You can't just grind cat-litter tier silica gel and expect it to work for column chromatography. Chromatography grade silica gel is mesoporous, with a high surface area. It is made from waterglass and a surfactant like sodium lauryl sulfate, first precipitating the silica, drying at 110°C, then calcifying at 400°C. Then you have to sieve them and only keep the fraction between 40 and 63 microns for column and flash chromatography. Mesoporous silica gel is used in beer brewing however, to clear the haze without affecting foam, by selectively adsorbing proteins. You can use this kind of silica for chromatography purposes, but it is probably too finely divided to use in a column, it will take ages for the solvent to run through. It"s more suitable for making your own TLC plates.
Worst attempts at column chromatography.. ever 😂😂😂 Take ur time and think before doing so u dont waste time overall, but too much thinking can be detrimental lol Cool content regardless!!
Sorry mate, but you have not only 1 mg of cubane there. If you take a look at the dexter-electron transfer, then you can easily see, that O2 is a problem there. The energy will be transferred to the O2 instead of the product and that's your problem. You need an inert gas without any mg of O2. I have done this mistake three times. So sorry, but you have to run it again.
Then why does the brown precipitate react with acids and bases like that? I ran the UV reaction for so long that even through there was oxygen present some of the diketal must have reacted.
@@Amateur.Chemistry and no, I guess not, because the Cycloaddition doesn't take so long. If you have O2, the triplet sensitizer benzophenone will just transfer the energy from the excited state to the oxygen, not to the diketone. And the products have to be pretty clean for the cycloaddition.
The real cubane is the tar we made along the way.
Wow you finished it in 4 months i think that as a final video you should make a tar tier list congrats
You can't just grind cat-litter tier silica gel and expect it to work for column chromatography. Chromatography grade silica gel is mesoporous, with a high surface area. It is made from waterglass and a surfactant like sodium lauryl sulfate, first precipitating the silica, drying at 110°C, then calcifying at 400°C. Then you have to sieve them and only keep the fraction between 40 and 63 microns for column and flash chromatography. Mesoporous silica gel is used in beer brewing however, to clear the haze without affecting foam, by selectively adsorbing proteins. You can use this kind of silica for chromatography purposes, but it is probably too finely divided to use in a column, it will take ages for the solvent to run through. It"s more suitable for making your own TLC plates.
Glad you finally made it! Congratulations!
Congrats man! Great to see!
"Mom can we have HPLC?"
"We have HPLC at home"
HPLC at home: 17:10
The ultimate chemistry equipment
Amazing, I wish you success, friend
Rly looking forward to the nmr. Some of the intermediates looked pretty pure
Congratulations bro this is amazing! Hope you have more long synthesis projects like this for us! W Cubane 🎊👏🏼🎉
Fire man!
Well you started in 2023 and finished in 2024, that's a new record for amateur chemistry!
impressive amount of work! congratulations!!!
What an enjoyable journey this has been.
polska gurom
Ingenious !!!
Poor guy in an abandoned shed somewhere in Australia has finally finished his cube synthesis
Good job!
still did it faster than Extractions and Ire (Tom) who is either a PHD candidate or a PHD at this point so good job
That's probably the thickest and shortest column I have seen!
nice work
4:34 - pooping apparatus XD
Szybciej od tego ozzi ez i pytanko skąd bierzesz kwas siarkowy? Dobra z bateri chyba masz jeszcze jakieś źródła?
This guy is among the "indian math channels" of science on on youtube.
Ex&F couldn't make it for few years and you did it in couple months. now i feel bad for him.
To be fair, Tom was doing his PHD at the same time as the Cubans.
Legendary.
Where is the nmr video?
anny update on the NMR?
Miraculous !!!
Chemiolis made cubane without handles already.
This video is not showing in my subscription tab, wtf? Checked on multiple devices. Actually found it in recommendations instead
Yeah, it seems like I accidentally turned off the notifications for this one, won't make this mistake again
Boy, @ExtractionsAndIre is going to be pissed that you did this so fast :P
Fuck yeah, cubane🎉
The heart attack when reaction goes yellow/tarry😭
(is tarry even a real word?) Idk
Polska górą!
rubiks cubanes (real)
Face Reveal 🎭
Worst attempts at column chromatography.. ever 😂😂😂
Take ur time and think before doing so u dont waste time overall, but too much thinking can be detrimental lol
Cool content regardless!!
Sorry mate, but you have not only 1 mg of cubane there. If you take a look at the dexter-electron transfer, then you can easily see, that O2 is a problem there. The energy will be transferred to the O2 instead of the product and that's your problem. You need an inert gas without any mg of O2. I have done this mistake three times. So sorry, but you have to run it again.
Then why does the brown precipitate react with acids and bases like that? I ran the UV reaction for so long that even through there was oxygen present some of the diketal must have reacted.
@@Amateur.Chemistry that's a good question, my benzophenone also reacted with acids and bases, which is interesting and in general not possible.
@@Amateur.Chemistry and no, I guess not, because the Cycloaddition doesn't take so long. If you have O2, the triplet sensitizer benzophenone will just transfer the energy from the excited state to the oxygen, not to the diketone. And the products have to be pretty clean for the cycloaddition.
Please weigh out your product and you'll see it's nearly the same mass of the benzophenone you used.
You are aming the greatest of this platform 🫡.
Great videos sir !