Another way to remember the effects of anticholinergics is "can't see, can't spit, can't pee, can't shit" (if you don't swear, switch it out for poop, which follows the 1st letter pattern "s-s-p-p")
Awesome mnemonic! Let me add something to that :D : Can't see, can't spit, can't sweat Can't pee, can't shit nor do anything in bed. (lower sweat secretion and erectile dysfunction are also effects of anticholinergics)
First of allas a Med Student, I'll definitely say that you've summed up 2 hours long work into a video of around 14 minutes. It's really helpful. But, I would like mention one thing that Cisatracurium has an elimination half life of around 22 minutes (Intermediate Acting), not ~90 minutes as you've mentioned... And thanks a lot for your great work... 👍🏽
This video is really good! Once I calmed down and got back it emwas way easier ❤️, but How is nicotine used to help ppl quit smoking if it's part of the sigrates smok? And how can it be used as antagonist and agonist in the same time? I don't get it!
Leaving smoking at once can show withdrawl symptoms due to nicotine tolerance. Which makes it difficult to leave smoking. Also, smoking is dangerous primarily because of its effects on lungs due to inhalation. Nicotine patches completes the need for nicotine while smokers work towards quitting. And the dose in patches can also be reduced, gradually. It's very effective during the quitting process.
At lower doses, nicotine stimulates the receptors bcz ofc they are sensitive to nicotine and thus cause release of other neurotransmitters like epinephrine, dopamine etc resulting in increased cholinergic effects but at higher doses, it paralysis the receptors and stimulatory effects cease.
Nondepolarizing agents doesnt "allow for lower doses of general anesthesia" as you indicate around 9:00!!!!!!! These aren't painkillers or sleep medications!!! They make patients cannot move!!!! That doesnt mean that they are well asleep or don't have pain.
"paralysis may permit use of lower doses of general anesthetic agents, which may speed recovery and avoid side effects of these agents" Reference: anesthesiology.pubs.asahq.org/article.aspx?articleid=1945289
Good lectures. You said cisatracurium was superior to atracurium as it is metabolised free from the liver, atracurium is also metabolised by Hoffman degradation
I thought midriasis occured when the pupillary muscles contracted... which is what happens if sympathetic NS is favored over the parasympathetic NS. Isn't the Ciliary muscle for accomodation?
You have told that, unlike atropine scopolamine has loner duration of action ,..... But in books as well as in Google, I have read that scopolamine has short duration of action. Which one is right?
thanks for pointing that out. both drugs have relatively short duration of action, depending on the formulation... when I said scopolamine has longer duration of action, I was thinking about the scopolamine patch... I could have done better job explaining the differences
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YOU have just turned 2 lectures (4 hours) in faculty of pharmacy into 14 min ,GREAT WORK thx
U r right
mechenism of action is not included in thi video..
Explaining an entire medical school pharmacology lecture in less time and so much more clearly! Can't thank you enough!
Bro i just wached a full 2 minute advertisement for you😄😄
Keep doing what you are doing bro,you are fantastic in this!👍
Another way to remember the effects of anticholinergics is "can't see, can't spit, can't pee, can't shit" (if you don't swear, switch it out for poop, which follows the 1st letter pattern "s-s-p-p")
liltenshi39 i love u
liltenshi39 I'm sorry but this is a Christian comment section. Your comment can not contain swear words like 'frick', 'heck' or 'shit'.
Awesome mnemonic! Let me add something to that :D :
Can't see, can't spit, can't sweat
Can't pee, can't shit nor do anything in bed.
(lower sweat secretion and erectile dysfunction are also effects of anticholinergics)
Bullpoop
Thanks.
You're making such light work of what I have to learn in my Clinical Pharmacology course, Great job! Thank you for doing what you do.
loved the Neuromuscular blocker section, so clear, and images very reinforcing! thanks!
Your videos are amazing, short, clear and easy to remember. Thank you for helping us everytime we need a quick reminder to a pharmacology topic.
Dude you just let me understand a lecture of 5 hours in 14 mins.. thank u so muchhhhhh !
First of allas a Med Student, I'll definitely say that you've summed up 2 hours long work into a video of around 14 minutes. It's really helpful.
But, I would like mention one thing that Cisatracurium has an elimination half life of around 22 minutes (Intermediate Acting), not ~90 minutes as you've mentioned...
And thanks a lot for your great work... 👍🏽
Fantastic!! you really made it very simple!!
keep posting your videos, please!
thanks
agree!
Pharmacology the back bone of medication. What a wonderful lecture
I hv been reading this subject for 2 hrs and i got nth while ur 14 mins video explains everyth.
Thank you so much 😁😁
Thank you for all of your wonderful videos. They help put everything together
It’s a great work sir❣️
Keep it up to make pharmacology more easier.
Thank you 😊
Thankyou for making pharmacology this easy. ❤️
Out standing pharma lectures in entire TH-cam channels.....Completely following pharma Tara book
Thank you for this wonderfully crafted video
BEST CHANNEL FOR ALL THE MEDICOS
Your video is light for CNS pharmacology, thanks master
Just confirming that I'm a beneficiary of your videos
Thank yewwww sooooo much .....finally I've searched bestttttt video on this topic after searching for 20 mins on u tube😢😢😢
Every video is a jewel.
Very good video! Love the animations!
Your videos are really helpful,please consider making more of these with a bit of detailing 🥺
You the best lecture , you make things simpler that seems difficult
Thank you very much, very composed and beautifully
summarised, good for revision.
Well done your videos are short and sharp thank you very much
Great efforts at these vids , thank you very much
I have a way better understanding anticholinergic drugs, thanks to you!
An amazing job done here ⭐
You're a life savior ! thank you
deserves immediate subscription...
