These two gents can’t give enough long chem/med names and orders of creation and interaction for my liking. Tell Jeffrey the skeleton to ‘hang in there’ while we get our fill of med speak.
As a high school graduate, your videos really helped me understand a lot of my body, which in turn, helped me pass anatomy and physiology. I was hoping to go to med school but since I has no money I'm learning from home. If every school did this it would make people more excited to be doctors/nurses. You're doing more for this world than I think your crew realizes.
Don't give up!! There are many grants and scholarships. Especially for financially needing students. Check out PELL grants. That's how I got started. Best of luck!
@@shannonobrien9922 Seriously... ...One little typo! That's all it takes for some people! I has many typos on mine messages and yorn un Nicks dun look so hot kneever.
Please young one ( I’m probably old enough to be your grandparent) don’t give up! We need good , qualified people in the medical field. If this is your passion please look into financial aid ( scholarships, grants, loans as a last resort). I had one excuse after another not to chase my dream.. finally got the family off and own their own and here I am at 57 finally getting my degree. Don’t give up!! I’m rooting for you!
Being disabled from birth with hydrocephalus I never was able to take anatomy or health classes so in saying thst your shows are very informative to me . Thanks very much guys for providing them for mr keep up the great work!!!!
I didn't get to take Biology because my high school counselor thought all kids were stupid. Luckily, she was fired soon after I graduated so none of the other students would have to deal with it.
A topic I'd like info on is eczema. The more I read about it, the more confused I get, so a lecture would be great! Is it some kind of auto-immune reaction?
@Noctina Tatakai it's called phototherapy and there is a lot you can find online on the subject. Usually, they say it requires going to the doctor for a treatment. I have personally found phototherapy helps with my eczema outbreaks. One year, it got so bad I was in tears over the frustration of it. My skin was inflamed, bleeding, and blisters started arriving. I hate using steroids of any kind, and felt like they never really worked that well for me. So, I decided to do some research on the matter, and I started going to tanning beds (consult your doctor on that) twice a week, for 6 weeks at 10 minutes each. No longer as I wasn't trying for a tan. My outbreak started to ease, and eventually, I was free of it for a year. I currently have a small patch on the back of my neck and in my hairline this time. 😅 Please note, I don't advise constant use of a tanning bed for obvious reasons but that's what worked for me. When I spoke to my physician on the matter, he advised that I just use caution when using a tanning bed. Some offices can refer you to a specialist for phototherapy. Phototherapy is also a treatment commonly used for jaundice in babies.
@Noctina Tatakai thinking upon this, 🤔 this could be where the Natural Health Connection could have a plausible connection with nutrients. Seeing how our skin takes the UV rays and transforms it into Vitamin D. If you're not already, try taking extra Vitamin D, if you are bothered by eczema, and see if that possibly helps any symptoms. I haven't tried that but I also take multi vitamins everyday just for my own extra precautions. I think I may of found another subject to look into on this matter.
I have been a pharmacist for over 35 years, and I love your videos. I think you provide a great foundation for difficult concepts. Thanks for what you do!
The video was NOT too long. Another excellent job of explaining without getting too technical and, at the same time, not being so simple that it's worthless. Keep up the good work.
I get up around 4 every morning and Bing watch these videos. I love how they explain things in a way that the general public can understand. Thank you and Keep up the amazing work!
I'm so glad I found this video. I have patients ask me how Tylenol works, and I have felt bad not having a great answer. Well, it appears that no one else does, either. Now I don't feel quite so dumb. I love watching your videos. It has been decades since I took my A & P classes, and this format is a great way to remind me of all of the tiny details that I have filed away. Thank you so much!
I am a pharmacist and nursing instructor. I want to say this video and explanation is the best I’ve ever seen! I am retired now but I wish this video was available to show my students when I was teaching. BTW, I am a BIT surprised you did not mention Substance-P. However, I guess it’s because we do not know all that much about it and due to the length of the video. Perfect job! 🥇💯‼️
Interesting point of clarity on the topic of overdose. As is mentioned, toxic NAPQI is produced, but then degraded. However, if this degradation is overloaded, overdose results. A common example used is how a city can be flooded. The drainage system removes water from the streets of the cities. However, if the water supply increases to the point there is more water than can fit into the drainage system, it is not possible for the drainage system to remove more water than it can fit into the drain. Similarly, while the liver does possess the ability to degrade toxins, if a larger amount of toxin is produced than the number of enzymes to degrade the toxin, the only possible option is for the toxin to remain. Thus, it is not that the liver does not have the ability to protect from toxins, but that this ability simply has a fixed number of how much it can break down at one time.
Wow, you worded this to where I can actually understand it! Thank you so much! I'm not a medical student or anything, I just have a brain lesion in the pons of my brain and like to learn about the reason I have different ailments.
I’m curious, does your ability to convert NAPQI (or, in other words, metabolize acetaminophen) diminish with age? I ask because I sometimes take large doses to treat migraines.
@@Stunbunny That's going to be a big fat "It depends"... Very slightly more nuanced than that, "It tends to, but doesn't have to." With age, here on planet Earth, we tend to endure a lot of things... from common colds and flu, to catastrophes, highs and lows of emotions, and adventures that may enter exploration into recreational or self-medicating drug use... or even catastrophic collapse into depravity (not judging) and outright self abuse. As such, many of the things we endure damage various parts of our bodies, including the liver... We heal (including the liver)... BUT there's also "scar tissue" to consider... AND wherever it happens, scar-tissue does very little more than hold healthy tissue together. Many scars on your skin (for instance) have little or no sensation. Having a friend with a fine enough instrument "stimulate" JUST the scar tissue while you look away, and you can demonstrate this... Just try to notice WITHOUT LOOKING when your friend is touching the scar and not. You won't get a perfect result like you can literally anywhere else with "healthy" tissue... The bigger and more "gnarly" the scar, the less sensation you'll be able to feel... Not all the healed damage in a liver is necessarily scar tissue... AND like your skin, scar tissue DOES "fade" or diminish over time.... It's just rare (once you've got a scar) for it to go completely away at the cellular level... The pattern of cells is "messed up" and that almost never goes away "like nothing ever happened"... Live a reasonably healthy lifestyle, and with a little luck, you won't get into anything that does so much damage as to cause too much liver scarring... A little function might drop occasionally (everyone and everything has bad days) but other than a temporary deficiency (like dehydration) you won't lose a significant amount of liver function over MANY years or decades of life... Relax... Remember to BREATHE... I've known people who drank at LEAST more than recommended frequently throughout their lives, and lived long lives without serious side effects... In their old ages, doc's seemed mystified, saying things like "I wish I could have numbers like these." SO it's not that even periodically hitting your limits is necessarily bad... It's not good, but "chronic" over-use tends toward daily or (at least) multiple times weekly levels of over-use... Finally, I'm not even suggesting your levels of use are necessarily over-use. THAT is something to be talked over between you and a doctor... You CAN (btw) look up a document on Acetaminophen called an "MSDS" and under the "toxicity" category a number labeled the "LD50". This is how much of the Acetaminophen tested in a lab setting killed about 50% of the test subjects (usually rats)... AND it's usually listed as "XXmg/1Kg", which means how much of the drug per Kilogram (2.2 lbs) of body weight was dosed in said subject... There's usually some technical garble about what subjects and how it was tested or if there's some other measurement that was used... BUT with the LD50 number, you can also do the math and estimate about how much it would take to have a 50% chance of killing you.... It's not a great guide, but it gives a rudimentary number to scale that you can understand... AND if that number worries you, maybe worth a talk with your doctor, too... If (on the other hand) it's on a scale of 100 or 1000 TIMES as much as you've ever even contemplated taking in a day, you can breathe a sigh of relief... It's likely (by luck or otherwise) you've escaped causing yourself any harm... It's worth saying that you MIGHT be able to search "LD50 Acetaminophen" as a shortcut. I just happen to KNOW you can find the number as LAW REQUIRES it be listed on every MSDS... (AND there's an MSDS for everything, including ordinary WATER)... "just for fun"... BTW... NEVER be afraid to talk to your doctor about alternative treatments for things like migraines. It's especially important if you notice a change in their regularity or persistence. It may be "nothing to worry about", but you're FAR better off to get that reassurance from a Doctor you actually know and trust than some document online or a faceless mook you only just met through a YT comment... (haha... called myself a mook) Sorry for the length... JUST hope you find something helpful... and maybe a tad entertaining for your time. ;o)
I actually enjoy the longer videos. I am fascinated by the human body and how it works. Please keep them coming and the longer the video the better for me because it’s more useful information. Thank you so much for this. I had no idea that Tylenol had this affect on the body
WOW! Can I relate to this video. Tylenol has absolutely played havoc with my liver. I told my liver doctor, and regular MD, that they should quit advising people to take it because of pain. Hospitals would always give it to me when needed. It's horrible and I cannot thank you enough for making this video. I wish everyone could hear this truth. BTW, your video was not too long. They never are.
I have never ever come across such a knowledgable and yet relatable and “easy” to understand man in my entire existence! (I say easy… but you know what I mean, it is so well articulated and explained!!!) Do / could you make any content re SLE (systemic lupus) and or Addison’s disease and how these effect the body / different organs?
@@theanatomylab actually, biochemistry class in undergrad finally made sense to me, thanks to your videos! Been watching since fall last year, glad to have these vids recommended to me 🥺✨
a recent peer reviewed article (examining over 1000 articles on the efficacy of Acetaminophen/Paracetamol) was simultaneously published in the British Medical Journal, The New England Journal of Medicine & The Lancet. The article clearly demonstrated that taking Tylenol, (Acetaminophen/Paracetamol) was far more dangerous & toxic than advertised or prescribed. It also showed that the drug only had a very small/negligible 'pain relief' effect on most injuries/trauma (including headaches & back pain).
Pharmacist here. At first, the title made me feel like this was some kind of fear-mongering attempt, but I stand corrected. This is quite accurate info and on point
The medication video series are so interesting, cant wait for future videos about opiate use, antihistaminic, benzodiazepines and ambien, ssri, adhd medication, benadryl, ketamine. The medicinal use of these prescribed drugs, what benefits can they provide and the cons and consequences of long-term use/abuse. Absolutely love these videos. Smarter every day
I suffer from cysts on my spine, running from the thoracic to upper lumbar. I'd love to see a video detailing CNS injury and at what level you'd expect to see corresponding numbness and loss of limb control. Also, this was perfect timing. I've been taking the max daily dose of Tylenol for over a month now and have been really wanting to know more about what it could be doing to the body. Thanks a ton for the info! I'm on a chemotherapy that prevents me from taking NSAIDs so thats all i'm stuck with using for now.
I work on a pcu unit that deals with liver diseases. You may need gabapentin for your nerve pain, your limit to 4g of acetaminophen per day but you should have your doctor check your liver enzyme levels since you've been taking that much acetaminophen for a while. You should see a pain specialist.
