Hey Andrew Huberman. I am a 14 year old. I have been watching you since 2 years. Just wanted to say thank you for all the invaluable information you give for free. ❤
My mom grew up in a family with little to no money and shared the house with a lot of siblings. Her father would buy m&ms, separate them by color, put each color in a fancy jar, and label it properly with their respective "medical properties", such as "Painkillers" for red ones and "Sleep pills" for blue ones. I grew up listening my mom insist on how effective those "pills" were, and laughing at her. Now, decades later, Mr. Huberman teaches me on the effects of color, labels and beliefs on placebo, and I find myself thinking: "My grandpa was a true genius. Made medicine out of sugar, and healed his family despite having little to no money at all." - Thank you Andrew! You make me humbler every day.
Hi Andrew I was a heavy drinker and addicted to seroquel. Since watching your podcasts I haven't touched any in 3 months. Amazing don't even feel like it. A big Thank you to you my life is really changing. I can't thank you enough
I don't even know why they prescribe that demonic drugs. I can't see how anyone can actually function on seroquel. I had severe insomnia and no sleep meds were working. And the doc gave me a moderate dose of seroquel and I always set 5 alarms for work in the morning. I slept through all 5. I woke up and saw sunlight after sleeping 13 hours and said "oh shit" and called my boss and told him what happened. Then I rushed getting ready, heart pounding, ran outside. Ran down the stairs adrenaline rush and everything. Got in my truck turned it on. And then the next thing I remember is waking up with someone knocking on my window still in the parking lot. I went from a full on sprint, with adrenaline pumping, terrified of getting fired to passed out cold asleep after already sleeping 13 hours. Then slept another 6 hours in my truck with it running.
Sorry for my English, I had severe Anhedonia after I quit my job. The job caused my mental breakdown and I had no other option but to resign. I couldn't sleep at night and it worsened my mental state. The ability to not fall asleep is like torture. You feel like screaming and going mad. It caused me to become paranoid and I thought I was becoming schizophrenic. I had no feeling or any emotions. It's like my soul died inside. No feeling, no pleasure. Only thing i felt was extreme agitation and that's when I decided to put on my running shoes and I ran 5km. It didn't really improve my mood but i consistently jogged every day and I gradually got my feeling back. I believe the sun exposure played a massive part in my healing. First thing every morning i went to the beach and swam in cold water. That brought me back to life. Why? Because it fixed my sleep. I believe the most important thing when depressed is to fix your sleep and daily sunlight, cold exposure, cardio exercises like running, hiking or breathing exercises does improve your sleep rapidly and that's the road to recovery right there. I highly recommend Wim Hof ,David Goggins, Alan Watts and Dr Hubberman if you feel paranoid or depressed.
Good for you, glad you’re doing better! I heard people say that when you’re feeling mentally numb, do things that will force you to feel things externally. So like you said, cold water exposure, sunlight exposure, running and activities that will connect the mind to the body. I think a lot of people don’t do this because we’re told when you’re stressed you’re dealing with mental problems. Of course, the mental work needs to be done but can’t forget how much physical work matters too
My sister in law has MS and has just had it confirmed that she has moved to the progressive form of the disease. It's so hard to see her feel so hopeless (and my brother). I have tried to research but as a lay person it is so difficult to know which is the trust worthy information. We are in the uk and although we are so lucky to have the NHS they can't offer or recommend the wide range of treatments that are available privately and around the world. it would be beyond amazing if you felt that an episode on this condition might be of interest to more of your audience. I completely understand you must get inundated with requests, but I'm feeling a little useless too so thought it was worth a try. Thank you
Beliefs, expectations, mindset.... I heard the word subconscious mentioned once. Core beliefs passed thru centuries and from our environment can be deeply rooted, and yet can be discovered and modified, eliminated or replaced with something positive. What are the limits of the mind? Meditation, mindfulness, affirmations... Possibilities are many and great. Thanks for the video. All the best.
Andrew. Top 0.1% fan according to Spotify here! Love your work. Regular listener since the beginning and have taken so much from your content. Please do an episode on Alopecia, in particular Alopecia Areata. The link between the autoimmune disease & the gut microbiome in particular fascinates me and I’ve been trying for years now to alter gut microbiome to see if I can send mine into remission. You thank us all for our interest in science, but I just want to thank you, for your interest in science, as without it, I speak for a lot of people in saying we’d be incredibly less informed if you hadn’t started your podcast. I sincerely mean that. Keep it up!
00:28 💊 Placebo, nocebo, and belief effects influence biology and psychology independently of physical or chemical properties of treatments. 01:23 🧠 Neural circuits in the brain modulate biological functions such as heart rate and blood pressure in response to expectations. 02:33 🩺 Placebo, nocebo, and belief effects can be harnessed as unique treatments for various diseases alongside traditional approaches. 07:29 🔬 Placebo effects are distinct from nocebo effects and belief effects, each with unique impacts on symptoms and performance. 09:26 🧠 The prefrontal cortex plays a key role in placebo, nocebo, and belief effects by modulating neural circuits that control physiological functions. 13:49 🧪 Placebo, nocebo, and belief effects rely on information and experiences shaping expectations, leading to physiological changes in the brain and body. 19:52 💡 Expectation strength varies across individuals and impacts the magnitude of placebo effects, highlighting the importance of placebo controls in clinical trials. 20:06 🧠 The placebo effect measures the expectation of a drug's effects in a trial, illustrating the impact of belief on outcomes. 21:30 🩸 Placebo effects show high specificity based on what individuals believe about a treatment, even impacting hormone levels. 23:31 💉 A placebo injection, even of saline, can lead to hormone changes based on prior knowledge or expectation of treatment. 31:48 🛎 Classical conditioning demonstrates how unrelated stimuli, like a bell, can trigger physiological responses like insulin release. 34:36 💊 Expectations about treatment quality, packaging, and color significantly impact the placebo effect. 39:15 🏥 The placebo effect is stronger with more invasive or complex treatments, showing the brain's association of complexity with larger outcomes. 40:37 🩸 Expectations, not just psychological, have real biological effects through specific brain circuitry. 41:06 🩸 Placebo effects have limitations, such as in cancer treatment, where they alleviate symptoms but do not shrink or eliminate tumors. 45:00 🎩 Placebo effects, while powerful, are specific and cannot completely eliminate conditions like asthma or cancer. 49:09 💡 Belief systems significantly shape how drugs, supplements, and behavioral protocols affect physiology and brain function. 53:01 🧠 Placebo effects scale with the degree of expectation one has, influencing outcomes even with the same dosage of a substance. 57:01 🍔 Beliefs about the calorie content and indulgence of food impact hormonal responses, affecting feelings of satiety and hunger regulation. 01:01:02 🏋♂ Beliefs and mindsets can also impact exercise outcomes, suggesting a significant interplay between psychology and physiology. 01:02:39 🏥 Simply believing that daily activities, like work, mimic exercise can lead to improvements in health metrics such as blood pressure and body weight. 01:05:23 🧠 While thoughts from the prefrontal cortex may not directly impact muscle growth, they can affect basic bodily functions like stress response through neural pathways. 01:06:06 🐀 A study on rats demonstrates a pathway from the prefrontal cortex to the hypothalamus, controlling stress responses, which has implications for understanding psychosomatic effects in humans. 01:10:06 💡 The placebo effect, influenced by genetics like the CT Gene, varies among individuals, showing different levels of response to placebo conditions. 01:12:21 🧬 Genetic variations, such as the CT Gene, correlate with differences in placebo response, indicating a biological basis for individual susceptibility to the placebo effect.
I have written word by word of what he says, constituting about 5792 words on MS WORD. It will help me in my medical journey, Thank you Dr. Andrew it was great listening to you as you simplified placebo effect for me. Long live hero!!
Hey I’ve got some really great news to share with you, Jesus Christ, the Son of God, died on a cross and resurrected on the third day so you may all have eternal life. If you believe and repent of your sins and put your faith and trust in Him as you would a parachute jumping off a plane at 25000 feet up in the air, He will give you eternal life in heaven as a free gift and I promise you, He will change your life forever as He did mine. He is the ONLY way to heaven and He loves you all. Please think deeply about this with urgency because this is your eternal life and soul, you don’t know when you could die, meaning you could die at any moment, so please consider this with all your heart. If anyone tells you that Jesus isn’t the only way, they are lying to you and they don’t care about your future.
Hey I’ve got some really great news to share with you, Jesus Christ, the Son of God, died on a cross and resurrected on the third day so you may all have eternal life. If you believe and repent of your sins and put your faith and trust in Him as you would a parachute jumping off a plane at 25000 feet up in the air, He will give you eternal life in heaven as a free gift and I promise you, He will change your life forever as He did mine. He is the ONLY way to heaven and He loves you all. Please think deeply about this with urgency because this is your eternal life and soul, you don’t know when you could die, meaning you could die at any moment, so please consider this with all your heart. If anyone tells you that Jesus isn’t the only way, they are lying to you and they don’t care about your future.
Russian teenager listening, I'm 15 and have been listening to your podcasts for more than a year now. You have changed my life forever! Episode with David Goggins made me read his book, and I will never be the same. Also, not to mention dosens of different themes and protocols. Huge thank you. I really appreciate the availability of your content in other countries ❤
If you are here looking for information that’s actually based on factual science you’re in the right place. Ive been here since 500k subs and I’ve watched almost every episode. I am in a much stronger place and constantly helping others with some useful information that they can experiment with to create a more fulfilling life
Hey Andrew Huberman, from my 4 grandparents, 2 had diabetes and one had the most awful illness i have seen, parkinson. I started two entrepeneurments in order to help people take care of themselves by working out, eating healthy and studying. I cannot be more grateful with you for all your work. I know we will meet some day and i hope you can participate in one of my talks, thank you again, greetings from Argentina. AGUANTE LA YERBA MATE Y ANDREW HUBERMAN!!
Thank you for all your content. Your work has motivated me to pursue my masters degree in neuroscience. I’ve always had a passion for learning the relationship between the brain and body, and didn’t understand what the field of that interest was termed as until I discovered this podcast. Thank you again Dr Hubberman. I appreciate you more than you know
Hey I’ve got some really great news to share with you, Jesus Christ, the Son of God, died on a cross and resurrected on the third day so you may all have eternal life. If you believe and repent of your sins and put your faith and trust in Him as you would a parachute jumping off a plane at 25000 feet up in the air, He will give you eternal life in heaven as a free gift and I promise you, He will change your life forever as He did mine. He is the ONLY way to heaven and He loves you all. Please think deeply about this with urgency because this is your eternal life and soul, you don’t know when you could die, meaning you could die at any moment, so please consider this with all your heart. If anyone tells you that Jesus isn’t the only way, they are lying to you and they don’t care about your future.
Greetings! German teacher with MS here. I love your content, and I'm able to use so much of your teaching into professional development sessions for teachers. My last presentation integrated your research /analysis of neuroplasticity and mindset effects. Life-changing information for students and teachers alike, and I always direct my audience to you and Dr. Crum. You mentioned you had never seen The Matrix. Um... You absolutely have to see this movie -- for a lot of reasons -- but its dive into mindset effects goes along with everything you've been saying. "The mind makes it real" is one of my favorite moments of the movie, and there are so many moments that speak to the power of the mind and of belief systems. It's worth a deep dive on its own. I promise. 💜
I am 16 years old now & I'm deeply passionate about neuroscience and my dream is to become a neuroscientist one day. Thank you for showing me the beauty of this career❤Amazing episode, by the way:)I'm currently reading "You are the placebo" by Joe Dispenza right now
Youre on the way to a bright future. If youre this passionate at such a young age and know what you want to do, youre ahead of 99,9% of people. Keep it up!
Hey I’ve got some really great news to share with you, Jesus Christ, the Son of God, died on a cross and resurrected on the third day so you may all have eternal life. If you believe and repent of your sins and put your faith and trust in Him as you would a parachute jumping off a plane at 25000 feet up in the air, He will give you eternal life in heaven as a free gift and I promise you, He will change your life forever as He did mine. He is the ONLY way to heaven and He loves you all. Please think deeply about this with urgency because this is your eternal life and soul, you don’t know when you could die, meaning you could die at any moment, so please consider this with all your heart. If anyone tells you that Jesus isn’t the only way, they are lying to you and they don’t care about your future.
I have so many life experiences to prove this belief! I have always said and believed our life Is the placebo. I Have used this to achieve the impossible in diagnosis,health,and life on general. So grateful scientists are catching up to this and giving alchemy recognition.❤
Hey I’ve got some really great news to share with you, Jesus Christ, the Son of God, died on a cross and resurrected on the third day so you may all have eternal life. If you believe and repent of your sins and put your faith and trust in Him as you would a parachute jumping off a plane at 25000 feet up in the air, He will give you eternal life in heaven as a free gift and I promise you, He will change your life forever as He did mine. He is the ONLY way to heaven and He loves you all. Please think deeply about this with urgency because this is your eternal life and soul, you don’t know when you could die, meaning you could die at any moment, so please consider this with all your heart. If anyone tells you that Jesus isn’t the only way, they are lying to you and they don’t care about your future.
