Melatonin KILLS Cancer: REVERSES Warburg Effect & INHIBITS Glucose
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- เผยแพร่เมื่อ 23 ก.ย. 2024
- Welcome back fellow mitochondriacs! Today we get to the micro series finale on melatonin. We discuss its role at shutting down the Warburg effect and cancer metabolism via multiple mechanisms.
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#cancer #melatonin #chemotherapy
Melatonin is a must for whatever paradigm of treatment you decide to employ for cancer. Is that fairly clear at this point?
What is the sufficient dose of melatonin? We take 0.5 mg to facilitate sleep. But in the case of manipulation with cancer cell metabolism?
@@przemkowaliszewski3290exactly... im sure it's just the normal dose tho😮😮😮
Well, I guess considered the amount of studies that point out at least 7 different mechanism through which melatonin act on cancer celles directly and indirectly, the answer is yes. This being said, I still struggle with the massive dosage that many healhcare influencers recommend for this (180 - 300 mg daily).... I understand that studies shows that there seems to have a benefit at any doses without signifiant side effects, the benefit being higher at higher doses ,,,, very cool indeed and sounds like a major potential breakthrough... but man ... sounds a bit like the far west at this point in time from a clinical perspective as the long term effect of high doses are not known ... This being said , sounds like a very little risk compared to cycling chemo, radio, immuno ...
So how about quoting Dr. Reiter in San Antonio, who's studied Melantonin for over 30 yrs, & who is going to logically tell the public just how much Melantonin stops the Warburg effect?? Y'all are talking in circles, with No shared mg amount of a suggested dose??
After all isn't that the point???
@@drskidzo Yah, sure seems that way.
Dr. Casey Peavler, you are an incredible human being. This material and the way you have laid the ground work and have instructed and informed on every detail of such important information is of great service to mankind. You truly care about the health and wellness of others. Bravo! These presentations are so far beyond the quality anyone would find in medical school. You have a great talent in presenting difficult biochemistry and making it interesting and easy to understand. Thank you for ALL you do. It is so appreciated and hopefully your passion and service causes an awakening in patients and their doctors.
Well said
Wow that is very kind of you to say. I am a bit at a loss for words but I appreciate your support. I really hate seeing sick people. I know it’s hard to maybe fathom for a hospitalist/internist to say that, but considering what I have learned at this point, the majority of pain and suffering I have to see daily, I believe is preventable in many cases. If there is some tidbit of a lecture that helps prevent even 1% of that, it is totally worth it. Thank you again.
Dr. Reiter in San Antonio has been researching Melantonin over 30 yrs; this Dr.'s basically repeating Dr. Reiter's work. I do appreciate the repeat of any info, but don't understand why this isn't more widely known..???
@@DrCaseyPeavler Yah, sure seems that logically, society should be throwing a huge % of medical funding into all the research it can for prevention! First line of defense.
Then looking pointedly at root causation!, treatment could follow that in the priorities.
Without prevention and root causation knowledge, there is just too much guess work in drug development, often with wrong results...... except the rich get richer. IMHO
@@liberty8424 Profit margin not high enough?!?
which rely primarily on mitochondrial oxidative phosphorylation to generate the energy needed for cellular processes, most cancer cells instead rely on aerobic glycolysis, a phenomenon termed “the Warburg effect.”
True.
Thanks for Sharing about
Watching this exciting video while taking a 10 mg melatonin capsule one hour before bed. I am on it just 5 days and I see the difference.Would be great if more videos are created on the impact of melatonin on diseases and pathologies other than cancer.
That’s awesome! Prevention or for some other reason? 10mg isn’t much either.
@@DrCaseyPeavler Hopefully it 's helpful for prevention and also as an anti-aging tool. Already I noticed the fast clearance of the swelling of my righy parathyroid gland and the increased energy and good mood I have at 76 yrs. Maybe I would in the future even take the maximum I can easily find in the market , which is 60 mg.
Dude, most Docs have no idea about melatonin, so it would be helpful if you could do a standard of care video to help them
What do you think would be helpful for them in addition to what I have laid out today?
@@DrCaseyPeavler Gently, try to remind them of their oaths? Or, take a hint from Jack's abrasiveness, and confront them with their laziness in figuring it all out better to help far more people?
So all these;
antioxidant properties,
blockage of lactate production,
inhibition of glucose uptake,
inhibition of mTOR etc
seems to indicate that melatonin supplementation might interfere with exercise benefits like muscle hypertrophy. So it might be better to restrict melatonin supplementation to nights away from exercise time.