Look into trying kratom if it is legal in your area. I used it to get off of oxycodone following a surgery, and now I continue to use it for pain. It's an Asian herb that is usually eaten as a powder, capsulized powder, or compressed powder tablet from the ground-up leaves of the tree. It can also be consumed as a tea (I find that gross) or as an extract liquid. It is a weak, low addiction potential, pseudo-opiate. It isn't a true opiate but it interacts on the μ opioid receptors and that is how it can treat pain or ease withdrawal symptoms from things like oxycodone or heroin. :) Many people use kratom to self medicate their pain when they want something that can be purchased and used without a prescription, and is more powerful than Tylenol but not as powerful as oxycodone or hydrocodone and not nearly as addictive either. It is phenomenal. I do caution you though, to discuss using it with your doctors because it does contain a variety of alkaloids which inhibit a few liver enzymes, in some cases very powerfully. That means your medicines may not work as well or may work much more potently. Doctors may say "Don't take that; it's addictive and unregulated and you can even die from it." They're just trying to cover their ass because they don't ever like patients self medicating. They'll say not to use kratom, but then wrote you a prescription for Vicodin and Xanax which are way more harmful. They won't bat an eye if you tell them you drink 3-4 beers each afternoon 3-4 days a week. 😸 It's just ignorance and ego. Do your own research on it and decide for yourself, but I'll tell you that kratom changed my life in many ways for the better. I would be much less happy if I didn't discover and use it.
@@Plainsman1300 It isn't. NSAID is a class of drugs which are somewhat simmilar in structure and simmilar in action - they are all COX-2 (some also COX-1, to a various degree) inhibitors. While, yes, acetaminophen is not a steroid, it doesn't belong to NSAID group, because it doesn't imhibit COX enzymes to a significant degree, the mechanism of action of paracetamol is different.
However, with the war on drugs, those of us with severe chronic pain have had our prescription pain relievers decreased below the threshold of efficacy. Thus being forced to take more and more Acetaminophen and ibuprophen to try to have some semblance of quality of life and periods of time with lowered pain each day. I was put on prescription pain medications when I ended up in the hospital with an enlarged liver and acute abdomen from taking so much OTC pain med.'s to be able to work...as a nurse. Now I'm basically bed bound now that I am disabled d/t back, hip, and other chronic injury related pain.
I'm so sorry to hear that. Prayers that you find a way to feel better. Have you researched natural remedies or gone to a doctor of naturopathic medicine (ND)? Research wild medicinal herbs used for pain, esp back in the civil war days and the depression. Very interesting @@phillipnesmith2698 I was in liver failure, and was put on the RX pain medications or I wouldn't be here or had to have had a liver transplant. I took so much Ibuprofen and Tylenol, and asparin as well to be able to function and work starting basically with my nursing career in my 40's. I was a hard worker, doing retail on my days off just for fun! I'm enjoying retirement even though I'm disabled and not at all in good health.
Thank you, thank you, as a nurse I feel your channel is more valuable than all the CEU classes I have to pay for. I 😘 ve keeping up with all the current research via your videos.
I have several budged disc's in my lower back along with sciatica and bursitis. I would be very appreciative if you could touch on any of these problems so that I could understand my condition better. You have a great simple way of explaining everything you talk about. You are an excellent teacher. 💎💗
You have a very commanding voice that is easy to listen to. The delivery of the content is exquisite. I'm big on vocabulary and it helps to imagine their definitions. All of your videos are changing minds and understandings. Many thanks. Continued success.
Very interesting, as always. I learned a lot. You have the art of delivering material with clarity without "dumbing down" the scientific language. Much appreciated.
Hate to tell you mate but these videos are very “dumbed down”. There’s some use of medical terminology, but a lot of content is skipped in explanations
Thanks for this video. I come from a medical household as my Dad was trained in medicine in England. He was very cautious when it came to prescriptions and any over the counter meds. We never had multi vitamins in the house. He did the cooking and we got everything we needed from the foods we ate. I recently pulled a muscle in my chest and bruised the ribs there. I’ve only been taking one Tylenol when going to bed for the pain. If I can I try not to take one. It’s hard to lay down though. I just found out my neighbor in senior housing complex. She has kidney damage from taking too much Advil. I’m very careful taking any meds if not at all. You are the only one so far to talk about the dangers of taking too much, Thanks!
I wish you were around when I took Gross Anatomy in 1990. The clinical aspect of Anatomy weaved with the physical anatomical body that is dissected into the corresponding body parts make the subject much more understandable. Then you add the normal and pathophysiology along with the "big picture" of biochemistry. This is a much better way of teaching than 25 years ago where you bought books, worked on a cadaver and lectured by professors who expected you to put the clinical pieces together on your own. Great presentation.
Also need to watch out for people in early stages of Alzheimer's or dementia -- they can forget if they've already taken a dose of acetaminophen and re-dose repeatedly. Thankfully I've never encountered this personally, but am given to understand it is a potential risk, and why even OTC medications should be closely monitored in the elderly.
Some should be taken with a food for a better absorption because some vitamins (A, D…) are lipid soluble and some (C) are water soluble. (Vitamin C helps iron absorption) Some should be taken before food because they can inhibit the absorption of some vitamins in our food. (Example calcium inhibit iron absorption) and like he said while taking Tylenol you cannot be drinking alcohol because the effects are not advantageous…
I really love this channel. I teach statistics and programming languages, but I'm fascinated by the human body. This channel makes all topics so understandable. Thank you very much ❤️
NEVER NEVER APOLOGIZE FOR THE LENGTH OF ANY OF YOUR VIDEOS, YOU ARE A SMART YOUNG MAN AND I LEARN SO MUCH FOR YOUR WELL EXPLAINED VIDEOS, THANK YOU SO VERY VERY MUCH FOR SHARING AND YOUR WONDERFUL WISDOM!!!!!!!
I really appreciate the time and effort you spend on explaining all of these different topics and details.... I love science...keep up the good works..... you are absolutely helping people... thank you and I am grateful.
I'm an engineer and really appreciate a thorough explanation of anything technical within my ability to understand. Therefore, explaining complex mechanisms such as human health require an appropriate time to deliver. Your videos are never too long. Thanks a lot.
I prefer Ibuprofen over acetaminophen because I find most of my pain is caused by inflammation. When it's really bad, I take both. 30 minutes after the first one. Rarely though. I am aware of the effects of medications on the body so I limit everything
Tylenol does nothing for the pain, only dulls it for a few minutes. I have taken ibuprofen which worked well with the pain. ( I am not allowed to take it cause of my Kidney transplant. )
Tylenol very nearly killed me a few years ago. One of the attending physicians thought I might be in pain, & prescribed some Vicodin, *without* reading my chart first! Long story short, the Tylenol in the Vicodin very nearly did me in. Turns out, I'm one of those folks who is quite literally *deathly allergic* to Tylenol!
My girlfriend was in the hospital and they did kill her with Tylenol. Now it's getting people ADHD and Alzheimer's and heaven knows what else I take aspirin I like to break them up so they dissolve faster in my stomach
@@rileylois545, Tylenol allergy is known, but not too well, unfortunately. It's rare enough that I now wear a Medic-Alert bracelet. My condolences & sympathies to you on your GF's passing.
Absolutely the most informational videos I've ever seen. The few I've seen have changed the way I treat my body from day 1. Thank you. I may live past my 76th birthday which is right around the corner.
I work in a hospital as a respiratory therapist. We had a young woman come in who definitely had “brain damage”(she definitely wasn’t herself, unable to take care of herself) and she had been on a ventilator and eventually needed to be trached. She had taken an overdose of acetaminophen which caused all of her problems. I was kind of surprised because I guess I had always thought of Acetaminophen as a rather benign medication. I received a great addition to my education that day and it was so sad to see her condition because of acetaminophen. She was only in her 20s
Back in the early 1970's Tylenol was a new product on the market. We had a patient admitted for taking an overdose of Tylenol with Codeine. I so clearly recall the doctors scratching their heads saying they knew how to treat to codeine overdose, but not the Tylenol, and were not sure what to do for her liver. She died.
I work at a mental health facility for teens. Many of them come to us after making attempts. Kids often try to OD on Tylenol because it's easily available at home or easy to shoplift. I wish I could explain to the kids that death by Tylenol is a slow, painful process.
Your videos are great! I love them. They're explained so well and they also help me out with my anatomy/physiology/sports medicine classes. Never apologize for the times of your videos.
Video topic suggestion: my mom has benign essential tremors and has recently started seeing a neurologist for them. How my mom described it was that a part of her brain was overactive and it caused her to shake. I'd be interested in seeing a video on which parts of the brain cause shaking like in benign essential tremors and how that shaking differs from shaking caused by Parkinson's.
I also have benign essential tremor and I have found that taking Benadryl (i.e. Diphenhydramine) will make the tremors ease up a bit (not go away). Probably because it seems to make some people sleepy. I don't get sleepy but that is just me.
When we move our skeletal/voluntary muscles, we call that the "somatic motor" system. It involves many steps and many parts of the brain. For example, you want to reach down and pick up a coffee cup to take a sip of coffee. You start off the process of moving that arm by making the decision in your frontal lobe. You then use your somatic motor cortex portion of your cerebrum to plan and formulate the neuron action potentials (APs) that need to be sent to the specific arm muscles needed to move that arm and pick up the cup. Your motor cortex figures out these APs and sends the signals to structures called the "basal nuclei." The basal nuclei contains many small functional clusters of neurons which fine tune these motor signals coming from your somatic motor cortex. The globus pallidus for example, is an inhibitory structure which takes these very rough APs and inhibits them to smooth them out and make them more controlled. The basal nuclei filter out random or unwanted motor APs which would cause twitching and convulsing if allowed to reach our muscles. After the signals have been fine tuned and smoothed out and highly processed, the cerebellum also does some coordinating and further refining before sending the signals to the anterior spinal cord or the cranial motor nerves to get those APs to the proper muscles. Parkinson's disease involves the death of an area in the basal nuclei known as the substantia nigra. Those cells release dopamine and they are involved in filtering our unwanted movements and refining these erratic APs. When they die, they no longer do that and you end up with the shaking and severe tremors and muscle rigidity that makes walking and talking difficult. The dopamine part of the basal nuclei fights the acetylcholine part to regulate the movements. When the inhibitory dopamine is gone, the excitatory ACh is left and there is an imbalance causing the inability to smooth out and filter out the unwanted jerky movements. You can have many other types of movement disorders too, like your mom's tremors when there is an issue with any of the basal ganglia structures. You can also have medication-induced phenomenon. These are called "extra pyramidal symptoms." I myself actually take a medicine called "lamotrigine" which treats my bipolar disorder. It rarely can cause EPS and it does with me. I get random, short lived myoclonic jerks. My arms and legs will just randomly twitch and contract. My leg might kick out for 1/2 a second while laying in bed. My head may turn to the side in a quarter of a second and return to normal position. My arm may twitch and move a little harder or faster than I intended when reaching for something. My feet and toes experience the worst of it. It's harmless, and it stops when I have stopped taking it briefly in the past. It's pretty noticeable at night. My feet and toes and lower legs twitch and kinda dance around every 10 seconds or so and my core muscles do too. It's annoying for me and my partner who I spoon with when falling asleep. I take Benadryl to fall asleep and it also helps stop these twitches almost completely. Benadryl is an anticholinergic in addition to being an antihistamine. As I said, dopamine inhibits and acetylcholine excites. Taking an anticholinergic that decreases ACh means less excitatory input in my basal nuclei and that means less twitching. :) There are other primarily anticholinergic medicines like benztropine for example, which are very strong and effective anticholinergics. Benadryl is just an antihistamine that coincidentally also has some anticholinergic effects too. These anticholinergics like benztropine are used to treat Parkinson's symptoms and movement disorders caused by antipsychotics because the death of the substantia nigra leads to excessive ACh control of the basal nuclei and suppressing it helps lessen the imbalance and ACh overload of the system. :) Antipsychotics also work on dopamine receptors so they can produce movement disorders. They are usually either EPS in nature, or Parkinsonian in nature. Antipsychotics often cause something called tardive dyskinesia which is due to the eventual homeostatic failure of the dopamine-ACh balancing system and it leads to uncontrollable movements, usually of the face. :( So, TL;DR your mom is correct. She has some sort of issue in her brain's basal ganglia that cause her to have less inhibitory signaling than normal due to a dysfunction of one of the structures within it. Perhaps she has not enough dopamine, or perhaps too much ACh, or perhaps just low response of some neurons in the globus pallidus for example that don't produce as high of a voltage to inhibit and block these unwanted tremors. Has she looked into medication to treat it, such as benztropine or many others that help regulate the basal ganglia? Hope this info helped you. It's really fascinating how complex our brains are even doing something as simple as moving our arm to pick up a coffee cup. So many steps in the process, and it happens almost instantly! Next time you watch someone juggle, think of how many things have to happen from the reception of light from vision when looking at the juggling pins, to calculating the trajectory, to formulating the motor plan to catch the next pin, to smoothing and refining those movement signals, to sending them down the spinal cord, to sending them to the correct muscle fibers and recruiting just enough motor units to put the arm in the correct spot and throw the next pin with the correct force, and the process of releasing ACh at the synapse of each of the individual muscle cells which leads to them depolarizing and releasing calcium and unblocking the actin and myosin so they can bind and contract to make the muscle tense up, and the constant binding and unbinding if ATP to make these actin and myosin fibrils climb along each other just enough to contract properly, and then the collection of all that calcium within the muscle cell back again into its storage container so that the muscle stops contracting and can relax, only to have another AP sent through the whole chain of events again and make the muscle cell contract all over again. It all happens in the blink of an eye, and it's absolutely mind blowing!!!