Hey I’ve got some really great news to share with you, Jesus Christ, the Son of God, died on a cross and resurrected on the third day so you may all have eternal life. If you believe and repent of your sins and put your faith and trust in Him as you would a parachute jumping off a plane at 25000 feet up in the air, He will give you eternal life in heaven as a free gift and I promise you, He will change your life forever as He did mine. He is the ONLY way to heaven and He loves you all. Please think deeply about this with urgency because this is your eternal life and soul, you don’t know when you could die, meaning you could die at any moment, so please consider this with all your heart. If anyone tells you that Jesus isn’t the only way, they are lying to you and they don’t care about your future.
Huberman I just want to state the fact that your videos are so accessible that a 15 year old watches them since 1year. I even have a sorta note book just for the knowledge bestowed upon me by your videos. I would love to see an episode on skin health. P.S. just love the way your videos are consistent with the intro and the sound track.
Dr Andrew, with the back of my head bashed in I'm still waking up each day, I believe I live because of your directions. After 2 years I've improvement, I desire to reincarnate as your child. I can't imagine I life better than that! Thank you so much for all that you do for me and everybody else!😊
I work as a medical interpreter in Australia. Years ago I had a patient who came to ED due to heart issues and high blood pressure. He was going to undergo an emergency open heart surgery. He was so nervous about dying on surgery table that his blood pressure couldn’t be controlled by medicine through the drip very 15 minutes. His daughters came to see him before the surgery, they told him to pray as their family believes in God. The two daughters held his hands and prayed for a few minutes, his blood pressure came down and stabilised. Today’s podcast clearly explained why and how belief can have placebo effect.
Hey I’ve got some really great news to share with you, Jesus Christ, the Son of God, died on a cross and resurrected on the third day so you may all have eternal life. If you believe and repent of your sins and put your faith and trust in Him as you would a parachute jumping off a plane at 25000 feet up in the air, He will give you eternal life in heaven as a free gift and I promise you, He will change your life forever as He did mine. He is the ONLY way to heaven and He loves you all. Please think deeply about this with urgency because this is your eternal life and soul, you don’t know when you could die, meaning you could die at any moment, so please consider this with all your heart. If anyone tells you that Jesus isn’t the only way, they are lying to you and they don’t care about your future.
This is the BEST Andrew! It is the acknowledgement of the Science of ENERGY before the Science of MATTER. Reality is created with ENERGY. We wield energy with our MIND. Energy is contagious, the more powerful energy, the contagion. Disconnecting from the cage of thoughts (law of man and its common "sense" - i.e. FEAR) FREES the mind to be in CONTROL instead of the AUTOMATION that's been conditioned.
Belief as a means to conduct ones own neurology into performing feats which used to be attributed to mass-parallelized imaginary friends is freakin awesome.
An episode on brain damage from you would be awesome. Concussions and how they affect people in general, from brutal sports like some martial arts, rugby to other cases where brain damage is common. A topic not often talked about
Hey I’ve got some really great news to share with you, Jesus Christ, the Son of God, died on a cross and resurrected on the third day so you may all have eternal life. If you believe and repent of your sins and put your faith and trust in Him as you would a parachute jumping off a plane at 25000 feet up in the air, He will give you eternal life in heaven as a free gift and I promise you, He will change your life forever as He did mine. He is the ONLY way to heaven and He loves you all. Please think deeply about this with urgency because this is your eternal life and soul, you don’t know when you could die, meaning you could die at any moment, so please consider this with all your heart. If anyone tells you that Jesus isn’t the only way, they are lying to you and they don’t care about your future.
Very interesting topic. Short story when I was a resident one (hospitalized)patient told me that only one particular IV injection could release her pain, nothing was mentioned in her therapeutic sheet, when I asked my colleague what was the drog he gave her: he told me 10 ml of isotonic saline!
I'm 14, I've been watching your podcasts since 13, thank you for giving these invaluable information for free, I have used many tools and received many positive benefits ❤
I am EXCITED for this one Andrew! Been hoping you would unpack this for a while now. Perhaps you might have Bruce Lipton or Joe Dispenza on the podcast too? We cant spell belief without a lie in the middle and if we don't know the lies in our beliefs, we will always be vulnerable to manipulation by those who do. Thanks for being here, you are deeply appreciated.
🎯 Key Takeaways for quick navigation: 00:14 *🧠 Placebo, nobo, and belief effects are related to the brain's ability to place expectations, influencing biology independently of chemical properties.* 01:37 *🤯 Placebo, nobo, and belief effects can modify core biological functions like heart rate, blood pressure, and neuromodulator release.* 02:18 *💊 Placebo, nobo, and belief effects impact physiology beyond mere psychological perceptions, leading to changes in brain and body functions.* 03:00 *🌡️ Sleep quality affects mental health and performance, emphasizing the importance of temperature control, supported by products like eight sleep.* 04:33 *☕ Aeropress, a coffee maker, provides a superior taste compared to other brewing methods, contributing to a delightful coffee experience.* 05:53 *📉 Continuous glucose monitoring with Levels helps understand how different foods, activities, and sleep patterns impact blood glucose levels.* 07:29 *🚫 Distinguishing between Placebo and Nocebo effects - Placebo improves symptoms, while Nocebo worsens them, both beyond what's expected from the substance or treatment.* 09:00 *🧠 The prefrontal cortex, a neural hub behind the forehead, plays a crucial role in controlling and modulating various brain and body functions.* 11:03 *🤔 Prefrontal cortex suppresses impulses and evaluates context, acting as an expectation or prediction-making machine, influencing physiological responses.* 13:35 *🌐 Placebo, nobo, and belief effects are interconnected, relying on the prefrontal cortex to shape expectations that, in turn, influence various physiological processes.* 15:13 *🧠 Placebo effects illustrated through a Parkinson's study where placebo administration increased dopamine release, challenging conventional drug treatments.* 19:23 *💡 While placebo effects can influence physiological changes, the strength of expectation and the inability to anchor expectations universally limit their practical use as substitutes for actual drugs.* 40:37 *🧠 Placebo effects are real and have biological effects through true biological circuitry, activated by expectations.* 41:06 *🩹 The placebo effect is not limitless; its effects are specific to certain symptoms and contexts, as seen in cancer treatment.* 42:58 *🚫 Placebo effects cannot directly act on tumors to reduce size or eliminate them; they are limited by the prefrontal cortex's outputs.* 44:47 *📉 Placebo effects are about knowledge, belief, and expectation; they do not act directly on physiological systems like tumor reduction.* 50:33 *💡 Belief effects, like Placebo effects, influence physiological responses; a study on nicotine consumption showed cognitive performance modulation based on beliefs about nicotine concentration.* 54:56 *🤔 Expectation shapes experience; belief effects scale with the degree of expectation, influencing the outcomes of cognitive tasks.* 56:47 *🍔 Beliefs about the calorie content and nature of a milkshake impact hormonal responses, revealing the powerful influence of beliefs on physiological reactions.* 01:00:48 *🏋️♂️ Beliefs and mindsets about exercise can influence its positive effects, highlighting the role of expectation in shaping physiological outcomes.* 01:02:39 *🏨 Placebo effect in daily activities: A study with hotel service workers showed that those who believed their work was exercise experienced health metric improvements compared to those who were told their work was just important but not exercise-related.* 01:03:48 *🧠 Prefrontal cortex impact: The prefrontal cortex doesn't directly control muscle growth but has output pathways to brain regions like the hypothalamus, influencing stress response parameters (blood pressure, heart rate, etc.).* 01:06:21 *🧠 Study on stress response: Specific pathways from prefrontal cortex to dorsal medial hypothalamus influence stress responses, illustrating how psychological stressors impact physical health.* 01:12:07 *🧬 Genetic influence on placebo response: Certain genes, like the CT gene, show variation in individuals and correlate with the magnitude of the placebo response, specifically linked to dopamine, epinephrine, and norepinephrine regulation.* 01:15:22 *🌐 Placebo effect is biological: The placebo effect is not just a psychological trick; it has a real biological substrate, influencing various biological systems throughout the brain and body.* 01:16:30 *🌟 Support and follow: Support the podcast by subscribing on TH-cam, Spotify, and Apple, leaving reviews, and checking out sponsors. Follow Huberman Lab on social media for additional content and updates.* Made with HARPA AI
Hey I’ve got some really great news to share with you, Jesus Christ, the Son of God, died on a cross and resurrected on the third day so you may all have eternal life. If you believe and repent of your sins and put your faith and trust in Him as you would a parachute jumping off a plane at 25000 feet up in the air, He will give you eternal life in heaven as a free gift and I promise you, He will change your life forever as He did mine. He is the ONLY way to heaven and He loves you all. Please think deeply about this with urgency because this is your eternal life and soul, you don’t know when you could die, meaning you could die at any moment, so please consider this with all your heart. If anyone tells you that Jesus isn’t the only way, they are lying to you and they don’t care about your future
Incredible episode. Blown away by how our brains work! Now, I'm excited to share and discuss all these amazing facts with my kids. Thanks for such a great listen, you're the absolute BEST 🙏
This explains why for majority of human history, priests/religious groups were associated with healing. It's not that it was a hoax or whatever, but their belief towards their religion really had an effect that lead to the curing of many of their symptoms.
…brothers, whatever is true, whatever is honorable, whatever is just, whatever is pure, whatever is lovely, whatever is commendable, if there is any excellence, if there is anything worthy of praise, think about these things… for as You Think, So You Are
Did you notice brother, that the equations for every item you listed can not have FEAR included. So, to simplify this "fraction" divide by FEAR and it takes care of all the rest. 🧡
@@JORMUNGANDReyeS Totally, fear is the emotion that engages the imagination. It is based on assumed beliefs and their projection in the hippocampus (as Dr. Huberman so skillfully pointed out). Problem is they cloud our connection to the power of now. When it comes to true freedom, the only one we really have is what we choose to think, and even that can be a struggle. BTW, Yes, I should’ve taken out the word “brothers” As this was a quote from Philippians 4:8, ESV. But it’s the same concept as Zen in Buddhism, or the watercourse in Taoist practices, which naturally applies to all humans regardless of sex :-)
@@robertcurrea2451 I took no offense to the brother ❤️ You would love a fun fact that I learned today... That humans are only born with two innate fears... Falling and Load Sounds.... These are the laws of nature. Every other fear we have is man-made and keeps us from our genius. 🤜🤛
Hi Dr Huberman, I'm 2 months old and your podcasts have been an invaluable resource in my journey to further my intellectual capacities. I cannot yet walk, let alone crawl, but I am already making great strides towards my future!
01:01:05 this portion made me think about how imprtant it is to avoid submerging yourself into the negative or unrealistically positive environments of tv / internet news and social media.
This was very timely for me. I just stopped a medication for eczema (Dupixent) and I was ‘expecting’ a rebound at week ten. I just told myself this was likely. I tried to not think that way but I really felt it inside and couldn’t stop thinking about it. Sure enough I had a major eczema flare right at week ten! Your podcast really helped me realize the power of these thoughts and now I’m going to try to harness my mind to expect healing. I wish I could get saline needles to inject every two weeks. I bet my body would think it was Dupixent!!!
Hey Andrew Huberman, I'd love to see the neuroscientist and memory expert, Professor *Christine Ann Denny*. Her lab has pioneered a method of being able to turn memories off and on! Mindboggling. I'm obsessed with studying Memory engrams (memory traces). They are after all the building blocks, the units of meaning we give everything. According to my memory, Huberman, your channel is the one I watch most. You helped me change my routines/ life.
Rating: 8.0/10 (Rank 107 out of 202) In Short: Belief can literally change your brain... Notes: This is an outlier huberman podcast, as it is concise and to the point. I kind of enjoyed this style for a niche podcast like this--when these are 2+ hours it can be a bit too much. A nice mention of a handful of past podcasts (Lembke and Ali Krumb) who talk a bit about mindset and belief, and with some nice mentioning of a handful of studies. There was a little mechanism throughout, but not really necessary to just reiterate the point that placebo, which is just believing something will happen, actually causes physiological and neurological changes to happen. This idea kind of blows my mind, and having an entire podcast where that is just stated a dozen or so times, as it is here, was really nice and well done. A good niche podcast!
I told my mom that eating after 2 PM and moving around while doing household work butns fat. She started doing it and lost 2 kgs in 1.5 weeks. Now she is motivated to continue. Not placebo directly but the perspective change helps alot.
Only words suffice to make us fascinated by all this information. I can only imagine taking the narration of the most popular episodes of the Huberman podcast as a backbone to create a series of documentaries about how humans works. Adding images and animations in a minimalistic way, prioritizing the original narration over flashy HD scenes and useless special effects stuff. That could be very popular. We have this impression that everything has been done but we never get enough of this kind of quality documentaries like they used to make.
I used tDCS for a few years with great results (depression/addiction) and later read a paper that suggested tDCS itself WAS generating the placebo response. This fascinated me because if you can deliberately facilitate the placebo effect the limitations could just be material? i.e. You can reverse depression but not repair a broken bone. I am also amazed at how many people think the placebo effect is so common that the positive results of taking something like Vit D or any new supplement "may just be placebo" as if it is MORE likely to be the case when the double blind studies show that only a small percentage of people show clinical results when given a placebo.
