I find this presentation very interesting, because I have used an insecticide with pyrethrum just a slight bit in my apartment down a drain. It's well-ventilated, but I seem to fall asleep better (Instead of sleeping pills), and I get less guilt-feeling from self-doubt thoughts. Quite interesting. Edit: This makes so much sense because nicotinic receptor response by this interaction is from smoking, and it is from a plant-extraction.
Could I get some help with this board question? Which of the following occurs when epinephrine is administered intravenously A. Decrease in diastolic pressure. ? B. Decrease in glycogenolysis. C. Increase in arrhythmias. ? D. Increase in muscular contractility
So how does such a small amount of inhibitors have such a widespread effect on the body and not a small and non-noticeable amount? Does it only take a small concentration of the inhibitor at each nerve ending to have a impactful effect? Thx!
Think of drugs in a class having multiple receptor effects rather than being exclusively specific to a the receptor they are named. Many drugs, especially older drugs are simply nonspecific for their class. Diphenhydramine is an example. Its called an antihistamine , but it has effect on ACh and 5HT receptors and others. The antipsychotic agents affect more than just D2 or D4 receptors. We like to think that a specific drug is specific for a receptor, but there is alot of cross activity with the biologically active amine systems. Ergots alkaloids are another example of mixed actions. Hope this helps.
Acetylcholinesterase or cholinesterase is the enzyme that breaks down the neutrotransmitter acetylcholine. So inhibiting that enzyme increases the levels of acetylcholine in the synapse
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omg finally a video on this that is simple and easy to understand thank you
Excellent…well spoken presentation as well
Well said, and easy to understand. Thank you!
I love the pacing and reiterating of important points
Here because of the Navalny poisoning, hope he recovers fully.
I wanna be a pharmacist 😭 but it's so hard to get to the medical school here may Allah help me
I find this presentation very interesting, because I have used an insecticide with pyrethrum just a slight bit in my apartment down a drain. It's well-ventilated, but I seem to fall asleep better (Instead of sleeping pills), and I get less guilt-feeling from self-doubt thoughts. Quite interesting.
Edit: This makes so much sense because nicotinic receptor response by this interaction is from smoking, and it is from a plant-extraction.
Wow sir thoroughly impressed by your method of teaching. Hope to be like you one day :)
I wish my professor made things this easy to understand
amazing. thank you so much
Very good, thank you very much.
What medication is a acetylcholinesterase reuptake agonist ?
What medications are acetylcholine inhibitors ?
does acetylcholine just remain in the cleft? how would action potential be reached again without choline going back into the synapse?
Could I get some help with this board question? Which of the following occurs when epinephrine is administered intravenously A. Decrease in diastolic pressure. ?
B. Decrease in glycogenolysis.
C. Increase in arrhythmias. ?
D. Increase in muscular contractility
Cortez Monagas it definitely increases cardiac contractility
And to make things ridiculously complicated. www.ncbi.nlm.nih.gov/pubmed/24214613/
Thank you
So how does such a small amount of inhibitors have such a widespread effect on the body and not a small and non-noticeable amount? Does it only take a small concentration of the inhibitor at each nerve ending to have a impactful effect? Thx!
The response depends on the potency, efficacy and a host of other factors... Have you already gotten an answer?
very useful thank you :D
Thank you sir
Hi, sorry for another related question but why are so many drugs known as having anticholinergic actions?
Think of drugs in a class having multiple receptor effects rather than being exclusively specific to a the receptor they are named. Many drugs, especially older drugs are simply nonspecific for their class. Diphenhydramine is an example. Its called an antihistamine , but it has effect on ACh and 5HT receptors and others. The antipsychotic agents affect more than just D2 or D4 receptors. We like to think that a specific drug is specific for a receptor, but there is alot of cross activity with the biologically active amine systems. Ergots alkaloids are another example of mixed actions. Hope this helps.
@@PHRM203 Thanks much, that helps a lot...the light bulb came to me that a given molecule can react with more than one other molecule
What is meaning of colenesterase
Acetylcholinesterase or cholinesterase is the enzyme that breaks down the neutrotransmitter acetylcholine. So inhibiting that enzyme increases the levels of acetylcholine in the synapse
@@PHRM203 So acetylcholinesterase and cholinesterase are the same?
@@PHRM203 are there foods that are acetylcholinesterase inhibitor’s?