May I ask you to possible consider doing a video on the thyroid? Over 24 million people in the US struggle with the painful effects from this organ every day! Thank you!
Omgosh. I have never heard say they are allergic only me.since I was 16.I am 64 .aspirin. Tylenol. Aspirin. Naproxen. Valtarin. Septra.it's terrible trying to get pain meds.
Really good information here. I suffer from chronic headaches and therefore end up taking quite a bit of Tylenol or Ibuprofen. Would love to see an additional video on how Ibuprofen functions. I definitely have had the irritability you discussed especially if my headaches are bad, and I dose close to max. Will definitely have to try Tylenol more to avoid that. Although I have generally used Ibuprofen more currently as it seems to be more effective at combating my headaches.
have you been checked out for migraines? because migraines can be combated by other medication and you can even take some meds to prevent them. they are really nasty headaches with sometimes neurological difficiencies. (its what I have and ibuprofen and tylenol dont really do much compared to sumatriptan)
A situation happened with a young lady in my town which reportedly involved an overdose with Acetaminophen. She became infected with dengue fever and became relatively ill. She wasn't hemorrhagic, so she stayed home and was attended by a family doctor to treat her symptoms. The problem was that the main popularly known treatment for dengue is Acetaminophen, and perhaps nobody quite knew the dangers that could result from taking more than you should. Her illness kept getting worse and she reportedly kept taking the pills, until it was all her liver could take. She was taken to the hospital but there was nothing that could be done. It was a very hurtful and tragic death for her family and friends, especially because she was a young, active and perfectly healthy person.
Hi there, Nursing student here! Long time subscriber and love your channel! In medical terminology, isn't a fever reducing drug an "Antipyretic" not an "Antipiuretic"? Are there a variety of spellings? Thanks!
Jonathan even if this video was twice a long it is worth watching because all the pertinent information needed to be covered and understood. So nice to know the pros and cons of Tylenol and to take it with consideration to your pain level. Thanks
For headaches try ginger powder and cayenne first.. Just like a half a tsp each in a glass of small water and chug. It gets rug of most mild to medium headaches.
Thank you for this video! Now I understand why my liver hurt from paracetamol. These videos are very informative, it’s comforting to know a bit more about medication and how it works
Tylenol never seemed to work for me. I could only get through periods with ibuprofen prescription, taking them as needed, the first full day of each month. But every medicine has its downside, and Ibuprophen can cause bone loss.
Could you do a show about arthritis and it's affects? I am an RN and worked in the OR for many years so saw damaged joints. I now have RA and take methotrexate. I would love a show about arthritis. Thanks
These videos are never too long. It's a lot of information to absorb, but we can pause or come back later. I view these videos multiple times because I'm slow to absorb information. I like being able to do that, like reading books; I can go at my own pace.
This was such a good and useful information for me. Since Percoset has been taken away from my pain management by the government Tylenol has been my only hope and savior. It has proven quite affective although my dosage is a bit more than what is recommended on the over counter box. I am well with in the perimeters given for max dosage in this information though. I take 3 200mg caps on average 3 times a day so that's a total of 1800mg a day. On most days that seems to do a pretty good job yet on occasion I do have the bad day and for that I now have Tramodoll. It causes some minor side problems but at least I don't have to take it daily. Having 4 spinal surgeries and nerve damage is not easy to live with but thank God for Tylenol.
Agreed with comments about video length: I have followed a handful of other channels that have increasingly made shorter and shorter videos - probably in an attempt to maximize views - some explicitly state that this is a new content strategy and others do not but in almost all instances the content suffers. Especially when it is something supposed to be educational. I very much appreciate the thorough and carefully delivered nature of these scientific videos. If monetizing is an issue, I (and I am sure many other viewers) would be happy to support the channel through Patreon or other platforms.
Very interesting video. I have fibromyalgia that is pretty severe and significantly affects my daily life. I'd love to see a video regarding fibromyalgia. I know there isn't too much known about it's cause but I'd like to see what we do know. Thanks. :)
As a theoretical question, if let’s say a person abused the antidote to Tylenol, would the body have a less natural desire to produce more glutathione to metabolize Tylenol or alcohol into metabolites causing the daily allowance to decrease?
Gosh back when I had endometriosis and the nurses would ignore me when I would call, I was taking 15 Tylenol and 15 ibuprofen a day. Didn't know I had endometriosis at the time. Finally demanded to talk to my RN and told her. She had me come in. Have to find the right people to listen......
Hi! praise for you! Apologies aren’t necessary, cause in this particular case, you’re sure well worth listening to and you sound tremendously eloquent, with all that rich vocabulary of yours, as well. Needless to say that you’re absolutely instructive, informative and as a result of your work, your experience bears the fruit of all your knowledge... and it really shows! Great! going young man, for you’re a scholar and a gentleman. By far, you stand among the very best pathologists that i’ve heard so far, especially on the entire TH-cam channel. Thank you for this magnificent presentation. All the best to you! Greetings! and salutations! Johnny, Montréal, Canada.🇨🇦
I've always wondered if it's really a good idea to take medications that reduce fever. After all, fever is part of the body's defences against some invader. Aren't we impeding it's abilities by forcing a fever reduction? Similarly if you have a cough and you take cough drops or cough syrup to inhibit coughing, aren't you fighting against the body's attempts to expel an invader from the lungs or throat?
@@adamcboyd Is that medical fact or just your opinion? I'm not saying it's wrong, I know practically nothing. I just always wondered about this. It didn't stop me taking medications to reduce fever or inhibit coughing, just had me questioning if it's right. Did those "million if not billions" die directly because of the fever and having their brain "cooked" or just being overwhelmed by the attack of whatever illness they had.
Fever is a counterproductive measure from the body. It kills the bacteria, yes, but our own cells cant handle the heat either. Medicine helps you combat the virus while preventing your body from self destruction :) hope it helps!
@@kassyyar97 So it's the body trying to do the right thing for the right reasons, but not knowing it can also be negative. Kind of like the body over-reacting to harmless things like pollen and cat dander and peanuts. The invader itself is harmless, the reaction can be deadly. Thanks Kass and Adam, I'm learned up now :-)
Im not sure if IHA has done a video about this but can you do a video about Anxiety/Panic Attacks. How it happens, whats happening, can we die? Etc, etc, etc. I think this would help relieve a lot of stress for those (like myself) who suffer everyday with this.
Awesome channel! Your delivery of the facts concise and easily understood! So glad I found you, even though I am an ER RN of many years it helps! Keep up the good work, and you are very easy on the eyes as well! 👍🏻😉
🤔- I worked as a pharmacist at an alcohol and drug detox center. In about 20% of the clients who ingested a total of between 30-60 tabs of Percocet daily yet had normal LFTs (liver function tests): Keep in mind that a regular strength Percocet tablet contains 325 mg of acetaminophen which equals 0.325 g. in addition to working there, I was also responsible for doing drug utilization reviews and attending physician meetings. Since the maximum amount of acetaminophen the normal adult body can handle is approximately 4 g in 24 hours, these people up to 20 grams daily! The doctors I spoke with speculated that an addict maymetabolize acetaminophen. But why? That’s been my question for years. If you or anyone has any proposed answers, I would really appreciate hearing them. BTW, at least half of those patients worked in the medical field and were stealing the Percocet. Also, the average age of these patients was approximately 35 and they had been using the drug for at least five years. I’ve heard of tolerance, but this is crazy! 💊
Thanks for this video. Good to hear you confirm what my PCP said too: that damage only occurs when exceeding 4000 mg daily. I have osteoarthritis in one hip, both knees, and at the bottom of spine that makes it painful to walk. For the past 2 years, I've taken 2600 mg of 8 hour-Tylenol Arthritis daily, and 3900 mg on more painful days. Somedays I don't need to take any. I'm 73 so I figure it won't really matter how much I take. The odd thing is that I know when it's time for the next dose because I start to feel very fuzzy-brained. Does that mean I'm addicted to it? Has any research been done on the effects of long-term use?
I suffer from fibro and neuropathy...my doctor only gives aleve !? What is your opinion doctor? Do you think I should switch to Tylenol! My age is 74 would appreciate an answer😊
Great video, do naproxen or allergy pills next (I'vealways curious of why they call cetiricine a 2nd gen medicine), this is really valuable information, love the channel
This is the best channel I ever stumbled across. I wish youtube was a thing back when I was in my study days. You explain everything beautifully. I love learning new things, these videos are wonderfully interesting! Thank you for putting the time in to make them!
Your videos make anatomy interesting! I’d be grateful if you could do a video on “frozen shoulder”, as I’ve had this condition twice already, and wondering how to avoid it! Also, why does it occur and how does it heal over time?
Great video. Thank you. I worked with a woman who accidentally overdosed on it. She had the flu and was medicating herself. Very sad. We figured she must have forgotten she had already taken a dose; or combinations like you said. But since then, whenever I've had to take medication for a time, I write the times down. Because the thought that possibly she had just forgotten a dose, really brought it home for me. How many times have I forgotten. So it's real folks.
I always like other sources of information, especially when you break it down so simply. I'm a liver transplant recipient, and due to the anti-rejection meds and a physical job, I'm constantly in pain. The only pain reducer I'm allowed to take is acetaminophen, and no more than 1000mg daily, but that at least makes life tolerable. :D
real question , and please reply. Is weed not allowed? Ask your doctor about weed. Either edibles or smoking it. Marijuana is proven to reduce pain and helps make life manageable in just these sorts of situations. Plus it doesnt give you that "medicated head fog" that tylenol and other OTCs tend to give. Although it does have its own type of head fog, lol.
Before my HCV was cured they told me to only take tylenol because if something goes wrong, they can most easily predict what will happen in hospital. I always thought it should be avoided because it's bad for the liver.