🎯 Key Takeaways for quick navigation: 00:00 *🧠 Introduction to Placebo, Nocebo, and Belief Effects* - Introduction and explanation of placebo, nocebo, and belief effects. - These effects relate to the brain's expectation and can change biological functions. 02:18 *🏥 The Impact of Placebo, Nocebo, and Belief Effects on Physiology* - The significant physiological impact of placebo, nocebo, and belief effects. - They can work alongside traditional treatments to change brain and body functions. 03:00 *🛌 Sponsor Segment: Eight Sleep* - Introduction and benefits of Eight Sleep's smart mattress covers. - Focus on the importance of sleep temperature for quality sleep. 04:21 *☕ Sponsor Segment: Aeropress* - Introduction and benefits of Aeropress for making coffee. - Personal endorsement and comparison with other brewing methods. 06:07 *🍽️ Sponsor Segment: Levels* - Introduction to Levels and continuous glucose monitoring. - The importance of monitoring blood glucose for health and energy levels. 07:29 *🔬 Detailed Explanation of Placebo, Nocebo, and Belief Effects* - Deep dive into the definitions and differences of placebo, nocebo, and belief effects. - Explanation of how these effects are related to the brain's expectation mechanisms. 09:12 *🧠 Prefrontal Cortex and Its Role in Expectation* - The role of the prefrontal cortex in forming expectations and its impact on physiology. - Explanation of how the prefrontal cortex can influence physiological functions through expectation. 14:04 *📚 Examples of Placebo Effects in Research* - Specific examples of placebo effects from scientific studies, especially in Parkinson's disease. - Discussion on how placebo can increase dopamine levels, illustrating the power of expectation on physiology. 19:09 *🧪 The Specificity and Limitations of Placebo Effects on Dopamine* - Exploration of placebo effects on dopamine and the variables affecting their efficacy. - Placebo effects can stimulate dopamine release, but not as robustly as actual drugs. - The strength of the placebo effect varies between individuals and diminishes if the subject is aware it's a placebo. 21:30 *🧬 Hormonal Responses Influenced by Placebo* - Study demonstrating how placebo can specifically alter hormone levels. - Injection of saline, after information and expectations were set, altered levels of growth hormone and cortisol, showcasing the body's response to expectation rather than substance. - The placebo effect's specificity is linked to the context and information provided to the participants. 28:35 *🍽️ Classical Conditioning and the Placebo Effect* - Explanation of classical conditioning as a form of placebo effect. - Examples include the insulin response to food smells and sounds, highlighting how context can induce physiological changes. - This section connects classical conditioning with the broader concept of placebo effects, emphasizing context's role in modifying expectations and physiological responses. 32:58 *🌱 Sponsor Segment: AG1* - Brief sponsor mention highlighting the benefits of AG1 for ensuring daily nutritional needs. - Discussion on the importance of gut health for brain function and overall wellness, promoted through the use of AG1. 34:22 *💊 The Influence of Context on Placebo Effects* - Overview of various factors that can modify the placebo effect, demonstrating its sensitivity to context. - Branding, packaging, pill color, and method of administration can all significantly impact the strength of placebo responses. - Illustrates how placebo effects are not just about what we're told a treatment will do, but also how the treatment is presented and administered. 38:48 *🔄 The Influence of Treatment Complexity on Placebo Effects* - Discussion on how the complexity and invasiveness of treatments increase placebo effects. - Higher complexity or invasiveness of treatment (e.g., capsules vs. tablets, injections, medical devices) leads to greater placebo effects. - This relationship highlights the brain's association of treatment complexity with expected outcomes. 41:06 *🚫 Limitations of Placebo Effects in Cancer and Asthma Treatments* - Examination of the limitations of placebo effects in treating cancer and asthma. - Placebos can alleviate symptoms like pain and nausea from cancer treatment but cannot reduce tumor size. - In asthma treatment, placebos reduced discomfort but did not improve actual breathing function, illustrating placebo effects' boundaries. 48:12 *🧪 Sponsor Segment: InsideTracker* - Brief mention of InsideTracker, emphasizing personalized nutrition and health goals. 49:09 *🧠 Nicotine Study: Expectation Influences on Cognitive Performance* - Study showing belief effects on nicotine intake and cognitive performance. - Subjects performed better on cognitive tasks when they believed they had ingested higher doses of nicotine, regardless of actual dose. - Brain activity levels matched the expected nicotine dose, highlighting belief effects on physiological responses. 56:06 *🍦 Mind Over Milkshakes: Mindsets Impact on Ghrelin Response* - Study on how beliefs about calorie content in milkshakes affect hunger hormone ghrelin. - Subjects who thought they consumed a high-calorie shake showed greater reductions in ghrelin than those who believed they consumed a low-calorie shake. - Demonstrates how mindset can influence physiological responses to food. 59:14 *🍦 Impact of Beliefs on Food's Hormonal Effects* - Study showing how beliefs about calorie content influence hormonal responses. - Belief about consuming a high-calorie shake versus a low-calorie shake affects ghrelin levels. - Demonstrates the power of belief in altering physiological responses to food, beyond the actual nutritional content. 01:01:02 *🏋️♀️ Exercise Perception and Health Outcomes* - Discussion on how perceiving daily activities as exercise can improve health metrics. - Hotel service workers who believed their work was beneficial exercise saw improvements in health metrics. - Highlights the effect of mindset and belief on physical health outcomes, emphasizing the role of perception in health. 01:04:16 *🧠 Neural Pathways for Stress Response* - Explanation of the neural circuitry from the prefrontal cortex to the hypothalamus involved in stress response. - Identification of specific neural pathways that mediate physiological stress responses. - Offers a biological explanation for how beliefs and mindsets can impact stress and other physiological responses. 01:11:27 *🔬 Genetic Variability in Placebo Response* - Discussion on genetic factors that influence variability in placebo response. - The COMT gene's role in modulating neurotransmitter regulation and its correlation with placebo effect susceptibility. - Provides evidence that placebo effects have a biological basis and are influenced by individual genetic makeup.- 59:14 🍧 Influence of Beliefs on Hormonal Responses to Food - Study showing how beliefs about calorie content impact the hormone ghrelin. - Beliefs about consuming a high-calorie vs. low-calorie shake affect satiety and ghrelin response. - Highlights the significant role of expectations in the physiological responses to food. 01:01:02 *🏋️♀️ Belief Effects on Exercise Outcomes* - Study on how beliefs about daily activities as exercise can improve health metrics. - Hotel service workers who believed their work was beneficial exercise saw health improvements. - Demonstrates the power of belief and mindset in influencing physical health outcomes. 01:04:44 *🧠 Neural Pathways for Psychosomatic Responses* - Details on the neural pathways from the prefrontal cortex to the hypothalamus controlling stress responses. - Illustrates how thoughts and beliefs can influence physical states like blood pressure and body temperature. - Provides a biological explanation for how expectations affect our physiology. 01:11:41 *🧬 Genetic Variation and Placebo Susceptibility* - Discussion on genetic factors influencing placebo effect variability among individuals. - The COMT gene's role in modulating responses to placebo treatments related to dopamine and stress hormones. - Evidence of biological substrates underpinning the variability in placebo responses. 01:15:22 *🧪 Conclusion on Biological Basis of Placebo Effects* - Summarization of the placebo effect as a genuine biological phenomenon. - Emphasizes the role of knowledge, belief, and expectations in shaping physiological outcomes. - Placebo effects are not merely psychological but result in tangible changes in the body's biology. Made with HARPA AI
I used to play music at work for people with Parkinson's - they can dance and forget all about it with a song they like. I taught a 15 year old boy with severe autism how to play a video game, and win every time. His dad was sure he just bashed the keyboard without purpose - so far he'd trashed every computer. Then I covered all the keys except for the arrow key. Immediately he realised the connection between the key and the screen. Bit by bit I uncovered more keys and he practically taught himself to play. Another time, I hooked up a camera to a wall-sized screen and let him take photos of himself. He was so happy to see himself on screen after each shot. They were the happiest photos his father had ever seen of him. Then I cared for a man in my street with BGDD. After three years, he lost all movement and speech. But I could make him laugh even when he couldn't talk anymore. I knew when he needed toileting and could hoist him out of bed alone (four nurses at the hospital couldn't do it - his whole bed used to be wet). I have so many stories from 20 years experience but I'm nobody you've ever heard of
Ensure to subscribe to Andrew Huberman and Like the video - [00:00] 🧠 Understanding Placebo Effects - Placebo, nobo, and belief effects are all related to the brain's ability to alter outcomes based on expectations.
- [07:29] 💊 Differentiating Placebo, Nobo, and Belief Effects - Placebo effects occur when inert substances or treatments improve symptoms or performance. - Nobo effects worsen symptoms or performance despite inert substances or treatments. - Belief effects involve specific knowledge altering expectations and outcomes. - [14:04] 🧪 Biological Mechanisms of Placebo Effects - Prefrontal cortex acts as an expectation/prediction maker, influencing physiological functions. - Placebo, nobo, and belief effects involve changes in prefrontal cortex activity and subsequent modulation of deeper brain regions. - Examples of placebo effects include alterations in dopamine release in Parkinson's patients. - [19:09] 🧠 Placebo effects and dopamine regulation - Placebo-induced increases in dopamine are generally less robust than those induced by actual drugs. - Expectation effect plays a crucial role in the placebo effect, impacting the strength of dopamine increase. - Placebo controls are used in clinical trials to differentiate between drug effects and placebo effects. - [21:42] 🤯 Specificity of placebo effects - Placebo effects demonstrate a high degree of specificity based on the beliefs and expectations of individuals. - Beliefs about a drug's function can influence its perceived effects, even if the actual drug action differs. - The example of hormone function illustrates how placebo effects can mimic the effects of active drugs. - [24:56] 🔄 Conditioning and placebo responses - Classical conditioning can evoke placebo responses, such as conditioned insulin release in response to sensory cues. - Context plays a significant role in modifying placebo effects, demonstrating the brain's ability to anticipate and respond to environmental cues. - The placebo effect extends beyond laboratory settings to everyday life scenarios, showing the influence of context on perceived treatment outcomes. - [38:48] 🧠 Placebo effect and treatment invasiveness - Placebo effects are magnified by the perceived invasiveness or complexity ofa treatment. - The brain associates treatment complexity with larger outcomes, enhancing the magnitude of the placebo effect. - Despite the inert nature of treatments, such as pills or medical devices, they activate specific neural circuits in the prefrontal cortex, influencing biological responses. - [41:06]💊 Limits of placebo effects in cancer treatment - Placebos can alleviate specific symptoms associated with cancer treatment, such as pain and nausea. - However, placebo effects cannot directly reduce tumor size or eliminate cancerous tumors. - Expectation effects are real but have limitations, especially concerning biological outcomes like tumor reduction. - [45:00] 📚 Placebo effects in asthma treatment study - A study on asthma patients showed that placebo treatments reduced discomfort but didn't change breathing patterns. - Unlike bona fide drug treatments, placebos couldn't restore normal breathing patterns or eliminate asthma symptoms entirely. - Placebo effects are powerful but specific, affecting perceptions rather than directly altering physiological conditions. - [49:09] 🧪 Influence of belief on drug response - Beliefs about drug dosage can significantly impact cognitive performance, even when individuals receive the same amount of the drug. - The brain's activity levels change according to expectations about drug dosage, affecting cognitive outcomes. - Placebo and belief effects demonstrate the power of expectation in shaping physiological responses. - [56:19] 🥤 Mindsets and hormone response in milkshake study - Expectations about calorie content and healthiness influenced hunger hormone responses in a milkshake study. - Individuals who believed they consumed a high-calorie indulgent shake experienced greater reductions in hunger hormones compared to those who believed they consumed a low-calorie sensible shake. - Mindsets, shaped by beliefs and expectations, can modulate physiological responses, influencing feelings of satiety and hunger hormone levels. - [59:14] 🍔 Impact of Beliefs on Hormonal Response to Food - Beliefs about food consumption strongly affect hormonal responses. - Specific knowledge about calorie content and indulgence vs. sensibility impacts hormonal release. - Our beliefs communicate with neurons in the gut, altering hormonal responses to food. - [01:01:02] 🏋♂ Influence of Beliefs on Exercise Benefits - People's beliefs about their daily activities affect their health outcomes. - Being informed that daily activities mimic exercise leads to improvements in health metrics. - Belief in the health benefits of daily activities induces actual health improvements. - [01:04:44]🧠 Biological Basis of Placebo Effects - Understanding the neural pathways from the prefrontal cortex to other brain regions is crucial. - Specific neural circuits mediate the placebo effect, impacting stress responses and bodily functions. - The placebo effect has a real biological substrate, involving neural, hormonal, and genetic mechanisms. - [01:11:41] 💊 Genetic Correlates of Placebo Response Variability - Genetic variations, such as the CT Gene, influence susceptibility to the placebo effect. - Genes related to dopamine regulation show correlations with placebo response levels. - Individual variances in placebo response can be attributed to specific genetic expressions.
😮Are you suggesting that there are certain individuals that are more or less susceptible to a placebo or belief effect? ?????Like there is for hypnosis?
