The Vital Cells of Existence: The Science of Your Microbiome
ฝัง
- เผยแพร่เมื่อ 16 มิ.ย. 2024
- For every cell in your body, there’s another tiny single-celled creature that also calls your body home. Far from being germs we should eradicate, these ancient friends allow us to digest food, breathe air, and fight off disease. They were here long before us and will undoubtedly remain long after we’re gone. They are our microbiome, and after eons of cohabitation, we are finally getting to know one another better. Of course, we aren’t always the best of neighbors. Autoimmune diseases, allergies, depression, and Alzheimer’s may be diseases of an unhappy microbiome.
PARTICIPANTS: Martin Blaser, Jo Handelsman, Rob Knight, and David Relman
MODERATOR: Dr. Emily Senay
MORE INFO ABOUT THE PROGRAM AND PARTICIPANTS: www.worldsciencefestival.com/...
This program is part of the Big Ideas Series, made possible with support from the John Templeton Foundation.
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TOPICS:
- Program introduction 03:12
- Participant introductions 03:40
- When do we acquire our microbiome? 04:50
- Connection between the microbiome and our immune system 07:00
- Using mice to study the microbiome 07:45
- When does your microbiome stabilize? 08:55
- What is the Human Microbiome Project? 11:20
- How unique is each person's microbiome? 14:02
- Mapping the microbiome on different areas of the body 14:54
- The effects of extensive antibiotic use on the microbiome and cause of modern diseases 15:19
- Are the microbes in dirt good for us? 18:01
- Rates of asthma in the Amish and Hutterites 19:50
- Hygiene hypothesis 21:20
- Antibiotic use and the rise of obesity in the US 23:25
- Obesity and the microbiome 25:05
- How do changes in the microbiome get passed from generation to generation? 29:30
- C. difficile and fecal transplants 33:20
- Can fecal transplants be used to treat other diseases? 37:57
- Connection between the gut and the brain 42:00
- Can the microbiome cause depression? 43:20
- How do you study depression in mice? 46:25
- Is there a strong association between what is happening in the gut and behavior? 49:35
- Is the microbiome connected to autism? 50:51
- How do the microbiomes of hunter-gatherers living in primitive conditions compared to people with high exposure to antibiotics? 52:45
- Is it possible that we'll never recapture our full ancestral microbiota diversity? 54:15
- How can we keep our microbiome happy and healthy? 56:51
- The role of the microbiome in precision medicine and drug efficacy 59:15
- Do probiotics really work? 1:03:04
PROGRAM CREDITS:
- Produced by Nils Kongshaug
- Associate Produced by Laura Dattaro
- Opening film produced / directed by Vin Liota
- Music provided by APM
- Additional images and footage provided by: Getty Images, Shutterstock, Videoblocks, Kishony Lab at Harvard Medical School and Technion--Israel Institute of Technology, Mazmanian Lab at California Institute of Technology, CDC
This program was recorded live at the 2018 World Science Festival and has been edited and condensed for TH-cam. - วิทยาศาสตร์และเทคโนโลยี
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What a panel! And what an educated moderator (looks like a Dr herself). Beautifully conducted. Made me feel that I want to get more education on Microbiome myself. Thanks 🙏.
True story. I grew up in the Philippines. As a kid, me and my friends all play outside in dirt. And I've never been sick.
I just loved this, the informations were delivered in such a clear manner with a bit of humor evey while and then... This is what I was looking for
From Amish lack of Asthma to why kids eat dirt, such a fascinating talk
Mhm 🤔
Mmmm Mac Dirt
I need some more dirt then
Did you all watch the video?
Silly people & so-called doctors won't teach future/ sick costumers about pre & pro biotics! It's bad for business! They will pimp Godless faith based evolution on suckers! So you can get "treatment$" die early in this short life only to spend eternity in Hell! How cool is that?
Im 60 this year and I think I've left it too late to become a microbiologist.
It's a really interesting field....it seems to be where the majority of our problems stem from but also where the solutions to EVERYTHING will be found....yo!!
It's never too late. There's no age limit to anything.
