Is This NEW Probiotic a Gut Microbiome Miracle? Akkermansia Muciniphila
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- เผยแพร่เมื่อ 13 มี.ค. 2024
- Have you ever heard about Akkermansia Muciniphila and wondered what it's all about? Some think this new probiotic is a miracle, but is it? Let's look at the probiotic benefits and science behind the Akkermansia probiotic.
We know it’s a commensal bacteria that resides in the human gut, thriving in the mucus layer, but its popularity in the wellness world has many asking: Are the benefits to your microbiome truly substantial?
To answer this question let’s go over some common claims and what the research actually tells us.
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Featured Studies
Akkermansia muciniphila: 18 years after its first discovery www.frontiersin.org/articles/...
Akkermansia muciniphila, a human intestinal mucin-degrading bacterium
pubmed.ncbi.nlm.nih.gov/15388...
Role of Akkermansia in Human Diseases:
pubmed.ncbi.nlm.nih.gov/37111...
Akkermansia muciniphila improves glucose homeostasis
pubmed.ncbi.nlm.nih.gov/33820...
Spatial Characteristics of Colonic Mucosa-Associated Gut Microbiota in Humans
pubmed.ncbi.nlm.nih.gov/34223...
Next-Generation Probiotic in Modulating Human Metabolic Homeostasis and Disease Progression
pubmed.ncbi.nlm.nih.gov/36835...
Gut Bifidobacteria Populations in Human Health and Aging
pubmed.ncbi.nlm.nih.gov/27594...
Akkermansia muciniphila in the Human GI Tract
pubmed.ncbi.nlm.nih.gov/30041...
Intestinal Lactobacillus in health and disease, a driver or just along for the ride?
pubmed.ncbi.nlm.nih.gov/28866...
Akkermansia lower in severe obesity
pubmed.ncbi.nlm.nih.gov/31265...
Impairment of Insulin Secretion and Glucose Homeostasis in Lean Type 2 Diabetes
pubmed.ncbi.nlm.nih.gov/34085...
Akkermansia muciniphila in IBD:
www.ncbi.nlm.nih.gov/pmc/arti...
Mucosa-Associated Microbiota in Patients with IBS
pubmed.ncbi.nlm.nih.gov/33271...
Differences in the Composition of Gut Microbiota between Patients with Parkinson's Disease
pubmed.ncbi.nlm.nih.gov/34884...
Gut microbiome of MS patients
pubmed.ncbi.nlm.nih.gov/36113...
Probiotics fortify intestinal barrier function
pubmed.ncbi.nlm.nih.gov/37168...
Outcome-Specific Efficacy of Different Probiotic Strains and Mixtures in IBS
pubmed.ncbi.nlm.nih.gov/37686...
Clinical effects and gut microbiota changes of using probiotics, prebiotics or synbiotics in IBD
pubmed.ncbi.nlm.nih.gov/33555...
Effects of probiotics on functional constipation
pubmed.ncbi.nlm.nih.gov/32005...
Probiotics for Preventing and Treating SIBO
pubmed.ncbi.nlm.nih.gov/28267...
Probiotics as an effective therapeutic approach in alleviating depression symptoms
pubmed.ncbi.nlm.nih.gov/35348...
Diets that differ in their FODMAP content alter the colonic luminal microenvironment
pubmed.ncbi.nlm.nih.gov/25016...
Prebiotic Effect on Gut With Altered FODMAP Intake in Patients with Crohn's Disease
pubmed.ncbi.nlm.nih.gov/27077...
Efficacy of a low FODMAP diet in IBS
pubmed.ncbi.nlm.nih.gov/34376...
Lipoprotein and Endotoxemia Improvement in Metabolic Syndrome with Gut Microbiota Modification
pubmed.ncbi.nlm.nih.gov/31451...
Regulation of gut microbiome by keto diet
pubmed.ncbi.nlm.nih.gov/36313...
Islamic fasting leads to an increased Akkermansia
pubmed.ncbi.nlm.nih.gov/31854...
