Enhancing Solubility Using Lipid-Based Formulation Technology

September 26, 2013
Lipid-based formulations (LBF) have become a well-established strategy to improve bioavailability and reduce food effect or variability of poorly soluble compounds. Although awareness of LBF technologies is widespread, systematic science-based formulation approaches are not common. Capsugel's Dosage Form Solutions' team discuss the variety of LBF possibilities, from solution or dispersions to SEDDS/SMEDDS and the key physicochemical and biological characteristics to be considered with the LBF approach. Case studies will demonstrate the technologies’ range of application and the resultant solubility improvement achieved.