Fascinating. Beautiful to see these experts excited about the frontiers of this field. Would love to see a follow up
I have said this before, humanity will solve the mysteries of matter and cosmology much before it gets a comprehension on the relation between diet and health. But given the remarkable influence on mental and physical health shouldn't we be funding more on this branch of science? Given the lack of data the presenters continuously remind us of it appears we're not doing enough.
Check out microbiologist, Kiran Kirshnan's work. He is reputable and has come up with some amazing solutions to many health issues.
I love this, I hope more research helps!
Great work by the host!
Incredibly fascinating information in this video, but I can't help but to clearly see the correlations between what older civilizations have said about the importance of what and how you eat (take care of you microbiome) and how it will dictate how you behave and think. Now imagine an entire society that does that and what that society can achieve.....my brain is about to explode lol
As long as you don't take pre & pro biotics you can help the/ a *leading cause of death & 5 billion in fruad fines/ i.e. USA's big pharma's cancer industry grow! *see Dr. Null's well cited book, "Death by Medicine." Google the Johns Hopkin's [low-ball] iatrogenic study, claiming "medicine" kills [only] 250,000 each year just in the USA! I.E. stuff groupthink so-call doctors won't teach you about, for fear of reprisal! Colonoscopy's for folks who have no familial history run about the same risk of harm from the invasive procured i.e. punctured bowl, crone’s disease! A stool DNA test checks for abnormal DNA and hidden blood in the stool. Is over 90% effective & is safe! BUT not as profitable for the sickness industry!
Ayurvedha already knows the cause of depression is your stomach.
We been knowing the cause of most disease is in the gut since like the 4th century but for some reason we just ignored this organ until now
Its low serotonin that makes you happy, high serotonin is a stress state where you get learned helplessness.
Disappointed they didn't talk about Price's or Pottenger's research, especially when they delved into indigenous groups around the world. Also nothing about prebiotics, but wow a great brief overview.
Thanks for this perspective. Your points are well taken. 'Looks like another video should be in the making.
@martywilson wonderful! Also I would like to know what their opinion on Dr. Berman's study on commercial probiotics and their efficacy and if not capsules what about fermented food like raw sauerkraut.
" change in our micro ecology is parallel to what we do in our macro ecology"
Quite the resounding quote yo!
It really reverberates, and makes you rethink how humanity is conducting itself~
This is mindblowing
Problem with the Six Second Rule:
Germs 🦠 can’t count.
Wow, this was published on 2/8/2019... so, quite new at the time I'm writing this comment. I was looking for a comprehensive overview of the microbiome and our relationship with the inhabitants of our bodies. 'Looks like this could be promising.
enroll in college, get a major in the subject.
Need more on this topic with the same panelists....with even latest developments and NEWS
17:02 "Every time you turn the ignition, the ice cap in Greenland is going to melt a little"
Wonderful information
36:30 best moment. I lol'd.
Amazing!
Yeah, farmers gave antibiotics to farm animals to make them bigger and thus get more money. And NOW we are facing the epidemic of antibiotic resistant microbes!! Really great. And of course, probably lucky that all these antibiotics somehow didn't completely obliterate the symbiotic microbiome.
please sometimes discuss about plant lifes too...or the works going on in that field...it will be helpful for many.....thank you
BTW, wish WSF had covered marine biology or ocean life in at least one of these talks. That'd have been great. I do hope they cover it in 2019 (unless the 2019 is already over?)
I wish they weren't so cautious...it's going to take forever...go for it guys !!
What if we are just meat sacks evolved to feed and protect microbes?
We are.
Their success is amazing, we have even pansperm them to Mars, the moon, they are on Voyager 1 & 2
Etc..
Latasha Thomas In that case evolution failed, because we are killing them with antibiotics. :)
Then score 1 for the microbes 😆
Latasha Thomas that’s exactly what we are!
@Daniel Hanrahan Not for long if we can't set aside our petty differences and make something to escape from extinction events.
My children were born through C section
I missed the coating on them.