@@hubermanlab has there been any reproducible studies showing this effect of certain individuals being more susceptible? Would you expect experienced meditators , one’s that have great control over there autonomic nervous system, to be in that group?
Surprised that you didn't include the research on placebo/sham surgery. Fascinating & surprising work has been published for over a decade on the success of sham knee surgery. And at least 6 years of published research on success in sham spinal surgery. The brain is powerful & capable of so very much
0:00: 🧠 The power of placebo, nobo, and belief effects in altering biological functions through brain circuits. 6:04: 💉 Innovative health monitoring program tracks blood glucose levels to optimize energy and metabolic health. 12:04: ⚛️ Understanding the Influence of Expectations on Physiological Responses 17:51: ⚛️ Placebos can mimic the effects of dopamine by increasing its release in the brain. 24:00: ⚛️ Placebo injections can influence growth hormone and cortisol levels independently of expectations. 29:58: 🔔 Conditioned stimuli can trigger insulin release independently of food presence. 36:08: ⚛️ Color association influences placebo effects on sleep and stimulation. 42:29: ⚛️ The limitations of prefrontal cortex in influencing biological systems, including tumors, contrasted with proven mind-body techniques for improving cancer treatment outcomes. 48:37: ⚛️ Impact of Belief Systems on Physiology and Brain Function 54:56: 💡 The impact of belief on biological and psychological responses, beyond placebo effects. 1:01:04: ⚽ Study on the impact of exercise on physiology initiated by Dr. Crum's conversation with her adviser. 1:07:12: 🧠 Mapping connections from prefrontal cortex to dorsal medial hypothalamus reveals stress response involvement. 1:13:38: 🧬 Genetic variations influence placebo response through neurotransmitter regulation.
I haven't done any research on my own, beyond listening to this podcast. However, as a young 22 year old male with schizoaffective d/o, I've found that I have this weird mental ability, "mind over matter." It has worked very similarly as the placebo affect, however it's very delicate, and the moment I consciously or subconsciously discover any doubt, the trick loses all effect. I'm primitive with the ability, I can convince myself right now that if I chug a water bottle, it doesn't hydrate me and actually dehydrates me, but if I sip or drink it slowly, it hydrates me. However, I'm a cigarette smoker, and I've encountered a weird problem with my habit. I've had my share of personal issues, been on and off working hourly jobs, when I've worked a full day and make it to the end of a shift, I'm more likely to enjoy one cigarette fully. But when I haven't been working, or haven't done anything productive throughout the day, I'm way more likely to find myself chain smoking, as one cigarette gives me way less of that "relief" feeling. I've found myself in a carrot and stick lifestyle, where I know that if I don't accomplish anything during my day, and stay in bed enjoying videogames or shows, I'll end up paying the consequence later in the day when I have no dopamine to work off of. So, I've found myself, unemployed, starting each day off by asking, "what can I do today, even if it's just research into my mental and physical conditions." But then, I end up in the same place, whether I'm working a job or just knocking out some self-made to-do list, feeling like it's too much to handle, and even if I wanted to pause, break it up, slow myself down, I can't, because I'm too far in. Being human is complicated, man.
Would you consider having Ellen Langer on the podcast? This ep made me realize how much I would love to hear you both talk all about mindfulness & its impact on our health/reality... Thank you for your beautiful mind & heart. Besides be so fun & fascinating, your podcast continues to bear such fruit in my life daily. Hope it nourishes you as much as it does all of us! -Amy
They had certain bio markers in “ age regression” but as with all these “ anti-aging claims, never look younger. I’ll settle for better health and feeling better, however.
@@jackm.1628 the one I’m thinking of is “Understand and Improve Memory” - which I’m *fairly* sure addresses spacing effects, etc. He also has at least two other episodes on learning, though one is much more focused on motor learning… but many of the same principles apply. I can’t recall him talking about mind maps, but (as a long-time mind-mapper) I would also like to see him go down that rabbit hole.
Andrew, can you please consider making episodes with Dr. Joe Dispenza. I believe it would be interesting to hear you two discussing the topic of neurobiology, neuroplasticity, placebo, nocebo, etc. For me personally, Doctor Joe had a huge impact in the field of neuroplasticity and self work. I believe there are more people who share the same thoughts. Thank you for your effort and all that you are doing for the world! 🙏🏻🙏🏻🙏🏻
🎯 Key Takeaways for quick navigation: 00:14 *🧠 Los efectos placebo, nocebo y de creencias influyen poderosamente en la biología y psicología del individuo.* 01:23 *🩸 Estos efectos pueden modificar funciones biológicas básicas como la frecuencia cardíaca, la presión arterial y la liberación de neurotransmisores como la dopamina y la adrenalina.* 02:33 *🌱 Algunos investigadores médicos sugieren que los efectos placebo, nocebo y de creencias podrían ser utilizados como tratamientos únicos para diversas enfermedades.* 07:29 *💊 Los efectos placebo se refieren a cambios en los síntomas o el rendimiento inducidos por sustancias o tratamientos que no tienen actividad biológica o psicológica directa.* 08:34 *🧪 Los efectos de creencias ocurren cuando el conocimiento específico cambia las expectativas sobre un resultado fisiológico o psicológico.* 09:26 *🧠 El córtex prefrontal, responsable de las expectativas y predicciones, controla otros circuitos neurales y funciones fisiológicas básicas del cuerpo.* 13:49 *🧠 Los efectos placebo, nocebo y de creencias se basan en la capacidad de la información y las experiencias para generar expectativas que modifican la fisiología del cerebro y el cuerpo.* 20:06 *💊 El efecto placebo es una medida de la expectativa de lo que hará un tratamiento con medicamentos en un ensayo clínico.* 21:42 *🧠 Las expectativas y creencias sobre un tratamiento tienen una alta especificidad en los efectos placebo.* 23:17 *💉 La asociación entre recibir una inyección y cambios hormonales demuestra la influencia del efecto placebo en el cuerpo y la mente.* 31:07 *🛎️ La respuesta placebo se puede condicionar incluso a estímulos no relacionados directamente con el tratamiento, como el sonido de una campana.* 34:36 *🌈 El efecto placebo se ve potenciado por factores como la marca del medicamento, su presentación y el color de la pastilla.* 38:35 *🏥 La invasividad y complejidad de un tratamiento placebo aumentan su efectividad, demostrando la influencia de la percepción en los resultados.* 40:37 *💊 Las expectativas tienen efectos reales en nuestra biología y psicología a través de la activación de la corteza prefrontal.* 41:06 *🩺 Los placebos pueden reducir el malestar en el tratamiento del cáncer, pero no pueden reducir el tamaño ni eliminar los tumores.* 45:00 *🧠 Los efectos placebo son poderosos pero tienen límites; no pueden eliminar completamente las condiciones como el asma o el cáncer.* 49:09 *🚬 Las creencias relacionadas con el consumo de nicotina pueden modular las respuestas cerebrales, incluso cuando todos reciben la misma cantidad de nicotina.* 57:01 *🥤 Lo que creemos sobre los alimentos que consumimos impacta significativamente las respuestas hormonales del cuerpo, incluso cuando se trata de la misma comida.* 01:02:12 *🧠 El simple hecho de creer que las actividades diarias son ejercicio puede llevar a mejoras en la salud, según un estudio con trabajadores de hoteles.* 01:04:02 *💡 Las expectativas, creencias y mentalidades pueden impactar profundamente nuestra fisiología, incluida la liberación de hormonas y la percepción del dolor.* 01:05:38 *🧬 Existe un circuito neural específico desde la corteza prefrontal hasta el hipotálamo que puede influir en respuestas al estrés, demostrando la conexión mente-cuerpo.* 01:11:41 *💊 La respuesta al placebo varía entre individuos, y ciertos genes, como el gen CT, están relacionados con la magnitud de la respuesta al placebo, especialmente en neurotransmisores como la dopamina.* 01:15:22 *🧪 Los efectos del placebo son efectos biológicos reales, no solo ilusiones mentales, y pueden influir en una amplia gama de sistemas biológicos en el cuerpo humano.* Made with HARPA AI
"Exploring the Robust Link between Hypnosis and Placebo Effects: One paramount inquiry arises: Can we discern a sturdy correlation between the effects of hypnosis and the placebo effect? Additionally, a pivotal aspect yet to be fully elucidated pertains to the strategic alteration of mindset or belief systems to optimize the benefits of the placebo effect. Mere acknowledgment of non-established scientific effects without thorough research may inadvertently reinforce uncertainty rather than maximise the desired outcomes. Thus, how can we methodically adjust our mindset, within the realms of scientific inquiry, to achieve the most favourable outcomes? I would like to conclude my comment by conveying my heartfelt appreciation for the remarkable dedication you have shown towards advancing public education. Your invaluable efforts are truly commendable and deeply cherished
I love your work - please consider interviewing Dr Stephen Porges. His work on Polyvagal Theory helped me understand my daughters Chronic Fatigue Syndrome (including POTS and a whole host of other symptoms). She recovered once we found people who knew how to work with this - it wasn't the medical system.... Dr Porges describes the nervous system as the intervening variable, often not considered in science and medicine. I am sure it would be a great episode.
Andrew, please consider having Iain Mcgilchrist on the podcast. The way he thinks/speaks is so invigorating yet beautiful I cant get enough of him lately and I think you might agree and find his thoughts on the brain hemispheres/ perception+ reality to be fascinating!
Can you make an episode on genetics, how it works and what we can do to change what we inherit ? By the way I don’t miss an episode and I thank you for sharing your knowledge free of cost..otherwise I could not have access to this information. Thank you again
Hey Huberman, I just wanted to express how much I love your videos. Since day one, I've been a fan and have watched every single episode. I've got a suggestion for a topic that I think would be super helpful and interesting for many of us: emotional stability. After all, it's something we all struggle with at times. Why do we feel all over the place sometimes, and more importantly, what can we do about it? It would be amazing to have a science-based view of it and methods to improve ourselves. Thank you for the awesome work, and I'm looking forward to whatever you've got coming up next." 🇧🇷❤
Interesting as always. Thank you so much ☺️! As I suffer quite a lot of slow COMT (it’s getting worse with high estrogen during perimenopause as the enzyme breaks down also estrogen and histamine to some extent), I should take advantage of the fact that I am genetically predisposed to have a stronger placebo effect ❣️❣️❣️
Hey Andrew, just a spitballing but would love to see you talk a little about neurodegenerative progress or diseases. As a person with such disease it would clear so much unknown and questions, that not only me, but a lot of other people touched by such diseases have. Love the incentive of sharing such knowledge in these podcasts btw, keep doing you :)
Hey Andrew Huberman. I am a 14 year old. I have been watching you since 2 years. Just wanted to say thank you for all the invaluable information you give for free. ❤
Thank you for your interest in science!
W lil bro, good luck to you brodie
Big W having access to this so young is unreal
Enies lobby is a W aswell
huge W bro... many teens play video games or do unnecessary things.. your parents raised you very well
My mom grew up in a family with little to no money and shared the house with a lot of siblings. Her father would buy m&ms, separate them by color, put each color in a fancy jar, and label it properly with their respective "medical properties", such as "Painkillers" for red ones and "Sleep pills" for blue ones. I grew up listening my mom insist on how effective those "pills" were, and laughing at her. Now, decades later, Mr. Huberman teaches me on the effects of color, labels and beliefs on placebo, and I find myself thinking: "My grandpa was a true genius. Made medicine out of sugar, and healed his family despite having little to no money at all." - Thank you Andrew! You make me humbler every day.
What an amazing story!
@@springpena9873 thank you!
Hi Andrew
I was a heavy drinker and addicted to seroquel. Since watching your podcasts I haven't touched any in 3 months. Amazing don't even feel like it. A big Thank you to you my life is really changing. I can't thank you enough
I don't even know why they prescribe that demonic drugs. I can't see how anyone can actually function on seroquel.
I had severe insomnia and no sleep meds were working. And the doc gave me a moderate dose of seroquel and I always set 5 alarms for work in the morning. I slept through all 5. I woke up and saw sunlight after sleeping 13 hours and said "oh shit" and called my boss and told him what happened. Then I rushed getting ready, heart pounding, ran outside. Ran down the stairs adrenaline rush and everything. Got in my truck turned it on. And then the next thing I remember is waking up with someone knocking on my window still in the parking lot. I went from a full on sprint, with adrenaline pumping, terrified of getting fired to passed out cold asleep after already sleeping 13 hours. Then slept another 6 hours in my truck with it running.
This video itself is a placebo that made me feel better about all the other placebos I know I do.
Sweet haha, love this.
Sorry for my English, I had severe Anhedonia after I quit my job. The job caused my mental breakdown and I had no other option but to resign. I couldn't sleep at night and it worsened my mental state. The ability to not fall asleep is like torture. You feel like screaming and going mad. It caused me to become paranoid and I thought I was becoming schizophrenic. I had no feeling or any emotions. It's like my soul died inside. No feeling, no pleasure. Only thing i felt was extreme agitation and that's when I decided to put on my running shoes and I ran 5km. It didn't really improve my mood but i consistently jogged every day and I gradually got my feeling back. I believe the sun exposure played a massive part in my healing. First thing every morning i went to the beach and swam in cold water. That brought me back to life. Why? Because it fixed my sleep. I believe the most important thing when depressed is to fix your sleep and daily sunlight, cold exposure, cardio exercises like running, hiking or breathing exercises does improve your sleep rapidly and that's the road to recovery right there. I highly recommend Wim Hof ,David Goggins, Alan Watts and Dr Hubberman if you feel paranoid or depressed.
