ฝัง
- เผยแพร่เมื่อ 29 ก.ย. 2020
- September Pin of the Month: store.dftba.com/collections/s...
It might sound like a concept from science fiction, but artificial intelligence is already facilitating the development process behind some pharmaceuticals.
Hosted by: Michael Aranda
SciShow has a spinoff podcast! It's called SciShow Tangents. Check it out at www.scishowtangents.org
----------
Support SciShow by becoming a patron on Patreon: / scishow
----------
Huge thanks go to the following Patreon supporters for helping us keep SciShow free for everyone forever:
Bd_Tmprd, Harrison Mills, Jeffrey Mckishen, James Knight, Christoph Schwanke, Jacob, Matt Curls, Sam Buck, Christopher R Boucher, Eric Jensen, Lehel Kovacs, Adam Brainard, Greg, Ash, Sam Lutfi, Piya Shedden, Scott Satovsky Jr, Charles Southerland, charles george, Alex Hackman, Chris Peters, Kevin Bealer
----------
Looking for SciShow elsewhere on the internet?
Facebook: / scishow
Twitter: / scishow
Tumblr: / scishow
Instagram: / thescishow
----------
Sources:
pubmed.ncbi.nlm.nih.gov/21698778
www.jstor.org/stable/44450759...
blog.rasa.com/nlp-vs-nlu-what...
www.wired.co.uk/article/ai-ca...
www.berghealth.com/research/h...
cancerres.aacrjournals.org/co...
exscientia.cdn.prismic.io/exs...
www.frontiersin.org/articles/...
www.iptonline.com/articles/pub...
journals.sagepub.com/doi/full...
journals.sagepub.com/doi/full...
ieeexplore.ieee.org/document/...
www.ncbi.nlm.nih.gov/pmc/arti...
core.ac.uk/download/pdf/34617...
phys.org/news/2020-07-robot-s...
www.nature.com/articles/d4158...
www.ncbi.nlm.nih.gov/pmc/arti...
www.fda.gov/drugs/new-drugs-f...
www.ncbi.nlm.nih.gov/pmc/arti...
www.nature.com/articles/d4157...
www.britannica.com/technology...
jamanetwork.com/journals/jama...
www.bbc.com/news/technology-5...
blog.benchsci.com/startups-us...
www.future-science.com/doi/10...
blog.benchsci.com/6-things-we...
www.ddw-online.com/informatic...
Image Sources:
bit.ly/3n17N06
bit.ly/3imijvH
bit.ly/3iiHZJf
www.istockphoto.com/photo/you...
www.istockphoto.com/photo/sci...
www.istockphoto.com/photo/spr...
www.istockphoto.com/photo/two...
commons.wikimedia.org/wiki/Fi...
www.storyblocks.com/video/sto...
bit.ly/3ig64AB
www.istockphoto.com/photo/nev...
commons.wikimedia.org/wiki/Fi...
www.istockphoto.com/photo/pet...
bit.ly/2S6PjgH
www.istockphoto.com/photo/lar...
www.istockphoto.com/photo/clo...
www.istockphoto.com/photo/pet...
www.storyblocks.com/video/sto...
www.storyblocks.com/video/sto...
www.storyblocks.com/video/sto...
www.istockphoto.com/photo/pip...
We are getting closer to creating Curie from Fallout 4.
That's not a bad thing.
@@sneakerbabeful what could go wrong? Lol
Guilty Spark or Geth
I loved her so much
Ms. Handy Curie? or sexy synth Curie?
I love how this video subtly taught us the process of developing a new drug (from scratch), after drawing us in with robot scientists. ;D
You're right! They tricked me into learning something. Brilliant
I love that you made a video about this! I wrote my research paper on this topic last year, and it’s such a fascinating topic!
Existenceisillusion it was never published but thank you for your interest!
Feel free to publish it, or upload it to arxiv for peer review
Aleesa, hi! I’m a pharmacy student and I’m actually planning to do my thesis on “AI in drug discovery”. It would mean the world to me if I could somehow talk to you about your paper or if I could simply read it. Take care :)
@@arsakellariadisas a pharmacy student from Switzerland, i am writing a paper on the subject as well. Would love to have your insights
Brings a whole new meaning to designer drugs.
An adorable kitten cloud is no blunder.
It's a direct hit to my heart!