I would not supplement with it at all unless you have cancer. That is where risk vs benefit comes in. I do not believe it will damage your exercise personally. If you have noticed during this series, melatonin has opposite effects in normal cells vs cancer cells when it comes to ROS, autophagy and mitophagy at least. My gut tells me its further reaching than that.
" I do not believe it will damage your exercise personally. If you have noticed during this series, melatonin has opposite effects in normal cells vs cancer cells when it comes to ROS, autophagy, and mitophagy at least. My gut tells me it's further reaching than that."
Okay, that puts doubts to rest. Since the Melatonin series has come to an end (I hope for the present only, that is, until something else is brought to light) whats next on the agenda, NAC, Niacin, something else?
Thank you doctor keep up the good work
Thank you, I will!
You are a rock star. 😃 Thank you. ❤
You are too kind! Thank you for your support!
Good night moon, good night community, may you sleep even better!
Take care Ray!
Casey, WOW!
I know Ray lol, it’s unbelievable
Thanks- very interesting. I have doubts about finding a doctor willing to recommend melatonin for cancer though. If only someone could put together a video titled Melatonin for Doctors with links to the papers so us laypeople could forward to our docs.
Some doctors know (others don't care) but are not allowed (lose license and are ostracized) if not towing the party money line.
@@HCW2855HCW I wonder if Gleason 6 prostate cancer would be a good test. It usually is just put under active surveillance. It’s a low grade cancer, mitochondrial functional score of about 2.8, so perhaps melatonin could rescue the mitochondria before becoming Gleason 7. ATP synthase probably still works somewhat.
It seems this could reach a variety of audiences including clinicians. I use the medical literature as my guide so the evidence is there. Question is, will your doctor listen or read the studies themselves….
How many mg to take?
@@DrCaseyPeavler how many mg to take?
i wonder how much of this played a part of the sunlight therapy in the late 1800's, early 1900's ?
My guess, HUGELY
Me too
Yes, and WHY did we move away from understanding this??? A false accounting of benefits, to bring more 'profit at any cost'????
AND, now we live in fear of daylight, as a rule, and poison ourselves as society bathed in isolated 'blue light', that our brains see as white light.
@@raykinney9907 yes (disclaimer: my personal opinion)
Thank you.
You're very welcome!
I took a 10 mg sublingual tablet of melatonin last night. It dissolves under your tongue so you can absorb all of it and it doesn’t have to travel through the high acid environment of your stomach.
Slept longer than usual and still felt like a zombie for most of the morning.
Not ready to give up though. Going to get a lower dose sublingual tablet, maybe 2 or 3 mg and see if I can work my way up to higher doses. Maybe a 2 mg a couple times a day.
Thank you thank you
You are very welcome! My pleasure!
Dr. Casey, do those studies say how melatonin should be delivered to create this environment? IV, under the tongue, mix in the fat of your meal.
I would have to dig into the methods but I would bet it’s all oral administration.
BrilLIANT ! THANK YOU
Thank you for your support! I am glad you enjoyed it!
Dr Jack Kruse…upload with him please
I’d love to some day but I’m not sure he would be on board with my message. I’ve been a member of his for years. He’s pretty tough on anyone other than a straight quantum clinician. I am probably too functional/integrative for his taste.
@@DrCaseyPeavler Well, it will probably come to that anyway. His brilliance, comes out WITH his abrasiveness, but it DOES teach! It is a scary prospect, but the point seems to be.... that time is running out before this ship of medical paradigm has us sailing right toward the edge of the world without much room to make it turn much in time! I have always shied away from abrasiveness of this degree in my personal life, but now I think it is a great tool he using. Your work and bravery to 'put it out there' is another great tool! You are BOTH doing great work for humanity! I'd be for 'taking the hits' and using any resultant energy to feed your work forward, and upwards into the LIGHT. INHO
Dr. Peavler, Do you personally get sun exposure as a preventive measure, and if so, what do you recommend (amounts, time of day, etc.) Thank you for your work!
I get A LOT of sun, and I live here in Miami at 25th latitude North. I really like using the d-minder app. Once you have it on your phone, you will plug in your skin type, it will geolocate you, then you plug in skin exposure and cloud cover. It will help guide you. For me, and my skin type and melanin level (solar callus), I am usually out for 30-60 minutes daily of direct sun exposure. I try to get out several times in the morning, afternoon, and evening for circadian and infrared purposes.
I’ve been taking 30 mg but the next day my head is kind foggy. It’s like I’m light headed. Do you think there’s something I can do to counteract this. Thank you
I hear you. I personally when I was experimenting with melatonin pills felt the same. What I would ask is why are you taking it? Do you have cancer?
