Apoptosis, pathology, morphology, pathway, initiation, intrinsic, extrinsic, execution, degradation

Apoptosis Pathology, Pathway, mechanisms
In this video we talk about #apoptosis
apoptosis is a programmed #cell death pathway by which the organism gets rid of faulty cells without provoking a host #inflammation.
apoptosis can happen in both #physiologic and #pathologic instances.
The apoptosis has 3 phases: initiation, execution and degradation. initiation itself has three distinctive pathways: #intrinsic or #mitochondrial pathway and #extrinsic or death receptor-mediated pathway.
the intrinsic pathway is activated by internal factors such as growth factor deprivation, DNA damage, or protein misfolding.
the extrinsic pathway is activated by external signals via receptors. Relevant receptors are from TNF family for example TNFr-1 or Fas receptor. Fas ligand produced by T-cells would be the ligand for Fas receptor.
The execution phase is done by activating execution caspases.
Eventually what is left behind are apoptotic bodies which are phagocytosed by macrophages without provoking inflammation.
Jump to wherever you want:
00:07 Definition
00:16 Introduction
01:42 Morphology
02:37 Mechanisms overview
03:21 Intrinsic Pathway
04:06 BCL-2 Family
09:57 Extrinsic Pathway
13:16 Execution phase
14:01 Degradation Phase
16:06 Summary
Sources:
KUMAR, V., ABBAS, A. K., FAUSTO, N., ROBBINS, S. L., & COTRAN, R.S. (2015). Robbins and Cotran pathologic basis of disease. Philadelphia, Elsevier Saunders.
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Credentials
Audio: Bahaar Kasi
Illustration: Bahaar Kasi
Script: Bahaar Kasi
Editor: Saeede Kasi
#medicine #medschool #education #apoptosis #celldeath #initiation #execution #degradation #intrinsic #extrinsic #mitochondrial #deathreceptor #growthfactor #DNAdamage #proteinmisfolding #caspase #fas #FasL #TNF #receptor #ligand #T-cell #FADD #apoptotic bodies #bleb #macrophages
#medicine #medschool #physiology #biology #cell #cellmetabolism #cellmembrane #cellinjury #cellsurvival #doctor #health #neet #nurse #doctors #surgery #hospital #education #synapsss #cellularhealth #cellular #cellularresponse #medstudent#pathology #pathologylab #YouCanLearnAnything #cytokine #apoptose

[@Baharaakbari]

The most amazing ever explanation of cell death (apoptosis) , thank u soooooo much .🙏🙏🥰🥰🥰

[@synapse-academy]

Glad it helped!

[@DasheManzi]

Been stuck...but now feeling better about apoptisis.thank u

[@abhashthakur0461]

Thank you very much for this vedio
We need more such precise vedio

[@fredmagoma4823]

This video is sooo good💯💯💯💯💯...thumbs up👍

[@ashwinishende171]

Very useful video!!!!

[@marziejafari6167]

Pls, start video make, you best. 👌👌👌

[@empire8008]

Insane..😮😮😮

[@daniellaperez2768]

thank you very much ♥

[@nmesomavictor2900]

Do more videos, please

[@synapse-academy]

I sure will!

[@anushabachchu1273]

Great!

[@akashkashyap367]

🙏🏻❤️