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- เผยแพร่เมื่อ 16 พ.ค. 2024
- As part of his reporting for “The Last Alzheimer’s Patient” documentary, CNN Chief Medical Correspondent Dr. Sanjay Gupta travels to Jackson Hole, Wyoming, to learn more about an ethnobotanist’s audacious theory on treating Alzheimer’s disease. After Dr. Paul Cox, founder of the nonprofit Brain Chemistry Labs, discovered the source of a mysterious neurodegenerative disease afflicting people in Guam, those clues led him to a novel way of thinking about Alzheimer’s and a simple amino acid called L-serine. His novel theory and possible treatment are now being tested in Mild Cognitive Impairment patients at Houston Methodist. Editor’s note: “Dr. Sanjay Gupta Reports: The Last Alzheimer’s Patient” airs at 8 p.m. ET Sunday, July 7, on CNN.
Listen to how the true scientist answers questions. He doesn’t make overly enthusiastic claims. He didn’t just endorse L-Sering, he was is specific speaking to what the question was, what they did to investigate, what they tried and simply what the result was. THIS is doing your research looks like and why trusting actual trained and practicing experts is so important.
That's right.
Yes! Exactly what I was thinking!
To go even further, this way of assessing information is, in my opinion, the best way to deal with misinformation.
In fact, the term misinformation is problematic as it's a subjective label that suggests that it's objective, but it's not. Galileo Galilei was thought to be spreading misinformation in his time.
So the best way to protect yourself against misinformation is to assess it.
Assessing information is becoming the new Darwinian filter.
Exactly I was very impressed by the scientific ethic of his responses. This is how scientists I know talk but so frequently what we hear on TV are salesman instead of scientists. This was excellent.
Great comment. For the record, it is L-Serine. It can be synthesized in the human body under normal physiological circumstances, making it a nonessential amino acid. But given the prevalence of neuro cognitive disorders in the world now and all of the toxins we are exposed to these days may be humans need more than we used to in order to stay healthy.
@@ErikBongers Importantly, Galileo was persecuted by ignorant religious leaders who did no work to replicate or invalidate his work. Cranks and their fans like to drag Galileo out whenever they get criticized for spreading misinformation by claiming they’re challenging “scientific dogma” (which is not a thing) just like Galileo challenged religious dogma. Or “just asking questions” - which they pose to laypeople and journalists, rather than the experts. The best way to deal with misinformation, IMO, is say “don’t try to convince me - I’m not an expert. Wake me when you’ve convinced the experts.”
As someone who was born into a family with a high rate of this disease, this is a breath of fresh air and I hope more advances like this will save millions. Thank you so much for your work Dr. Paul
Me too. So worried for my husband and kids 😳
@@jkgermany2182look into the books of the neurologists Perlemutter and Bredesen. It doesn’t have to happen and you don’t need a pill.
Thank you for your kind response. Our clinical trial for Mild Cognitive Impairment has not yet concluded, but your encouragement is appreciated.. Dr. Paul Cox
old rich people can now live longer. hooray.
Stop eating toxins bruh
It won’t help my mom, who is too far gone. But it might save my sisters … and me
Hugs!
5:20- L. Serine is found in:
- Eggs
- soy tofu
- edamame
- sweet potatoes
- turkey
- pork
All of what Asians eat.
100grams of top round beef has 1.52 grams. 5.2% on dry basis.
in all our proteins = what life is.
My mom has dementia and does not like meat and no longer eats eggs. I do not know if I can get her to eat tofu products but will try. She cannot eat sweet potatoes due to she has ckd and has to watch potassium intake. If I could buy a pill I would, anything to help her.
@@000_x9edamame salads, slaws, " mayo salads, maybe related beans will have the l-serine and be effective, roll in cooked ginger bits or wedges, get y'r mirin and rice wine vinegar and salt substitutes, lots o fun.
Great "Human interest story" CNN....we need more good news like this.....Kudos.
HAFA ADAI from Guam...The study of "Lytico-bodig" disease, aka Guam disease, or amyotrophic lateral sclerosis-parkinsonism-dementia (ALS-PDC)[ has been ongoing for many years. I knew of many elders who met their demise with this horrible affliction. I look forward to the findings. Si Yu'os Maåse (Thank you).
I am 67, was widowed in 1998. I am totally alone now. I do live a very healthy life style, but I am concerned since my grandmother died, so slowly from this horrific disease. I just don’t want to be a burden to my kids. Praying and following!
