Thank you so Much. you have no idea how much i appreciate you and your teaching. I am a medical student in germany and education/ teaching is horrible here, well at least from what i experienced (haha you really taught me not to generalize ANYTHING) my professors are more occupied with maintaining some kind of status or maybe even brag with their knowledge (you get the impression that the circumference of their knowledge equals everything there is to know) than to give medical students (which are in fact future doctors) some kind of guideline throughout everything. You know, like a tour guide through a city who points a stuff, but you go and look at it closely and read up on it yourself. It really takes away your spirit, but people like you bring it back. You have a way to be humble and modest, that is not pretentious in any way, but merely the pure and authentic ,almost childlike passion about sience and understanding how the human body, hell how everything works. And frankly in the face of everything there is to know how can you be anything but humbled. you are awesome and you really remind me of why i wanted to become a doctor and what kind of doctor i wanna be. Thank you so much, sir and have a nice day:)
Dear, I am so glad that you have enjoyed and found value in my talks. These are the product of my own learning of these topics. I am grateful to be able to present the way I needed to lay the foundation and then build upon it. You share my journey for these topics as well. Thank you again. Much love from the USA.
Thank you Dr. Mobeen! I was wondering if you had any lecture on lymphoid tissue & structure, such as the spleen or lymph node? Once again, I am very great full for a brilliant doctor like you! Thank you so, so much.
Minor point but at 2:27 it sounds like what you're describing is the thryoid, not the thymus. The thymus, like the thyroid, is lobulated however it is not located in the neck. Also the structure is more elongated than the "bowtie" shape of the thyroid. Again, minor points.
+Raman Kutty I agree, i was about to say the same. Please dont point to your throat, and draw a bowtie figure if you are talking about the thymus. its just bad association that can cause people to mix them up because they remember the visual ques. Otherwise a good and informative video!
+Anja Dahl you both are totally correct. Somehow I pointed at the thyroid to talk about the thymus. I am wrong there. I will see if I can edit over to provide this information.
I just want to say thank you so very much for your lecture. You have helped me a lot! I am so appreciative of professors who like to teach and am passionate about it. You sir rock!- PS can you teach at my medical school? :)
I think it will be enough for me today to finish lecture 7😘👍 .I really see these lectures are very enjoyable and i wonder how was it published in 2011 and it's very common up till now ,Thank you so mucth doctor 😊💖
What does is mean when a child has a high cd3, cd4, and cd8 count? He also has elevated platelets (480) and elevated sed rate (25). Here are the counts from lymphocyte panelCd3 - 5113 (700-4200 normal range)Cd4-2790 (300-2000 normal range)Cd8-2306 (300-1800 normal range)Cd19- 865 (200-1600 normal range)Cd16+cd56+ 475 (90-900)
Hello Dr. Syed I really appreciate all what you are doing by posting these videos. They are extremely helpful. I really do have a question that I am still not clear, though. In the lectrue here you said that the T cells are tested if they bind to MHC class I or MHc class II by the cortical epithelium cells in the cortex. If that is the case, why would T cells remain to be double positive passed this stage when they should have become either CD8 or CD4 right away? Is there any immunologic or evolutionary rationales for them not to commit their linneage right at that stage? They become single positive after negative selection, long after they were tested by the cortical epithelium cells. If what determines in their eventual destiny of being CD8 or CD4 T cells is whether or not they bind to MHC class I or MHC class II as presented to them by the cortical epithelium cells, why then were they stll double positive, passed that phase until they undergo negative selection? Or did I miss something in grasping the concept? My other question is that you have emphasized at the beginning of the lecture that T cells are not educated or trained. They are only selected. Those that do not meet the requirement are only convinced to committ suicide. However, one of the mechanisms of negative selection is clonal editing in which second or third chances are given in rearranging a non self-reactive TCR alpha gene. Wouldn't that be considered as taming or training them? If that is the case, would there be any inconsistency in our previous initial premises that T -cells will only be killed if they do not meet the requirement. I believe my questions make sense to you. Please help me understand . I really appreciate your swift reply as I am having an exam in a couple of days. Best Regards
Good questions. *T cells move to become single positive after interacting with MHC I and II. It is only a matter of time but the trigger is MHC interaction. *Yes gene rearrangement can be seen as taming however, it is not external stimuli that cause the rearrangement. Hence no external training stimuli, just patient selectors waiting for the T cell to be in appropriate state! Hope this was a swift response :-)
Thank you so Much. you have no idea how much i appreciate you and your teaching.
I am a medical student in germany and education/ teaching is horrible here, well at least from what i experienced (haha you really taught me not to generalize ANYTHING)
my professors are more occupied with maintaining some kind of status or maybe even brag with their knowledge (you get the impression that the circumference of their knowledge equals everything there is to know) than to give medical students (which are in fact future doctors) some kind of guideline throughout everything. You know, like a tour guide through a city who points a stuff, but you go and look at it closely and read up on it yourself.
It really takes away your spirit, but people like you bring it back. You have a way to be humble and modest, that is not pretentious in any way, but merely the pure and authentic ,almost childlike passion about sience and understanding how the human body, hell how everything works. And frankly in the face of everything there is to know how can you be anything but humbled.
you are awesome and you really remind me of why i wanted to become a doctor and what kind of doctor i wanna be.
Thank you so much, sir and have a nice day:)
Dear, I am so glad that you have enjoyed and found value in my talks. These are the product of my own learning of these topics. I am grateful to be able to present the way I needed to lay the foundation and then build upon it. You share my journey for these topics as well. Thank you again. Much love from the USA.
