How do mutations in genes responsible for homologous recombination, such as BRCA1 and BRCA2, contribute to cancer susceptibility? What molecular mechanisms differentiate the accuracy of homologous recombination (HR) from non-homologous end joining (NHEJ) in repairing double-strand DNA breaks? How do reactive oxygen species (ROS) generated during cellular metabolism specifically influence the efficacy of base excision repair (BER) pathways?
How do mutations in genes responsible for homologous recombination, such as BRCA1 and BRCA2, contribute to cancer susceptibility?
What molecular mechanisms differentiate the accuracy of homologous recombination (HR) from non-homologous end joining (NHEJ) in repairing double-strand DNA breaks?
How do reactive oxygen species (ROS) generated during cellular metabolism specifically influence the efficacy of base excision repair (BER) pathways?