If praying to an imaginary deity works, why follow a scientist's advice? Or is your deity not as powerful as you'd like to believe? lol
@@LaBamba690 oh I so sorry I offended your tickle bone! What deity? Again?
Praying, for me is an active participation in my life. Gratitude for the most part. Religions are for others and for tickle bones.
Blessings dear.
My imaginary creator said you and I are one!
Hugs! 🥰
@@LaBamba690 Context is key. Sounds like it was just a turn of phrase so maybe lay off a bit?
@@jenkem4464probably just a smartass atheist. Tends to be their mo. Their claws comes out whenever God or some type of religion or religious belief is mentioned! 😂
@@LaBamba690 as a scientist i also pray many times, please don't be ignorant
Being half Japanese and half Okinawan, some day I will visit my ancestors islands. Hoping a long healthy life forALL ! Aloha from Hawaii
This is a Nobel Prize worthy
If it works. Which I really hope it does, but let's see what further studies show.
My husband has been suffering from dementia for almost 5 years. My strength in taking care of him comes from my faith in God. I’m very blessed because no matter what I ask of Him, He always answers. I pray that God bless this man and his work. I also pray that through his studies a viable answer, a cure will be found and made available to those that are recently diagnosed with this deadly disease that robs them of all the wonderful memories of their lives and those that love them to pass them on. If it’s possible for us to donate in any way possible please let us know. (A true love story…Pass it on)💕
The Brain Chemistry Labs is a 501(c)3 charity in Jackson, Wyoming. Charitable gifts can help accelerate the research.
Wow! Thank you, Drs. Gupta and Paul!!!
I really hope they find the cause of Alzhemiers and the cure.
I really hope next they try to find the cause and cure for ME/CFS.
I was stuck down with this disease at 55. I had a good life.
I have a friend whose son was diagnosed at age 15. He is now in his 30s, and mostly bedbound. His life was cut short by this awful disease.
I can't think of an illness more neglected in terms of severity and number of victims in regard to its severity. It's destroyed my life.
@@hillsofwi Yes, people really don't understand what it is like to basically be flat in your bed most of the day and night. Alive but not...
2:57 This video said that in this case, the cause was blue-green algae, also known as the cyano bacteria, from the sea. "It contains toxins, such as BMAA."
Bats can't catch a break. Stop eating them.
Eat foods with L-Serine, such as Sweet potatoes, Edible seaweed, Nuts, especially peanuts, almonds, and walnuts, Chickpeas, and Lentils.
Bats have the best immune system of all mammals, that's why they're carriers of diseases
Peanuts are legumes, not nuts
Completely wrong, these vegetables contain many poisons and sugars, plants do not want to be eaten and people do not know what damage they will cause over years of eating them. There are now a number of houses in America that treat people simply by letting them eat meat and heal people or improve them at a distant stage.
@@danielmartin7838 so are chickpeas and lentils, he was just enumerating food rich in L-serine.
Chamorros don't eat bats like our relatives did decades ago. This film is somewhat inaccurate and the pics they show are definitely from decades ago. So to say, "now we can save our children", is somewhat misleading. FYI
This researcher helps to restore my faith in humanity.
This man is a true ambassador for science and I’m thankful for his and his teammates efforts!
Please keep us updated. If it can be prevented, I would be willing to do whatever can help prevent it.
I hope you Americans are proud of this man.
EXTREMELY PROUD. Thanks.
How kind of you you to say that! While I had no part in any of this and the credit goes completely to him, I am so proud of him. He is pursuing his talents.
So pleasing to hear some actual news that's not part of the dog and pony show.😁 Thanks
Good luck to the researchers and thank you. Is it possible to donate to support them?
The Brain Chemistry Labs is a 501 (c) 3 not-for-profit organization.
Thank you! Looking forward for successful research. I hope this Dr receives an extraordinary support for this extensive research.
Wow!!!!! What a breakthrough in medicine !! I see a possible Nobel prize in his future ! I was born into this potential threat. I hope this study becomes a realty for prevention and treatment !!
Thank you, Leslie.
I appreciate the real responses from actual people. There is also a ton of troll bots in today's comments.
@RandyWatson-xx5fmThank you. I rip on YT via feedback weekly, for what it's worth. They need to screen. Last winter Meta shut down 5,000.
@RandyWatson-xx5fm fool tube is a snake, takes other sites down claiming bots boost numbers, its all political.