Good for you, glad you’re doing better! I heard people say that when you’re feeling mentally numb, do things that will force you to feel things externally. So like you said, cold water exposure, sunlight exposure, running and activities that will connect the mind to the body. I think a lot of people don’t do this because we’re told when you’re stressed you’re dealing with mental problems.
Of course, the mental work needs to be done but can’t forget how much physical work matters too
Thank you for opening up and sharing your experience, I'm glad that you're feeling better! Sending lots of love and prayers your way 💖
@@mariacolucci6958 thanks 😊 🙏
Thanks for opening up man, I got similar problems. Shit is tough. We're in this together. Stay strong everyone!
Alan Watts is a great author!!
My sister in law has MS and has just had it confirmed that she has moved to the progressive form of the disease. It's so hard to see her feel so hopeless (and my brother). I have tried to research but as a lay person it is so difficult to know which is the trust worthy information. We are in the uk and although we are so lucky to have the NHS they can't offer or recommend the wide range of treatments that are available privately and around the world. it would be beyond amazing if you felt that an episode on this condition might be of interest to more of your audience.
I completely understand you must get inundated with requests, but I'm feeling a little useless too so thought it was worth a try.
Thank you
Beliefs, expectations, mindset.... I heard the word subconscious mentioned once. Core beliefs passed thru centuries and from our environment can be deeply rooted, and yet can be discovered and modified, eliminated or replaced with something positive. What are the limits of the mind? Meditation, mindfulness, affirmations... Possibilities are many and great. Thanks for the video. All the best.
Andrew. Top 0.1% fan according to Spotify here!
Love your work. Regular listener since the beginning and have taken so much from your content.
Please do an episode on Alopecia, in particular Alopecia Areata. The link between the autoimmune disease & the gut microbiome in particular fascinates me and I’ve been trying for years now to alter gut microbiome to see if I can send mine into remission.
You thank us all for our interest in science, but I just want to thank you, for your interest in science, as without it, I speak for a lot of people in saying we’d be incredibly less informed if you hadn’t started your podcast.
I sincerely mean that. Keep it up!
00:28 💊 Placebo, nocebo, and belief effects influence biology and psychology independently of physical or chemical properties of treatments.
01:23 🧠 Neural circuits in the brain modulate biological functions such as heart rate and blood pressure in response to expectations.
02:33 🩺 Placebo, nocebo, and belief effects can be harnessed as unique treatments for various diseases alongside traditional approaches.
07:29 🔬 Placebo effects are distinct from nocebo effects and belief effects, each with unique impacts on symptoms and performance.
09:26 🧠 The prefrontal cortex plays a key role in placebo, nocebo, and belief effects by modulating neural circuits that control physiological functions.
13:49 🧪 Placebo, nocebo, and belief effects rely on information and experiences shaping expectations, leading to physiological changes in the brain and body.
19:52 💡 Expectation strength varies across individuals and impacts the magnitude of placebo effects, highlighting the importance of placebo controls in clinical trials.
20:06 🧠 The placebo effect measures the expectation of a drug's effects in a trial, illustrating the impact of belief on outcomes.
21:30 🩸 Placebo effects show high specificity based on what individuals believe about a treatment, even impacting hormone levels.
23:31 💉 A placebo injection, even of saline, can lead to hormone changes based on prior knowledge or expectation of treatment.
31:48 🛎 Classical conditioning demonstrates how unrelated stimuli, like a bell, can trigger physiological responses like insulin release.
34:36 💊 Expectations about treatment quality, packaging, and color significantly impact the placebo effect.
39:15 🏥 The placebo effect is stronger with more invasive or complex treatments, showing the brain's association of complexity with larger outcomes.
40:37 🩸 Expectations, not just psychological, have real biological effects through specific brain circuitry.
41:06 🩸 Placebo effects have limitations, such as in cancer treatment, where they alleviate symptoms but do not shrink or eliminate tumors.
45:00 🎩 Placebo effects, while powerful, are specific and cannot completely eliminate conditions like asthma or cancer.
49:09 💡 Belief systems significantly shape how drugs, supplements, and behavioral protocols affect physiology and brain function.
53:01 🧠 Placebo effects scale with the degree of expectation one has, influencing outcomes even with the same dosage of a substance.
57:01 🍔 Beliefs about the calorie content and indulgence of food impact hormonal responses, affecting feelings of satiety and hunger regulation.
01:01:02 🏋♂ Beliefs and mindsets can also impact exercise outcomes, suggesting a significant interplay between psychology and physiology.
01:02:39 🏥 Simply believing that daily activities, like work, mimic exercise can lead to improvements in health metrics such as blood pressure and body weight.
01:05:23 🧠 While thoughts from the prefrontal cortex may not directly impact muscle growth, they can affect basic bodily functions like stress response through neural pathways.
01:06:06 🐀 A study on rats demonstrates a pathway from the prefrontal cortex to the hypothalamus, controlling stress responses, which has implications for understanding psychosomatic effects in humans.
01:10:06 💡 The placebo effect, influenced by genetics like the CT Gene, varies among individuals, showing different levels of response to placebo conditions.
01:12:21 🧬 Genetic variations, such as the CT Gene, correlate with differences in placebo response, indicating a biological basis for individual susceptibility to the placebo effect.
Thank you
I have written word by word of what he says, constituting about 5792 words on MS WORD. It will help me in my medical journey, Thank you Dr. Andrew it was great listening to you as you simplified placebo effect for me.
Long live hero!!
This episode caused several segments of tear shedding from being enlightened, most pleasantly overwhelmed.
Hey I’ve got some really great news to share with you, Jesus Christ, the Son of God, died on a cross and resurrected on the third day so you may all have eternal life. If you believe and repent of your sins and put your faith and trust in Him as you would a parachute jumping off a plane at 25000 feet up in the air, He will give you eternal life in heaven as a free gift and I promise you, He will change your life forever as He did mine. He is the ONLY way to heaven and He loves you all. Please think deeply about this with urgency because this is your eternal life and soul, you don’t know when you could die, meaning you could die at any moment, so please consider this with all your heart. If anyone tells you that Jesus isn’t the only way, they are lying to you and they don’t care about your future.
I am a 13yr old and l am exceptionally grateful for the value that you provide in these kinds of long form videos😊
Im 12 and even more grateful
i am still in my mom's stomach and I am even more grateful@@haakoncj6887
Hey I’ve got some really great news to share with you, Jesus Christ, the Son of God, died on a cross and resurrected on the third day so you may all have eternal life. If you believe and repent of your sins and put your faith and trust in Him as you would a parachute jumping off a plane at 25000 feet up in the air, He will give you eternal life in heaven as a free gift and I promise you, He will change your life forever as He did mine. He is the ONLY way to heaven and He loves you all. Please think deeply about this with urgency because this is your eternal life and soul, you don’t know when you could die, meaning you could die at any moment, so please consider this with all your heart. If anyone tells you that Jesus isn’t the only way, they are lying to you and they don’t care about your future.
Iam 8 and I think this content is fantastic 🎉
I’m 3 and this information is phenomenal I’m so grateful too 🙏🏼
Russian teenager listening, I'm 15 and have been listening to your podcasts for more than a year now. You have changed my life forever! Episode with David Goggins made me read his book, and I will never be the same. Also, not to mention dosens of different themes and protocols. Huge thank you. I really appreciate the availability of your content in other countries ❤
If you are here looking for information that’s actually based on factual science you’re in the right place. Ive been here since 500k subs and I’ve watched almost every episode. I am in a much stronger place and constantly helping others with some useful information that they can experiment with to create a more fulfilling life
Hey Andrew Huberman, from my 4 grandparents, 2 had diabetes and one had the most awful illness i have seen, parkinson. I started two entrepeneurments in order to help people take care of themselves by working out, eating healthy and studying. I cannot be more grateful with you for all your work. I know we will meet some day and i hope you can participate in one of my talks, thank you again, greetings from Argentina. AGUANTE LA YERBA MATE Y ANDREW HUBERMAN!!
Thank you for all your content. Your work has motivated me to pursue my masters degree in neuroscience. I’ve always had a passion for learning the relationship between the brain and body, and didn’t understand what the field of that interest was termed as until I discovered this podcast. Thank you again Dr Hubberman. I appreciate you more than you know
Hey I’ve got some really great news to share with you, Jesus Christ, the Son of God, died on a cross and resurrected on the third day so you may all have eternal life. If you believe and repent of your sins and put your faith and trust in Him as you would a parachute jumping off a plane at 25000 feet up in the air, He will give you eternal life in heaven as a free gift and I promise you, He will change your life forever as He did mine. He is the ONLY way to heaven and He loves you all. Please think deeply about this with urgency because this is your eternal life and soul, you don’t know when you could die, meaning you could die at any moment, so please consider this with all your heart. If anyone tells you that Jesus isn’t the only way, they are lying to you and they don’t care about your future.
Greetings! German teacher with MS here. I love your content, and I'm able to use so much of your teaching into professional development sessions for teachers. My last presentation integrated your research /analysis of neuroplasticity and mindset effects. Life-changing information for students and teachers alike, and I always direct my audience to you and Dr. Crum.
You mentioned you had never seen The Matrix. Um... You absolutely have to see this movie -- for a lot of reasons -- but its dive into mindset effects goes along with everything you've been saying. "The mind makes it real" is one of my favorite moments of the movie, and there are so many moments that speak to the power of the mind and of belief systems. It's worth a deep dive on its own. I promise.
💜
Who's up early to listen to the Huberman!? 🧠 Growth time baby
Hope that cup of coffee is at least an hour after waking! 😝
Up here before work with coffee in hand! 😊
It drops in the early afternoon here.
get your sleep!
Dr Huberman is inspiration
I am 16 years old now & I'm deeply passionate about neuroscience and my dream is to become a neuroscientist one day. Thank you for showing me the beauty of this career❤Amazing episode, by the way:)I'm currently reading "You are the placebo" by Joe Dispenza right now
Great career choice! Proud of you! You got this 👍
Good❤
Youre on the way to a bright future. If youre this passionate at such a young age and know what you want to do, youre ahead of 99,9% of people. Keep it up!
Hey I’ve got some really great news to share with you, Jesus Christ, the Son of God, died on a cross and resurrected on the third day so you may all have eternal life. If you believe and repent of your sins and put your faith and trust in Him as you would a parachute jumping off a plane at 25000 feet up in the air, He will give you eternal life in heaven as a free gift and I promise you, He will change your life forever as He did mine. He is the ONLY way to heaven and He loves you all. Please think deeply about this with urgency because this is your eternal life and soul, you don’t know when you could die, meaning you could die at any moment, so please consider this with all your heart. If anyone tells you that Jesus isn’t the only way, they are lying to you and they don’t care about your future.
Just last week I was thinking about requesting an episode on belief effects in the comments section and here we are ❤️
I have so many life experiences to prove this belief! I have always said and believed our life Is the placebo. I
Have used this to achieve the impossible in diagnosis,health,and life on general. So grateful scientists are catching up to this and giving alchemy recognition.❤
Excellent. This is the kind of content that made me fall in love with this podcast
Hey I’ve got some really great news to share with you, Jesus Christ, the Son of God, died on a cross and resurrected on the third day so you may all have eternal life. If you believe and repent of your sins and put your faith and trust in Him as you would a parachute jumping off a plane at 25000 feet up in the air, He will give you eternal life in heaven as a free gift and I promise you, He will change your life forever as He did mine. He is the ONLY way to heaven and He loves you all. Please think deeply about this with urgency because this is your eternal life and soul, you don’t know when you could die, meaning you could die at any moment, so please consider this with all your heart. If anyone tells you that Jesus isn’t the only way, they are lying to you and they don’t care about your future.
Oh, just finished the Alia Crum episode on belief effects! Perfect timing! ❤ Thank you for everything!
Hey I’ve got some really great news to share with you, Jesus Christ, the Son of God, died on a cross and resurrected on the third day so you may all have eternal life. If you believe and repent of your sins and put your faith and trust in Him as you would a parachute jumping off a plane at 25000 feet up in the air, He will give you eternal life in heaven as a free gift and I promise you, He will change your life forever as He did mine. He is the ONLY way to heaven and He loves you all. Please think deeply about this with urgency because this is your eternal life and soul, you don’t know when you could die, meaning you could die at any moment, so please consider this with all your heart. If anyone tells you that Jesus isn’t the only way, they are lying to you and they don’t care about your future.
Huberman I just want to state the fact that your videos are so accessible that a 15 year old watches them since 1year. I even have a sorta note book just for the knowledge bestowed upon me by your videos. I would love to see an episode on skin health.
P.S. just love the way your videos are consistent with the intro and the sound track.
