Antibiotics: Protein Synthesis Inhibitors: Part 3
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- เผยแพร่เมื่อ 27 เม.ย. 2024
- Watch the Updated Lecture on ABX: • Antibiotics
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Ninja Nerds!
In this lecture Professor Zach Murphy will be teaching you about antibiotics! During part 3 of this series, we will be talking about how antibiotics are targeting protein synthesis. We hope you enjoy this lecture and be sure to support us below!
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#ninjanerd #Antibiotics #Microbiology
****Correction***** at 11:08 I said Lyme's disease is caused by the Borrelia Burgdorferi protein, this is true! However; Borrelia Burgdorferi is actually a bacteria that expresses protein antigens which cause the disease. Sorry for that mistake ninja nerds!
At 5:48 you said Clarithromycin is better for Gram-negative, however, it is actually more effective against Gram-positive bacteria. The best macrolide for Gram-negative bacteria is Azitrhomycin. Nonetheless, great video! Keep it going!
Aminoglycosides are for 30s subunit I think ninja nerd can you cheak again
Akhil Sagar yes it is
If I may , Aminoglycosides act on P site of 30s subunit is what I've learned . Although I don't know who's correct . Can you please recheck
Also at 7:15 aminoglycosides target 30s not 50 s subunit
BTW Aminoglycosides binds to 30S subunt
+Zade Batarseh Dang it!! You are so right I'm sorry about that. Yes as you said aminoglycosides inhibit the the 30s ribosomal subunit by inhibiting tRNA from attaching with the complementary mRNA codons. I'm sorry again for that mistake. I will put that in the information box.
Thanks
Zade Batarseh thanks i also noticed that
That’s what I I thought too. My professor got sarcastic when I said 50s WTH!!! I love your videos still 🤣
You got me in trouble 😝
You are an excellent teacher, thank you for giving some of us the opportunity to understand something that is so difficult. Having one suggestion if you could make another video without that small mistake and replace it with this, would save you from some bad negative comments. I say this because you are a great teacher. Thank you.
You're a good explainer you're making everything easy
All videos are great and I really appreciate your hard work. Please add more items like side effects pharmacokinetics kind of stuffs to make it better.
To be very honest..u teach the best pharmacology out of all the subjects that u teach...
Thank you for making this more understandable than my books do!!!
I ll never bored to say this. Im so fall in love with ur geniusity
Hello nija nerd thank you so much you have simplified my life. But a correction aminoglycosides according to some text books they target 30s subunit
Aminoglycoside except streptomycin acts on 30s as well as 50s and also at the 30s-50s interface..
Dunno why but I like the sound when he squeezes open his Marker pens :)
LoL same here
Replay that part again and again:3
I had an oral exam today ,the case was UTI and the pharmacology questions were the easiest for me because of your antibiotics series so THANK YOU!
You're simply the best
Thanks Prof God bless you
This is awesome
Please make a video on protein sorting
Thank you
warm regards
Best #antibiotic explanation
Amazing thank you
Good information about medicine
Very nice video as always, i hope this channel gets more likes, and subscribes. 🤩🤩🤩
You are good teacher .thanks sr
thanks
very good
Thanks so much for your effort , my question is Aminoglycosid affects 30 s or 50 s subunit?
Aminoglycosides affects the 30s.
30 s , he just told the tetracycline mechanism
At 7:18 aminoglycosides are 30s ribosome inhibitors right ,??? But y sir its 50 s in this ???
U right man.
Doxy is also heavily used as a Malaria prophylaxis drug. If memory serves, it is not good at treating Malaria once you have it but it is good at preventing you from getting it.
hey i just wanted to inform you that the consecutive 3 videos starting with this (pharmacology playlist) don't have the speed regulating option. please fix it. thanks❤️
Instead of explaining the mechanism of aminoglycoside you explained the mechanism of tetracyclines, I mean that just change the word aminoglycoside to tetracyclines, it would be correct!
Thanks so much for your great lectures!
i thought the same
GPC also said the same bro
Aminoglycosides binds to 30 or 50? Most text book said 30, but you mentioned 50. Little confused
30s
great
Tnku🥰
Does tetracycline bind to 30s wubunit and inhibit juwt like tetracycline? I don't understand the difference
Ты очень крутой чувак. Спасибо за твои видео
You said the macrolides are bacteriostatic, because they inhibit the movement of the ribosome along the RNA. The aminoglycosides are bacteriocidal because they prevent the mRNA from binding to the A site. But tetracycline and doxycycline are bacteriostaticm even though they perform the same function as the aminoglycosides?
Aminoglycosides irreversible block the site but tetracycline doesn't..
good
Can you please do a video on immunity
Does this mean it inhibits human protein synthesis also? As in skeletal muscles.
my textbook also said that aminoglycoside bind to 30s
Im confused, its aminoglycoside that bind in the a site or its tetracycline?
