CORRECTION !!!!! On page 18 at the top of the notes and at 0:52 it should say: Pyridines as Nucleophiles: Electrophilic Aromatic Substitution • 6-Membered heterocycles are electron poor so are not good NUCLEOPHILES. • The nucleophilic nitrogen lone pair reacts first, creating a pyridinium salt whose positive charge makes the system even less NUCLEOPHILIC. Then the electrophilic aromatic substitution occurs and finally, salt breaking delivers the product.
CORRECTION !!!!! On page 18 at the top of the notes and at 0:52 it should say:
Pyridines as Nucleophiles: Electrophilic Aromatic Substitution
• 6-Membered heterocycles are electron poor so are not good NUCLEOPHILES.
• The nucleophilic nitrogen lone pair reacts first, creating a pyridinium salt whose positive charge makes
the system even less NUCLEOPHILIC. Then the electrophilic aromatic substitution occurs and finally, salt
breaking delivers the product.