Dr Andrew, with the back of my head bashed in I'm still waking up each day, I believe I live because of your directions. After 2 years I've improvement, I desire to reincarnate as your child. I can't imagine I life better than that! Thank you so much for all that you do for me and everybody else!😊
I work as a medical interpreter in Australia. Years ago I had a patient who came to ED due to heart issues and high blood pressure. He was going to undergo an emergency open heart surgery. He was so nervous about dying on surgery table that his blood pressure couldn’t be controlled by medicine through the drip very 15 minutes. His daughters came to see him before the surgery, they told him to pray as their family believes in God. The two daughters held his hands and prayed for a few minutes, his blood pressure came down and stabilised. Today’s podcast clearly explained why and how belief can have placebo effect.
Hey I’ve got some really great news to share with you, Jesus Christ, the Son of God, died on a cross and resurrected on the third day so you may all have eternal life. If you believe and repent of your sins and put your faith and trust in Him as you would a parachute jumping off a plane at 25000 feet up in the air, He will give you eternal life in heaven as a free gift and I promise you, He will change your life forever as He did mine. He is the ONLY way to heaven and He loves you all. Please think deeply about this with urgency because this is your eternal life and soul, you don’t know when you could die, meaning you could die at any moment, so please consider this with all your heart. If anyone tells you that Jesus isn’t the only way, they are lying to you and they don’t care about your future.
This is the BEST Andrew! It is the acknowledgement of the Science of ENERGY before the Science of MATTER. Reality is created with ENERGY. We wield energy with our MIND. Energy is contagious, the more powerful energy, the contagion. Disconnecting from the cage of thoughts (law of man and its common "sense" - i.e. FEAR) FREES the mind to be in CONTROL instead of the AUTOMATION that's been conditioned.
Belief as a means to conduct ones own neurology into performing feats which used to be attributed to mass-parallelized imaginary friends is freakin awesome.
An episode on brain damage from you would be awesome. Concussions and how they affect people in general, from brutal sports like some martial arts, rugby to other cases where brain damage is common. A topic not often talked about
My body has the expectation that this will be a good video 💯
Mr. Huberman, I can go on about what you’re teachings have done for me but to keep it simple… thank you, I really appreciate you.
Hey I’ve got some really great news to share with you, Jesus Christ, the Son of God, died on a cross and resurrected on the third day so you may all have eternal life. If you believe and repent of your sins and put your faith and trust in Him as you would a parachute jumping off a plane at 25000 feet up in the air, He will give you eternal life in heaven as a free gift and I promise you, He will change your life forever as He did mine. He is the ONLY way to heaven and He loves you all. Please think deeply about this with urgency because this is your eternal life and soul, you don’t know when you could die, meaning you could die at any moment, so please consider this with all your heart. If anyone tells you that Jesus isn’t the only way, they are lying to you and they don’t care about your future.
Very interesting topic. Short story when I was a resident one (hospitalized)patient told me that only one particular IV injection could release her pain, nothing was mentioned in her therapeutic sheet, when I asked my colleague what was the drog he gave her: he told me 10 ml of isotonic saline!
Yes, the MIND rules ALL for REALZ 🙌
I'm 14, I've been watching your podcasts since 13, thank you for giving these invaluable information for free, I have used many tools and received many positive benefits ❤
I am EXCITED for this one Andrew! Been hoping you would unpack this for a while now. Perhaps you might have Bruce Lipton or Joe Dispenza on the podcast too? We cant spell belief without a lie in the middle and if we don't know the lies in our beliefs, we will always be vulnerable to manipulation by those who do. Thanks for being here, you are deeply appreciated.
🎯 Key Takeaways for quick navigation:
00:14 *🧠 Placebo, nobo, and belief effects are related to the brain's ability to place expectations, influencing biology independently of chemical properties.*
01:37 *🤯 Placebo, nobo, and belief effects can modify core biological functions like heart rate, blood pressure, and neuromodulator release.*
02:18 *💊 Placebo, nobo, and belief effects impact physiology beyond mere psychological perceptions, leading to changes in brain and body functions.*
03:00 *🌡️ Sleep quality affects mental health and performance, emphasizing the importance of temperature control, supported by products like eight sleep.*
04:33 *☕ Aeropress, a coffee maker, provides a superior taste compared to other brewing methods, contributing to a delightful coffee experience.*
05:53 *📉 Continuous glucose monitoring with Levels helps understand how different foods, activities, and sleep patterns impact blood glucose levels.*
07:29 *🚫 Distinguishing between Placebo and Nocebo effects - Placebo improves symptoms, while Nocebo worsens them, both beyond what's expected from the substance or treatment.*
09:00 *🧠 The prefrontal cortex, a neural hub behind the forehead, plays a crucial role in controlling and modulating various brain and body functions.*
11:03 *🤔 Prefrontal cortex suppresses impulses and evaluates context, acting as an expectation or prediction-making machine, influencing physiological responses.*
13:35 *🌐 Placebo, nobo, and belief effects are interconnected, relying on the prefrontal cortex to shape expectations that, in turn, influence various physiological processes.*
15:13 *🧠 Placebo effects illustrated through a Parkinson's study where placebo administration increased dopamine release, challenging conventional drug treatments.*
19:23 *💡 While placebo effects can influence physiological changes, the strength of expectation and the inability to anchor expectations universally limit their practical use as substitutes for actual drugs.*
40:37 *🧠 Placebo effects are real and have biological effects through true biological circuitry, activated by expectations.*
41:06 *🩹 The placebo effect is not limitless; its effects are specific to certain symptoms and contexts, as seen in cancer treatment.*
42:58 *🚫 Placebo effects cannot directly act on tumors to reduce size or eliminate them; they are limited by the prefrontal cortex's outputs.*
44:47 *📉 Placebo effects are about knowledge, belief, and expectation; they do not act directly on physiological systems like tumor reduction.*
50:33 *💡 Belief effects, like Placebo effects, influence physiological responses; a study on nicotine consumption showed cognitive performance modulation based on beliefs about nicotine concentration.*
54:56 *🤔 Expectation shapes experience; belief effects scale with the degree of expectation, influencing the outcomes of cognitive tasks.*
56:47 *🍔 Beliefs about the calorie content and nature of a milkshake impact hormonal responses, revealing the powerful influence of beliefs on physiological reactions.*
01:00:48 *🏋️♂️ Beliefs and mindsets about exercise can influence its positive effects, highlighting the role of expectation in shaping physiological outcomes.*
01:02:39 *🏨 Placebo effect in daily activities: A study with hotel service workers showed that those who believed their work was exercise experienced health metric improvements compared to those who were told their work was just important but not exercise-related.*
01:03:48 *🧠 Prefrontal cortex impact: The prefrontal cortex doesn't directly control muscle growth but has output pathways to brain regions like the hypothalamus, influencing stress response parameters (blood pressure, heart rate, etc.).*
01:06:21 *🧠 Study on stress response: Specific pathways from prefrontal cortex to dorsal medial hypothalamus influence stress responses, illustrating how psychological stressors impact physical health.*
01:12:07 *🧬 Genetic influence on placebo response: Certain genes, like the CT gene, show variation in individuals and correlate with the magnitude of the placebo response, specifically linked to dopamine, epinephrine, and norepinephrine regulation.*
01:15:22 *🌐 Placebo effect is biological: The placebo effect is not just a psychological trick; it has a real biological substrate, influencing various biological systems throughout the brain and body.*
01:16:30 *🌟 Support and follow: Support the podcast by subscribing on TH-cam, Spotify, and Apple, leaving reviews, and checking out sponsors. Follow Huberman Lab on social media for additional content and updates.*
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Hey Andrew!!! You are my Dopamine! I learn so much from your podcast! Thank you for sharing your knowledge! Keep up the great work! Thanks MJ 🏃♀️
Hey I’ve got some really great news to share with you, Jesus Christ, the Son of God, died on a cross and resurrected on the third day so you may all have eternal life. If you believe and repent of your sins and put your faith and trust in Him as you would a parachute jumping off a plane at 25000 feet up in the air, He will give you eternal life in heaven as a free gift and I promise you, He will change your life forever as He did mine. He is the ONLY way to heaven and He loves you all. Please think deeply about this with urgency because this is your eternal life and soul, you don’t know when you could die, meaning you could die at any moment, so please consider this with all your heart. If anyone tells you that Jesus isn’t the only way, they are lying to you and they don’t care about your future
You are a true gem Andrew!!! Thank you for your great contents.
Incredible episode. Blown away by how our brains work! Now, I'm excited to share and discuss all these amazing facts with my kids. Thanks for such a great listen, you're the absolute BEST 🙏
¡Hola Profe! Such a fascinating and thought provoking topic. Thank You for all Your hard work and care for all of us
This explains why for majority of human history, priests/religious groups were associated with healing. It's not that it was a hoax or whatever, but their belief towards their religion really had an effect that lead to the curing of many of their symptoms.
I can say now that there is a dopamine circuit in my brain that activates every time you release a podcast 😅😂
TH-cam plays with our dopamine system pretty well. They make us addicted
…brothers, whatever is true, whatever is honorable, whatever is just, whatever is pure, whatever is lovely, whatever is commendable, if there is any excellence, if there is anything worthy of praise, think about these things… for as You Think, So You Are
Did you notice brother, that the equations for every item you listed can not have FEAR included. So, to simplify this "fraction" divide by FEAR and it takes care of all the rest. 🧡
@@JORMUNGANDReyeS Totally, fear is the emotion that engages the imagination. It is based on assumed beliefs and their projection in the hippocampus (as Dr. Huberman so skillfully pointed out). Problem is they cloud our connection to the power of now. When it comes to true freedom, the only one we really have is what we choose to think, and even that can be a struggle.
BTW, Yes, I should’ve taken out the word “brothers” As this was a quote from Philippians 4:8, ESV. But it’s the same concept as Zen in Buddhism, or the watercourse in Taoist practices, which naturally applies to all humans regardless of sex :-)
@@robertcurrea2451 I took no offense to the brother ❤️ You would love a fun fact that I learned today... That humans are only born with two innate fears... Falling and Load Sounds.... These are the laws of nature. Every other fear we have is man-made and keeps us from our genius. 🤜🤛
Hi Dr Huberman, I'm 2 months old and your podcasts have been an invaluable resource in my journey to further my intellectual capacities. I cannot yet walk, let alone crawl, but I am already making great strides towards my future!
That's funny!
Thanks
01:01:05 this portion made me think about how imprtant it is to avoid submerging yourself into the negative or unrealistically positive environments of tv / internet news and social media.
Would love to see huberman interview Dr. Dispenza.
I believe I’m going to love this episode ❤️
This was very timely for me. I just stopped a medication for eczema (Dupixent) and I was ‘expecting’ a rebound at week ten. I just told myself this was likely. I tried to not think that way but I really felt it inside and couldn’t stop thinking about it. Sure enough I had a major eczema flare right at week ten! Your podcast really helped me realize the power of these thoughts and now I’m going to try to harness my mind to expect healing.
I wish I could get saline needles to inject every two weeks. I bet my body would think it was Dupixent!!!
Hey Andrew Huberman, I'd love to see the neuroscientist and memory expert, Professor *Christine Ann Denny*. Her lab has pioneered a method of being able to turn memories off and on! Mindboggling. I'm obsessed with studying Memory engrams (memory traces). They are after all the building blocks, the units of meaning we give everything. According to my memory, Huberman, your channel is the one I watch most. You helped me change my routines/ life.
Yay! I've been waiting for this topic, thanks 😊
I'm not sure I believe in the placebo effect.
I don't have time to watch this right now, but I feel better just knowing Dr. Huberman uploaded this.
😂
Same here maybe listen on the commute to work or walking on the treadmill! Let's listen together, lol
Rating: 8.0/10 (Rank 107 out of 202)
In Short: Belief can literally change your brain...
Notes: This is an outlier huberman podcast, as it is concise and to the point. I kind of enjoyed this style for a niche podcast like this--when these are 2+ hours it can be a bit too much. A nice mention of a handful of past podcasts (Lembke and Ali Krumb) who talk a bit about mindset and belief, and with some nice mentioning of a handful of studies. There was a little mechanism throughout, but not really necessary to just reiterate the point that placebo, which is just believing something will happen, actually causes physiological and neurological changes to happen. This idea kind of blows my mind, and having an entire podcast where that is just stated a dozen or so times, as it is here, was really nice and well done. A good niche podcast!
I told my mom that eating after 2 PM and moving around while doing household work butns fat. She started doing it and lost 2 kgs in 1.5 weeks. Now she is motivated to continue. Not placebo directly but the perspective change helps alot.
Only words suffice to make us fascinated by all this information. I can only imagine taking the narration of the most popular episodes of the Huberman podcast as a backbone to create a series of documentaries about how humans works. Adding images and animations in a minimalistic way, prioritizing the original narration over flashy HD scenes and useless special effects stuff. That could be very popular. We have this impression that everything has been done but we never get enough of this kind of quality documentaries like they used to make.
I used tDCS for a few years with great results (depression/addiction) and later read a paper that suggested tDCS itself WAS generating the placebo response. This fascinated me because if you can deliberately facilitate the placebo effect the limitations could just be material? i.e. You can reverse depression but not repair a broken bone.