Strategies to promote Akkermansia
pubmed.ncbi.nlm.nih.gov/30416...
Adjuvant Probiotics Attenuate Glycemic Levels and Inflammatory Cytokines in Type 1 Diabetes Mellitus
pubmed.ncbi.nlm.nih.gov/35299...
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I've been trying AKKERMANSIA for 40 days. Despite loving the positive metabolism help, my depression is uncomfortable. I will either adjust or stop taking this, expensive, therapeutic.
Please doctor what happens if my test says I’m low in akkermansia muciniphila?
This video is interesting. On the one hand, you laid out a series of very simple facts and studies that seem to refute some of the hype around Akkermansia. On the other hand, many of the interviews I've seen with Colleen Cutcliffe of Pendulum Life gave me the impression that they are very serious researchers who would be aware of all the data you mentioned. And even unaffiliated researchers with no Akkermansia products like Kiran Krishan of Microbiome Labs frequently talk about the importance of Akkermansia in the gut. I would love to see you have either of them on your channel (or someone similar) to discuss these claims in more detail. Any chance you might make this happen?
Deng wish I found this yesterday before ordering 6 month supply of akkremensia supplement. 😢
Always excellent information superb vidios everytime. Your really easy to listen to and understand very much appretiated
I appreciate that!
In an interview with Ari Whitten, Dr Jason Harlak said that supplementing with akkermansia does not move the needle in the microbiome as far as his testing goes. He said eating dragon fruit and cranberries feed akkermansia and do show some improvement. Since dragon fruit is so expensive, I buy dragon fruit extract powder as well as cranberry powder and mix these in water
Apparently also pomegranate and especially skin (!) is a favorite food for Akkermansia. Having cancer, I've also found out that people with it in their gut had some advantage in healing. Possibly from the treatments more than from the cancer itself, but needs more research.
Amazing guy. Gentle and to the truth point.
Thanks a lot.
You're one of the only doctors on TH-cam that I've found who focuses specifically on the microbiome. I'm curious what you think of Dr William Davis and his book Supergut, he talks a bit about Akkermansia in there. Just curious as to your general opinion on the book
William Davis is a quack
I don't know anything about him.
Dr David is awesome and so is his book!
Thank you for such an informative video.
Glad it was helpful!
I would like to see your thoughts about Butyrate and pre butyrate
Butyrate is best endogenously synthesised from gut bacteria which in turn requires polyphenols, prebiotic fiber & integrity of gut lining .
However, if you must take a supplement , have enteric coated butyrare empty stomach, empty bowels although the therapeutic impact will Not be as powerful as endogenous synthesis by gut bacteria.
Polyphenols are essential cofactor for butyrate and they are found mostly in Cherries, all sorts of Berries, Plums, Grapefruit, to a smaller extent in brocolli sprouts etc .
Butyrate being SCFA can cross blood brain barrier and stimulate BDNF - nerve cell regeneration.
good science. i was already subscribed, yet would do so now had i not already been. good science judgement.
Fascinating stuff. My functional med doctor had me do a stool test as I'd been having thyroid issues, gall bladder issues and a Progressive MS diagnosis (no disability as yet though). My akkermansia levels were undetectable and most of my dysbiotic and overgrowth bacteria were elevated.
I should add that I've read a few studies showing that MS patients with higher akkermansia levels had less disability than those with high levels of akkermansia. I'm not adding akkermansia (Pendulum sell it) but am starting a process to improve overall gut health. We'll see on subsequent GI testing if that has an effect on my akkermansia levels.
Excellent explanation 👍
Glad it was helpful!
@17:04 You should make this part into a short/reel/TT, doc! I wish people saw markers like this as a PROXY for overall health, diet, or behaviors, rather than trying to zoom in and micromanage an individual marker. 👏👏
Since Akkermansia is so expensive, I have been trying to pare other things from my budget to purchase a 2nd month supply (of course, the company recommends at least 90 days to see results). I have seen no results from the first 30 days and simply cannot afford this product. Thank you!