@@fastcar42069 Nope, many of my physicians have told me that weed is not allowed, primarily because it reacts with other drugs and the fact that it is metabolized in the liver. I also am just straight up not allowed to use it at work, for obvious reasons.
I learn more here than from any doctor or the Internet! Thanq for taking the time to teach us the RIGHT way of body function and medications so so so helpful
Video topic idea: Currently, thanks to the pandemic and working at home, I started noticing that I dont move much and my back started to hurt, I cant even turn around the bed while asleep and Im only 24. What does sitting around for long lengths of time does to your body??
No idea what it does to the body, but I think you already clearly identified the most likely cause of it. I would like such a video as well but I'd strongly recommend trying to get some more activity in your routine. A few things I've tried are to start a kitchen timer when sitting down at the desk, blocking a few moments in the day to take a walk outside and such. And adding trivial activities like every time you're going to the kitchen to get something to drink/snack to eat also walk up the stairs and down again before going back to the desk might make a difference. My employer also runs a nagging software that tries to suggest to take brief breaks if you're active with the keyboard and/or mouse for extended periods, it only suggests to take a break by default but I think there's an option to set it to lock your session unless you explicitly snooze it. In my case the kitchen timer kinda worked and being aware of the punishment by my back if I don't move enough a few days later. That said if additional activity doesn't help alleviate the back pain consider looking into it if there's not some other underlying cause that can be addressed, I walked around with intermittent back pain for more years than I'd like to think about which turned out to be axial spondyloarthritis that was ruining my back and hip. Basically resulting in a very sensitive lower back on bad days and reduced back and neck mobility, oh and a total hip replacement was needed before 40 years old. Sometimes I would like to know how much of that could've been prevented but as far as I'm aware we don't have time machines yet to fix such things.
I was taking naproxin everyday for months when I tore my shoulder. Almost wound up in dialysis. My GFR was down to 31. Doctor told me to quit taking Naproxin, which I did and fully recovered. I am 75 BTW. I only take tylenol. no more then 1000mg in a day and I use it sparingly.
This video was very informative and helpful to me! I have a blood disorder and since Ibuprofen and advil are blood thinners, I can only take tylenol for pain relief. I’ve heard over and over again from doctors not to take more than the recommended dosage, but knowing in detail why definitely makes me want to be extra cautious while taking tylenol.
This may not be the most exciting of your videos but I paid extra attention to it. My mother passed in 2015 from liver failure and this video really helps me understand some of the reasons why. The doctors never explained this to my father or me. Thank you for the detailed explanation about NAPQI.
@@theanatomylab can you clarify is supplementing glutathione and NAC going to save these long term high use Tylenol patients who are now in chronic UTI situations? Or/ and utilizing kidney cleanse. Patient elderly. Your amazing!!! Thanks for info, could be lifesaving!!!!
I’m frequently concerned over a friends use of Tylenol and alcohol and have stated so numerous times, but NOW I have the science to back it up and bring my point home. THANKS!! I’m a new subscriber, but thus far have enjoyed the videos I’ve seen, lots of interesting topics!! Thanks a bunch guys!
I've always been curious about Tylenol and Alcohol. I've always steered clear of one if I used the other, going as far as forcing myself to vomit if I mistakenly used both in the same 24 hour period. Sounds like I've just been extremely paranoid.
It may seem paranoid, but if you are a frequent drinker or have to frequently take Tylenol for pain, having them within 24-48 hours of each other is generally bad. To my understanding, both of these substances together significantly increases the amount of work your liver has to do as opposed to just having one or the other in your system.
I love this channel. I didn't go to med school because I was afraid of anatomy class and this channel and a recent health crisis where doctors and surgeons saved me has me reconsidering. Can we see a pancreas video? I am very curious about the vasculature of it and what the ducts look like!
Thank you for the wonderful information, Jonathan! I have a question though, you mentioned Acetaminophen is an anti-piuretic I thought it's spelled as "anti-pyretic"?
excellent channel, i have a question about the use of the antihistaminics and corticosteroids for the allergies, now that is coming the spring, i know that corticosteroids are dangerous if you take it during a long time but i don't know why, and i'd like to know what are the effects and how it affects the body. thx
I'm sure the video they're making will be much more useful, but the problem with steroids long term is basically that it works by suppressing your immune system to reduce inflammation. Unfortunately, that makes you more likely to get infections etc, and on top of that, because corticosteroids in the body are used in a lot of processes, it also messes with those too - for example, it can cause osteoporosis, too, etc. It's a powerful medication that acts in very broad strokes, and so when used systemically, it causes these problems. It's not so much of an issue if you're using steroid creams, inhalers or nasal sprays, but it can still thin tissues etc. Another big issue is that if you take steroids long term, it can suppress your own natural corticosteroid production in the adrenal glands. Stopping suddenly - particularly of a long-term, large dose - can send a patient into a huge crisis and potentially be very serious. This is why if you take oral steroids long-term, you should make sure that you are carrying something that can inform emergency services that you use them, as it may affect not just their treatment of you, but ensure that you don't end up in a crisis because they don't know to keep giving you the steroids while you might be incapacitated and unable to tell them so. That said, if you need them, your doctor has probably decided that the benefits outweigh the risks, and that's the issue with all medications. Balancing the risks and the benefits, and deciding on an individual basis.
This is a fantastic video; in-depth well done, very helpful to those of us who practically live on the stuff. Please don't worry about the length of your videos anyone who gets bored can just click away. Some of us are having entirely too much fun watching your videos no matter what they're about.
Man I love these videos. One question I had was: up to a certain point (i.e. for children), medicine doses are based on weight, but why do we seem to stop doing that at adulthood? For example I am 6'4" 210 lbs while my wife is 5'4" 110 lbs. We run into issues with medication all the time, e.g. Nyquil will put her out of commission for some time into the next morning, but the same dose wears off for me before I wake up. The COVID vaccine gave me a mild headache which may have even been partially from mild dehydration, but she had fever, chills, and nausea for like two days. You mentioned 4000 mg of acetaminophen was the recommended maximum daily intake, but how did they choose those numbers? I'd guess that my tolerance is significantly higher than my wife's, but I don't know if 4000 mg is based on some sort of average, or based on a relatively small person just to give plenty of margin for error. Are there any medications that have the same effects regardless of patient size? Or perhaps it's related to organ size? That might make more sense, like a morbidly obese man the same height as me might have the same size liver and kidneys (ignoring complications like fatty liver), making our effective dosage the same. Anyway, again, great video! I love this channel!
It really has to do more with organ development than weight. Pretty much no matter how much you weigh your organs are the same level of developed. Where as they are not in a child
a recent peer reviewed article (examining over 1000 articles on the efficacy of Acetaminophen/Paracetamol) was simultaneously published in the British Medical Journal, The New England Journal of Medicine & The Lancet. The article clearly demonstrated that taking Tylenol, (Acetaminophen/Paracetamol) was far more dangerous & toxic than advertised or prescribed. It also showed that the drug only had a very small/negligible 'pain relief' effect on most injuries/trauma (including headaches & back pain).
You should never apologize for the length of your videos! The content you provide is important and greatly appreciated. ❤️
Totally this is amazing content 👏 👌 🙌 😍
Anyone thinking this video is too long probably isn't interested in this topic anyway.
These two gents can’t give enough long chem/med names and orders of creation and interaction for my liking. Tell Jeffrey the skeleton to ‘hang in there’ while we get our fill of med speak.
Exactly
Agreed
As a high school graduate, your videos really helped me understand a lot of my body, which in turn, helped me pass anatomy and physiology. I was hoping to go to med school but since I has no money I'm learning from home. If every school did this it would make people more excited to be doctors/nurses. You're doing more for this world than I think your crew realizes.
Don't give up!! There are many grants and scholarships. Especially for financially needing students. Check out PELL grants. That's how I got started. Best of luck!
you has to get a loan
@@bazookabong23 🤣 be NICE!
@@shannonobrien9922 Seriously... ...One little typo! That's all it takes for some people! I has many typos on mine messages and yorn un Nicks dun look so hot kneever.
Please young one ( I’m probably old enough to be your grandparent) don’t give up! We need good , qualified people in the medical field. If this is your passion please look into financial aid ( scholarships, grants, loans as a last resort). I had one excuse after another not to chase my dream.. finally got the family off and own their own and here I am at 57 finally getting my degree. Don’t give up!! I’m rooting for you!
Being disabled from birth with hydrocephalus I never was able to take anatomy or health classes so in saying thst your shows are very informative to me . Thanks very much guys for providing them for mr keep up the great work!!!!
I didn't get to take Biology because my high school counselor thought all kids were stupid. Luckily, she was fired soon after I graduated so none of the other students would have to deal with it.
If it's not too rude to ask or anything, what specifically about those classes prevented you?
Yay Science
@@kittycatmeowmeow963 I couldnt open up a dead cat. Animal lover here.
A topic I'd like info on is eczema. The more I read about it, the more confused I get, so a lecture would be great! Is it some kind of auto-immune reaction?
This is a gluten and a nutrient deficiency issue.
@The Natural Health Connection would need proof on that. And if that's the case, why does UVB light help ease the outbreak?
@@ms.milianko wait.. what? UVB helps on eczema treatment ?
@Noctina Tatakai it's called phototherapy and there is a lot you can find online on the subject. Usually, they say it requires going to the doctor for a treatment. I have personally found phototherapy helps with my eczema outbreaks. One year, it got so bad I was in tears over the frustration of it. My skin was inflamed, bleeding, and blisters started arriving. I hate using steroids of any kind, and felt like they never really worked that well for me. So, I decided to do some research on the matter, and I started going to tanning beds (consult your doctor on that) twice a week, for 6 weeks at 10 minutes each. No longer as I wasn't trying for a tan. My outbreak started to ease, and eventually, I was free of it for a year. I currently have a small patch on the back of my neck and in my hairline this time. 😅 Please note, I don't advise constant use of a tanning bed for obvious reasons but that's what worked for me. When I spoke to my physician on the matter, he advised that I just use caution when using a tanning bed. Some offices can refer you to a specialist for phototherapy. Phototherapy is also a treatment commonly used for jaundice in babies.
@Noctina Tatakai thinking upon this, 🤔 this could be where the Natural Health Connection could have a plausible connection with nutrients. Seeing how our skin takes the UV rays and transforms it into Vitamin D. If you're not already, try taking extra Vitamin D, if you are bothered by eczema, and see if that possibly helps any symptoms. I haven't tried that but I also take multi vitamins everyday just for my own extra precautions. I think I may of found another subject to look into on this matter.
I have been a pharmacist for over 35 years, and I love your videos. I think you provide a great foundation for difficult concepts. Thanks for what you do!
The video was NOT too long. Another excellent job of explaining without getting too technical and, at the same time, not being so simple that it's worthless. Keep up the good work.
😊😅
I get up around 4 every morning and Bing watch these videos. I love how they explain things in a way that the general public can understand. Thank you and Keep up the amazing work!
Nobody uses Bing, get some sleep.
@@oo7moses Pretty sure they meant 'binge' watch. There's this thing called sleeping, I suggest you try instead.
I'm so glad I found this video. I have patients ask me how Tylenol works, and I have felt bad not having a great answer. Well, it appears that no one else does, either. Now I don't feel quite so dumb. I love watching your videos. It has been decades since I took my A & P classes, and this format is a great way to remind me of all of the tiny details that I have filed away. Thank you so much!
I am a pharmacist and nursing instructor. I want to say this video and explanation is the best I’ve ever seen!