Also I feel pet parents also may have unique microbiome. Dog tapeworm, Parvo resistance
This pademic made us more careful in our children and adults and we have prevent other desices like the every year flu
Link to where to get biome tested please.
Luckily, I only had to get to antidepressant #2 to find the one that worked best.
Walter from the TV show Fringe knew what he was doing when he adopted Gene!
Let's go.
Like it and not to offend. Centuries ago when there was no antibiotic human life expectancy less than thirty years. Today with all those antibiotics humans live more than 70 years. It may go up to 100 or more in the future irrespective of any treatment for the Microbiome.
Life expectancy wasn't 30 years, average lifespan was - due to large numbers of infant deaths. If you got past 10 or so, you were just as likely to reach 70 as you are today.
Yeah, a very simplistic view of the history of humankind.
The truth is in the middle, most of the gain is in the progress of reducing child mortality, but we have extended life expectancy significantly for any age.
Microbes are our best friends lol
put your gut in tune, go W,F,P,B
Yes!!! Organic. No Monsanto roundup veggies🙏🏻
Schools can have farm animals! I think that will be good start! Next public place can be pubs and then shopping malls:) Why not? Every visit to these place can be an opportunity to smell, sniff and stroke them. Let's think and add more suggestions 🤠
Bacteriophage are abundant in soil, so maybe 'self-medicating' by eating dirt is a means of both gaining beneficial bacteria and killing off parts of the microbiome with phage.🤔
NOICE
great talk but it would help if they where more animated...
What's astonishing about human incapacity to learn, is that Alexander Fleming warned against penicillin overuse back around 1940, trying to develop public realization that limited, use is the key to preventing such problems as MRSA.
The commercial use for domestic food animals has resulted in vastly more likely antibiotic resistance - that industry had discovered increased early growth, and therefore psychopathically used and influenced the present lack of constraints on overuse of antibiotics.
Too bad they didn’t listen to him.
We’ve come along way from this info.
This one guy ice cream or rice which is better… neither! Lol
love the picture of the depressed mouse ahhh
Go whole food plant based organic vegan.
Gluten free dr Gregor daily dozen take vitamin b12 and vit D3 with k2
Sorry but the depressed mice got me
I hope these experts aren't being silenced now with the dominant "pandemic "groupthink?!
To have a clean organized place for your kids is good but when you give a sterilized option and be very district then the asthma can come up
Curious how sexual relationship with people can pass on microbiome to each other... In addition curious how using a worm bin to create a natural soil microbime can be used to better our microbiome when working with this type of compost....
.
[ Vit B-12, in soil ]
.
What would happen if you did the double-slit thing and only leave the part of the screen that the smallest number falls on?
Is this a reupload or a part 2?
Reupload
:o/
49:07
The same with viruses.
33:27
you are what you eat.... :)
pulling ourselves by the bootstraps... was never true anyway kinda silly that you would need to understand the microbiome for that.... it's simply about paying attention to environment to understand the myriad ways in which socioeconomic status is very important.
Antibiotics may make animals bigger because the microbes get killed off and the animals absorb more calories because less microbes are using the food.
Bacteria are about a thousandth the size of an animal cell. Even though there's many more of them, it should not have that steep an impact.
Yes and antibiotics given to the animals causes inflammatory microbes that causes animals to get bigger because of inflammation!
Why not just have cultures of all the myriads of microbiomes grown - to take as pills or inject.
make them a part of your own DNA - to make them
So how is it people with a total colectomy such as myself live very happily for a normal life expectancy (given that one is cured of Ulcerative Colitis and thus open to die of something completely unrelated).
Seems evolutionarily quite illogical that we might be so dependent on a microbiota which could change very rapidly say after a bout of diarrhea. Nobody has really any idea what happens to the gut flora during life. Seems to me yes we can do fecal transplants for both C dificile infections and perhaps obesity but that may really mean nothing much since not everyone is obese and we know little of the enterohepatic circulation and its control or variations between individuals, and replacing lost flora to compete with CD may have nothing to do with anything that happens naturally except that the gut flora does not normally allow it to grow.. make hypotheses and test them by all means but do not believe gut microbiota to be “vital” or “key” in any major way that greatly influences human health. It might be more akin to fine tuning but without it we will not die.
