear them be so adamant in take no profit from this is very heartwarming.
this video dropped right as I got my first continuous glucose monitor prescribed. Remembering my 2 weeks of this made it almost too hard to finish the video, those poor children :/ Thanks Extra Credits team for being so wonderful.
My brother actually has diabetes type 1, so this was a very informational video and I loved it!
To think that without four people constantly fighting with each other to achieve the same goal, I wouldn’t be here without them. That’s truly amazing, and I’m glad they could do this
As a type-1 diabetic it is very cool that you bring up the history of this lifesaving medicine.
Being a type 1 diabetic, there discovery really saved my life and allowed me to grow to an age to have children and make memories with my family. However, there is still cost to it that is causing me great harm. From the high cost of the drug that keeps me alive day to day that has driven me into thousand of dollars in debt to the constant testing of my blood to keep track of my blood sugar levels and the hardness of trying to find nutrition information that I need to take the right amount of insulin. With these things still prevalent, it feels like there is no cure yet to the type 1 diabetes at least not until an artificial pancreas is made which I hope is soon. 🙏🙏
You can buy handheld testers for a few tens of $. You need the test strips and those little snap pin things (don't know the technical term) but those will give you enough information about where your blood sugar is. Places like aliexpress or ebay or even Amazon if you want to buy Bezos more yachts. I'm guessing you are in the US - and Dr's will connive with the companies to reel you in for unnecessary lab tests that can be done on this sort of unit at home.
Ex partner had it amongst other people. Test in the morning first thing and at night - if yours tends to go on the low side keep chocolate or something similar available at all times.
I owe my life to these researchers
As a diabetic who was diagnosed as I was 6, I owe my life health through a pretty easy way to control my situation to these people ❤❤❤
Thanks for making this to educate people about diabetes and im honestly tired of explaining it to new people
I have type 1
brilliant, a series on exactly how my life was saved! not living under the deadly healthcare system of the U.S that withholds live saving treatments behind a paywall only surmountable with one's life savings and getting insulin nearly for free (as these great men intended) I am very interested in how they not only came up with the treatment, but how doctors in the 1920s managed to stay in agreement to not profit off of the literal lifeline of thousands of people.
I’m not usually one for tears but thank you guys. I really hope you can bring some more attention to this with your special touch. A 3 month supply of just one type of insulin can cost 1700 without insurance here in the US
Type 1 since 2018
It's so interesting learning about the people two schools near me are named after. Dr Charles Best secondary and Banting elementary
Dr. Fredrick Banting was born in Alliston, Ontario, Canada. My highschool is named after him n his childhood home is a protected building in the town.
I myself have type 1 diabetes, so glad that we have insulin today, but I really wish that insulin was affordable here in the US
they sold it for a $1. one Canadian dollar. because no one should profit from it. but the recent changes to insulin prices is leaving me in tears the whole video. and that is the fault of no one at Extra Credits. This channel is doing a great job
It's great watching this and how intent they were on not profiting from it and then seeing that a month of insulin costs hundreds of dollars
This series is going to be awesome and it’s so great you said how type 1 and type 2 are different
I love seeing more being informed about this, as I got Diabetes type 1 at age four.
In recent years awareness has grown a lot more but when I was younger I've often gotten either bullied or confused by others that I didn't exercise or diet good enough etc. etc., often stemming from a confusion between type 1 and type 2.
The big difference between the two is that type 2 is more becoming resistant to insulin, not having as big of an effect while type 1 is a lack of production of insulin in the body, having to inject it manually.
Having more people be aware of this disease others often dismissed as just a joke on obesity, makes me happy that others won't have to endure what I did mentally, while still having to struggle with a chronic disease on top of that.
I love how almost everyone in that research team hated/disliked eachother yet they United for sake of humanity
As a university of Toronto alumnus, this story makes me beam with pride that I walked the same grounds as these men
These medical histories have ended up being my favourite stories EH does. From John Snow to JDR's polio drive, they've all been really interesting :)
Yet another reason we owe everything to dogs and need to cherish and love them forever.
As a med student, I’ve been waiting for this!
100 years ago there is a drama that saves millions of lives.