I am retired now but I wish this video was available to show my students when I was teaching. BTW, I am a BIT surprised you did not mention Substance-P. However, I guess it’s because we do not know all that much about it and due to the length of the video. Perfect job! 🥇💯‼️
M Stephens in your opinion which is better the Tylenol if so the hydrocodone..?
I’ve never liked Tylenol!!! Seems useless to my body!
@@dianenims hopefully you don't like advil
@@me3said2aweyah68 Why?
@@me3said2aweyah68 what? Why?
Interesting point of clarity on the topic of overdose. As is mentioned, toxic NAPQI is produced, but then degraded. However, if this degradation is overloaded, overdose results. A common example used is how a city can be flooded. The drainage system removes water from the streets of the cities. However, if the water supply increases to the point there is more water than can fit into the drainage system, it is not possible for the drainage system to remove more water than it can fit into the drain. Similarly, while the liver does possess the ability to degrade toxins, if a larger amount of toxin is produced than the number of enzymes to degrade the toxin, the only possible option is for the toxin to remain. Thus, it is not that the liver does not have the ability to protect from toxins, but that this ability simply has a fixed number of how much it can break down at one time.
Wow, you worded this to where I can actually understand it! Thank you so much! I'm not a medical student or anything, I just have a brain lesion in the pons of my brain and like to learn about the reason I have different ailments.
I’m curious, does your ability to convert NAPQI (or, in other words, metabolize acetaminophen) diminish with age? I ask because I sometimes take large doses to treat migraines.
@@Stunbunny That's going to be a big fat "It depends"... Very slightly more nuanced than that, "It tends to, but doesn't have to."
With age, here on planet Earth, we tend to endure a lot of things... from common colds and flu, to catastrophes, highs and lows of emotions, and adventures that may enter exploration into recreational or self-medicating drug use... or even catastrophic collapse into depravity (not judging) and outright self abuse.
As such, many of the things we endure damage various parts of our bodies, including the liver... We heal (including the liver)... BUT there's also "scar tissue" to consider... AND wherever it happens, scar-tissue does very little more than hold healthy tissue together. Many scars on your skin (for instance) have little or no sensation. Having a friend with a fine enough instrument "stimulate" JUST the scar tissue while you look away, and you can demonstrate this... Just try to notice WITHOUT LOOKING when your friend is touching the scar and not. You won't get a perfect result like you can literally anywhere else with "healthy" tissue... The bigger and more "gnarly" the scar, the less sensation you'll be able to feel...
Not all the healed damage in a liver is necessarily scar tissue... AND like your skin, scar tissue DOES "fade" or diminish over time.... It's just rare (once you've got a scar) for it to go completely away at the cellular level... The pattern of cells is "messed up" and that almost never goes away "like nothing ever happened"...
Live a reasonably healthy lifestyle, and with a little luck, you won't get into anything that does so much damage as to cause too much liver scarring... A little function might drop occasionally (everyone and everything has bad days) but other than a temporary deficiency (like dehydration) you won't lose a significant amount of liver function over MANY years or decades of life...
Relax... Remember to BREATHE... I've known people who drank at LEAST more than recommended frequently throughout their lives, and lived long lives without serious side effects... In their old ages, doc's seemed mystified, saying things like "I wish I could have numbers like these."
SO it's not that even periodically hitting your limits is necessarily bad... It's not good, but "chronic" over-use tends toward daily or (at least) multiple times weekly levels of over-use...
Finally, I'm not even suggesting your levels of use are necessarily over-use. THAT is something to be talked over between you and a doctor... You CAN (btw) look up a document on Acetaminophen called an "MSDS" and under the "toxicity" category a number labeled the "LD50". This is how much of the Acetaminophen tested in a lab setting killed about 50% of the test subjects (usually rats)... AND it's usually listed as "XXmg/1Kg", which means how much of the drug per Kilogram (2.2 lbs) of body weight was dosed in said subject... There's usually some technical garble about what subjects and how it was tested or if there's some other measurement that was used... BUT with the LD50 number, you can also do the math and estimate about how much it would take to have a 50% chance of killing you.... It's not a great guide, but it gives a rudimentary number to scale that you can understand... AND if that number worries you, maybe worth a talk with your doctor, too... If (on the other hand) it's on a scale of 100 or 1000 TIMES as much as you've ever even contemplated taking in a day, you can breathe a sigh of relief... It's likely (by luck or otherwise) you've escaped causing yourself any harm...
It's worth saying that you MIGHT be able to search "LD50 Acetaminophen" as a shortcut. I just happen to KNOW you can find the number as LAW REQUIRES it be listed on every MSDS... (AND there's an MSDS for everything, including ordinary WATER)... "just for fun"...
BTW... NEVER be afraid to talk to your doctor about alternative treatments for things like migraines. It's especially important if you notice a change in their regularity or persistence. It may be "nothing to worry about", but you're FAR better off to get that reassurance from a Doctor you actually know and trust than some document online or a faceless mook you only just met through a YT comment... (haha... called myself a mook)
Sorry for the length... JUST hope you find something helpful... and maybe a tad entertaining for your time. ;o)
Chubbyemu has a great video on this: th-cam.com/video/VSqrCgFMsCI/w-d-xo.html
gnarth d'arkenen:
Any tips on OCD?
One of the top channels on TH-cam hands down. Can’t get enough
Thank you!!!
I actually enjoy the longer videos. I am fascinated by the human body and how it works. Please keep them coming and the longer the video the better for me because it’s more useful information. Thank you so much for this. I had no idea that Tylenol had this affect on the body
WOW! Can I relate to this video. Tylenol has absolutely played havoc with my liver. I told my liver doctor, and regular MD, that they should quit advising people to take it because of pain. Hospitals would always give it to me when needed. It's horrible and I cannot thank you enough for making this video. I wish everyone could hear this truth. BTW, your video was not too long. They never are.
I am going to guess that you have other problems and medications.
I have never ever come across such a knowledgable and yet relatable and “easy” to understand man in my entire existence! (I say easy… but you know what I mean, it is so well articulated and explained!!!)
Do / could you make any content re SLE (systemic lupus) and or Addison’s disease and how these effect the body / different organs?
Lupus is getting worse and worse for .me I'm afraid
I've been in and out if multiple hospital s as if late
Finally! I've been very curious about how acetaminophen really works, and how does it differ and have similarities with ibuprofen! Thank you guys!
Glad we could help and thanks for watching!
@@theanatomylab actually, biochemistry class in undergrad finally made sense to me, thanks to your videos! Been watching since fall last year, glad to have these vids recommended to me 🥺✨
a recent peer reviewed article (examining over 1000 articles on the efficacy of Acetaminophen/Paracetamol) was simultaneously published in the British Medical Journal, The New England Journal of Medicine & The Lancet. The article clearly demonstrated that taking Tylenol, (Acetaminophen/Paracetamol) was far more dangerous & toxic than advertised or prescribed. It also showed that the drug only had a very small/negligible 'pain relief' effect on most injuries/trauma (including headaches & back pain).
@@wilson2455link?
Pharmacist here. At first, the title made me feel like this was some kind of fear-mongering attempt, but I stand corrected. This is quite accurate info and on point
The medication video series are so interesting, cant wait for future videos about opiate use, antihistaminic, benzodiazepines and ambien, ssri, adhd medication, benadryl, ketamine. The medicinal use of these prescribed drugs, what benefits can they provide and the cons and consequences of long-term use/abuse. Absolutely love these videos. Smarter every day
I suffer from cysts on my spine, running from the thoracic to upper lumbar. I'd love to see a video detailing CNS injury and at what level you'd expect to see corresponding numbness and loss of limb control. Also, this was perfect timing. I've been taking the max daily dose of Tylenol for over a month now and have been really wanting to know more about what it could be doing to the body. Thanks a ton for the info! I'm on a chemotherapy that prevents me from taking NSAIDs so thats all i'm stuck with using for now.
I work on a pcu unit that deals with liver diseases. You may need gabapentin for your nerve pain, your limit to 4g of acetaminophen per day but you should have your doctor check your liver enzyme levels since you've been taking that much acetaminophen for a while. You should see a pain specialist.
Look into trying kratom if it is legal in your area. I used it to get off of oxycodone following a surgery, and now I continue to use it for pain. It's an Asian herb that is usually eaten as a powder, capsulized powder, or compressed powder tablet from the ground-up leaves of the tree. It can also be consumed as a tea (I find that gross) or as an extract liquid. It is a weak, low addiction potential, pseudo-opiate. It isn't a true opiate but it interacts on the μ opioid receptors and that is how it can treat pain or ease withdrawal symptoms from things like oxycodone or heroin. :) Many people use kratom to self medicate their pain when they want something that can be purchased and used without a prescription, and is more powerful than Tylenol but not as powerful as oxycodone or hydrocodone and not nearly as addictive either. It is phenomenal. I do caution you though, to discuss using it with your doctors because it does contain a variety of alkaloids which inhibit a few liver enzymes, in some cases very powerfully. That means your medicines may not work as well or may work much more potently. Doctors may say "Don't take that; it's addictive and unregulated and you can even die from it." They're just trying to cover their ass because they don't ever like patients self medicating. They'll say not to use kratom, but then wrote you a prescription for Vicodin and Xanax which are way more harmful. They won't bat an eye if you tell them you drink 3-4 beers each afternoon 3-4 days a week. 😸 It's just ignorance and ego. Do your own research on it and decide for yourself, but I'll tell you that kratom changed my life in many ways for the better. I would be much less happy if I didn't discover and use it.
Tylenol is a NonSteroidAnti-InflamatoryDrug. That for short is NSAID.
@@Plainsman1300 It isn't. NSAID is a class of drugs which are somewhat simmilar in structure and simmilar in action - they are all COX-2 (some also COX-1, to a various degree) inhibitors.
While, yes, acetaminophen is not a steroid, it doesn't belong to NSAID group, because it doesn't imhibit COX enzymes to a significant degree, the mechanism of action of paracetamol is different.
@@Plainsman1300 no Tylenol is NOT an NSAID…IBUPROFEN is, as well as torodol, etc…but Tylenol has no anti inflamatory action. I am a 27 year RN.
However, with the war on drugs, those of us with severe chronic pain have had our prescription pain relievers decreased below the threshold of efficacy. Thus being forced to take more and more Acetaminophen and ibuprophen to try to have some semblance of quality of life and periods of time with lowered pain each day. I was put on prescription pain medications when I ended up in the hospital with an enlarged liver and acute abdomen from taking so much OTC pain med.'s to be able to work...as a nurse. Now I'm basically bed bound now that I am disabled d/t back, hip, and other chronic injury related pain.
Yes, I understand; I have CIDP and they took away the effective pain meds and give you acetaminophen and NSAIDS.
I'm so sorry to hear that. Prayers that you find a way to feel better. Have you researched natural remedies or gone to a doctor of naturopathic medicine (ND)? Research wild medicinal herbs used for pain, esp back in the civil war days and the depression. Very interesting
@@phillipnesmith2698 I was in liver failure, and was put on the RX pain medications or I wouldn't be here or had to have had a liver transplant. I took so much Ibuprofen and Tylenol, and asparin as well to be able to function and work starting basically with my nursing career in my 40's. I was a hard worker, doing retail on my days off just for fun! I'm enjoying retirement even though I'm disabled and not at all in good health.
Thank you, thank you, as a nurse I feel your channel is more valuable than all the CEU classes I have to pay for. I 😘 ve keeping up with all the current research via your videos.