Really nice to hear AI being talked about in a balanced and fair way. So often, the capabilities of AI are over stated or misrepresented. It is so, so, so important that the limitations of AI are talked about freely, (e.g. the fact that the AI doesn't know what a Tchaikovsky is) to avoid fear mongering.
Yes! That's right. These statistical models and such (e.g., transformers) are really limited. They can only recognize statistical patterns (really, correlations) between words and make predictions based on that. It's like giving a baby, since birth, the entirety of Wikipedia (just the text). Sure, the baby can recognize patterns between the words, but without actually seeing them and how they act and interact with other things, the baby will not really understand what they are. The words are not literally that: they're representations of the much more abstract "meaning" the speaker (or writer) is trying to convey, in which some real-world experience with the actual objects (concrete or abstract) it talks about is a prerequisite. It's the infamous "grounding problem" that I'm sure will take a bit of AI research to resolve.
Don't be fooled by how good OpenAI's GPT-3 performs; it really doesn't "understand" much. Try giving it "the square root of thirty-two times five is " and ask it to predict what the next word is; it gets it hilariously wrong, because it's not doing actually "understanding" the sentence and doing the underlying computations but rather analyzing the text and making a statistical prediction on the next word based on a huge corpus of text it has previously analyzed. It doesn't understand the "meaning" of the sentence, just the associations and patterns of already composed text.
Boston Dynamics' dog robot making and giving new drugs would be cute. Maybe dress them in a lab coat or just have a white paint scheme.
"Lab" coat?
I work for a company called BenevolentAI, in January our AI platform correctly identified an existing drug that could be used to treat covid-19 symptoms... Lily are now in human trials for it.
Aalong as they put some creatine in the mix ill be ok
"they never have to duck out for coffee"
As I take a sip of my coffee..
Coffee doesn't exist.
J.J. Shank let me check...
No coffee so sad
This shall soon happen to the judicial system
Same
Hey robot scientists, cure headaches.
and all mental illnesses pls. I'm tired of having anxiety 😂
I received a response: Remove head.
...
I mean... That works, I guess?
@@camramaster If can figure out how to separate me from my head I'd at least give it a listen.
@@harvest5218 Petition to request that our future robot overloards remove our heads and replace them with something more useful, like say, nintendo switches
Weed. I suffer terribly with migraines and have three different types of specific migraine medication.
Since I started vaping fresh weed, I've only had 1-4 a year, compared to 1-2 debilitating migraines a month.
If I do have a headache or the start of a migraine weed kills the pain.
Excited to see the safe psychotropic drugs that could be found because of this. Major therapeutic potential
I'm really impressed by the Complexly logo - have seen it lots now but never took the time to tell you how satisfying it is to see the components coalesce into that nice big "C"
Kudos to the designer!
Bah, I'm a lab tech. The robot overlords can pry the pipette from my cold, dead hands!
That can be arranged, Ketchup!
Boston dynamics 'Spot' has an optional arm for that...
You mean to say: "Sudo, pry the pipette from my cold dead hands."
This 100% reads more like a "scary" PSA, this is still good to know.
Take this medicine that is totally not slow-acting poison.
@@BigMobe "What do you mean 'mercury isn't the elixir for immortality'?!"
Excellent presentation. Thank you.
I'm using this for a presentation in my machine learning class, thanks for making my research easier!
very well made. Thank you for this excellent video
Thinking of microscopic robots to fix your health I always think of Drix
Developing a potential drug is the fraction of the cost of the clinical trials, and this part AI can not accelerate. You should have mentioned that at the end with the numbers.
Great video!
Michael Aranda is by far my favorite host
"The future looks kinda like a robot handing us a miracle pill."
Eat the ice cream.
Sounds like a *wonderful* idea
Fantastic overview of the R&D side of pharma.
Imagine one day you can just make your very own medicine specifically to your body using AI,.... This is a wide topic
This sounds more like an advanced search engine than a drug designer
So basically Breaking Bad but with robots?
Whoa I love this guys hair, he looks great
This is crazy. And btw you presentator you got so much better and I like the earrings bro
The Optimist: that’s incredible soon no more decease!
Me: teaching AI what chemical can kill us?