It has been said that insulin was the last medical advancement not motivated by profit. Additionally, the development of insulin is a point of great pride among Canadians.
I'm alive today because of the work of these scientists.
Sad how it all started with dogs but as a type 1 diabetic im so happy this product was made and helps me live today!
This made me tear up. Great story
Finally a Canadian story!
And one of the best!
My grandmother has type 2 diabetes. My family’s grateful that we can afford the healthcare necessary for her to buy insulin. It’s terrible that companies are forcing people to pay for this life saving medicine. Healthcare is a right not a privilege
I’m very glad he’s covering this. It really was a game changer.
A whole series of medical discoveries would be interesting. Some interesting ones would be the first successful surgery of any organ i.e. kidney and heart. Or the discovery of certain medications that revolutionized the way we treat patients today. Excellent video.
Extra history is my favourite history channel been watching it for like 4 or 5 years now
Sounds like this could make a good TV-show with all that drama.
I love your medicine related videos! Please make more of them!
I am loving this drama over such a good discovery.
I'm now not only looking forward to part two, but to the future medical breakthrough episodes
Really helps young people nowadays to watch something entertaining, but also educational
So from the bottom of my heart, thank you Extra Credits for making History fun for me and my family
As someone who attended Banting High School in the very town where Banting was from I am most interested in this.
I like how they succeeded at the end despite all their disagreements
So happy you guys are doing a story on this my whole family on my dads side struggles with type 2 diabetes and high glucose I've personally been borderline diabetic for 5 or 6 years and have to watch my sugar intake my dad b4 he died though i remember his doctor telling him and me the story about the insanity of insulins creation on a regular visit i took him 2 but nowhere near in depth like this so i find it fascinating can't wait for part 2
Wow this is a great start to the series. In BC we have high schools named after Banting and Best, and I didn't know they were the doctors behind the discovery of Insulin!
The animation and timing of the music on your intro is divine. Shoutout to whoever worked of that. It’s genius.
Fun Fact: Sir Frederick Banting did get his due and was one of the last Canadians given a knighthood.
These are some of my favourite EH series!
How upsetting to learn that insulin was developed with the intention of being free to anyone who needs it. Pharmaceutical companies charge 25x the cost to produce insulin, and our government just sits back and says nothing while taking "donations" from those same companies.
I have to thank these men for my existence as without their discovery my mother would have most likely died as a child from type 1 diabetes. From the bottom of my heart, I thank them.
Scientists and Doctors: "Insulin is such a required substance that we've made it literally cheaper than dirt so everyone that requires it to survive can get it when they need it!"
Unbridled murrikan ancap phama corps: "Hhehe literally captive customers have to pay ransom or die."
Well-trained apologists: "Ah-ah-ah! Saying that's wrong mean you're a communist!"
It's not literally cheaper than dirt to produce, but it is fairly cheap to produce. There's a massive markup.
i get it for free in Brazil. Free Healthcare is great
I doubt evryone who don't agree with American pharma looting it's people are communist like the capitalist pharma companies of india and china would like very much of there cheaper product would get access to American markets and break the monopolies.
Damn corpos ruin everything. Curses upon them all.
@@SafavidAfsharid3197 That's the point. People who call those who want America to get better healthcare system "communists" are wrong.
I've been a type 1 diabetic for 10 years come this Dec and I am thankful for this invention but man...I didn't know the history was so tumultuous.
As a Type 1 Diabetic, it’s sobering to think that I would have perished in middle school before the 1920’s. If not for the work of these four men, I would not be alive today.
Super proud to see my university (and our most proud contribution) featured in an Extra History! Thanks for the informative video!
man its a good day when extra credits posts a new series
I understand the trigger warning but I also understand that sometimes it took experiments such as this to find cures and treatments.
As a diabetic from age 12 i know how gratefull i am....
Such an important innovation.
Alright guys listen. I’ve been here since the first Punic war but this was the first time since Flanders fields that an episode of EC has brought me to tears. Those poor children.
I avoided watching this series for 6 months. I was pre-diabetic at my last doctor's appointment. But I JUST got my bloodwork back in the last half hour, and I am not even pre-diabetic anymore! There's other stuff to do to improve my health, but this is such a weight off.