I’m listening either way Sir! I’ve lost loved ones to Alzheimer maternal grandmother and Parkinson’s disease maternal grandfather. Cancer paternal side of my family. I’m blessed to still have my parents and fear I will lose them to it.
II am so PROUD a wonderful brilliant scientist friend of mine works here. Also she is a fabulous photographer, she is in love with the beauty of where she works.
Dr. Dunlop is a brilliant scientist and we are lucky to have her with us. She played a key role in identifying BMAA as the neurotoxin.
Foods high in serine are eggs, soybeans and shellfish.
I heard about this research years ago but they’ve made progress!!
Anytime there is hope. I am all in.
Good work, there, on Guam, and thank you, Sanjay, for your great reporting. I am still plant based after seeing your broadcast about preventing heart disease. I recommend playing it again.
Amazing research and reporting
Great interview, God speed to these scientists!
Wow, I wonder if this might apply to other mental conditions like schizophrenia and anxiety. I keep hoping we can find answers in things we can control like diet.
If you read up a bit about it, you will see that it is also for those conditions and help you to sleep better too.
There's a kind of schizophrenia where a part of the brain pushes up against the skull. I don't know if all forms of schizophrenia are like that.
Anxiety is correlated to the gut microbiome and there is a lot of study into it right now. I believe there are even diets that reduce anxiety due to after a handful of months they change the gut biome. Anxiety is interesting because it's also psychological, a blend of both the gut and the mind. Usually both aspects need to be addressed. On the psychological side both CBT and DBT both are proven in studies to work, and both of them I believe are 12 sessions, 1 session a week. A lot of progress can be done quite quickly thankfully.
Good luck with everything.
The one thing missing in most research about different cognitive diseases is that alzheimers is much like heart disease in that it is plaque build up in the brain that is preventable by diet.
So, it's encouraging to see one about an amino acid that you get in food.
Thank you for this report - I am looking forward to the results of the trials .
The man is an impressive scientist. Thank you for your work.^
Wonderfully exciting! Hopefully it results in an effective fight against a really horrid disease. Thank you so much!
Thank you for your encouragement. We also hope that it works, but won't know for sure until next year. Dr. Paul Cox
@@paulcox880Thank you, thank you, thank you! Is there a way we can support your work?
How very interesting!!! Keep us informed.
This is so great, thank you.
My heartfelt thanks to those scientists who work tirelessly to find a glimmer of hope in retreating all diseases, Alzheimer's especially. If they can cure/treat ALS, wow. They've made strides with the lymphoma diseases, too. All i can say is support your local science teachers and classrooms. Those kids will carry on the work and save more lives. The Nobel prize would help tremendously pay for more research...
Well presented by not saying it's a 'magic pull' but waiting for results. Thank you for your work
Yes, indeed. Atypical for science reporting.
Yes, please keep your fingers crossed that our clinical trial will demonstrate efficacy! Paul Cox
@@paulcox880 Fingers and toes crossed!
Wow - great story indeed 👍🏼👏🏼
Really interesting research. Hopefully they get some good results
With these great doctors there’s hope for everyone
Yes SYMPTOMS (plaques & tangles)
This alone to get thru to the AMA is huge!
Great scientific divergent thinking by DR Cox
Awesome story! One question though-what made them decide to test the l-serine as a means to offset the effects of the cyan bacteria?
Very Interesting and I hope the results show a favorable response.
Hello
This story reminds me of how the root cause of Kuru was discovered. I’m so thankful for unorthodox thinkers and the intellectual excellence of scientists like this. ❤ (this was also cool because I live in the WY mountains!)
Many thanks. Dr. Carleton Gajdusek, who studied Kuru, was very interested in our early work in Guam. Come see our lab in Jackson! Dr. Paul Cox
Lytico-bodig (ALS-PDC), which so many of our service people based in Guam developed, my father included.
@@Lee-jh6cr I am unfamiliar with this but will be researching it now! I too have vets in my family who have paid a high price for their service to our country. They are truly the best of us. Best wishes to you and yours.
My dad was stationed on Guam during WWII. He thought it was beautiful there but there is no way he would have eaten a flying bat, or something like that, of any kind. He died of Non-Hodgkins lymphoma. It was my mother that had vascular dementia, similar symptoms to Alzheimer's but not the same. My best wishes go out to all the scientists working so diligently to make the world 🌎🌍 a better place.
Awesome!
