got my exam tomorrow, i must've looked through so many videos on diabetes. none of which mentioned anything about GLUT 4!! i assumed glucose made its way through the insulin receptors once it had insulin connected to it like a funnell!! great video your a lifesaver!!!!!
Although this was an excellent explanation I have to be a bit semantic on one small thing. Glucose itself isn't "toxic" - not literally, physiologically speaking at least. The reason why high glucose levels have adverse effects has to do with the principles of tonicity; i.e. when a high concentration of a solute exists in a certain location it will pull water towards it. (Incidentally this is why medics don't use 50% Dextrose solutions with diabetic patients anymore - because the concentration of the sugar was so high that after a few minutes of use it would begin to necrose the tissue around the IV site). At any rate it was an excellent explanation but I couldn't help myself in correcting that small piece at the end. Cheers!
Thanks for posting, and taking us past the basics of insulin. ...after watching this a few times, I'm wondering how the "exercise induced" glut-4 receptors work...how does exercise work to engage them?
lowers the blood sugar by triggering cells to accept glucose (blood sugar) into them for energy. sorry if this sounds basics but I am trying to understand this insulin, blood sugar, fat thing. If I knew was going to be fat in Bio class maybe this wouldn't be necessary. But Im learning thanks to Drs like you.
Man you good! This is real helpful for me to know! I take the knowledge that I learn from you and help others..azz well azz myself! Thanks..Keep doing your thing!!!
Really insightful and i know this video was posted years ago but I am interested in the physical activity aspect. You stated that if you are physically active then no insulin is needed for GLUT4 to transport glucose into the cells, how is that possible? I thought physical activity only increased insulin sensitivity, allowing less for the facilitated diffusion to occur, not that it doesn't need insulin at all. If anyone can help me understand, I would really appreciate it :)
Great lesson! I had a question about GLUT4, can glucose leave the cell via GLUT4? In the absence of insulin, would the increased rate of glycogenolysis result in a greater cellular glucose output? Many thanks
@Bennyhidef Any sort of muscle contraction will work to cause translocation of GLUT-4. Strength training will recruit more muscle fibers for a limited period of time whereas aerobic exercise will recruit fewer muscle fibers for an extended period of time. Both have their benefits. I'd prescribe aerobic exercise because it is easier and has more health benefits than strength training, but people like to look good too.
GLUT 4 is always dependent on insulin to uptake glucose from what i know from text books. GLUT 1 is insulin independent. If you can give me the source of the information that exercise can induce glucose uptake into the cell without insulin, please post me a link. I really much would appreciate it.
Glucose can enter the cell via GLUT1 under basal condition. Insulin increases the uptake by increasing GLUT4 expression. This is the reason why T1 diabetics don't need to inject as much insulin if they exercise.
No, because if the glucose-levels in the cells are too high they will turn them into fatty acids and store them as fat in adipose tissue. That's how you get fat from Cola even though it contains zero fat.
Very elegantly explained. You're a fantastic teacher.
Daniel Holley he sure is.
How can anyone give this a thumbs down! He summarised brilliantly a complex subject
This is really cool. Had to study this for a biology exam, and its a little bit complicated, so thank you for making it a lot easier to understand!
You are a brilliant teacher ... what a great video! Thank you.
got my exam tomorrow, i must've looked through so many videos on diabetes. none of which mentioned anything about GLUT 4!! i assumed glucose made its way through the insulin receptors once it had insulin connected to it like a funnell!! great video your a lifesaver!!!!!
by far the best easy-to-understand explanation of why exercise is so important for insulin resistance. thank you!!!!
Thank You!! This helped me in my BioMed class. It was very informal and straight to the point, which helped me A LOT!
Although this was an excellent explanation I have to be a bit semantic on one small thing. Glucose itself isn't "toxic" - not literally, physiologically speaking at least. The reason why high glucose levels have adverse effects has to do with the principles of tonicity; i.e. when a high concentration of a solute exists in a certain location it will pull water towards it. (Incidentally this is why medics don't use 50% Dextrose solutions with diabetic patients anymore - because the concentration of the sugar was so high that after a few minutes of use it would begin to necrose the tissue around the IV site). At any rate it was an excellent explanation but I couldn't help myself in correcting that small piece at the end. Cheers!
you are right on the money.
BRIAN YOU ARE FANTASTIC...MAKE THESE ESOTERIC TOPICS VERY UNDERSTANDABLE !!THANK YOU
I found this very helpful because I have to explain how insulin is used to get glucose into the cell in a project at school, thanks a lot.
Excellent, straightforward explanation. Learned a lot very fast. Can't ask for anything better. Thanks very much!
I have to make a model of this process and I just found the missing explanation I needed to finish ! Thank you SO much .
Thank you sooooo much!! I am from Peru and tomorrow I have my phisiology exam and this video has helped me a lot ! thanks again! U ROCK!
A good explanation of the Insulin pathway and function.
Easy , simple, great explanation
Fantastic
Thanks :)
I'm a student in Biomedical Sciences and this was so simple and clearly explained. Thank you so much!!!!
Excellent explanation! The best I have ever heard
Great diagram and explanation, all in a few mins. Kudos.
Wow thanks!!! I am getting ready to take a pathophysiology test on this and you really made it easy to understand! thanks.
Very good, specially about why we say that excercise is good, you made it clear to me . Thanks
I have a presentation today and after watching this video I'm very confident 😊 and ready
Dude great video, maybe the greatest simply video I have watched on meds.✌✌, Many thanks.