I have several budged disc's in my lower back along with sciatica and bursitis. I would be very appreciative if you could touch on any of these problems so that I could understand my condition better. You have a great simple way of explaining everything you talk about. You are an excellent teacher. 💎💗
You have a very commanding voice that is easy to listen to. The delivery of the content is exquisite. I'm big on vocabulary and it helps to imagine their definitions. All of your videos are changing minds and understandings. Many thanks. Continued success.
Very interesting, as always. I learned a lot. You have the art of delivering material with clarity without "dumbing down" the scientific language. Much appreciated.
Hate to tell you mate but these videos are very “dumbed down”. There’s some use of medical terminology, but a lot of content is skipped in explanations
Thanks for this video. I come from a medical household as my Dad was trained in medicine in England. He was very cautious when it came to prescriptions and any over the counter meds. We never had multi vitamins in the house. He did the cooking and we got everything we needed from the foods we ate. I recently pulled a muscle in my chest and bruised the ribs there. I’ve only been taking one Tylenol when going to bed for the pain. If I can I try not to take one. It’s hard to lay down though. I just found out my neighbor in senior housing complex. She has kidney damage from taking too much Advil. I’m very careful taking any meds if not at all. You are the only one so far to talk about the dangers of taking too much, Thanks!
I'm going to be a doctor or nurse and you helped me a lot thank you❤️❤️
Glad to hear that we can help!
With a nick like that, u r certainly going to be a good one...
Be a doctor or travel nurse.. travel nurses make more money
Lol how does this video help you in becoming a doctor? Serious question.
@@theanatomylab everyone likes ur lengthy videos
I wish you were around when I took Gross Anatomy in 1990. The clinical aspect of Anatomy weaved with the physical anatomical body that is dissected into the corresponding body parts make the subject much more understandable.
Then you add the normal and pathophysiology along with the "big picture" of biochemistry.
This is a much better way of teaching than 25 years ago where you bought books, worked on a cadaver and lectured by professors who expected you to put the clinical pieces together on your own.
Great presentation.
Also need to watch out for people in early stages of Alzheimer's or dementia -- they can forget if they've already taken a dose of acetaminophen and re-dose repeatedly. Thankfully I've never encountered this personally, but am given to understand it is a potential risk, and why even OTC medications should be closely monitored in the elderly.
Fascinating, thanks guys! Could you explain why some medications should be taken on an empty stomach and some should be taken after food?
Oo yes
Some should be taken with a food for a better absorption because some vitamins (A, D…) are lipid soluble and some (C) are water soluble. (Vitamin C helps iron absorption)
Some should be taken before food because they can inhibit the absorption of some vitamins in our food. (Example calcium inhibit iron absorption) and like he said while taking Tylenol you cannot be drinking alcohol because the effects are not advantageous…
Even a few soda crackers constitute "food". It's just something to pad your stomach against any corrosive effects of the drug.
I really love this channel. I teach statistics and programming languages, but I'm fascinated by the human body. This channel makes all topics so understandable. Thank you very much ❤️
Statistics is an awesome math subject. What are your favorite programming languages?
@@aarondelgado3421 Thank you for your comment! My favorite languages are python and R, since I apply them in data science 🙂
@@siqueirapaty You are welcome! Ah, that definitely makes sense!
@@aarondelgado3421 Are you also interested in programming languages?
@@siqueirapaty I've been programming since I was about 14. I like the following programming languages: Visual Basic, C++, C# and PHP.
NEVER NEVER APOLOGIZE FOR THE LENGTH OF ANY OF YOUR VIDEOS, YOU ARE A SMART YOUNG MAN AND I LEARN SO MUCH FOR YOUR WELL EXPLAINED VIDEOS, THANK YOU SO VERY VERY MUCH FOR SHARING AND YOUR WONDERFUL WISDOM!!!!!!!
I really appreciate the time and effort you spend on explaining all of these different topics and details.... I love science...keep up the good works..... you are absolutely helping people... thank you and I am grateful.
I'm an engineer and really appreciate a thorough explanation of anything technical within my ability to understand. Therefore, explaining complex mechanisms such as human health require an appropriate time to deliver. Your videos are never too long. Thanks a lot.
I prefer Ibuprofen over acetaminophen because I find most of my pain is caused by inflammation. When it's really bad, I take both. 30 minutes after the first one. Rarely though. I am aware of the effects of medications on the body so I limit everything
Funny thing. Ibuprofen doesn't help me with pain and inflammation as much as tylenol does.
@@SuiLagadema That's weird, most people find the opposite. But whatever works, just keep below that 4 grams a day maximum!
You can take them together actually
I can't do Ibuprofen it raises my blood pressure😞
Tylenol does nothing for the pain, only dulls it for a few minutes. I have taken ibuprofen which worked well with the pain. ( I am not allowed to take it cause of my Kidney transplant. )
This is the best TH-camr I have seen so far! Keep up the great work. And thanks for helping pass my NCLEX.
Tylenol very nearly killed me a few years ago. One of the attending physicians thought I might be in pain, & prescribed some Vicodin, *without* reading my chart first! Long story short, the Tylenol in the Vicodin very nearly did me in. Turns out, I'm one of those folks who is quite literally *deathly allergic* to Tylenol!
..and we're all deadly allergic to incompetent numbskull arrogant doctors and nurses too! There are too many with an attitude, around the whole world!
My girlfriend was in the hospital and they did kill her with Tylenol. Now it's getting people ADHD and Alzheimer's and heaven knows what else I take aspirin I like to break them up so they dissolve faster in my stomach
@@rileylois545, Tylenol allergy is known, but not too well, unfortunately. It's rare enough that I now wear a Medic-Alert bracelet. My condolences & sympathies to you on your GF's passing.
I added Tylenol allergy on my medic-alert bracelet. Thanks for the suggestion!
Your videos are wonderful it keeps you from having to dig through all the books you are doing a great service to humanity thanks again
Absolutely the most informational videos I've ever seen. The few I've seen have changed the way I treat my body from day 1. Thank you. I may live past my 76th birthday which is right around the corner.
I work in a hospital as a respiratory therapist. We had a young woman come in who definitely had “brain damage”(she definitely wasn’t herself, unable to take care of herself) and she had been on a ventilator and eventually needed to be trached. She had taken an overdose of acetaminophen which caused all of her problems. I was kind of surprised because I guess I had always thought of Acetaminophen as a rather benign medication. I received a great addition to my education that day and it was so sad to see her condition because of acetaminophen. She was only in her 20s
Acetaminophen was only her 'weapon' of choice, the cause was something else wasn't it. Yes, very sad indeed. Thanks for sharing.
Back in the early 1970's Tylenol was a new product on the market. We had a patient admitted for taking an overdose of Tylenol with Codeine. I so clearly recall the doctors scratching their heads saying they knew how to treat to codeine overdose, but not the Tylenol, and were not sure what to do for her liver. She died.
I work at a mental health facility for teens. Many of them come to us after making attempts. Kids often try to OD on Tylenol because it's easily available at home or easy to shoplift.
I wish I could explain to the kids that death by Tylenol is a slow, painful process.
It’s so great having such a nerd hunk like you educating us all! Keep up the great work! Thank you!
Your videos are great! I love them. They're explained so well and they also help me out with my anatomy/physiology/sports medicine classes. Never apologize for the times of your videos.
Jonathan, please do a video on the microbiome, how it’s affected by antibiotics, and how to restore it.
Video topic suggestion: my mom has benign essential tremors and has recently started seeing a neurologist for them. How my mom described it was that a part of her brain was overactive and it caused her to shake. I'd be interested in seeing a video on which parts of the brain cause shaking like in benign essential tremors and how that shaking differs from shaking caused by Parkinson's.
I also suffer with essential tremor. Mine is genetic, my father has it even worse. I'd also be very interested in seeing a video regarding this.
Tell your mom to control her emotions, stress, anxiety they bring most of the diseases
I also have benign essential tremor and I have found that taking Benadryl (i.e. Diphenhydramine) will make the tremors ease up a bit (not go away). Probably because it seems to make some people sleepy. I don't get sleepy but that is just me.
I think it's the cerebellum in the back bottom
When we move our skeletal/voluntary muscles, we call that the "somatic motor" system. It involves many steps and many parts of the brain. For example, you want to reach down and pick up a coffee cup to take a sip of coffee. You start off the process of moving that arm by making the decision in your frontal lobe. You then use your somatic motor cortex portion of your cerebrum to plan and formulate the neuron action potentials (APs) that need to be sent to the specific arm muscles needed to move that arm and pick up the cup. Your motor cortex figures out these APs and sends the signals to structures called the "basal nuclei." The basal nuclei contains many small functional clusters of neurons which fine tune these motor signals coming from your somatic motor cortex. The globus pallidus for example, is an inhibitory structure which takes these very rough APs and inhibits them to smooth them out and make them more controlled. The basal nuclei filter out random or unwanted motor APs which would cause twitching and convulsing if allowed to reach our muscles. After the signals have been fine tuned and smoothed out and highly processed, the cerebellum also does some coordinating and further refining before sending the signals to the anterior spinal cord or the cranial motor nerves to get those APs to the proper muscles.
Parkinson's disease involves the death of an area in the basal nuclei known as the substantia nigra. Those cells release dopamine and they are involved in filtering our unwanted movements and refining these erratic APs. When they die, they no longer do that and you end up with the shaking and severe tremors and muscle rigidity that makes walking and talking difficult. The dopamine part of the basal nuclei fights the acetylcholine part to regulate the movements. When the inhibitory dopamine is gone, the excitatory ACh is left and there is an imbalance causing the inability to smooth out and filter out the unwanted jerky movements. You can have many other types of movement disorders too, like your mom's tremors when there is an issue with any of the basal ganglia structures. You can also have medication-induced phenomenon. These are called "extra pyramidal symptoms." I myself actually take a medicine called "lamotrigine" which treats my bipolar disorder. It rarely can cause EPS and it does with me. I get random, short lived myoclonic jerks. My arms and legs will just randomly twitch and contract. My leg might kick out for 1/2 a second while laying in bed. My head may turn to the side in a quarter of a second and return to normal position. My arm may twitch and move a little harder or faster than I intended when reaching for something. My feet and toes experience the worst of it. It's harmless, and it stops when I have stopped taking it briefly in the past. It's pretty noticeable at night. My feet and toes and lower legs twitch and kinda dance around every 10 seconds or so and my core muscles do too. It's annoying for me and my partner who I spoon with when falling asleep. I take Benadryl to fall asleep and it also helps stop these twitches almost completely. Benadryl is an anticholinergic in addition to being an antihistamine. As I said, dopamine inhibits and acetylcholine excites. Taking an anticholinergic that decreases ACh means less excitatory input in my basal nuclei and that means less twitching. :) There are other primarily anticholinergic medicines like benztropine for example, which are very strong and effective anticholinergics. Benadryl is just an antihistamine that coincidentally also has some anticholinergic effects too. These anticholinergics like benztropine are used to treat Parkinson's symptoms and movement disorders caused by antipsychotics because the death of the substantia nigra leads to excessive ACh control of the basal nuclei and suppressing it helps lessen the imbalance and ACh overload of the system. :) Antipsychotics also work on dopamine receptors so they can produce movement disorders. They are usually either EPS in nature, or Parkinsonian in nature. Antipsychotics often cause something called tardive dyskinesia which is due to the eventual homeostatic failure of the dopamine-ACh balancing system and it leads to uncontrollable movements, usually of the face. :(
So, TL;DR your mom is correct. She has some sort of issue in her brain's basal ganglia that cause her to have less inhibitory signaling than normal due to a dysfunction of one of the structures within it. Perhaps she has not enough dopamine, or perhaps too much ACh, or perhaps just low response of some neurons in the globus pallidus for example that don't produce as high of a voltage to inhibit and block these unwanted tremors. Has she looked into medication to treat it, such as benztropine or many others that help regulate the basal ganglia? Hope this info helped you. It's really fascinating how complex our brains are even doing something as simple as moving our arm to pick up a coffee cup. So many steps in the process, and it happens almost instantly! Next time you watch someone juggle, think of how many things have to happen from the reception of light from vision when looking at the juggling pins, to calculating the trajectory, to formulating the motor plan to catch the next pin, to smoothing and refining those movement signals, to sending them down the spinal cord, to sending them to the correct muscle fibers and recruiting just enough motor units to put the arm in the correct spot and throw the next pin with the correct force, and the process of releasing ACh at the synapse of each of the individual muscle cells which leads to them depolarizing and releasing calcium and unblocking the actin and myosin so they can bind and contract to make the muscle tense up, and the constant binding and unbinding if ATP to make these actin and myosin fibrils climb along each other just enough to contract properly, and then the collection of all that calcium within the muscle cell back again into its storage container so that the muscle stops contracting and can relax, only to have another AP sent through the whole chain of events again and make the muscle cell contract all over again. It all happens in the blink of an eye, and it's absolutely mind blowing!!!
