Interstitial space and fluid distribution.

Fluid that leaks out of capillaries goes into "interstitial space" but if you look closely, interstitium has different subspaces which equilibrate at different rates. There are spaces in interstitium where fluids and albumin cannot enter thereby affecting their volume of distribution. There are other important nuances about interstitium, especially during inflammation and sepsis. Interstitium is not a mere passive reservoir but is major determinant of fluid balance regulation during sepsis.
In this video we will learn in details about structure and function of interstitium, a topic that is not discussed commonly.
please review:
1. Edema : What causes edema - starling principle ? • The starling principle !!
2. Edema : Why edema occurs differently in different organs ? • Why all organs don't d...
3. EDEMA - Modified Starling Equation • The Modified Starling ...
references:
1. derangedphysio...
2. Interstitial fluid and lymph formation and transport: physiological regulation and roles in inflammation and cancer. Helge wiig and melody a. Swartz . physiol rev 92: 1005-1060, 2012 .
3. Role of the interstitium during septic shock: a key to the understanding of fluid dynamics? Auguste dargen. Journal of intensive care (2023) 11:44.
4. Transcapillary exchange: role and importance of the interstitial fluid pressure and the extracellular matrix Rolf K. Reed. Cardiovascular research (2010) 87, 211-217.
5. A modern view of the interstitial space in health and disease. Randolph H. Stewart. Front. Vet. Sci. 7:609583.
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
Unless otherwise specified, these lectures are intended only for adult population and may not apply to pediatric/neonates.