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The Infamous Drug Trial That Shocked Britain | Real Stories Full-Length Medical Documentary

  • เผยแพร่เมื่อ 10 เม.ย. 2018
  • On Monday 13 March 2006, eight healthy young men took part in a clinical trial of an experimental drug known as TGN1412. The drug was intended to treat leukaemia and had already been successfully tested on monkeys but never on humans.
    It should have been a routine clinical trial but it soon spiralled into one of the most infamous medical emergencies in recent British history.
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ความคิดเห็น • 21K

  • @adamdadds4566
    @adamdadds4566 4 ปีที่แล้ว +8218

    Patient “am I going to die?”
    Doctor “the real question is am I going to prison?”

    • @obelisk5358
      @obelisk5358 4 ปีที่แล้ว +469

      @Kimber 10MM wtf are you talking about

    • @itz_bk
      @itz_bk 4 ปีที่แล้ว +158

      @Kimber 10MM don't you understand it's just a joke , if you don't understand, Okey let me tell you it's a human thing & you need to settle up in a zoo

    • @diallogazali7538
      @diallogazali7538 4 ปีที่แล้ว +19

      That’s funny

    • @johnimusic12
      @johnimusic12 4 ปีที่แล้ว +9


    • @0906blue
      @0906blue 4 ปีที่แล้ว +62

      It's an experimental drug, he volunteered.

  • @matt391
    @matt391 4 ปีที่แล้ว +3428

    Everyone else:
    *screaming in pain*
    That one dude:
    *mom come pick me up im scared*

    • @tonypasma1707
      @tonypasma1707 4 ปีที่แล้ว +3


    • @duck3819
      @duck3819 4 ปีที่แล้ว +22

      That guy would be me

    • @MsT-xm8xz
      @MsT-xm8xz 4 ปีที่แล้ว +1

      @Saint Beelzebub 😭😭😭

    • @whipchick90
      @whipchick90 4 ปีที่แล้ว +2

      「 Cinderblock 」 😂

    • @michaelsmith7328
      @michaelsmith7328 4 ปีที่แล้ว +1


  • @burns1921
    @burns1921 ปีที่แล้ว +2143

    I have been receiving a type of monoclonal antibody infusion every 4 weeks for the last 10 years to treat an autoimmune disease. This medication saved my life and allows me to continue surviving. The people who are willing to submit themselves to clinical trials like this are part of the reason I’m still alive, and I have so much respect for them.

    • @loveisreal7766
      @loveisreal7766 9 หลายเดือนก่อน +19

      True but 😅😅😅😅

    • @sondragraf7609
      @sondragraf7609 9 หลายเดือนก่อน +35

      My son has a number of symptoms that are autoimmune in nature rendering him at 35 unable to work and using a cane but some days unable to leave the bed. He has been given possible bur never firm diagnosis for everything from MS to Parkinsons to Meneirs to heavy metal intoxication as he shows signs of all. One of the neurologists who seemed most hopeful finding neuropathy and all the signs of his own immune system attacking his digestive and nervous systoms suggested a drug to him which was described as a chemo drug originally for cancer patients but has shown to aid patients such as he. God i wish we coyld speak to you to somehow find out if you have a similar set of issues. If so much comfort it would be while making this very important and heart wrenching decision

    • @StrangerInMorocco2023
      @StrangerInMorocco2023 9 หลายเดือนก่อน +28

      I also have an autoimmune disease. I am taking Telfast and Montelukast daily. If I stop, my throat gets tight and itches all over the body. I live with misery and doctors couldn't help me.

    • @lady4191
      @lady4191 9 หลายเดือนก่อน +6

      There probably not so happy

    • @yuliaschannel6288
      @yuliaschannel6288 9 หลายเดือนก่อน +29

      Maybe try prolonged water only fast around 10 days? Prolonged fast is the only thing that treats and cure autoimmune diseases. And then carnivore diet.

  • @india1422
    @india1422 3 หลายเดือนก่อน +112

    I'm being treated for ovarian cancer. I cannot express my gratitude to the people who have risked their life to try to save mine

  • @jojoshaw5349
    @jojoshaw5349 4 ปีที่แล้ว +2936

    me: oh man my knees hurt again
    *watches documentary *
    never mind i’m good

  • @intothemystic5223
    @intothemystic5223 4 ปีที่แล้ว +2992

    I've got to stop reading comments while watching documentaries. The amount of times I have to rewind is absurd.

    • @ethank5681
      @ethank5681 4 ปีที่แล้ว +29

      into the mystic comment section is better than the vid

    • @overthehedge7591
      @overthehedge7591 4 ปีที่แล้ว +6

      @@ethank5681 there would be no comments without the video

    • @EdderzX1
      @EdderzX1 4 ปีที่แล้ว +8

      Keep doing the same lmao

    • @reggie6871
      @reggie6871 4 ปีที่แล้ว +14

      thanks for the reminder, i wouldve gone 10 minutes deeper without this comment

    • @AdriCr4ft
      @AdriCr4ft 4 ปีที่แล้ว +3

      I was thinking the same... lol

  • @Stiasteny
    @Stiasteny 10 หลายเดือนก่อน +861

    It is glanced over so quickly that Ryan lost his finger tips and got a part of his toes and foot amputated. Wow my heart goes out for him ♥️.