Impressive! I'm curious why and how the Dr. zeroed in on L-serine as a possible treatment.
Thank you for your Care and commitment to our community 🙏 ❤🎉
Great info. Another great endorsement to japanese okinawa diet?
HOW WONDERFUL GREAT REPORT THANKS
Very significant findings for Florida, where blue-green algae in polluted water is a major problem.
The story ended on a cliffhanger 😮
Sounds very promising🙏
What an amazing discovery. I am going to purchase L-Serine to see if this helps my dad ❤
Wonder what Dr. Paul Cox found to be the diet of the Okinawans. I do know they do eat alot of the L-Serin menu shown except turkey but the islanders also eat alot of fish/seafood variety and local vegetables. Can't wait to see the results of Dr.Roman's trial on L-Serin that may help with mild cognitive symptoms.👍
It’s good to have hope.
My Great grandma and grandma had it. Last child out of 21 kids. Part Cherokee Black. (Alabama)
You could offer my Dad with Alzheimer’s a cure that would make him 40 years younger. And he’ll probably curse you out and remove you from his Will. Then he’ll get mad that you don’t call everyday.
Keep in mind that it's not him speaking, it's the disease. Not his fault, try to remember him as he was before the Alzheimer's. So sorry you are going through this.
@@vintagelady1Wise words, my friend. Best wishes to those dealing with this awful disease.
just what we need, ways to make old people live longer.
@@simulationkoyo You'll get old too, I suppose you want Alzheimer's when you get there.
Hey, he can still tell you didn't sauce it up and start eating it all the time yourself!? Like the stories about pocket packs of extra ham from Alinea.
Interesting 🤔
If safe, why not add it to your diet?
I would have asked the researcher, has this changed your diet?
CNN has NO captions?
Use the CC and read along ✌🏼
This is great news!
I, for one, will definitely stay tuned. And it certainly can’t hurt to eat more of those foods in the meantime, especially the plant-based sources.
Amazing 😀🇨🇦
Amazing.
Important.
Good luck!
Hello. Will Phosphatidyl Serine accomplish the same results?
Wow 👏🏼👏🏼
Love it I hope dr Gupta follows up with clinical results . I pray they get this through and it’s affordable to everyone ! Like insulin is not!!!
Since it's in every day foods a pill won't be necessary. Just a diet change.
This should have CC enabled.
I have a hearing Impairment and this background music makes it impossible for me to hear the dialogue.
I do also. Use the CC and read along.
This is incredible. Thanks for your perspective, Dr. Cox.
Many thanks! Paul Cox www.brainchemistrylabs.org
The Japanese and other Asian cultures have had and maintained an enormous body of knowledge about the effects of all the different foods we consume. When a patient visits a doctor, food is always discussed and practical remedies are offered. Nutrition is also taught in public school, starting in primary school. Here in the west, we don’t even teach this to doctors, and they aren’t capable of addressing the effects of food on their patients. We also feed children heaps of ultra-processed foods in the public schools. This is incredibly ignorant on our part given that this knowledge has been accumulated and passed down for millennia. It’s time the authorities and influencers of policy started moving in the right direction.
Blue green algae worked very well on my symptoms. Maybe it depends on where it comes from.
L-serine is dirt cheap too.
He mentioned a mix of ALS and Alzheimer's symptoms. Neurodegenerative symptoms. I never knew those could be related.
Neurological conditions are all toxin related and often have pathogenic activity involved. Clearing the metals and toxins from the brain and improving the body's immune system are crucial to recovery. Sweet potatoes clear metals out while boosting the immune system. Bananas and citrus are plentiful in tropical regions. Papaya, mango, coconut, jackfruit, etc. are also big healers.
Yes, food is good medicine. But laughter, supportive family and friends, movement, spiritual growth, a sense of purpose, positive affirmations, play, love, and creativity all play important roles in healing and staying well.
Motor Neuron Diseases (MND)...of which both you mentioned are included.
Fun fact
Bat in Chamorro is "fani'hi"
Fah-knee-hee
That's crazy to hear. Grew up there for 20 years.
Kind of Mercury exponentially growing in fish.
Yikes. Google "Minamata disease."
Explains why Ozzy Osbourne lost his marbles.
Magnetic density and direction ..if we reduce magnetic below weber then people and computer lose most data
Was there any follow up that eliminating bats from the diet reduced the incidence of cognitive impairment? Seems a giant leap from bats and Cyanobacteria to L-serine.