I tried for 3 months and saw no difference in gut health or weight loss
@@barbarabeckes5387Thank you. I am underweight, and continue to have gut issues also. I hope you find relief!
Try metabolic daily from pendulum. It has more strains.
@@anon5091 Thank you!
In my personal experience with probiotics and spore probiotics - if it works I see results pretty much right away. And I mean it. Right away. I take a capsule, I may have some turbulence and other symptoms- I know it’s working, in a few days it’s making things better that’s how I know it works. Unless your gut health is so badly destroyed that you need more time but even so you still should feel some sort of shift happening (whether it’s good or bad symptoms wise). If I take something and in a week time I feel nothing - it’s very unlikely that I’m gonna feel any improvement in a month or 2-3. I just gave up wasting my money. I did it so many times and never had any improvement if it didn’t happen within the first week or so. But it’s also essential to remove anything that could be ruining the flora - things like antibiotics and other medications, tap water drinking, even filtered water doesn’t filter out chlorine/fluoride and they affect microbiome a lot. You also need to keep in mind it’s not enough to put some probiotics into your guts, they’re living organisms and need food to eat. If you don’t eat prebiotics every day - you will find it hard to sustain results.
Well done presentation. I truly appreciate your use of data to assess healthy outcomes.
Honestly I am a doctor myself, also been working in a lab on microbiome studies, and I am struggling with a severe disbiosis that doesn't want to go away. I once did a PCR fecal test to "assess" the microbial community that currently lives in my body and Akkermansia levels were extremely high, something tells me that having a high akkermansia load can also be linked with disbiosis.
I don't think we can take much away clinically, from dysbiosis testing.
Try megaspore by microbiome labs, but start with low dosage if your disbiosis is really bad. This is the only product that worked on me and I’ve taken every probiotic under the sun I’ve been on all sorts of gut supplements and probiotic/prebiotics etc for 20 years. Megaspore just balanced everything out less than a week. Then I ate sashimi fish and felt something went wrong down in the pipes. Had loose stools before and that bloody fish brought me back to the same disbiosis problem. So I did vitamin c flash and megaspore after to rebalance. That seems to be the only thing that works for me personally. But now I know raw fish is what’s causing the issue for me, it must have some bacteria that throws my microbes off.
S boulardii literally fixes my gut in a day when ever I get any gut issues/diarrhea. S boulardii is a yeast based probiotic, since it's a yeast I use it to brew my own probiotic beer/cider.
@xmyxymx What is vitamin C flash?
@@worldupsidedown1 it's when you take vitamin c powder (buffered etc)every like 20 minutes until you have a bowels flash. google for proper procedure. but I wouldn't recommend if you already have bad symptoms, you may feel extremely bloated and then have bad diarrhoea or constipation after. but it apparently flashes all bad stuff out. Don't do it without proper practitioner advice, it may be not the right type of thing for you. I did it under my doctors supervision (had testing done and so on). I also follow doctor peter osborne, he also talks about vitamin c detox flash on his channel if you want to learn more.
Hi Dr Ruscio, any timing insights on the the 3 probiotic's, all at once or at different time? Thank you!
All at once for 1-3 months. If constipated up to 3 months then re-evaluate.
Can you tell me the strain info on your soil based probiotics? It's not listed
I think I'll stick with lacto and bifido probiotics for now. They are well researched and seem to be helping me.
In 2022 I randomly discovered that I had 637 IU/mL of Thyroglobulin antibodies (TgAb) and 290 IU/ML of Thyroid peroxidase antibodies (TPO). Since then my TgAb has fluctuated to 576 IU/mL and the latest reading is 787 IU/mL. The thing is that I have absolutely no symptoms whatsoever. As a matter of fact, I feel heathier than ever. I have been reading on TgAb and noticed that they are a marker for thyroid cancer. I am so worried. I have booked a thyroid scan but is there anything else I could do to discard the possibility of cancer please?
Dr R What are your thoughts on Dr. William Davis’s books “ - Wheat Belly “ and “ Super Gut” and Dr Perlmutter’s book “ Grain Brain”?