I am also amazed at how many people think the placebo effect is so common that the positive results of taking something like Vit D or any new supplement "may just be placebo" as if it is MORE likely to be the case when the double blind studies show that only a small percentage of people show clinical results when given a placebo.
🎯 Key Takeaways for quick navigation:
00:00 *🧠 Introduction to Placebo, Nocebo, and Belief Effects*
- Introduction and explanation of placebo, nocebo, and belief effects.
- These effects relate to the brain's expectation and can change biological functions.
02:18 *🏥 The Impact of Placebo, Nocebo, and Belief Effects on Physiology*
- The significant physiological impact of placebo, nocebo, and belief effects.
- They can work alongside traditional treatments to change brain and body functions.
03:00 *🛌 Sponsor Segment: Eight Sleep*
- Introduction and benefits of Eight Sleep's smart mattress covers.
- Focus on the importance of sleep temperature for quality sleep.
04:21 *☕ Sponsor Segment: Aeropress*
- Introduction and benefits of Aeropress for making coffee.
- Personal endorsement and comparison with other brewing methods.
06:07 *🍽️ Sponsor Segment: Levels*
- Introduction to Levels and continuous glucose monitoring.
- The importance of monitoring blood glucose for health and energy levels.
07:29 *🔬 Detailed Explanation of Placebo, Nocebo, and Belief Effects*
- Deep dive into the definitions and differences of placebo, nocebo, and belief effects.
- Explanation of how these effects are related to the brain's expectation mechanisms.
09:12 *🧠 Prefrontal Cortex and Its Role in Expectation*
- The role of the prefrontal cortex in forming expectations and its impact on physiology.
- Explanation of how the prefrontal cortex can influence physiological functions through expectation.
14:04 *📚 Examples of Placebo Effects in Research*
- Specific examples of placebo effects from scientific studies, especially in Parkinson's disease.
- Discussion on how placebo can increase dopamine levels, illustrating the power of expectation on physiology.
19:09 *🧪 The Specificity and Limitations of Placebo Effects on Dopamine*
- Exploration of placebo effects on dopamine and the variables affecting their efficacy.
- Placebo effects can stimulate dopamine release, but not as robustly as actual drugs.
- The strength of the placebo effect varies between individuals and diminishes if the subject is aware it's a placebo.
21:30 *🧬 Hormonal Responses Influenced by Placebo*
- Study demonstrating how placebo can specifically alter hormone levels.
- Injection of saline, after information and expectations were set, altered levels of growth hormone and cortisol, showcasing the body's response to expectation rather than substance.
- The placebo effect's specificity is linked to the context and information provided to the participants.
28:35 *🍽️ Classical Conditioning and the Placebo Effect*
- Explanation of classical conditioning as a form of placebo effect.
- Examples include the insulin response to food smells and sounds, highlighting how context can induce physiological changes.
- This section connects classical conditioning with the broader concept of placebo effects, emphasizing context's role in modifying expectations and physiological responses.
32:58 *🌱 Sponsor Segment: AG1*
- Brief sponsor mention highlighting the benefits of AG1 for ensuring daily nutritional needs.
- Discussion on the importance of gut health for brain function and overall wellness, promoted through the use of AG1.
34:22 *💊 The Influence of Context on Placebo Effects*
- Overview of various factors that can modify the placebo effect, demonstrating its sensitivity to context.
- Branding, packaging, pill color, and method of administration can all significantly impact the strength of placebo responses.
- Illustrates how placebo effects are not just about what we're told a treatment will do, but also how the treatment is presented and administered.
38:48 *🔄 The Influence of Treatment Complexity on Placebo Effects*
- Discussion on how the complexity and invasiveness of treatments increase placebo effects.
- Higher complexity or invasiveness of treatment (e.g., capsules vs. tablets, injections, medical devices) leads to greater placebo effects.
- This relationship highlights the brain's association of treatment complexity with expected outcomes.
41:06 *🚫 Limitations of Placebo Effects in Cancer and Asthma Treatments*
- Examination of the limitations of placebo effects in treating cancer and asthma.
- Placebos can alleviate symptoms like pain and nausea from cancer treatment but cannot reduce tumor size.
- In asthma treatment, placebos reduced discomfort but did not improve actual breathing function, illustrating placebo effects' boundaries.
48:12 *🧪 Sponsor Segment: InsideTracker*
- Brief mention of InsideTracker, emphasizing personalized nutrition and health goals.
49:09 *🧠 Nicotine Study: Expectation Influences on Cognitive Performance*
- Study showing belief effects on nicotine intake and cognitive performance.
- Subjects performed better on cognitive tasks when they believed they had ingested higher doses of nicotine, regardless of actual dose.
- Brain activity levels matched the expected nicotine dose, highlighting belief effects on physiological responses.
56:06 *🍦 Mind Over Milkshakes: Mindsets Impact on Ghrelin Response*
- Study on how beliefs about calorie content in milkshakes affect hunger hormone ghrelin.
- Subjects who thought they consumed a high-calorie shake showed greater reductions in ghrelin than those who believed they consumed a low-calorie shake.
- Demonstrates how mindset can influence physiological responses to food.
59:14 *🍦 Impact of Beliefs on Food's Hormonal Effects*
- Study showing how beliefs about calorie content influence hormonal responses.
- Belief about consuming a high-calorie shake versus a low-calorie shake affects ghrelin levels.
- Demonstrates the power of belief in altering physiological responses to food, beyond the actual nutritional content.
01:01:02 *🏋️♀️ Exercise Perception and Health Outcomes*
- Discussion on how perceiving daily activities as exercise can improve health metrics.
- Hotel service workers who believed their work was beneficial exercise saw improvements in health metrics.
- Highlights the effect of mindset and belief on physical health outcomes, emphasizing the role of perception in health.
01:04:16 *🧠 Neural Pathways for Stress Response*
- Explanation of the neural circuitry from the prefrontal cortex to the hypothalamus involved in stress response.
- Identification of specific neural pathways that mediate physiological stress responses.
- Offers a biological explanation for how beliefs and mindsets can impact stress and other physiological responses.
01:11:27 *🔬 Genetic Variability in Placebo Response*
- Discussion on genetic factors that influence variability in placebo response.
- The COMT gene's role in modulating neurotransmitter regulation and its correlation with placebo effect susceptibility.
- Provides evidence that placebo effects have a biological basis and are influenced by individual genetic makeup.- 59:14 🍧 Influence of Beliefs on Hormonal Responses to Food
- Study showing how beliefs about calorie content impact the hormone ghrelin.
- Beliefs about consuming a high-calorie vs. low-calorie shake affect satiety and ghrelin response.
- Highlights the significant role of expectations in the physiological responses to food.
01:01:02 *🏋️♀️ Belief Effects on Exercise Outcomes*
- Study on how beliefs about daily activities as exercise can improve health metrics.
- Hotel service workers who believed their work was beneficial exercise saw health improvements.
- Demonstrates the power of belief and mindset in influencing physical health outcomes.
01:04:44 *🧠 Neural Pathways for Psychosomatic Responses*
- Details on the neural pathways from the prefrontal cortex to the hypothalamus controlling stress responses.
- Illustrates how thoughts and beliefs can influence physical states like blood pressure and body temperature.
- Provides a biological explanation for how expectations affect our physiology.
01:11:41 *🧬 Genetic Variation and Placebo Susceptibility*
- Discussion on genetic factors influencing placebo effect variability among individuals.
- The COMT gene's role in modulating responses to placebo treatments related to dopamine and stress hormones.
- Evidence of biological substrates underpinning the variability in placebo responses.
01:15:22 *🧪 Conclusion on Biological Basis of Placebo Effects*
- Summarization of the placebo effect as a genuine biological phenomenon.
- Emphasizes the role of knowledge, belief, and expectations in shaping physiological outcomes.
- Placebo effects are not merely psychological but result in tangible changes in the body's biology.
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I used to play music at work for people with Parkinson's - they can dance and forget all about it with a song they like. I taught a 15 year old boy with severe autism how to play a video game, and win every time. His dad was sure he just bashed the keyboard without purpose - so far he'd trashed every computer. Then I covered all the keys except for the arrow key. Immediately he realised the connection between the key and the screen. Bit by bit I uncovered more keys and he practically taught himself to play. Another time, I hooked up a camera to a wall-sized screen and let him take photos of himself. He was so happy to see himself on screen after each shot. They were the happiest photos his father had ever seen of him. Then I cared for a man in my street with BGDD. After three years, he lost all movement and speech. But I could make him laugh even when he couldn't talk anymore. I knew when he needed toileting and could hoist him out of bed alone (four nurses at the hospital couldn't do it - his whole bed used to be wet). I have so many stories from 20 years experience but I'm nobody you've ever heard of
Amazing, truly.
It’s GREAT to know there are people like you in the health field AND it’s great to hear these stories.
Thank you very much man, you ve improve my life style
Ensure to subscribe to Andrew Huberman and Like the video
- [00:00] 🧠 Understanding Placebo Effects
- Placebo, nobo, and belief effects are all related to the brain's ability to alter outcomes based on expectations.
- [07:29] 💊 Differentiating Placebo, Nobo, and Belief Effects
- Placebo effects occur when inert substances or treatments improve symptoms or performance.
- Nobo effects worsen symptoms or performance despite inert substances or treatments.
- Belief effects involve specific knowledge altering expectations and outcomes.
- [14:04] 🧪 Biological Mechanisms of Placebo Effects
- Prefrontal cortex acts as an expectation/prediction maker, influencing physiological functions.
- Placebo, nobo, and belief effects involve changes in prefrontal cortex activity and subsequent modulation of deeper brain regions.
- Examples of placebo effects include alterations in dopamine release in Parkinson's patients.
- [19:09] 🧠 Placebo effects and dopamine regulation
- Placebo-induced increases in dopamine are generally less robust than those induced by actual drugs.
- Expectation effect plays a crucial role in the placebo effect, impacting the strength of dopamine increase.
- Placebo controls are used in clinical trials to differentiate between drug effects and placebo effects.
- [21:42] 🤯 Specificity of placebo effects
- Placebo effects demonstrate a high degree of specificity based on the beliefs and expectations of individuals.
- Beliefs about a drug's function can influence its perceived effects, even if the actual drug action differs.
- The example of hormone function illustrates how placebo effects can mimic the effects of active drugs.
- [24:56] 🔄 Conditioning and placebo responses
- Classical conditioning can evoke placebo responses, such as conditioned insulin release in response to sensory cues.
- Context plays a significant role in modifying placebo effects, demonstrating the brain's ability to anticipate and respond to environmental cues.
- The placebo effect extends beyond laboratory settings to everyday life scenarios, showing the influence of context on perceived treatment outcomes.
- [38:48] 🧠 Placebo effect and treatment invasiveness
- Placebo effects are magnified by the perceived invasiveness or complexity ofa treatment.
- The brain associates treatment complexity with larger outcomes, enhancing the magnitude of the placebo effect.
- Despite the inert nature of treatments, such as pills or medical devices, they activate specific neural circuits in the prefrontal cortex, influencing biological responses.
- [41:06]💊 Limits of placebo effects in cancer treatment
- Placebos can alleviate specific symptoms associated with cancer treatment, such as pain and nausea.
- However, placebo effects cannot directly reduce tumor size or eliminate cancerous tumors.
- Expectation effects are real but have limitations, especially concerning biological outcomes like tumor reduction.
- [45:00] 📚 Placebo effects in asthma treatment study
- A study on asthma patients showed that placebo treatments reduced discomfort but didn't change breathing patterns.
- Unlike bona fide drug treatments, placebos couldn't restore normal breathing patterns or eliminate asthma symptoms entirely.
- Placebo effects are powerful but specific, affecting perceptions rather than directly altering physiological conditions.
- [49:09] 🧪 Influence of belief on drug response
- Beliefs about drug dosage can significantly impact cognitive performance, even when individuals receive the same amount of the drug.
- The brain's activity levels change according to expectations about drug dosage, affecting cognitive outcomes.
- Placebo and belief effects demonstrate the power of expectation in shaping physiological responses.
- [56:19] 🥤 Mindsets and hormone response in milkshake study
- Expectations about calorie content and healthiness influenced hunger hormone responses in a milkshake study.
- Individuals who believed they consumed a high-calorie indulgent shake experienced greater reductions in hunger hormones compared to those who believed they consumed a low-calorie sensible shake.
- Mindsets, shaped by beliefs and expectations, can modulate physiological responses, influencing feelings of satiety and hunger hormone levels.
- [59:14] 🍔 Impact of Beliefs on Hormonal Response to Food
- Beliefs about food consumption strongly affect hormonal responses.
- Specific knowledge about calorie content and indulgence vs. sensibility impacts hormonal release.
- Our beliefs communicate with neurons in the gut, altering hormonal responses to food.
- [01:01:02] 🏋♂ Influence of Beliefs on Exercise Benefits
- People's beliefs about their daily activities affect their health outcomes.
- Being informed that daily activities mimic exercise leads to improvements in health metrics.
- Belief in the health benefits of daily activities induces actual health improvements.
- [01:04:44]🧠 Biological Basis of Placebo Effects
- Understanding the neural pathways from the prefrontal cortex to other brain regions is crucial.
- Specific neural circuits mediate the placebo effect, impacting stress responses and bodily functions.