You're looking at my yard
Too bad the full documentary is only available on CNN and MAX.
It's wonderful it's available! Doesn't matter where.
I remember reading about lydigo bodig disease in The Pacific Daily News back in the 1980s. Then the theory was that flour made from the kernel of the fadang palm (cycad) was the cause. So the cycad is still considered the source, but the route of ingestion has been more specifically identified.
Why did he not use pictures instead of words, in his tests on alzheimers patients?
Why are captions not available for this?
Alzheimer’s is not a fun thing to experience
And heartbreaking to watch
@@Muttinchopsforeverstrong it sucks ive seen people go from being a rly talented person drawing amazing art to not being able to pick up a pen
Neither is anything else. 🤷🤷🤷
@executionerofthedeepstate anything beats your zero
To the toxic trolls in the thread - Your futures may be cursed by your own words with neurodegenerative diseases.
Even without the algae, isn't cycad already toxic by itself?
If its a treatment, perhaps you are close to understanding a cure!!🎉🎉 thank you for your dedication, Dr!🎉🎉
I wish that it hadn't been necessary to test on animals. We do have other ways of finding this information. But thank you for showing that if we pay attention to our diet we can find both the causes and the cures of our diseases.
As he said, it wasn't ready to be used by humans yet. Unfortunately, people who have the disease are in no state to be aware of the legalities of being a test project. You can become an organ donor upon death with a preference and a signature; maybe if a person is of sound mind and body they can decide to be part of testing if and when that time comes before it happens. All it would take is a preference and a signature...
What are the current results??
I hope Bruce Willis is in this treatment research treatment.....❤
Cliffhanger. Hope I remember to look up the results next year😂
In the meantime, eat your edamame. They are good.
Dr Gupta, please search more angels like Dr Paul and tell us about them
There are many toxins that can contribute to one getting Alzheimer. The principal creator of some of these Toxins is the Fructose in our diet which has several downstream effects from Obesity, Insulin Resistance, high blood pressure, arteriolosclerosis and Alzh to name a few. The brain itself gets little direct Fructose, but its downstream effect of Insulin Resistance results in neuron mitochondria being full of glucose causing the creation of ROS (Reactive Oxidative Stress) substances. With the excess glucose and use of ATPs Fructose is created in the mitochondria. With a lack of ATPs (the energy of the cell/Neron), essentially starvation, it starts to protect itself in a manner by the creation of amyloid and tau as there are insufficient ATPs to keep the proteins from misfolding. It is very complex, but the main factors, first was the increase consumption of Sugar from sugar cane (1 Glucose + 1 Fructose) and then in 1965 with the development of high Fructose Corn Syrup which is cheaper to manufacture than Sugar. - Now 80% of folk are overweight, 60% higher Uric Acid levels than in blood of a person from 1890, (Uric Acid directly causes higher blood pressure) and the development of Alzh later in life. TH-cam has many videos with Dr. Johnston and Dr. Lustig discussing this topic. Do a search Ford and Fructose or Lustig and Fructose. (Eat an apple, don't drink Apple Juice or Soda.) An average person can eat 10 to 12 grams of Fructose a day which is equivalent to 24 grams of Sugar. Less than a can of coke cola. Beyond that it has a cascading effect on the body's metabolism including increase appetite and the signaling of the body to convert glucose to fat in the liver (similar to the effect of over drinking which causes fatty liver disease).
Not to mention, a regular pop is around 40-45 grams (8-9teaspoons) of hfcs per 12! ounces. Meaning a 20 oz bottle of pop is 13-15 teaspoons of high fructose corn syrup. I'm getting nauseated just thinking about it.
When I would eat at Burger King I always ordered a Large Coke 40oz (they recently downsized) which was larger than the McDonalds large at 32oz. If I only knew how much damage I was doing. Thank goodness for lots of Ice.
The music makes this impossible to listen to, probably good info, but lost in the annoying sounds
CNN should discover closed caption options.
I was actually looking for it coz some parts I can't understand what they're saying without having to raise the volume and realized there's no sub option, not even autogenerated
A
How much L-Serene are the using in the trial dose?
30 grams a day, according to the video
So I should probably not use my fish/turtle pond water to water my vegetable plants?
The body can already produce its own L-serine with the help of vitamin b6 (pyridoxal phosphate). This just demonstrates the necessity for balanced nutrition status.
I believe Vit B6 is also good for PCOS.