Dr. Davis is a cardiologist and also has a website where he sells his own products. Red flags right there. I personally follow Justin Sonnenburg. He is a microbiologist and is featured on several youtube videos.
@Dr Ruscio- you are right on spot. I have leaky gut, DM, A1c at 6.5, idiopathic Gastroparesis and post inf Sibo, (neg now). I tried Akkermanasia for diabetes and for gut biome. After trying 3 mos actually my symptoms got so bad. I had GP flare ups and I was miserable. I called them and gave my feedback. My A1c actually went up. Not sure what happened there. But it was a waste of money. The LPS went up. So I wouldn’t recommend. I feel much better from the probiotics you have recommended here. Just my opinion.
6:30 Could it be that event if it’s a lesser constituent, it plays a bigger role in boosting immune system?
Would there be a difference between taking S. Boulardii CNCM I-745 and CNCM I-1079? My goal is to heal leaky gut
What evidence you have about S.Boulardi healing leaky gut ?
should i use this probiotic if i do fodmap for resolve SIBO? or what do you recommend? is antibotic also a good idea or should i first do a fodmap for 4 months and watching how it works
Check out Dr.Davis and Lactobacillus reuteri yoghurt. It helped me 😊
There are plenty of high quality probiotics supplements on the market. Go to high quality and well educated natural health food stores. Pills are best. Not gummies or low dose liquids
Saccharomyces Boulardii was an absolute life saver for me! 🙏
Which brand please?
@@katiegoins5064 it's "NOW" brand from Amazon. $13.
In what way did s boulardi help?
@@katiegoins5064 NOW
@@katiegoins5064 $13 on Amazon
Drs / youtubers generalizing health tips for millions of folks with different unique health conditions, microbiome & genetic constitution is always amusing to observe :-)
much of the hype for akkermansia may be just sophisticated marketing attempting to push sales. Just like many supplements targeting gut issues.
Akkermensia is for a different use case. It is against leaky gut.
Increase Akkermensia not by taking a probiotic (with dead bacteria) but by eating polyphenols such as grape seed extract (for at least 1 month) .
Who is best probiotic for Leaky Gut and SIBO? (wiht interic coted capsule)???
You don't need enteric coated. If you want a personal recommendation i really like the D-Lactate free powder from Custom Probiotics. Its rhe only that calms my system down. I also occasionally do one with acidophilus and l plantarum. Its not a bad idea to try different ones. Make sure you look at other things like pelvic floor dysfunction, histamine intolerance, visceral hypersensitivity, and other sources of IBS.
Hey there. I have a couple of previous videos that cover this so I'll link those here:
th-cam.com/video/CEt0kdT5AOU/w-d-xo.html
th-cam.com/video/Ub7QYqIqvCw/w-d-xo.html
Hope that helps!
I have histamine and yeast intolerance. Probiotics kill me. What do you recommend? Any fiber makes matters worse. I did a boulardi and mixed probiotics in high doses before my histamine went crazy.
vit c, zn, vit d
Vit C, rutin, copper, methylation (b6/b9/b12), glycine, vit A, histamine degrading probiotics .
@@sgtanejacan’t tolerate any of that. I now have MCAS.
@OZMAZZ12 Mast cells release histamine when mobilized. You need to regulate your histamine. DAO is critical , DAO depends on copper. Stop having fermented foods or any OTC lactic acid bacteria probiotics.
Dr Li said high levels resulted in better immunotherapy outcomes.
Been eating salads and lots of fruits daily for years and exercising and still have low akkermansia
Try pomegranate or cranapple juice as either can cultivate this bacteria over time.
@@OfficeSpaceRedStapler been drinking pomegranate and cranberry juice every morning for years
@@darylfortney8081 Sorry your levels are still low. There may be others reasons for the low levels. Have you researched your condition?