You are welcome!
Glad to hear that Emma!
Unfortunately don't have the lymphoid tissue lectures yet. However it is a relevant topic, and I will plan to deliver it in the near future.
These lectures are amazing. You have the gift for teaching I wish my Immunology professor had!
Thank you... Keep studying!!
Thanks!
These video series helped me massively, many thanks from a medical student in Hungary!
Thank You so much Sir. Your every lectures are like pearls.
Thank you dear. Happy to hear it. Study hard and stay blessed.
whoa!you have come to me again!i love your lecture!
Thank you Dr. Mobeen! I was wondering if you had any lecture on lymphoid tissue & structure, such as the spleen or lymph node? Once again, I am very great full for a brilliant doctor like you! Thank you so, so much.
This has been so helpful!! thank you!!
Thank you so much, what a great teaching! from the depth of my heart I thank you again!
You are welcome. Study well!
Minor point but at 2:27 it sounds like what you're describing is the thryoid, not the thymus. The thymus, like the thyroid, is lobulated however it is not located in the neck. Also the structure is more elongated than the "bowtie" shape of the thyroid. Again, minor points.
+Raman Kutty I agree, i was about to say the same. Please dont point to your throat, and draw a bowtie figure if you are talking about the thymus. its just bad association that can cause people to mix them up because they remember the visual ques. Otherwise a good and informative video!
+Anja Dahl you both are totally correct. Somehow I pointed at the thyroid to talk about the thymus. I am wrong there. I will see if I can edit over to provide this information.
+Anja Dahl created an annotation to clarify the issue. Thanks for the correction.
+Raman Kutty created an annotation to clarify the issue. Thanks for the correction.
are you two the ones who disliked this video then? HAHAHAHAHA
Thank you Ciara... Let me know where you want me to deliver a lecture and I will gladly do so ;-)
Thank you Dr. Syed. That was indeed very swift. I really appreciate that.
My pleasure. Good luck for your exam.
Thank you for the informative videos! You are very knowledgeable about this topic.
Thank you Renae A.!
I just want to say thank you so very much for your lecture. You have helped me a lot! I am so appreciative of professors who like to teach and am passionate about it. You sir rock!- PS can you teach at my medical school? :)
"Do you know why this T-Cell is happy?" LOL you're awesome!
+Marjorie Morales :-) thanks! Have you tried drbeen.com for more lectures yet?
I think it will be enough for me today to finish lecture 7😘👍 .I really see these lectures are very enjoyable and i wonder how was it published in 2011 and it's very common up till now ,Thank you so mucth doctor 😊💖
Glad that you are enjoying the lectures. Happy studying. Also, check Drbeen.com for more lectures.
ThanKs you so much !!! You are really doing a nice Excellent LOVELY Job.
Thank you so much sir
The Thyroid is located in the front part of the neck and not the Thymus. Thank you for your efforts!
Thank you very much sir and for making this topic into a simpler manner.. it helped me a lot yo understand the basics. . :)
فكيت ازمه يا حبيلك ❤
What does is mean when a child has a high cd3, cd4, and cd8 count? He also has elevated platelets (480) and elevated sed rate (25).
Here are the counts from lymphocyte panelCd3 - 5113 (700-4200 normal range)Cd4-2790 (300-2000 normal range)Cd8-2306 (300-1800 normal range)Cd19- 865 (200-1600 normal range)Cd16+cd56+ 475 (90-900)
Thank you very much God bless! :)
i really understood T-cell selection and the reason why we not to call tje process as the education or tranining :-)
MUSTAFA KIRCA Good to know. Happy that lectures are useful to clarify the concepts.
hi, where is thymus located exactly? cause some source said it's between sternum in lungs.
Thank you :0)
Hello Dr. Syed
I really appreciate all what you are doing by posting these videos. They are extremely helpful. I really do have a question that I am still not clear, though. In the lectrue here you said that the T cells are tested if they bind to MHC class I or MHc class II by the cortical epithelium cells in the cortex. If that is the case, why would T cells remain to be double positive passed this stage when they should have become either CD8 or CD4 right away? Is there any immunologic or evolutionary rationales for them not to commit their linneage right at that stage? They become single positive after negative selection, long after they were tested by the cortical epithelium cells. If what determines in their eventual destiny of being CD8 or CD4 T cells is whether or not they bind to MHC class I or MHC class II as presented to them by the cortical epithelium cells, why then were they stll double positive, passed that phase until they undergo negative selection? Or did I miss something in grasping the concept? My other question is that you have emphasized at the beginning of the lecture that T cells are not educated or trained. They are only selected. Those that do not meet the requirement are only convinced to committ suicide. However, one of the mechanisms of negative selection is clonal editing in which second or third chances are given in rearranging a non self-reactive TCR alpha gene. Wouldn't that be considered as taming or training them? If that is the case, would there be any inconsistency in our previous initial premises that T -cells will only be killed if they do not meet the requirement. I believe my questions make sense to you. Please help me understand . I really appreciate your swift reply as I am having an exam in a couple of days.
Best Regards
Good questions.
*T cells move to become single positive after interacting with MHC I and II. It is only a matter of time but the trigger is MHC interaction.
*Yes gene rearrangement can be seen as taming however, it is not external stimuli that cause the rearrangement. Hence no external training stimuli, just patient selectors waiting for the T cell to be in appropriate state!
Hope this was a swift response :-)
Lol..the selection process..a typical example of “Many are called but few are chosen “
If thymus get atrophy at 12-13 years how are they cell formed in rest of life?
Looking Handsome 🥰🥰