- The placebo effect has a real biological substrate, involving neural, hormonal, and genetic mechanisms.
- [01:11:41] 💊 Genetic Correlates of Placebo Response Variability
- Genetic variations, such as the CT Gene, influence susceptibility to the placebo effect.
- Genes related to dopamine regulation show correlations with placebo response levels.
- Individual variances in placebo response can be attributed to specific genetic expressions.
I'm 3 years old and i love science
😮Are you suggesting that there are certain individuals that are more or less susceptible to a placebo or belief effect? ?????Like there is for hypnosis?
Yes.
@@hubermanlab has there been any reproducible studies showing this effect of certain individuals being more susceptible? Would you expect experienced meditators , one’s that have great control over there autonomic nervous system, to be in that group?
Very powerful episode right there, thanks a lot!
Surprised that you didn't include the research on placebo/sham surgery. Fascinating & surprising work has been published for over a decade on the success of sham knee surgery. And at least 6 years of published research on success in sham spinal surgery.
The brain is powerful & capable of so very much
0:00: 🧠 The power of placebo, nobo, and belief effects in altering biological functions through brain circuits.
6:04: 💉 Innovative health monitoring program tracks blood glucose levels to optimize energy and metabolic health.
12:04: ⚛️ Understanding the Influence of Expectations on Physiological Responses
17:51: ⚛️ Placebos can mimic the effects of dopamine by increasing its release in the brain.
24:00: ⚛️ Placebo injections can influence growth hormone and cortisol levels independently of expectations.
29:58: 🔔 Conditioned stimuli can trigger insulin release independently of food presence.
36:08: ⚛️ Color association influences placebo effects on sleep and stimulation.
42:29: ⚛️ The limitations of prefrontal cortex in influencing biological systems, including tumors, contrasted with proven mind-body techniques for improving cancer treatment outcomes.
48:37: ⚛️ Impact of Belief Systems on Physiology and Brain Function
54:56: 💡 The impact of belief on biological and psychological responses, beyond placebo effects.
1:01:04: ⚽ Study on the impact of exercise on physiology initiated by Dr. Crum's conversation with her adviser.
1:07:12: 🧠 Mapping connections from prefrontal cortex to dorsal medial hypothalamus reveals stress response involvement.
1:13:38: 🧬 Genetic variations influence placebo response through neurotransmitter regulation.
oh man this one was so informative always wondered about how this actually works.
I haven't done any research on my own, beyond listening to this podcast. However, as a young 22 year old male with schizoaffective d/o, I've found that I have this weird mental ability, "mind over matter." It has worked very similarly as the placebo affect, however it's very delicate, and the moment I consciously or subconsciously discover any doubt, the trick loses all effect. I'm primitive with the ability, I can convince myself right now that if I chug a water bottle, it doesn't hydrate me and actually dehydrates me, but if I sip or drink it slowly, it hydrates me. However, I'm a cigarette smoker, and I've encountered a weird problem with my habit. I've had my share of personal issues, been on and off working hourly jobs, when I've worked a full day and make it to the end of a shift, I'm more likely to enjoy one cigarette fully. But when I haven't been working, or haven't done anything productive throughout the day, I'm way more likely to find myself chain smoking, as one cigarette gives me way less of that "relief" feeling. I've found myself in a carrot and stick lifestyle, where I know that if I don't accomplish anything during my day, and stay in bed enjoying videogames or shows, I'll end up paying the consequence later in the day when I have no dopamine to work off of. So, I've found myself, unemployed, starting each day off by asking, "what can I do today, even if it's just research into my mental and physical conditions." But then, I end up in the same place, whether I'm working a job or just knocking out some self-made to-do list, feeling like it's too much to handle, and even if I wanted to pause, break it up, slow myself down, I can't, because I'm too far in. Being human is complicated, man.
Just by watching Huberman’s videos, I’m benefiting from the Placebo effect and feeling smarter already 😆
Would you consider having Ellen Langer on the podcast? This ep made me realize how much I would love to hear you both talk all about mindfulness & its impact on our health/reality... Thank you for your beautiful mind & heart. Besides be so fun & fascinating, your podcast continues to bear such fruit in my life daily. Hope it nourishes you as much as it does all of us! -Amy
They had certain bio markers in “ age regression” but as with all these “ anti-aging claims, never look younger.
I’ll settle for better health and feeling better, however.
Wow , another brilliant and relevant topic !!! Thanks Andrew!
Thank you Andrew, you blew my mind just by talking about what the prefrontal cortex does.
Thanks for this week's episode!
As a chronic pain patient, I would have liked to hear more about the Nocebo affect and how it relates to chronic illness such as pain.
Dr. Huberman, could you do an episode on the most efficient learning techniques? Mind maps and stuff like that?
He did an excellent one on this early in this podcast… search his archives.
@@KathySierraVideoHe did a video focusing on neuroplasticity. But he never made a video covering encoding techniques, spaced repetition, etc.
@@jackm.1628 the one I’m thinking of is “Understand and Improve Memory” - which I’m *fairly* sure addresses spacing effects, etc. He also has at least two other episodes on learning, though one is much more focused on motor learning… but many of the same principles apply. I can’t recall him talking about mind maps, but (as a long-time mind-mapper) I would also like to see him go down that rabbit hole.
Have you ever considered to make an episode on body grounding (earthing)
I am curious what is behind that.
The episode I’ve been waiting for 🙌🏼
Placebo is one of my favorite effects, thank you for making it more well-known today Andrew.
Andrew, can you please consider making episodes with Dr. Joe Dispenza. I believe it would be interesting to hear you two discussing the topic of neurobiology, neuroplasticity, placebo, nocebo, etc.
For me personally, Doctor Joe had a huge impact in the field of neuroplasticity and self work. I believe there are more people who share the same thoughts.
Thank you for your effort and all that you are doing for the world!
🙏🏻🙏🏻🙏🏻
Really was waiting for this! Thank you!
Finally no guests👌!!!
I am having trouble with sleep and focus, but it is not always so and there are bursts of focus which are enjoyable
🎯 Key Takeaways for quick navigation:
00:14 *🧠 Los efectos placebo, nocebo y de creencias influyen poderosamente en la biología y psicología del individuo.*
01:23 *🩸 Estos efectos pueden modificar funciones biológicas básicas como la frecuencia cardíaca, la presión arterial y la liberación de neurotransmisores como la dopamina y la adrenalina.*
02:33 *🌱 Algunos investigadores médicos sugieren que los efectos placebo, nocebo y de creencias podrían ser utilizados como tratamientos únicos para diversas enfermedades.*
07:29 *💊 Los efectos placebo se refieren a cambios en los síntomas o el rendimiento inducidos por sustancias o tratamientos que no tienen actividad biológica o psicológica directa.*
08:34 *🧪 Los efectos de creencias ocurren cuando el conocimiento específico cambia las expectativas sobre un resultado fisiológico o psicológico.*
09:26 *🧠 El córtex prefrontal, responsable de las expectativas y predicciones, controla otros circuitos neurales y funciones fisiológicas básicas del cuerpo.*
13:49 *🧠 Los efectos placebo, nocebo y de creencias se basan en la capacidad de la información y las experiencias para generar expectativas que modifican la fisiología del cerebro y el cuerpo.*
20:06 *💊 El efecto placebo es una medida de la expectativa de lo que hará un tratamiento con medicamentos en un ensayo clínico.*
21:42 *🧠 Las expectativas y creencias sobre un tratamiento tienen una alta especificidad en los efectos placebo.*
23:17 *💉 La asociación entre recibir una inyección y cambios hormonales demuestra la influencia del efecto placebo en el cuerpo y la mente.*
31:07 *🛎️ La respuesta placebo se puede condicionar incluso a estímulos no relacionados directamente con el tratamiento, como el sonido de una campana.*
34:36 *🌈 El efecto placebo se ve potenciado por factores como la marca del medicamento, su presentación y el color de la pastilla.*
38:35 *🏥 La invasividad y complejidad de un tratamiento placebo aumentan su efectividad, demostrando la influencia de la percepción en los resultados.*
40:37 *💊 Las expectativas tienen efectos reales en nuestra biología y psicología a través de la activación de la corteza prefrontal.*
41:06 *🩺 Los placebos pueden reducir el malestar en el tratamiento del cáncer, pero no pueden reducir el tamaño ni eliminar los tumores.*
45:00 *🧠 Los efectos placebo son poderosos pero tienen límites; no pueden eliminar completamente las condiciones como el asma o el cáncer.*
49:09 *🚬 Las creencias relacionadas con el consumo de nicotina pueden modular las respuestas cerebrales, incluso cuando todos reciben la misma cantidad de nicotina.*
57:01 *🥤 Lo que creemos sobre los alimentos que consumimos impacta significativamente las respuestas hormonales del cuerpo, incluso cuando se trata de la misma comida.*
01:02:12 *🧠 El simple hecho de creer que las actividades diarias son ejercicio puede llevar a mejoras en la salud, según un estudio con trabajadores de hoteles.*
01:04:02 *💡 Las expectativas, creencias y mentalidades pueden impactar profundamente nuestra fisiología, incluida la liberación de hormonas y la percepción del dolor.*
01:05:38 *🧬 Existe un circuito neural específico desde la corteza prefrontal hasta el hipotálamo que puede influir en respuestas al estrés, demostrando la conexión mente-cuerpo.*
01:11:41 *💊 La respuesta al placebo varía entre individuos, y ciertos genes, como el gen CT, están relacionados con la magnitud de la respuesta al placebo, especialmente en neurotransmisores como la dopamina.*
01:15:22 *🧪 Los efectos del placebo son efectos biológicos reales, no solo ilusiones mentales, y pueden influir en una amplia gama de sistemas biológicos en el cuerpo humano.*
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I can't wait to hear this one! I hope he goes over things like reiki and acupuncture as an example of placebo effects
"Exploring the Robust Link between Hypnosis and Placebo Effects:
One paramount inquiry arises: Can we discern a sturdy correlation between the effects of hypnosis and the placebo effect?
Additionally, a pivotal aspect yet to be fully elucidated pertains to the strategic alteration of mindset or belief systems to optimize the benefits of the placebo effect. Mere acknowledgment of non-established scientific effects without thorough research may inadvertently reinforce uncertainty rather than maximise the desired outcomes.
Thus, how can we methodically adjust our mindset, within the realms of scientific inquiry, to achieve the most favourable outcomes?
I would like to conclude my comment by conveying my heartfelt appreciation for the remarkable dedication you have shown towards advancing public education. Your invaluable efforts are truly commendable and deeply cherished
I love your work - please consider interviewing Dr Stephen Porges. His work on Polyvagal Theory helped me understand my daughters Chronic Fatigue Syndrome (including POTS and a whole host of other symptoms). She recovered once we found people who knew how to work with this - it wasn't the medical system.... Dr Porges describes the nervous system as the intervening variable, often not considered in science and medicine. I am sure it would be a great episode.
I feel like an episode doing a deep dive on the prefrontal cortex would be amazing.
Andrew, please consider having Iain Mcgilchrist on the podcast. The way he thinks/speaks is so invigorating yet beautiful I cant get enough of him lately and I think you might agree and find his thoughts on the brain hemispheres/ perception+ reality to be fascinating!
Can you make an episode on genetics, how it works and what we can do to change what we inherit ? By the way I don’t miss an episode and I thank you for sharing your knowledge free of cost..otherwise I could not have access to this information. Thank you again
Hey Huberman, I just wanted to express how much I love your videos. Since day one, I've been a fan and have watched every single episode.
I've got a suggestion for a topic that I think would be super helpful and interesting for many of us: emotional stability. After all, it's something we all struggle with at times. Why do we feel all over the place sometimes, and more importantly, what can we do about it? It would be amazing to have a science-based view of it and methods to improve ourselves.
Thank you for the awesome work, and I'm looking forward to whatever you've got coming up next." 🇧🇷❤
Placebo = Power of the Mind🧠Body 💪🏽 and heart (physical and metaphysical)💜
Please interview dr Bruce Lipton and dr Joe Dispenza on this topic!❤
Dr rly went off on this ep. I love it sm
Thank you Dr. Huberman for giving us the precious knowledge.❤
Please make an episode on bad breath/halitosis and how to get rid of it 😢
I believe there's an oral episode
Interesting as always. Thank you so much ☺️!
As I suffer quite a lot of slow COMT (it’s getting worse with high estrogen during perimenopause as the enzyme breaks down also estrogen and histamine to some extent), I should take advantage of the fact that I am genetically predisposed to have a stronger placebo effect ❣️❣️❣️
Hey Andrew, just a spitballing but would love to see you talk a little about neurodegenerative progress or diseases. As a person with such disease it would clear so much unknown and questions, that not only me, but a lot of other people touched by such diseases have. Love the incentive of sharing such knowledge in these podcasts btw, keep doing you :)
You've got all ropes in the world, Andrew :) Thank you for not flying away.
Hi, can you please make an episode about games like Chess, Sudoku,etc. and their impact on brain ?
Thank you for all that you do, this podcast is one of the few things keeping me going ❤
Such a fascinating episode on how the mind can impact the body. Love it
That was a great and very interesting episode. Thank you again sir!!