This is super helpful! The textbook we use (Klein) goes more into using visualization/models to figure out the relationship (ie: enantiotopic can be reflected in a mirror, homotopic can be rotated 180 degrees) but doesn't go into chiral centers and using those to help make a determination. Thank you!! Edit: Just realized you must also use Klein, since the video title uses the textbook chapter/section number that correlates to this topic (15.4). :)
Sir Plzzzzzzzzzzzzzzzzzzzzzz explain this, I am having this doubt from a long time Carbon carbon single bond can rotate freely, therefore on average both Diastereotopic hydrogens will have overall same environment, Hence should give only one signal? But why they give different signal? Plzzz reply
So a carbon-carbon single bond can rotate freely, and in many cases that will result in the attached hydrogen atoms experiencing the same average environment and will be magnetically equivalent. This is true for both homotopic and enantiotopic hydrogen atoms. But diastereotopic hydrogens are the exception. Even with free rotation they are in distinct environments (not the same). If you built a model and examined the environment around each diastereotopic hydrogen carefully, measuring distances to different atoms in the molecule and in different rotational conformations you would reach the conclusion that they really aren't in identical environments. But this isn't easy to determine visually which is why rely on the replacement test to determine this. I fear this won't be the most satisfying answer but hope this helps!
@@ChadsPrep Thanks a lot.. it's a good moment for me..I'm requested my subscriber to teach in Hindi language... otherwise u could understand.. anyway chemistry has its own language 😁..we are chemistry lover 👍👍
Yes I used the z test (aka replacement test). But when switching out one of the hydrogen atoms with a 'z' it not only makes the carbon that hydrogen is attached to a chiral center, it also makes the carbon the Cl is attached to a chiral center. The two structures we draw using the z test have one chiral center (the one with the Cl) in the same configuration but one chiral center (the one with the z) in the opposite configuration. This means they are not mirror images and are diastereomers and the the two hydrogen atoms we are comparing diastereotopic. Hope this helps!
@9:43 why are the methyl groups chemically equivalent to each other? Because if u rotate the molecule 180 degrees u could tell it was rotated. Someone please explain
Hey Saana! In this context "chemically equivalent" means they have a similar chemical environment (i.e. same neighbors). The methyl group H's on the left are next to CH2, then CHCl. And on the right the methyl groups are next to CH2, then CHCl. Since they have the same neighbors (we can also see this due to symmetry) they will give the same resonance on NMR.
you have done more for me in 10 minutes than my professor and TA have done over a week’s worth of classes, thank you so much
You're welcome, glad to hear it.
First time anyone ever talked about this and it made an ounce of sense omg. Thank you so much...
You're welcome!
This solved all my problems!
This is super helpful! The textbook we use (Klein) goes more into using visualization/models to figure out the relationship (ie: enantiotopic can be reflected in a mirror, homotopic can be rotated 180 degrees) but doesn't go into chiral centers and using those to help make a determination. Thank you!!
Edit: Just realized you must also use Klein, since the video title uses the textbook chapter/section number that correlates to this topic (15.4). :)
Glad you found this helpful Clare! Oftentimes, how things are defined and how they are identified are not the same 🙂
Loved the examples very helpful and can you also show us how you make the videos as well I find it really interesting. Thank You
You explaination is amazing man,keep it up
beautifully explained. thank you. i love you
Tremendous help. Thnx
You're a LEGEND
I have never heard such a succinct and detailed explanation :) Thank you so much!!
You're welcome, Jessie - glad it helped.
You're a legend, 10 minutes and everything is clear!
Thanks Mario! Glad this lesson helped clear it up for you!😊
@@ChadsPrep I just finished my exam and I was so happy to know the answers. Thank you for your help and for everything you do on TH-cam!
God damn , I was struggling with it until I found your videos man .
You are a HERO ❤
Great to hear you find the videos helpful :)
Thanks a lot! This helped tremendously!
Glad it helped!
Thank you so much! you are a life saver.
Glad it helped!
But for the example you used for homotopic atoms, isn't that example also enantiotopic?
really helpful thx
you are such a good etacher thank you
Thanks! Glad you're finding my videos helpful!
this saved me thank you so much
Such a great video, thank you! One showing ring systems would be great:)
Thanks for your comment, J - glad you liked the video!
Excellent explanation.
Make vedo on organic mechanism
thank you!
Great explanation! Thank you!!!
You're welcome, Tatiyanna V. - thanks for saying so!
Subscribed. Thank you for your great video.
Excellent - thank you!
thank you very much
THANK YOU SO MUCH! YOU SAVE ME
Sir Plzzzzzzzzzzzzzzzzzzzzzz explain this,
I am having this doubt from a long time
Carbon carbon single bond can rotate freely, therefore on average both Diastereotopic hydrogens will have overall same environment,
Hence should give only one signal?
But why they give different signal?
Plzzz reply
So a carbon-carbon single bond can rotate freely, and in many cases that will result in the attached hydrogen atoms experiencing the same average environment and will be magnetically equivalent. This is true for both homotopic and enantiotopic hydrogen atoms. But diastereotopic hydrogens are the exception. Even with free rotation they are in distinct environments (not the same). If you built a model and examined the environment around each diastereotopic hydrogen carefully, measuring distances to different atoms in the molecule and in different rotational conformations you would reach the conclusion that they really aren't in identical environments. But this isn't easy to determine visually which is why rely on the replacement test to determine this. I fear this won't be the most satisfying answer but hope this helps!
@@ChadsPrep thank you so much sir ❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️
You're welcome!
Preciseeeeee. Thank you 😊😊😊
You're welcome!
Nice video.. lots of love for ur effort from india 👍
Thanks from Arizona, USA - Happy Studying, Hassan Academy!
@@ChadsPrep even I start teaching chemistry..I have learn many things from you..see u someday 👍
Hello Hassan! Looks like you're off to a great start...I'm subscribed to your channel!👍
@@ChadsPrep Thanks a lot.. it's a good moment for me..I'm requested my subscriber to teach in Hindi language... otherwise u could understand.. anyway chemistry has its own language 😁..we are chemistry lover 👍👍
you sir are a legend! thank you
Thanks Maria! And you're welcome!🙂
Thank you, legend!
You're welcome, Offwhite TM!
Thank you ❤
You're welcome 😊
THANK YOU!!!
You're welcome Tristan!
for 8:44 the compound does not have a chiral center why is it diastereotopic you use the z test to make the compound a chiral center is that right?
Yes I used the z test (aka replacement test). But when switching out one of the hydrogen atoms with a 'z' it not only makes the carbon that hydrogen is attached to a chiral center, it also makes the carbon the Cl is attached to a chiral center. The two structures we draw using the z test have one chiral center (the one with the Cl) in the same configuration but one chiral center (the one with the z) in the opposite configuration. This means they are not mirror images and are diastereomers and the the two hydrogen atoms we are comparing diastereotopic.
Hope this helps!
Thank you so much
You're very welcome Sutapa! 🙂
I love you chad
Thanks Jayden! I'll take that this means you found this lesson helpful! Best in ochem!
@9:43 why are the methyl groups chemically equivalent to each other? Because if u rotate the molecule 180 degrees u could tell it was rotated. Someone please explain
Hey Saana! In this context "chemically equivalent" means they have a similar chemical environment (i.e. same neighbors). The methyl group H's on the left are next to CH2, then CHCl. And on the right the methyl groups are next to CH2, then CHCl. Since they have the same neighbors (we can also see this due to symmetry) they will give the same resonance on NMR.
I'm heterotopic for you
Chemisty humor is the best humor. 🙂
Thank you!
You're welcome