Does help me to understand the whole picture much better. Thank you so much!
Very nice, and not a moment of time wasted! Cheers!
Great video, mate. This has helped simplify this concept BIG TIME. Many thanks.
Thanks for posting, and taking us past the basics of insulin.
...after watching this a few times, I'm wondering how the "exercise induced" glut-4 receptors work...how does exercise work to engage them?
Uploaded 9 years ago but still very helpful for many😃
Thank you so much for this! just spent hr trying to understand my lectures note and you just did it in five... THUMBS UP
SUBSCRIBED
very smooth presentation = great mind !
honest , to the point, and really helpful...thank u
this is the best n da easiest way to understand. tqsm 4 da video
Thank you!! Very clearly explained. I now understand what GLUT4 translocation means. :)
You cleared my doubt sir ...thanku so much
Why does my blood sugar level increase to high levels after excercise?
Made my work so easy. Great Prof. Thank you so much. How do I get your videos?
you are a perfect teacher ♥️♥️♥️♥️♥️
Really appreciate your overview on that!
This is reallly well explained!!
Finally, I had to go through 6 videos b4 yours that explained GLUT 4
lowers the blood sugar by triggering cells to accept glucose (blood sugar) into them for energy. sorry if this sounds basics but I am trying to understand this insulin, blood sugar, fat thing. If I knew was going to be fat in Bio class maybe this wouldn't be necessary. But Im learning thanks to Drs like you.
thanx for the simplified explanation, really helped a lot....!!
Excellent explanation!
Very nice and clear concept
Very helpful and easy to understand. Thank you!
Sir ur explainations are fabulous keep on uploading videos
Very easy explanation. Thanks.
It's a great video. Very helpful 😊
That is a really good explanation which helps me a lot, thank u so much
excellent explanation, thanks for this!
Thank you so much, this video is really helping me to understanding about Glut4 Working.
I find this super helpful! Thanks for sharing.
Thank You sir helped me lot in my studies
Man you good! This is real helpful for me to know! I take the knowledge that I learn from you and help others..azz well azz myself! Thanks..Keep doing your thing!!!
brilliant teacher .... thank you
Really insightful and i know this video was posted years ago but I am interested in the physical activity aspect. You stated that if you are physically active then no insulin is needed for GLUT4 to transport glucose into the cells, how is that possible? I thought physical activity only increased insulin sensitivity, allowing less for the facilitated diffusion to occur, not that it doesn't need insulin at all. If anyone can help me understand, I would really appreciate it :)
Very nice explanation keep it up
Great lesson! I had a question about GLUT4, can glucose leave the cell via GLUT4? In the absence of insulin, would the increased rate of glycogenolysis result in a greater cellular glucose output?
Many thanks
How long does the exercise induced GLUT4 window last?
@Bennyhidef Any sort of muscle contraction will work to cause translocation of GLUT-4. Strength training will recruit more muscle fibers for a limited period of time whereas aerobic exercise will recruit fewer muscle fibers for an extended period of time. Both have their benefits. I'd prescribe aerobic exercise because it is easier and has more health benefits than strength training, but people like to look good too.
DR. Brian u just rocked my world!!! i think im in love
Epic explanation in Lehman's terms!
Do the cells also open when after a hard workout?
Very good explanation thank you
GLUT 4 is always dependent on insulin to uptake glucose from what i know from text books. GLUT 1 is insulin independent. If you can give me the source of the information that exercise can induce glucose uptake into the cell without insulin, please post me a link. I really much would appreciate it.
wow, it's so easy explanation. thank you so much.
Thank you for a wonderful explanation!
Makes so much more sense!!! Thank you
nice explanation sir
Thank you, very simple helped me to grasp physiology concept.
Very lucid and student friendly
beautifully explained
Thanks. This is a helpful review.
Thank you for simplifying!
I did find this very helpful! Thank you sir
Thank you so much! Very well explained.
How do you know your not producing enough insulin or the cell isn’t taking in glucose?
Thanks dad
Austin Paliga lol
Quick question: In the case of low insulin, can you offset the effects of diminished GLUT 4 activity at the cell membrane through exercise?
So how can we know where the problem is?
VERY helpful! Thank you!
Wow! great teaching!
Glucose can enter the cell via GLUT1 under basal condition. Insulin increases the uptake by increasing GLUT4 expression. This is the reason why T1 diabetics don't need to inject as much insulin if they exercise.
it's 2018 ! thank you so much sir!
Great explination!! Thank you
This was very helpful.
how many pathways does insulin have ?
love it god bless u n thank u so much very great n clear explanation awesome just love n love it
thanks helps heaps. keep them coming, cheers
Isn't Insulin resistance over saturated cells with Glucose just shutting out more Glucose?
Very helpful. Thank you for posting!
thank you very much!!...beautifully explained..
You are a legend.
very clear and it is really helpful thx!!!
That was really helpful, thank you!
yees! I finally undestood it! thanks, you explain very well
Nice info to the point.....
thanks, u help me lots ....
thanks, this was really helpful
Hi, can it happen that the insulin receptor is not working because the cell is already full with glucose? I forgot to say Thank you
No, because if the glucose-levels in the cells are too high they will turn them into fatty acids and store them as fat in adipose tissue. That's how you get fat from Cola even though it contains zero fat.
this is epic, well explained if you will