C-H activation

This is an introductory lecture describing the concept of C-H activation. The lecture covers the following topics: what is C-H activation?; the relation of C-H activations with cross-couplings; electrophilic aromatic substitutions are not C-H activations; historical overview of C-H activations; popularity of C-H activations; the reasons behind the popularity of C-H activations; the main issues in C-H activation; reactivity of saturated and unsaturated compounds in C-H activations; selectivity of C-H activation in saturated and unsaturated compounds; computational prediction of the reactivity and selectivity in C-H activations; the role of directing groups in C-H activation; overcoming the problems related to reactivity and selectivity; scope of C-C bond forming reactions by C-H activation; scope of C-heteroatom bond forming reactions by C-H activation; scope of reagents used for C-H arylation; scope of reagents used for C-H alkylation; scope of reagents used for C-H trifluoromethylation; scope of reagents used for C-H carboxylation; scope of reagents used for C-H amination; overview of the main mechanisms of C-H bond cleavage; C-H activation via oxidative addition; C-H alkylation of derivatives of urea; C-H silylation of aromatic compounds; C-H activation via sigma-bond metathesis; C-H alkylation of aniline derivatives; C-H activation via photoredox catalysis; intramolecular C-H thiolation of arenes; amination of benzylic C-H bond; C-H activations catalyzed by enzymes; C-H activations in nature; C-H activation via insertion of carbenes and nitrenes; C-H amination of arenes by azides; intramolecular allylic C-H alkylation with diazo compounds; C-H activation via heck-type insertion; C-H arylation of furans; C-H activation via concerted metalation-deprotonation; the difference between traditional and removable/modifiable directing groups; overview of the main removable/modifiable directing groups used for C-H activation of aromatic systems; overview of the main removable/modifiable directing groups used for C-H activation of saturated hydrocarbons; C-H halogenation of arenes enabled by removable directing groups based on pyridine; the main issues associated with the use of removable directing groups based on pyridine; nitro group as a directing group for C-H arylation of aromatic heterocycles; C-H functionalization of purine-like compounds; regioselective arylation of imidazoles and pyrazoles; removal and/or further transformations of the directing group; directed C-H acetoxylation of alcohol derivatives; what is an oxidizing directing group?; the main oxidizing directing groups used in C-H activation; N-oxides as oxidizing directing groups; C-H olefination of aniline N-oxides; mechanism of the external oxidant-free C-H olefination; what is a transient directing group?; the main transient directing groups used in C-H activation; transient directing groups for aromatic aldehydes; transient directing groups for phenols; transient directing groups for aliphatic carbonyl compounds; transient directing groups for aliphatic amines; C-H amination of aromatic aldehydes; C-H arylation of aromatic aldehydes; C-H halogenation of aromatic aldehydes; late-stage C-H functionalization of Celecoxib enabled by transient directing groups; transient directing groups for C-H arylation of aliphatic amines; the main strategies for the meta-selective C-H transformations; the main strategies for the para-selective C-H transformations; meta-selective C-H transformations enabled by specialized templates and directing groups; meta-selective C-H transformations enabled by weak interactions with specialized ligands; meta-selective C-H transformations enabled by norbornene; Catellani reaction; meta-selective C-H transformations enabled by cyclometallation; applications of the meta-selective C-H transformations in drug discovery; para-selective C-H transformations enabled by specialized templates and directing groups; preparation of oligomers and polymers by C-H activation; C-H arylation of thiophenes; common substrates for the preparation of oligomers and polymers via C-H activation; total synthesis of natural products involving C-H activation; Synthesis of Dragmacidin D; preparation of pharmaceuticals by C-H activation; synthesis of Diclofenac and Celecoxib; regioselective C-H iodination phenylacetic acids; innate C-H arylation of pyrazole; late-stage functionalization of pharmaceuticals via C-H activation; C-H functionalization of Hongoquercin A. Among others, this lecture describes the key figures in the field of C-H activation. The cover picture is adapted from the stock image library of Office 365.

[@bijan_films]

Amazing lecture ❤

[@Demon-pb5jm]

I would love to see a video covering enantioselectivity in radical chemistry? Particularly cyclization reactions…thank you for all you do ❤

[@sahhaf1234]

thanks

[@ОлегСаламаха-й2п]

Hi, where can I watch the newest videos from this channel? I mean educational one