Acute Fatty Liver of Pregnancy | aqorn learning | @rahat2021
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- เผยแพร่เมื่อ 5 มิ.ย. 2024
- @rahat2021
Acute Fatty Liver of Pregnancy (AFLP)
Overview
• Etiology: AFLP is a rare but serious liver disorder that typically occurs in the third trimester of pregnancy. It is believed to be related to a defect in the mitochondrial beta-oxidation of fatty acids, often associated with a deficiency in the enzyme long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD).
• Incidence: AFLP affects approximately 1 in 7,000 to 1 in 20,000 pregnancies.
Clinical Presentation
• Symptoms: Nausea, vomiting, abdominal pain, jaundice, malaise, headache, and confusion. Symptoms can progress rapidly.
• Signs: Jaundice, hepatomegaly, ascites, encephalopathy, coagulopathy, hypoglycemia, renal dysfunction.
• Diagnosis: Elevated liver enzymes (AST, ALT), elevated bilirubin, prolonged prothrombin time (PT), hypoglycemia, elevated ammonia, and leukocytosis. Imaging and liver biopsy may show microvesicular steatosis.
Management
• Immediate Delivery: Prompt delivery of the baby, regardless of gestational age, is the definitive treatment.
• Supportive Care: Intensive monitoring and supportive care, including management of coagulopathy, hypoglycemia, and renal dysfunction.
• Prognosis: With early recognition and prompt delivery, maternal and fetal outcomes can be significantly improved. However, it can be fatal if not promptly treated.
• Playlist
TH-cam channel
/ @rahatq2021
Hi, This TH-cam channel has been created to help postgraduate trainees in Obstetrics and Gynecology learn and develop clinical skills for history taking, communication, counselling, quality assurance, critical reading of the literature.
Very informative. Rare but lethal complication. All trainees must know about it.
❤very nice presentation short and comprehensive
Thanks. Please send names of topics for more videos