Just trying to fact check some of your assertions and so far, with regard to a. muciniphila not being the only microbe with it special gut barrier muscosa restorative and regenerative properties, I don't see that the other microbes that do reside within that domain (in the mucin layer) have anything comparable to the qualities of a. muciniphila
Yes, other gut microbes reside within the mucin layer of the gut mucosa alongside Akkermansia muciniphila. However, research on microbes that can replicate A. muciniphila's ability to consume old mucin cells and stimulate new mucin production is still ongoing.
Here are some examples of gut microbes residing within the mucin layer:
Blautia: These are a group of butyrate-producing bacteria that play a role in intestinal homeostasis and inflammation [1].
Faecalibacterium prausnitzii: This bacterium has been shown to reduce gut inflammation and is associated with a healthy gut microbiome [2].
While these microbes contribute to gut health, their functionalities may differ from Akkermansia muciniphila's specific ability to regenerate the mucus layer.
Scientists are actively looking for other microbes with similar capabilities to A. muciniphila. Understanding these microbes could lead to the development of probiotics or other treatments to improve gut health and barrier function.
Do you have conflicting info regarding this?
9:30 The sample sizes are significantly different in the researches. I’m not a medical scientist but I have experience in running tests on websites. Having dozens of visitors would be way too small a sample to draw conclusions. Anything could happen when the sample size grows… 🧐 Intuitively, it doesn’t feel right to juxtapose those clinical trials results. 🤔
💖❤️🙏❤️💖
Do you think it’s possibly dangerous?
👍
This may gross a lot of people out, but fecal transplants are the most amazing way to fix the gut biome and you can do it so easily at home.
No, you cannot do it easily at home. The feces has to be tested for so many diseases before it is transplanted
How would you go about doing that?
Also regarding the other MAAM species seem not to have been shown to have the same mechanisms and capabilities that a. muciniphila demonstrates:
The research currently suggests Akkermansia muciniphila might be unique among the other gut microbiota you mentioned which also live within the mucin layer in its combined ability to utilize degraded mucin and stimulate new mucin production. However, the field is still evolving, and other microbes with similar functions might be discovered.
Here's a breakdown of the evidence:
Mucin utilization: A. muciniphila possesses specific enzymes that break down complex sugars found in mucin (mucinolytic activity) [1]. This ability is less documented in the other gut mucosa-associated microbes you listed.
Mucin production stimulation: Studies have shown A. muciniphila can stimulate the production of mucins by intestinal epithelial cells [2]. This combined effect of utilizing old mucin and promoting new mucin production is less documented for other bacteria.
However, some nuances exist:
Mucin utilization by others: Some gut bacteria like Bacteroides might utilize mucin, but their specific role might differ from A. muciniphila [3].
Mucin layer enhancement by others: Certain gut microbes like Faecalibacterium prausnitzii contribute to gut barrier function, but the mechanism might not directly involve mucin stimulation [4].
Here's the key takeaway:
While other microbes play a role in gut health and barrier function, current research suggests A. muciniphila might be unique in its combined ability to:
Utilize degraded mucin.
Stimulate new mucin production.
This combination directly translates to enhanced structural and functional integrity of the mucin layer and potentially reduced gut permeability.
Still a lot more researching to be done, but so far, it seems that there is, nonetheless, fairly adequate reason to believe that a. muciniphila is a worthwhile supplement to take - especially in those individuals who may be lacking/deficient in gut microbiota diversity.
It's more of a marketing gimmick , many testimonies of folks having tried these expensive supp & not benefited.
If you want to improve integrity of gut lining & intestinal gut barrier func.....try free form amino acids esp EAA's (essential aminos), glutamine, glycine cysteine, vit B6, vit B12, essential trace minerals like zinc & manganese, and soil based probitics esp B.coaglans & B.subtilis...
And eat right !..less refined carbs & sugars...., more lean proteins & healthy fats.
Sorry. I meant MAM - not MAAM
can you please summarize the video. should we take akkermansia muciniphila or not?
quick take away.. get a dog
😊 Also - find out what good stuff is low or missing in the gut, find out what these like to eat, and help them join the crew for a balanced "good guys" microbiome.