May I ask you to possible consider doing a video on the thyroid? Over 24 million people in the US struggle with the painful effects from this organ every day! Thank you!
I have a Tylenol specific allergy (among others), so I'm usually given Toradol/Ketorolac instead. I'd love a video on the effects of that as well.
Toradol is very strong I used it after hip replacement surgery
I've had a stomach bleed from Toradol
I’m literally the opposite I’m allergic to ibuprofen and only take Tylenol for pain
Omgosh. I have never heard say they are allergic only me.since I was 16.I am 64 .aspirin. Tylenol. Aspirin. Naproxen. Valtarin. Septra.it's terrible trying to get pain meds.
@@michaelharned8741 I only use it when absolutely necessary. Unfortunately, that use has increased after my car accident.
Really good information here. I suffer from chronic headaches and therefore end up taking quite a bit of Tylenol or Ibuprofen. Would love to see an additional video on how Ibuprofen functions. I definitely have had the irritability you discussed especially if my headaches are bad, and I dose close to max. Will definitely have to try Tylenol more to avoid that. Although I have generally used Ibuprofen more currently as it seems to be more effective at combating my headaches.
He has already a video about ibuprofen works:)
have you been checked out for migraines?
because migraines can be combated by other medication and you can even take some meds to prevent them. they are really nasty headaches with sometimes neurological difficiencies.
(its what I have and ibuprofen and tylenol dont really do much compared to sumatriptan)
@@CristalianaIvor I really need to be, in the past my PCD always kind of shrugged them off as I am healthy otherwise.
A situation happened with a young lady in my town which reportedly involved an overdose with Acetaminophen. She became infected with dengue fever and became relatively ill. She wasn't hemorrhagic, so she stayed home and was attended by a family doctor to treat her symptoms. The problem was that the main popularly known treatment for dengue is Acetaminophen, and perhaps nobody quite knew the dangers that could result from taking more than you should. Her illness kept getting worse and she reportedly kept taking the pills, until it was all her liver could take. She was taken to the hospital but there was nothing that could be done. It was a very hurtful and tragic death for her family and friends, especially because she was a young, active and perfectly healthy person.
Never abuse meds this is what happens noone faukt but her own
I love your videos, don't apologize for the length, the longer the better if you ask me! Thank you for your content!
Hi there, Nursing student here! Long time subscriber and love your channel!
In medical terminology, isn't a fever reducing drug an "Antipyretic" not an "Antipiuretic"? Are there a variety of spellings?
Thanks!
You are correct!
You are correct, the editor used the incorrect spelling. Working on fixing that now. Thanks!
Jonathan even if this video was twice a long it is worth watching because all the pertinent information needed to be covered and understood. So nice to know the pros and cons of Tylenol and to take it with consideration to your pain level. Thanks
Can you make a video on NAC? I know a lot of people take it as a daily supplement. Is that safe? Thank you for yet another educational video ❤️❤️
For headaches try ginger powder and cayenne first.. Just like a half a tsp each in a glass of small water and chug. It gets rug of most mild to medium headaches.
AWESOME channel! Thank you for making all of this info UNDERSTANDABLE! 😊
You are so welcome! Thanks for watching!
Thank you for this video! Now I understand why my liver hurt from paracetamol. These videos are very informative, it’s comforting to know a bit more about medication and how it works
He needs to have the whole world watching his video. He is a great professor, 👍 Thank you 😊
Length was just fine; not once was I distracted given how engaging you were, and informative the content was. Thanks!
Tylenol never seemed to work for me. I could only get through periods with ibuprofen prescription, taking them as needed, the first full day of each month.
But every medicine has its downside, and Ibuprophen can cause bone loss.
I think that’s cause ibuprofen is an inflammatory
You even make your advertisements clear and understandable.. amazing👏😭
Could you do a show about arthritis and it's affects? I am an RN and worked in the OR for many years so saw damaged joints. I now have RA and take methotrexate. I would love a show about arthritis. Thanks
These videos are never too long. It's a lot of information to absorb, but we can pause or come back later. I view these videos multiple times because I'm slow to absorb information. I like being able to do that, like reading books; I can go at my own pace.
This was such a good and useful information for me. Since Percoset has been taken away from my pain management by the government Tylenol has been my only hope and savior. It has proven quite affective although my dosage is a bit more than what is recommended on the over counter box. I am well with in the perimeters given for max dosage in this information though. I take 3 200mg caps on average 3 times a day so that's a total of 1800mg a day. On most days that seems to do a pretty good job yet on occasion I do have the bad day and for that I now have Tramodoll. It causes some minor side problems but at least I don't have to take it daily. Having 4 spinal surgeries and nerve damage is not easy to live with but thank God for Tylenol.
You still take 1800 mg tylenol a day ? How long u been on it?
@@tbaby5650 too long but unfortunately there is no other choice.
@@kenjett2434 how is your liver I do the same
@@tbaby5650 I get regular checks so far so good
@@kenjett2434 you do it daily are do you go some days without
Agreed with comments about video length: I have followed a handful of other channels that have increasingly made shorter and shorter videos - probably in an attempt to maximize views - some explicitly state that this is a new content strategy and others do not but in almost all instances the content suffers. Especially when it is something supposed to be educational.
I very much appreciate the thorough and carefully delivered nature of these scientific videos. If monetizing is an issue, I (and I am sure many other viewers) would be happy to support the channel through Patreon or other platforms.
Very interesting video. I have fibromyalgia that is pretty severe and significantly affects my daily life. I'd love to see a video regarding fibromyalgia. I know there isn't too much known about it's cause but I'd like to see what we do know. Thanks. :)
Same here. Id love to learn more.
Same here.
Thanks
No problem!
As a theoretical question, if let’s say a person abused the antidote to Tylenol, would the body have a less natural desire to produce more glutathione to metabolize Tylenol or alcohol into metabolites causing the daily allowance to decrease?
Hell no
Gosh back when I had endometriosis and the nurses would ignore me when I would call, I was taking 15 Tylenol and 15 ibuprofen a day. Didn't know I had endometriosis at the time. Finally demanded to talk to my RN and told her. She had me come in. Have to find the right people to listen......
Hey, I didn't know alcohol and tylenol both needed the same enzyme. This really good to know. Let's be nice to our liver, folks.
No need to apologize for the length of the video, it was valuable information and well worth the time!
Can you do a video on how CBD works or what it does to the body? Love the content
Hi! praise for you! Apologies aren’t necessary, cause in this particular case, you’re sure well worth listening to and you sound tremendously eloquent, with all that rich vocabulary of yours, as well. Needless to say that you’re absolutely instructive, informative and as a result of your work, your experience bears the fruit of all your knowledge... and it really shows! Great! going young man, for you’re a scholar and a gentleman. By far, you stand among the very best pathologists that i’ve heard so far, especially on the entire TH-cam channel. Thank you for this magnificent presentation. All the best to you! Greetings! and salutations! Johnny, Montréal, Canada.🇨🇦
I've always wondered if it's really a good idea to take medications that reduce fever. After all, fever is part of the body's defences against some invader. Aren't we impeding it's abilities by forcing a fever reduction? Similarly if you have a cough and you take cough drops or cough syrup to inhibit coughing, aren't you fighting against the body's attempts to expel an invader from the lungs or throat?
Fevers also cook your brain and killed millions if not billions throughout human history. All of your reasoning is not accurate.
@@adamcboyd Is that medical fact or just your opinion? I'm not saying it's wrong, I know practically nothing. I just always wondered about this. It didn't stop me taking medications to reduce fever or inhibit coughing, just had me questioning if it's right. Did those "million if not billions" die directly because of the fever and having their brain "cooked" or just being overwhelmed by the attack of whatever illness they had.
@@adamcboyd I assume you're right btw, otherwise the doc would have mentioned in this video "btw, reducing fever is a bad idea" ... and he didn't.
Fever is a counterproductive measure from the body.
It kills the bacteria, yes, but our own cells cant handle the heat either. Medicine helps you combat the virus while preventing your body from self destruction :) hope it helps!
@@kassyyar97 So it's the body trying to do the right thing for the right reasons, but not knowing it can also be negative. Kind of like the body over-reacting to harmless things like pollen and cat dander and peanuts. The invader itself is harmless, the reaction can be deadly. Thanks Kass and Adam, I'm learned up now :-)
Im not sure if IHA has done a video about this but can you do a video about Anxiety/Panic Attacks. How it happens, whats happening, can we die? Etc, etc, etc.
I think this would help relieve a lot of stress for those (like myself) who suffer everyday with this.
Awesome channel! Your delivery of the facts concise and easily understood! So glad I found you, even though I am an ER RN of many years it helps! Keep up the good work, and you are very easy on the eyes as well! 👍🏻😉
The longer the videos, the better. It answers questions I keep asking as the video plays. Love this channel!
🤔- I worked as a pharmacist at an alcohol and drug detox center. In about 20% of the clients who ingested a total of between 30-60 tabs of Percocet daily yet had normal LFTs (liver function tests): Keep in mind that a regular strength Percocet tablet contains 325 mg of acetaminophen which equals 0.325 g. in addition to working there, I was also responsible for doing drug utilization reviews and attending physician meetings. Since the maximum amount of acetaminophen the normal adult body can handle is approximately 4 g in 24 hours, these people up to 20 grams daily! The doctors I spoke with speculated that an addict maymetabolize acetaminophen. But why? That’s been my question for years. If you or anyone has any proposed answers, I would really appreciate hearing them. BTW, at least half of those patients worked in the medical field and were stealing the Percocet. Also, the average age of these patients was approximately 35 and they had been using the drug for at least five years. I’ve heard of tolerance, but this is crazy! 💊
Are you taking 30 percs a day ? 20 grams a day from tylenol is no joke and very rare to not have a bad liver .
They are probably doing a "cold water extraction". Acetaminophen isn't water soluble but hydrocodone is.
I can listen to this helpful Information all day, so don't apologize for the length of the video, and thank you for all you do.