Both aminoglycosides and tetracyclines bind to 30s unit of the ribosome
Do protein synthesis affected by ultraviolet light or by dim light, dopamine is maximized by meat and light as pleasure neurotransmitter so the other way is the opposite, you know activate and inhibit like hormones, like neurotransmitter, ultraviolet light naturally from sun had been touched by soft positive energy and it's opposite is the electron powered fast light, which is which that treats specifically since both can be a treatment at the same time a negative effect depends on disease factor either stimulatory or depressive, does treating the negative bacteria in the Gastrointestinal tract with good bacteria is enough or protein needs to be balanced in the body or decreased according to neuro affectation, to what extent does genetic mutation that cause autoimmune diseases affect the synthesis and various receptors in the body and at the molecular level, does the bonds as predictive as it is or there are deviations from the normal or let us say, what we knew previously.
aminoglycosides bind to 30s ribosomal subunit.
Amino glycosides is 30s not 50s , thanks for the video
Peritonitis. Abx and blood brain barrier issues. ?
Aminogly side bind to 30 s
For all that you do for mankind, you ought to be more famous...you should be offered an award or something...
... no no no sir , aminoglycoside doesnt block 50s but it inhibits 30s and the mechenism of action u r saying about it isnt correct ... you are daying the mevhenism of action of tetracycline ... tetracycline inhibits Trna .... aminoglycosides blocks initiation process
Why are the macrolides bacteriostatic and the aminoglycosides/tetracydine bacterisidal? I dont understand why the macrolides wouldn't be deadly..
Tetracycline & macrolides are static..tetracycline concentration dependant cidal...while aminoglycosides are cidal
Bcz macrolids block protein synthesis Reversibly.. While aminoglycosides ( gentamicin) block protein synthesis irreversibly.. That's why AminoG... deadly and marco not 🥲
@@hamzamohsin3906 thanks
So everyone is saying abt aminoglycosides being 30s inhibitors
But I read in a text that only streptomycin is 30s inhibitors all other aminoglycosides bind to 50 s subunit as well as to 30 s- 50 s interface
Streptomycin is a type of aminoglycosides
06:30 aminoglycosides
Why can't sulfamethoxazole be given with amoxicillin?
Amoxicillin is bacteriocidal and sulfamethoxazole is bacteriostatic. So,When a cidal and static are given with each other they give a controversial effect and mostly antagonistic.
sir aminoglycosides binds to 30s
The antibiotic that irreversibly inhibits bacterial protein synthesis and whose adverse effects may include ototoxicity and nephrotoxicity is:
..ans... clindamycin...But how
Ans is gentamicin...not Clindamycin
Bcz gentamicin has higher concentration in ( phosphatidynl inositol diphosphate ) Phosphlipids.
[And phospholipid is type of complex lipid which have Glycerol +fatty acid+phosphate + alchol ]
And this type of lipids are greatly found in ear and kidney
Good video however Aminoglycosides inhibit the 30s ribosome
Amino gylcosides act on 30 s ribhosomal subunit .u said it acts on 50 s ???
HOW CAN AMINOGLYCOSIDES TREAT MENINGITIS WHEN THEY CAN NOT CROSS THE BBB?
Aminoglycosides cross BBB when there's inflammation of meningeal layer.. same as pencillin cross...
In normal conditions when there's no inflammation , aminoglycosides , pencillins can't cross BBB...
Awesome explination but you gotta do a do over! please too many error in this video
Amingoglycoside is in the 30's
Tetracycline is also in the 30's
and you swap them in the explanation
bummer! such a good video
regardless love your other videos! you are amazing just do a do over please
aminoglycosides bind to 30s not 50s
Yea ur MOA for aminoglycosides is very wrong as said their activity is on the 30s ribosome but their role is Aminoglycosides cause incorporation of incorrect amino acids into the peptide chain due to misreading of mRNA. Ur MOA u described about binding to the A site is for tetracyclines. Other effects:
- AG binding to the 30S ribosome also interferes with the initiation complex of peptide formation and block further translation,
- AGs cause premature termination of protein synthesis,
- AGs cause the breakup of polysomes into nonfunctional monosomes.
Where are Tetracyclines and Chloramphenicol
tetracycline blocks A site so that amino acyl trna cant bind
+saddam hussain yes that's correct.
Hi
ninja nerd bile güzel anlatamamış... böyle ders olmaz olsun
You say the macrolides treat gonnorhea its not true, gonnorhea is treated by 3rd gen cephalosporin like ceftriaxone. You use macrolides for the chlamydia portion only man
Ariel Terrani Macrolides do have activity against Ng and azithromycin is recommended (in combination) in large part to protect against resistance development to ceftriaxone. Also, for patients with a severe allergy to cephalosporins, CDC recommends a single 2 gram dose of azithromycin orally.
I said aminoglycosides are 50 s inhibitors and failed as I said that 🥵
Not good explain
You didnt even cover all the classea of antibiotics that inhibit protein synthesis. You only talked about 3....dissapointing
m seRs appreciate his efforts first...
good