How Do Drugs Get Invented?
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- เผยแพร่เมื่อ 9 มิ.ย. 2022
- With support from the National Institute for Health Care Management, we’re spending the next three episodes talking about how drugs get approved in the United States. In this first episode, we discuss the drug approval process from the discovery phase all the way to what happens after its approval.
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This isn't about invention, its about approval. The title is misleading.
Pharmaceuticals: "Can take up to 15 years for approval."
Supplements: "Sucks to be you!"
Except one has a much higher effectiveness rate than the other.
Which is why the overwhelming majority of supplements make suckers out of people.
Looks like a new attachment to my lecture in drug approvals. Thanks! I hope you also cover pharmacovigilance as well
"If there are already treatments on the market with fewer side effects, the benefits of the drug really need to be better to outweigh additional risks."
The onslaught of "me too" drugs with little to no benefit really makes me skeptical about this claim.
I think he means that they should be "noninferior". It can work just as well, then there's just more options on the market
At what point does the DEA assign a schedule to an addictive substance?
Helloooooooo, my MSc was in Drug Discovery and Development. Very good topic and made me a little more sympathetic towards the actual investments that need to be made in the the drug industry and the general regulations of the ICH etc.
Guessing a mention about the talks of fast track drug applications on the FDA to help reduce the upfront costs of drug development?
There's a lot to go through in just 3 episodes, good luck!
I'm conflicted into seeing this as a good thing or as a bad thing.
On the positive side, we have scrutiny, safety and lots of regulations to make sure only 1 of 5,000 is approved.
On the negative side, only big pharmaceutical companies would be able to afford putting out 5,000 researches only to have 1 approved and make a profit out of it meaning there is no way a lone researcher or the government would be able to pursue this without being affiliated or "selling their idea" to a pharmaceutical company.
This kinda monopolizes the market of R&D of drugs
Not really. Most drugs fail because they look like they might work in for example a cell culture, but wouldn't work in a human. And there's a lot that would prevent it like toxicity, no viable way to get it to the target location, practical issues like insane amounts, stability of the compound, only working temporarily, and the list goes on. And a lot of this already crops up before you even get to test it on a person.
Trust me, I know. As I've seen a lot of promising compounds fail after cell culture testing for the illness that I have.
@@CollinMaessen You completly missed my point.
@@Amantducafe No I didn't. What I was not clear about is that this basic research is done mostly by medical researchers. Who aren't working for pharmaceutical companies. Those companies most of the time get involved after a promising compound/mechanism/technique is found to fund that.
The vast majority of the research is funded by government grants. Pharma companies are too focused on profit to actually pay for their own research.
@@cbpd89 Exactly. Makes medical research and developing treatments for rare illnesses/diseases loads of fun.
Off topic a bit here: but what is the deal with this “cure for cancer” being popped up everywhere now? I know a cure hasn’t been officially found… that it’s a “hopeful cure”… but could you do a video for us non-medical people explaining fact from fiction that’s been traveling?
6 minute video to say "Not in your garage" :thinking:
🤔 I wonder if there's a way to fast track this process with the 1,000's of years of documented use of traditional medicines. Like mathematical proofs that can expedite the process and help more people.
drugs
One of the biggest problems is that about 90% of the funding goes to studying how chemical reactions happen in test tubes, or how isolated proteins react under controlled conditions. This was a problem with COVID, as a lot of the studies on disease didn't actually look at what disease does to the human body.
Yes because you can't skip over that part. It would be wrong if we just tested immediately on humans if we don't have sufficient data if the candidate drug would have the possibility of efficacy or have the chance of high toxicity / lethality. We need screen these compounds first in vitro, then through animal models then we can move to human trials
🆒‼️🌈