This Video is the second part of my 2 videos on Hemostasis.
In this video I start with coagulation cascade. We go through both intrinsic and extrinsic pathways of the coagulation cascade. For the initiation of intrinsic pathway we need contact with negatively charged particles which is provided by the platelets' phospholipids. Then we have coagulation factors being activated one after the other leading to the activation of Thrombin which helps convert fibrinogen to fibrin so that fibrin can polymerise and form fibrin strands. Fibrin strands would attach to platelet plug and consolidate it. The extrinsic pathway starts with Tissue Factor or coagulation factor III and ends up in producing fibrin from fibrinogen.
Then we talk about Prothrombin Time Assay (PT) as well as Partial Thromboplastin Time (PTT). These tests are used to assess the function of coagulation factors.
The next step is to speak more exclusively about the important role of thrombin and endothelium.
Jump to where you want:
00:07 Introduction
00:29 Coagulation Cascade
07:30 Prothrombin Time and Partial Thromboplastin Time assays
09:38 The role of Thrombin
12:23 How is coagulation limited to the site of injury?
14:01 The role of Endothelium
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Credentials
Audio: Bahaar Kasi
Illustration: Bahaar Kasi
Script: Bahaar Kasi
Editor: Saeede Kasi
#primaryhemostasis #secondaryhemostasis #coagulationcascade #plug #consolidation #endothelium #injury #vascular #vascularinjury #hemodynamic #hemodynamicdisorder #bleeding #stopbleeding #megakaryocytes #bonemarrow #vWF #bernardsoulier
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