This video is really good! Once I calmed down and got back it emwas way easier ❤️, but How is nicotine used to help ppl quit smoking if it's part of the sigrates smok? And how can it be used as antagonist and agonist in the same time? I don't get it!
Leaving smoking at once can show withdrawl symptoms due to nicotine tolerance. Which makes it difficult to leave smoking. Also, smoking is dangerous primarily because of its effects on lungs due to inhalation. Nicotine patches completes the need for nicotine while smokers work towards quitting. And the dose in patches can also be reduced, gradually. It's very effective during the quitting process.
And I don't know the answer of your other question. Maybe someone else can answer that for me as well.
At lower doses, nicotine stimulates the receptors bcz ofc they are sensitive to nicotine and thus cause release of other neurotransmitters like epinephrine, dopamine etc resulting in increased cholinergic effects but at higher doses, it paralysis the receptors and stimulatory effects cease.
@@ahmadmunir2215 Gorgeous clarity in your explanation. 🙏
Nondepolarizing agents doesnt "allow for lower doses of general anesthesia" as you indicate around 9:00!!!!!!! These aren't painkillers or sleep medications!!! They make patients cannot move!!!! That doesnt mean that they are well asleep or don't have pain.
"paralysis may permit use of lower doses of general anesthetic agents, which may speed recovery and avoid side effects of these agents" Reference: anesthesiology.pubs.asahq.org/article.aspx?articleid=1945289
One word: Thankyou
I salute u sir u made every topic so easy to learn 😊😊 appreciating 👏👏
Good lectures. You said cisatracurium was superior to atracurium as it is metabolised free from the liver, atracurium is also metabolised by Hoffman degradation
One of the best videos of pharmacology which is very simple, easy to understand. Cheers
Great speed
Can Nn antagonists used against Nm receptors coz both are nicotinic receptors ???????
Can't wait for more video from you. It's so clear and its help! :)
Really helpful..provide more videos please
I used to be on Amitriptyline, I hated the anticholinergic effects from it, which gave me Restless Leg Syndrome, often.
It literally helped me out seriously you made it so simple and especially I loved the abbreviation like always keep up the excellent work ♥️
Amazing simple explanation
Ur all lecture are really very helpful
thnaky You!
please make more videos they are very helpful :)
nicely presented n all topics covered in short😃 Thanks a lott😊
keep making such videos....grtt work👍
congratulations for these explanations. Could you tell me what program you use for your videos?
Holy crap that was awesome thank you!
you make it easy for me, great
presentation long live is my wish .
thanks for the very clear and high yield content
thanks please post a video on anticancer drugs
Very grateful for all your videos🙏.. they r simple to understand n very helpful :)
Amazing explanation
Excellent presentation
Your videos are simply AWESOME 😀👍THANKS
Looks like these lectures are going to be necessary revision material after month-long versions!
Your videos have always helped for clear concepts
Thankful to you
Keep uploading your updates
best pharmacology videos! thank you veryyyy veryy muuchhh
every thing is perfect in your videos.i thanks you a lot the only thing i miss is some words difficult to catch with your accent
Thank you so much sir your videos are very helpful and informative, thank you so much once again!
I find it really hard to understand but good video overall
you nailed it , fantastic.
very helpful video
Thank you for posting this presentation
Thanks a lot for teaching us
Great work 💯
thank you so much, thank you so much, THANK YOU SO MUCH
Loved the Video 🤩🤩😍
Anticholinergics
- atropine
- scopolamine
- iprateopium
- tiotropium
- tolterodine
- darifenacin
- solifenacin
- oxybutynin
- trospium
- fesoterodine
- benztropine
Trihexyphenidyl
Ganglionic blockers:
- Nicotine
Neuromuscular blockers:
Non depolarising: bind AchR but don't induce channel opening
- Curariform drugs (cis-atracurium, pancuronium, rocuronium, vecuronium)
Depolarising: Ach receptor agonists that are résistent to Ach-ase => prolonged depolarisation -> phase 2 block
- succinylcholine
Thank you for what you are doing and god bless you brother
Best channel ever!!!
Amazing ❤️ This made pharma easy for me
12:10 i dont quite understand this part here, if the channels are open and there's a deplorization, wont that make the calcium get released?
Which software you use for making your video ????
it's a very good video. thank you
I thought midriasis occured when the pupillary muscles contracted... which is what happens if sympathetic NS is favored over the parasympathetic NS.
Isn't the Ciliary muscle for accomodation?
Simple and to the point 👍✅
After watching These series I feel like I can discuss without research a book
Thank you so much.
Very impressive 👍🏽
Thank you sir you made my life easy
Excellent 👌 tnq for this ...
Very Nice Presentation
best video out there for anti colinergics!
You have told that, unlike atropine scopolamine has loner duration of action ,..... But in books as well as in Google, I have read that scopolamine has short duration of action.
Which one is right?
thanks for pointing that out. both drugs have relatively short duration of action, depending on the formulation... when I said scopolamine has longer duration of action, I was thinking about the scopolamine patch... I could have done better job explaining the differences
Hello,
Please can you do a video on drugs used for the eye (opticians) and the mechanisms of action.
thank u very much.. it was realy helpful...
Thanku so mch great mentor
why would you give someone scopolamine after they've been sedated with propofol before surgery? It would make urination almost impossible
thank you so much for your efforts i love this
Thank you so much 💜💜
Great work thanks
The lecture is very amazing but i dont get why the persistent depolarizing agents cause flaccid paralysis instead of spastic paralysis.Thank you
Thank you so much
Ur the best bro
Thank you. Great Job.
Good job 👍🏻
Nice videos, and motivate me towards study
Thank you very much best video ever thank you again to help in self study you are awesome sir 🙏🙏🙏