@@DrCaseyPeavler yes I do
Then that changes the game a bit. You can discuss this with your integrative oncology team but perhaps using it during the day only for now. Some doctors are giving it every 2-4hrs around the clock without side effects. But no matter how much and when you take supplements. You need max sun during the and max dark after sunset.
You are awesome Dr. How much melatonin and when should it be taken?
Thank you for your kindness and support. Ideally you first and foremost maximize endogenous production. The oral doses for example in cancer treatment would be a discussion between you and your healthcare provider.
Isn’t melatonin also considered by some health experts to be the most powerful antioxidant in the body? On par with glutathione perhaps.
Fyi, my naturally produced antioxidant Astaxanthin 10-12 mg daily (in divided doses, preferably) extracted from the natural microAlgae Haematococcus Pluvialis for its numerous health benefits (including against cancers) according to updated research.
Take enough of your naturally occurring Astaxanthin 10-12 mg as above with food & a tablespoonful of Coconut Oil for the best absorption! Thanks. Melville Jayathissa research from sunny Malaysia
Avoid the synthetic Astaxanthin supplements made from petroleum.
I believe it is far more powerful. Not only because of melatonin's and melatonin metabolites' direct antioxidant effects, but also because it up-regulates the endogenous antioxidant response elements (NRF2 and Klotho).
Is “Aerobic Glycolysis” the fermentation of Glutamine?
Aerobic glycolysis is another word for the Warburg effect but it is a bit more specific. It is specifically talking about the glycolysis arm (breaking down glucose to make pyruvate and ultimately lactate) of the effect which occurs in the cytosol outside the mitochondria. The fermentation of glutamine happens in the mitochondrial matrix when the TCA is located. I hope that helps!
@@DrCaseyPeavler That’s brilliant, Thanks Doc. The Aerobic part gets me as no oxygen is involved!
How much mg you would recommend to supplement to kill cancer cells and Tumors in body. Should someone will benefit if he take Vitamin D3 in Daylight and in the Evenings Melatonin. Thank you very much.
The exact dosing, timing, and schedule would be a discussion between a patient and their physician. I have seen a wide variety of dosing and scheduling from various integrative oncologist.
@@just_Freedom_Peace. Thats exactly what I do. My husband and kids (young adults) as well.
@DrCaseyPeavler Is it shown in clinical studies or similar that Melatonin kill cancer cells and Tumors? Can high Dose of Melatonin (like 100mg) be toxic for someone.
How about a 500 watt halogen lamp especially for the cancer region? It’s NIR spectrum seems appropriate and only $18
Sun first and foremost. But I think I would do a Sauna Space Bulb, RubyLux or TheraBulb instead or you could do Photobiomodulation Red/NIR panel.
@@DrCaseyPeavler well, I’m trying to find one at 3300-3400K but the 500 watt halogens only seem to reach 2800K, which provides mostly far infrared. Incandescents have shorter life at higher temperatures without some halogen to keep the tungsten surface clean from oxidation. Nothing is easy.
@@ws7001 a precise and optimized wave length composition is only possible through LED ... physics tells us
@@ws7001 I just looked up that sauna bulb, $595....I'd have to get a job to buy that and hope it doesn't break in the mail. Can you imagine? lol In the mean time I'll use the $12 infrared 250W chick warming bulb I got at Tractor Supply. Better than nothing and I read that cancer can't stand the heat, and it does get the area mighty hot.
@@ws7001 Look into infrared panels, devices and lamps. There are a lot on the market at different price levels.
What are the modalities of the press pulse that can damage the mitochondria besides metformin ? does HBOT do the same for healthy cells ?
That is a great question. I mean I guess what all does press pulse entail? There are many different ideas of what it could look like. But if you use strictly Dr. Seyfried’s framework, then metfromin would be the only obvious one. HBOT likely does cause a mild oxidative stress to normal cells also. But this may act as a hormetic stressor and overall boost health in process. I personally would not use HBOT unless I had cancer.
@@DrCaseyPeavler thanks for this. it helps
What levels of melatonin were they using in these studies
Thanks Dr. How can people get sun exposure and avoid skin cancer?
Simply don’t burn. Chronic sun exposure is associated with a roughly 15% decrease chance of developing melanoma (the most deadly skin cancer) and an almost negligible increase risk of basal cell and squamous cell skin cancer. When you look at the epidemiological data for cancer deaths those 3 combined make up WAY less than 1%. What people are actually dying from Breast, Colon, Lung, are all decimated by sun exposure. Just take it slow but get out there as much as you can.
@@riumudamc4686 Use sunlight in the mornings and evenings when the infrared part of sunlight that reaches your body is higher. Also look into Methylene Blue for UV damage protection.