To be fair, the AI only needs to know VX nerve gas(can be absorbed through the skin) and it has all it needs. Like how are we going to fight an AI that throws out VX gas like it is candy, everyone wears full body hazmat suits? Fighting against quadcopters armed with guns while in an uncomfortable rubber suit; yeah, no thank you.
+@@josephburchanowski4636 Universe: **Smiles In Solar Storm**
@@maxplaysgamez-sharesgaming1756 You know any AGI (artificial general intelligence) in a faraday cage will be able to survive a solar storm. EMPs and solar storms aren't nearly as effective as many people think they would be.
+@@josephburchanowski4636 I Knew That, I Just Don't Think It Was Worth Mentioning It, So AGI Could Take Note On That One. As A Matter Of Fact, They Would Be Thanking You In The Near Future, My Dear Friend. **Wink** **Wink** ;)
Joseph Burchanowski let’s keep the chemical between us! The smooches people lol
At worst we must convince them that we are good batteries lol
"The Voltron of modern pharmaceutical science". 😵
I wonder who forms the head?
spaghetti throwing is still a strong aspect that is commonly used
Yes, finally! AI medicine is awesome!
Yeah what if they create a deadly one
Will y’all shut up, you’ll give it ideas...
@@phillipatteberry9819 Ok sry
Leaf hmmm I bet no humans have ever made any dangerous medicine hmmm oh wait maybe giving everyone morphine wasn’t a good idea
inspiring times :)
I was really hoping this video would talk about Folding@home and the COVID moonshot project. In fact, I think this video would really have benefitted from a segment talking about how all this relates to the drug development process for COVID-19.
2050: We're Teaching Robots and AI to Design New humans
You just stole the thread lol!!!😭😭😭😭😭😭 They're gonna be like can you make LeBron James... but white?
It wouldn't be human if it was designed because flaws are part of what makes something human.
@@BigMobe are you on your meds? Because machines/robots design and make things that are flawed...like you know computer parts car parts etc?
Amazing
Nothing could possibly go wrong with this
Cant wait for the singularity :D
Hopefully it wont be too long ^^
(and hopefully its not a dystopian one )
Voltron drugbot got my like
The DreamLab app (by Vodafone) helps get some of this research done. It uses your phones processing power while it's charging to solve the equations that support these projects. They support the Imperial College, Garvan Institute, and AIRC and tackle issues like cancer and COVID. All you have to do is download it and the setup is super easy.
Wait, what do you mean target Coenzyme Q10? Is there something bad about it? Because everything I know about it makes it extremely important for things like heart, brain, and immune system health.
Wow, that sponsor segue almost knocked me out of my chair!
Can you discuss Icilin aka AG-3-5? I'm sure everyone whose ever discussed biochemistry has a video about Capsaicin and other TRP channel molecules, but nobody seems to care about extreme cold. I guess its trendy to Hot foods, so cold gets overlooked. Anyways Icilin is stronger than menthol, but menthol can be organically derived. Thanks for making great videos!
A traffic cone is the exact definition of what that pin doesn't look like lmao
A robot handing you a miracle pill... I approve of this potential future.
Watch this right after CGP Grey's How Machines Learn and you realize that spaghetti throwing is still the main method. But instead of looking for drugs in the spaghetti we're looking for bots that can look for the drugs for us.
Phinedroids and Ferbots are the best robots man has ever built
So many links in the description, could not see the one for the pin lol?
Raves gonna be insane
Sounds efficient
Great video! It's very hopeful, just hope the AI doesn't decide to poison us :/
.
.
.
But!
.
.
Musicians weep as Tchaikovsky turns in his grave by that pronunciation!
I hope this will be successful!
Oh gods, we're equipping them for the robot apocalypse...
My brother-in-law was recently diagnosed with pancreatic cancer. I wish that the research was finished before he was diagnosed (really wish he never had it). I do hope the research returns positive results.
Can you do one on why Cats are fascinated by water?
He sounds like he could be the voice of Kaz Brecker in the Six of crows audiobook
Just take a step back and realise how important this is for humans and how futuristic robot scientists are
Your hair reminds me of my hair. I don't know if this is good or bad because I haven't cut my hair since covid got big in the US
Bro I feel that I was fr thinking about commenting something like this.
I haven't cut my hair during this millennium.
Can you guys do more than english CC?