Thanks for this video. Good to hear you confirm what my PCP said too: that damage only occurs when exceeding 4000 mg daily. I have osteoarthritis in one hip, both knees, and at the bottom of spine that makes it painful to walk. For the past 2 years, I've taken 2600 mg of 8 hour-Tylenol Arthritis daily, and 3900 mg on more painful days. Somedays I don't need to take any. I'm 73 so I figure it won't really matter how much I take. The odd thing is that I know when it's time for the next dose because I start to feel very fuzzy-brained. Does that mean I'm addicted to it? Has any research been done on the effects of long-term use?
how long will it take tylenol
.
I suffer from fibro and neuropathy...my doctor only gives aleve !? What is your opinion doctor? Do you think I should switch to Tylenol! My age is 74 would appreciate an answer😊
Please stop taking Tylenol if you can, I’ve never exceeded 4000 mg and my liver has been affected after years of taking it.
You are a Great Instructer. You're easy to follow and understand.
Great video, do naproxen or allergy pills next (I'vealways curious of why they call cetiricine a 2nd gen medicine), this is really valuable information, love the channel
Naproxen is an NSAID, so it works like ibuprofen, which they made a video about.
These videos help me to connect lots of things in my job, life, and studies for Medical Billing and Coding! I love these!
This is the best channel I ever stumbled across. I wish youtube was a thing back when I was in my study days. You explain everything beautifully. I love learning new things, these videos are wonderfully interesting! Thank you for putting the time in to make them!
What is the timeline to achieve acute liver failure? One overdose? Several days? I love your channel, I learn so much from you guys, keep it up!
A single, sufficiently large, dose may cause acute liver failure.
@@alechall1218 thank you.
@@alechall1218 how large
Your videos make anatomy interesting! I’d be grateful if you could do a video on “frozen shoulder”, as I’ve had this condition twice already, and wondering how to avoid it! Also, why does it occur and how does it heal over time?
Great video. Thank you. I worked with a woman who accidentally overdosed on it. She had the flu and was medicating herself. Very sad. We figured she must have forgotten she had already taken a dose; or combinations like you said. But since then, whenever I've had to take medication for a time, I write the times down. Because the thought that possibly she had just forgotten a dose, really brought it home for me. How many times have I forgotten. So it's real folks.
I always like other sources of information, especially when you break it down so simply.
I'm a liver transplant recipient, and due to the anti-rejection meds and a physical job, I'm constantly in pain. The only pain reducer I'm allowed to take is acetaminophen, and no more than 1000mg daily, but that at least makes life tolerable. :D
My daughter is a recent kidney transplant recipient and is in the same boat as you. I'm sorry for your pain because I know what she has to endure.
real question , and please reply. Is weed not allowed? Ask your doctor about weed. Either edibles or smoking it. Marijuana is proven to reduce pain and helps make life manageable in just these sorts of situations. Plus it doesnt give you that "medicated head fog" that tylenol and other OTCs tend to give. Although it does have its own type of head fog, lol.
Before my HCV was cured they told me to only take tylenol because if something goes wrong, they can most easily predict what will happen in hospital. I always thought it should be avoided because it's bad for the liver.
@@fastcar42069 Nope, many of my physicians have told me that weed is not allowed, primarily because it reacts with other drugs and the fact that it is metabolized in the liver. I also am just straight up not allowed to use it at work, for obvious reasons.
@@fastcar42069 I smoke pot for soooooooo many reasons. Anxiety. Stress. Anger. IBS - D. Nausea. It is literally a cure all drug.
I learn more here than from any doctor or the Internet! Thanq for taking the time to teach us the RIGHT way of body function and medications so so so helpful
Video topic idea:
Currently, thanks to the pandemic and working at home, I started noticing that I dont move much and my back started to hurt, I cant even turn around the bed while asleep and Im only 24. What does sitting around for long lengths of time does to your body??
Stretch and exercise. Remember, "rust never sleeps" !
No idea what it does to the body, but I think you already clearly identified the most likely cause of it. I would like such a video as well but I'd strongly recommend trying to get some more activity in your routine. A few things I've tried are to start a kitchen timer when sitting down at the desk, blocking a few moments in the day to take a walk outside and such. And adding trivial activities like every time you're going to the kitchen to get something to drink/snack to eat also walk up the stairs and down again before going back to the desk might make a difference.
My employer also runs a nagging software that tries to suggest to take brief breaks if you're active with the keyboard and/or mouse for extended periods, it only suggests to take a break by default but I think there's an option to set it to lock your session unless you explicitly snooze it. In my case the kitchen timer kinda worked and being aware of the punishment by my back if I don't move enough a few days later.
That said if additional activity doesn't help alleviate the back pain consider looking into it if there's not some other underlying cause that can be addressed, I walked around with intermittent back pain for more years than I'd like to think about which turned out to be axial spondyloarthritis that was ruining my back and hip. Basically resulting in a very sensitive lower back on bad days and reduced back and neck mobility, oh and a total hip replacement was needed before 40 years old. Sometimes I would like to know how much of that could've been prevented but as far as I'm aware we don't have time machines yet to fix such things.
I was taking naproxin everyday for months when I tore my shoulder. Almost wound up in dialysis. My GFR was down to 31. Doctor told me to quit taking Naproxin, which I did and fully recovered. I am 75 BTW. I only take tylenol. no more then 1000mg in a day and I use it sparingly.
Wow and your GFR came up back to normal? So kidneys can recover it seems
This video was very informative and helpful to me! I have a blood disorder and since Ibuprofen and advil are blood thinners, I can only take tylenol for pain relief. I’ve heard over and over again from doctors not to take more than the recommended dosage, but knowing in detail why definitely makes me want to be extra cautious while taking tylenol.
This may not be the most exciting of your videos but I paid extra attention to it. My mother passed in 2015 from liver failure and this video really helps me understand some of the reasons why. The doctors never explained this to my father or me. Thank you for the detailed explanation about NAPQI.
She died from tylenol
@@tbaby5650 she died from washing excessive amounts of it down with a bottle of wine every day. Which caused her liver to fail.
@@Baddeye I'm sorry for ur loss
I also take 7 a day for the last 6 years they put it in my pain meds . Those bastards
Love this. Can you do a video of what peritol does to the body and it’s effects of overdose?
We will add it to the list! Thanks for watching!
@@theanatomylab can you clarify is supplementing glutathione and NAC going to save these long term high use Tylenol patients who are now in chronic UTI situations? Or/ and utilizing kidney cleanse. Patient elderly. Your amazing!!! Thanks for info, could be lifesaving!!!!
I’m frequently concerned over a friends use of Tylenol and alcohol and have stated so numerous times, but NOW I have the science to back it up and bring my point home. THANKS!! I’m a new subscriber, but thus far have enjoyed the videos I’ve seen, lots of interesting topics!!
Thanks a bunch guys!
@@tbaby5650 as a matter of fact I don’t drink at all but thank you so much for your concern and trolling 👍
Great video Jonathan i always enjoy you and Justin's amazing well detailed channel, keep up the good work. 👍
Thank you!
I’m so grateful for all of your extraordinary videos. Thank you 🙏🏻
Can you please do a video what prednisone does to the body good and bad??
I've always been curious about Tylenol and Alcohol. I've always steered clear of one if I used the other, going as far as forcing myself to vomit if I mistakenly used both in the same 24 hour period. Sounds like I've just been extremely paranoid.
Yup
It may seem paranoid, but if you are a frequent drinker or have to frequently take Tylenol for pain, having them within 24-48 hours of each other is generally bad. To my understanding, both of these substances together significantly increases the amount of work your liver has to do as opposed to just having one or the other in your system.
Have you noticed Advil now has a product with both Ibprofen and acetominophen together? I thought they weren't suppoed to be taken together
I love this channel. I didn't go to med school because I was afraid of anatomy class and this channel and a recent health crisis where doctors and surgeons saved me has me reconsidering. Can we see a pancreas video? I am very curious about the vasculature of it and what the ducts look like!
Thank you for the wonderful information, Jonathan!
I have a question though, you mentioned Acetaminophen is an anti-piuretic
I thought it's spelled as "anti-pyretic"?
Yes, the editor actually made a mistake and spelled it wrong. I'm working on fixing it now.
I don’t know if you’ve already had this recommendation, but I would love to see a video on sepsis! Thank you :)
excellent channel, i have a question about the use of the antihistaminics and corticosteroids for the allergies, now that is coming the spring, i know that corticosteroids are dangerous if you take it during a long time but i don't know why, and i'd like to know what are the effects and how it affects the body. thx
We have a video planned for what corticosteroids do to the body, so stay tuned!
I'm sure the video they're making will be much more useful, but the problem with steroids long term is basically that it works by suppressing your immune system to reduce inflammation. Unfortunately, that makes you more likely to get infections etc, and on top of that, because corticosteroids in the body are used in a lot of processes, it also messes with those too - for example, it can cause osteoporosis, too, etc. It's a powerful medication that acts in very broad strokes, and so when used systemically, it causes these problems. It's not so much of an issue if you're using steroid creams, inhalers or nasal sprays, but it can still thin tissues etc. Another big issue is that if you take steroids long term, it can suppress your own natural corticosteroid production in the adrenal glands. Stopping suddenly - particularly of a long-term, large dose - can send a patient into a huge crisis and potentially be very serious. This is why if you take oral steroids long-term, you should make sure that you are carrying something that can inform emergency services that you use them, as it may affect not just their treatment of you, but ensure that you don't end up in a crisis because they don't know to keep giving you the steroids while you might be incapacitated and unable to tell them so.
That said, if you need them, your doctor has probably decided that the benefits outweigh the risks, and that's the issue with all medications. Balancing the risks and the benefits, and deciding on an individual basis.
This is a fantastic video; in-depth well done, very helpful to those of us who practically live on the stuff. Please don't worry about the length of your videos anyone who gets bored can just click away. Some of us are having entirely too much fun watching your videos no matter what they're about.
Man I love these videos. One question I had was: up to a certain point (i.e. for children), medicine doses are based on weight, but why do we seem to stop doing that at adulthood? For example I am 6'4" 210 lbs while my wife is 5'4" 110 lbs. We run into issues with medication all the time, e.g. Nyquil will put her out of commission for some time into the next morning, but the same dose wears off for me before I wake up. The COVID vaccine gave me a mild headache which may have even been partially from mild dehydration, but she had fever, chills, and nausea for like two days.
You mentioned 4000 mg of acetaminophen was the recommended maximum daily intake, but how did they choose those numbers? I'd guess that my tolerance is significantly higher than my wife's, but I don't know if 4000 mg is based on some sort of average, or based on a relatively small person just to give plenty of margin for error.
Are there any medications that have the same effects regardless of patient size? Or perhaps it's related to organ size? That might make more sense, like a morbidly obese man the same height as me might have the same size liver and kidneys (ignoring complications like fatty liver), making our effective dosage the same.
Anyway, again, great video! I love this channel!
Sounds complicated, but good point.
It really has to do more with organ development than weight. Pretty much no matter how much you weigh your organs are the same level of developed. Where as they are not in a child
There are some things like fluid recitation and blood thinners that are dosed based on weight
a recent peer reviewed article (examining over 1000 articles on the efficacy of Acetaminophen/Paracetamol) was simultaneously published in the British Medical Journal, The New England Journal of Medicine & The Lancet. The article clearly demonstrated that taking Tylenol, (Acetaminophen/Paracetamol) was far more dangerous & toxic than advertised or prescribed. It also showed that the drug only had a very small/negligible 'pain relief' effect on most injuries/trauma (including headaches & back pain).