Does it mean that you need sunlight to increase melatonin? Near Infrared and infrared lights? Low blood glucose levels and sunlight?
Yes,but for a teatment itis better to use 40mg/d
Cancer cells could have disrupted melatonin production.
@@pterakau my mom tried, started with 5mg at evening and could not stay awake next day. She stopped.
@@p_peja Early morning (first two hours after dawn), is a great time to get near infrared light (outside in the LIGHT) for a half hour. this helps turn off the pineal gland melatonin production that tends toward sleepiness, and the early morning NIR starts up the mitochondrial production through the whole body (and does not induce sleepiness). This syncs up the whole hormonal process to be TIMMED right! If your mom avoids LED light in the evening, and sleeps in total darkness, goes out each morning to catch the first daylight, she will probably not even need to try to induce sleepiness with taking any melatonin a all, because her pineal-derived melatonin would be enough IMHO.Someone with cancer issues might however benefit greatly by higher doses, as SO WELL suggested by all of these research papers.
To answer the first question, I think that better describes prevention. Healthy weight, healthy diet w/ preserved insulin sensitivity, active lifestyle, perfect circadian rhythm, as much natural light as possible both direct and indirect.
When you have disease you need all the above with even more urgency and as alluded to in the video, likely endogenous melatonin because cancer cells loose their ability to produce melatonin which is really good for them but bad for us.
cool. Melatonin, the cryptonite fo disease and radiation.
The bg question is now how to translate that into practice, not only for cancer patients. After all, we are all cancer patients most of the time. But even putting that aside and focusing on mitochondria in aging but still more or less healthy cells, which kind of regime and dosis? sidemark: senescent cells are vey similar o cancer cells....
would it be possible to just raise melatonin 2 or 3 fold, while keeping the diurnal pattern, by seveal small doses throughout the day, and a bigger one in the evening? Would that come with side-effects?
I guess having the metabolism already trained to be abe to go keto would help....
I think you would benefit from the second video in this micro series talking about boosting your endogenous production via sunlight. You can do just what you hypothesized. Raise your melatonin during the day 2-3 fold the nocturnal circadian spike. Then of course video number one is about how nocturnal pineal melatonin works.
Yah, that seems to be what we were evolutionarily adapted too by living outside for countless thousands of years.
Can a cancer cell that start to regulates itself back to a normal-ish state through melatonin supplementation can produce new healthy mitochondria with normal cristae etc. ?
I think I would answer this by saying remember, a tumor is made up of millions and millions of cells, with thousands of different gene mutations.
If you look at a graph I posted in the first cancer as a metabolic disease video, part 1 I believe, there is a graph from Seyfried’s group of where energy comes from in cancer cells. The more malignant, the more Warburg metabolism, whereas earlier in the process, it relies more on mitochondrial oxphos. Melatonin appears to hold the keys to metabolic reprogramming the cells that still have enough mitochondrial mass to revert back to normal functioning cell. However, if Warburg effect has taken too much ahold of the cell, HIF1a will excessively stimulate mitophagy remember and essentially make the cell completely dependent on Warburg/glycolysis. Those cells I do not believe can be reprogrammed; those cells will be destined for destruction and written off as too dangerous to let live.
@@DrCaseyPeavler this is so interesting. Could we even hypothesize that the cells in the "early stage of warburg effect " are less likely to be killed by "traditional" metabolic therapy (therapeutic ketosis+glutamine inhibition+HBOT) as they are "less vulnerable" and might be able to survive on ketones ... . So melatonin could take "care" of such cells , thus preventing recurring cancer development even after traditional metabolic therapy ? Probably a very stupid question, but this is amazingly interesting
@@drskidzo Indeed!
But it also downregulates HIF-1, Wnt/Beta-catenin, IGF-1R, AR and TERT pathways, all of which are essential for male health, so please don't use melatonin as prevention, only if needed (and in synergy with astaxanthin, berberine, curcumin, lycopene, epigallocatechin gallate, selenium and myo-inositol)
I don’t know if I can agree or disagree with what you are saying. I would say I’m not a fan of supplementing for prevention. But I am a huge fan of maximizing endogenous production for prevention and treatment.
@@DrCaseyPeavler I think we can agree indeed! 🙏🏻
⁸@@DrCaseyPeavler
I take 3 MG before bedtime is that OK for 71 year male ?
I would ask you a question to better answer your questions. Are you healthy in in general or have a disease such as cancer?
@DrCaseyPeavler I'm healthy no cancer
Would this apply to metformin as well?