Currently AI is very narrow as to what it can do, but as it widens it we’ll probably see even faster progress Development in drugs. No doubt this will push for more funding in AI. The more use cases it gets, the more Funding This technology will get. Even now governments are starting to get how important this technology is now, realize its a national security issue. I can only imagine what's it's going to be in 10 years.
It's brazy that I have to even mention sickle cell but yeah, we are looking forward to quantum AI solving these simple ailments
One of the risks with using any such mechanized filter is false negatives: The AI could incorrectly rule out lots of potentially-useful drug candidates, with little sense as to why.
Neural networks are essentially pattern matchers, based upon *inductive, not deductive* “reasoning.” It’s almost massively-amplified intuition, so there’s no real “why” involved.
As you pointed out, humans can filter out false positives - cases where the AI suggested a drug that won’t work, but it’s much harder to revive drug candidates the AI ruled out.
"Drugs er baed m'kay?" - Mr. Garrison (SOUTH PARK)
Hero - one who risks their life to save another.
nice contents friend
And to help diagnose!!?
I'd like to see them cure (not just treat) allergies.
It's all just ones and zeros in the end
This would be awesome if the end goal were to create cures, but terrifying if the goal is to keep people just well enough to function.
yea...
The most important question is whether the US healthcare system will make these new AI-discovered drugs hella expensive or not. Insulin can be made for cheap by using modified yeasts, but the pharmaceutical giants can still make them cost hundreds of dollars per vial because...profits.
Thanks all you nerds out there!
@04:20 "researchers at the US company, Berg, grew cancerous and healthy cells from over a thousand donors in petri dishes"
*That's a lot of either some very large petri dishes, or very small donors, for them all to be in petri dishes!*
AI that use quantum computers... That would be interesting! Hmmm The Doctor in "Star Trek Voyager" comes to mind.
Ironically, robots will never need the drugs they make for us.
Won’t be long before Big Brother’s computer analyzes your total profile and then provides you with a customized, AI-concocted, drug regimen, for a monthly fee to Big Pharma.
well put Boomer John
As a person with many Things, I'll take it.
Scientists: We can use AI to create new drugs way faster now
Me: Cool but I think the goal is to be healthy enough so we don’t require drugs
Good luck with that.
That doctor-robot looks like it was made with tech from the 80s. So, 30-40 years before it matures/peaks?
It's super exciting to see this progress being made! Yay for robots! (Shame this probably means they're learning how to obsolete &/or kill us, but it'll take a good while longer before robots get that crazy, if at all.)
Robot drugs?
Okay I'm down
8:45 LitReally™
Design Ai that thinks like dmt elves
An ai analyzes our comments as we comment on ai 😳🔥
"No more spaghetti" 😔
What fresh hell is this
The next step will be identifying why a drug that looks like it should work fails.
Inshort:
Science is Hard,
Humans are bad,
AI-Robos are better.
I’m really scared we’re teaching robots to read
the cost of drugs is not in the basic science that is generally 30-50 million. the cost are mainly in the trials. a drug will average over 1.5 billion in costs because most drug candidates flame out in the trials at a few 100 mill each. U can see this in the path gap . A basic scientist with a phd/probably with a postdoc may make ~60-80 (with little longterm job security) a pharmd admininstering trials 110+. A biostatistician designing the trial 90-100. The major drug companies are now outsourcing a lot of the actual bench work or simply turning into licensing firms that acquire targets from smaller firms and then try to specialize in streamlining the trials. (salaries ofc are verry back of the envelope put u get the point )
And could you do one just on jumping spiders facts. And how smart they are?
_GLaDOS has entered the chat_
I wonder When the scishow guys Will have an ai to make your speech
So the development period is the justification for the obscene price-tags we see on prescription drugs.
One about the video on us humans preventing the next pandemic, please?
Yeah, it's more like a third that aren't cats in my experience. I just searched my google photos for cats, and I got two chicks.
they need to make a drug to treat MDMA comedown.
Speed it up, robots. My brain needs some stuff.
Oh, boy... we can't even teach cars how to drive by themselves without fail. Hell, people can't even drive so, sometimes we bite off more than we can chew.
We can't teach humans to drive by themselves without fail either.
Reading papers is a much easier thing to do than driving safely.
@@himanbam I see your point
What can human brain do that computer brains can't?
Imagine the high
Q10? Isn’t that the stuff that is in all the anti-aging face creams?