There is a huge amount of research showing that having a strong microbiota can prevent many populations of bacteria from overgrowing. The site also matters. Some microbiota is fine in some body did, but can have huge repercussions elsewhere. An example of the is the yeast "Candida," which is fine in the gut, but can overgrow in the vagina in women, causing a year infection. Communities can also become very hearty, so that the colon may be just one site where the microbiota develop, so something like diarrhea will certainly not develop. These are huge epidemiological studies across populations, so individual outcomes show variants, but these studies care more about what happens across large populations in "most people."
Solange Im a PhD microbiologist with 40y in food and nutrition including setting up and running EU projects on probiotics. I know all this, but I would really like someone to answer my question. I doubt anyone will because they are too busy trying to justify grant money with words like “important”, “key” and “viital” to do so.
one person accidentally downvoted this
@24 minutes, "obesity epidemic"? So, if I have this disease, I can eat a low calorie healthy diet and still grow to 400lbs can I ? Or, do I just have to eat fast food five times every day to accomplish that?
It's more about trends. It's easier to gain weight of your microbiota is insufficient to tell your body feels to do growing.
The microbiome tells you what to eat. That is the main issue.
Good to sell books..... and then caught up in their own hype. Way too deep in their own rabbit holes. General truth taken to extremes
Gotta. E honest I have no clue when the Irish dude talks. Can’t understand him
Another failure, this time in the discussion:
Throughout development and life, an organism MUST facultatively turn off and on different genes - therefore differing proteins,enzymes, metabolic products.
In this process, it is mistaken to imagine that microbiota are in any way "domestic."
Instead interactive stimulation o f CpG methylation, and the complex more seemingly transient release of rather specific portions of DNA for productive activity through acetyl molecules being attached and later removed (yes, there is great likelihood of histone acetylation and deacetylation - the latter a dozen DIFFERENT molecules, very specific to certain active processes - do the changeing that is mentioned as well as facilitate memory, its recovery, association, and the immune system's response to differing "habitats" that occur, with ingestion of different foods and molecules)., ENTIRELY changing body and metabolic states in vast cascades.
For those who question the absence of conceptual linking in the ENTIRE discussion, these, and a number of transcriptional effects, from RNA changes and other changes to a system's response, effect CONSTANT change.
Yes, the dissociation from complex natural ecosystems is perhaps THE major driver of the paucities involved in excessively fluctuating immune response.
NONE of the modalities I note have been remotely approached in this discussion.
An example - any microbe taken in orally causes cascades. Pretty much the bacteria in yogurt, for example, do not survive the upper GI. Instead they CHANGE the habitat, even in their death and fertilization of consistent and important mutualist bacteria. Injecting other human fecal contents is a profoundly CRUDE method in comparison with the selection that occurs through natural ingestion.
By 1:02 I have NOT heard the totally unnatural huge active molecules in plastics, many mimicking hormones, throwing metabolic cellular activity into VASTLY differing states. The emotiocognitive effect transiently discussed occur through such perturbances.
What”s so funny?
Wow , I'm not buying it
Super cool. Intrographics. God made dirt, dirt won't hurt. I've always welcomed filth and challenged all comers to micro battle. Still kicking. I draw the line at poo transplants.! ...please stop transplanting poo over a stupid rhyme about god. Not a goddamn one of us knows shit about beyond tomorrow p.s. no offense to those afflicted with problems associated with sub par digestive system. I'd take the healthy poo rather than deal with chronic symptoms.. ..
What has the fiction god anything to do with it?
@@Paul_C merely hedging my bets.. I do however, avoid religion like the plague.
God? its 2019 fam. Grow up
@@Metacognition88 I am grown. At least enough to know my tiny insignificant place in a extremely.hostile universe .You need to grow some more if
You believe you have all the answers.
You mentioned god... I guess that is enough dirt right there...
Keep that perturbed poop away from me.