We will talk about metformin and yes it does also antagonize the Warburg metabolism through several mechanisms. I personally would not take it for prevention because it damages mitochondria. For cancer, risk vs benefit discussion between you and your doctor.
@@DrCaseyPeavlerthank you for clarifying, I am looking forward to any and all future content 🙏
Oh it’s coming! I’ve got the next 45 videos planned out at least.
@@DrCaseyPeavler I hope you have a few GOOD breaks planned in too! When do you sleep? Maybe you need a little more melatonin and D3?
Hi, I saw several of these vieeos about melatonin and I have 2 questions and 1 concern.
1) if melatonin blocks some glucose transporters it does that not only in cancer cells but in healthy cells too, isn't it? I dont see the point here.
2) could it be a possible strategy instead of supplementing during daytime do that at night to boost melatonin levels higher as a press pulse strategy?
3) my concern us that all the cientific articles presented except one were all written by an author and his collegues. It is suspicious that nooneelse is following this discovery.
Thanks Dr Casey. It is a beautiful work you are doing here with these videos.
I suspect the glucose uptake would only affect cancer cells which rely on glucose, and bring in 10-30x more than a normal cell.
I have seen protocols that do it at night and during the day and both. I think dose, timing and scheduling is nuanced and needs to be in a good dialog with your doctor who knows your specific situation.
Yes, Russel Reiter, who is either the principal investigator or at least cited on most of the paper is kind of the guru for melatonin. He is likely the most prominent researcher in the space. I think the concern is valid. But these articles should be peer reviewed.
@@DrCaseyPeavler Well, if glucose is limited in healthy cells, and more focus put on ketone fueling of mitochondria, as used to be dominant in mid to northerly latitudes, ketones may fit right in to this. No?
@@miquelmm6157 There is a huge amount of sudies from all over the world on pubmed. Just take a look.
Seems all c patients need melatonin.
Certainly seems that way to me
They better not try to K themselves by overdosing melatonin pills.😂
@@earthinvader3517 360mg a day too much?
Can one overdose on Melatonin?
According to the words most preeminent researcher, Dr. Russel Reiter, they have not been able to find a toxic dose. I have to believe there is a toxic level but unlikely at the doses that would be used clinically.
Studies I have read say no.
Wow, and we can test for fluctuating melatonin levels!?! So, it sounds like it might be good to try to keep it present in the tumor (as well as elsewhere) as evenly as possible? Given the suggestions of half-life effects potentially dropping the levels cyclically somewhat, might NIR (especially perhaps the longer more tissue-penetrative wavelengths?) application to the general tumor sites every two or three hours round the clock, but probably only need ten minutes exposure at a time, to stay better 'topped off'??
Make mitochondria great again!
MMGA haha. You know Bobby Kennedy coined the term MAHA which I love.
If I had cancer I would be in sunlight getting NIR as much as I could. When inside I would be shining an EMR-tek or sauna space bulb on the location of my cancer during my waking hours. Just bathe that tumor in melatonin. Since melatonin has a paracrine effect you would have to imagine healthy adjacent cells would transport it into the diseased cells.
@@DrCaseyPeavler How would you prevent skin cancer from the sun exposure? Thanks for the videos, it is interesting info!
I think I answered this on another thread where you posted! God bless your journey back to health!
That would be a good video, "If I had cancer this is what I would do ".
THERE IS NO DISCUSSION. ONLY HE IS TALKING AND NO ONE UNDERSTANDS.
I acknowledge that this video in particular would be a tough place to start if you haven’t seen any of my prior videos. This is a very long series called cancer as a metabolic disease. Each video builds on the last one, and this is like video 40. It’s like coming into class halfway through the semester. If there is anything I can do to help you better understand, I would be happy to try.
@@DrCaseyPeavler No pain no gain. All of us have a lot of work to do, to put this information into our minds better. The lesson is the whole series of videos. I've watched them all, but barely scratched the surface, of what can be gained... and added to. A lot of us gain a great deal off essential knowledge from this, sure some might not be quite right, but that is the point of scientific method toward being able to increase predictability of new pathways forward to help the children of our grandchildren live well.
@@WolfmanMack In academics discussion means to take a deeper look into something.
It does not mean dialogue or conversation.
I took a 10 mg sublingual tablet of melatonin last night. It dissolves under your tongue so you can absorb all of it and it doesn’t have to travel through the high acid environment of your stomach.
Slept longer than usual and still felt like a zombie for most of the morning.
Not ready to give up though. Going to get a lower dose sublingual tablet, maybe 2 or 3 mg and see if I can work my way up to higher doses. Maybe a 2 mg a couple times a day.
Are you in general healthy or are you struggling with some disease such as cancer?