    • @JoyfulNerd400
      @JoyfulNerd400 8 หลายเดือนก่อน +56

      Considering he has sadly passed, I think this was the least of his problems. This entire trial was absolutely horrifically botched, whether by accident, on purpose, the medication simply didn’t work or otherwise

    • @BlackKiryuu
      @BlackKiryuu 8 หลายเดือนก่อน +29

      @@JoyfulNerd400 He died??!!
      When? As a result of this trial?

    • @JoyfulNerd400
      @JoyfulNerd400 8 หลายเดือนก่อน +58

      @@BlackKiryuu he did end up passing away, yeah. His organs failed and as far as I’m aware his treatment failed in the end

    • @BlackKiryuu
      @BlackKiryuu 8 หลายเดือนก่อน +33

      @@JoyfulNerd400 Oh my God. I feel soo sorry for him!
      Did his family get any help after his death? Like compensation for damage and what not?

    • @andrewbordeaux1344
      @andrewbordeaux1344 8 หลายเดือนก่อน

      @@JoyfulNerd400 Bullshit. A fast Google search leads to a Facebook post from January 2021 saying that Ryan "recently graduated with a First in BSc Economic & Social Policy", and from there one can find a "Birkbeck Events Blog" that states that in 2012 he had a son, in 2016 he started his part-time BSc Economic and Social Policy degree, and that in November (2020) he graduated, winning the prize for the best final year Economics and Social Policy student. Also, judging by you saying "the medication simply didn’t work" and "his treatment failed in the end", you don't even understand what a drug trial is (none of the volunteers needed the drug!). Please avoid saying ignorant and stupid things, everyone reading your comments could end being dumber as a result.

  • @karenbarnes852
    @karenbarnes852 ปีที่แล้ว +969

    I found this a very interesting article. My granddaughter had a rare cancer at the age of 2 and ALL of her treatment was through international clinical trials. Part of her treatment was immunotherapy, where one of the risks was a cytokine storm because of the use of monoclonal antibodies. After nearly four years of treatment she is now five years in remission. The harsh treatments she had have left her with a variety of health problems, but she is a happy 10 year old now and very precious to our family. Whilst she has contributed to many clinical trials through her treatments, we are indebted to the children who have gone before her and may have since died of the illness or the treatment. Anyone who contributes to the advance of medicine through participating in clinical trials (of whatever stage) is making a massive contribution to the rest of humanity.

    • @pamsam8933
      @pamsam8933 ปีที่แล้ว +29

      Amen. I agree. And with any trials, all precautions should be taken, and there should ALWAYS be an ESTABLISHED anecdotal plan in case of known, and especially unknown, side affects.

    • @jandoel
      @jandoel ปีที่แล้ว +5

      The posh doctor interviews between creepypasta-like reenactment scenes is such a mood

    • @sanderson2
      @sanderson2 ปีที่แล้ว

      @@pamsam8933 I I IC think ⁹I 99

    • @rylandavis2976
      @rylandavis2976 ปีที่แล้ว

      @@pamsam8933 the problem is that you can't know the side effects to 100% certainty in advance. You can inject them into mice and monkeys and test on human cells and determine it "might" be safe. When you are the one taking a drug that no human has taken before, nobody can predict with certainty what is going to happen, it's a big risk and they should (and almost always do) tell you that it is a risk.

    • @Tyler11821
      @Tyler11821 11 หลายเดือนก่อน +7

      The reason things like this are big stories is because of how rare events like this are. The vast, vast majority of first for human clinical trials have the worst problem of people withdrawing due to side effects. This occurs in both the cohort getting the drug and the cohort getting placebo. Multiple fatalities in a single trial is so unusual as to lead to videos like this. The risk is higher in rare illness, where there just fundamentally isn't as much data in. Even then, like in this case, actual death is exceptionally rare.

  • @kaylajohns1020
    @kaylajohns1020 5 ปีที่แล้ว +11889

    I can’t imagine being the person who received the fake medicine, and having to sit there, listening to all this wondering if you are next.

    • @scoobty4449
      @scoobty4449 5 ปีที่แล้ว +132

      Wait I don't get this where do they say that they were given the fake drug?

    • @kaylajohns1020
      @kaylajohns1020 5 ปีที่แล้ว +647

      two people recieve something completely else while the others recieve the drugs. But no one knows who got what but the doctor/nurse. i believe its explained in the beginning of the video.

    • @baljeep_gay
      @baljeep_gay 5 ปีที่แล้ว +436

      neither the docs nor the nurses knew, only the one who packaged them.

    • @neontv15
      @neontv15 5 ปีที่แล้ว +77

      at 8:03

    • @kaylajohns1020
      @kaylajohns1020 5 ปีที่แล้ว +18

      ah thats right, thanks.

  • @mb4692
    @mb4692 5 ปีที่แล้ว +3825

    I still remember how my 6th year biology teacher warned us to never volunteer to be a guinea pig. Thank you sir.

    • @Olivia-W
      @Olivia-W 5 ปีที่แล้ว +127

      See, I'm thankful I study chemistry, not biology or medicine. I can watch them do trials from another building, thanks.

    • @yudelleanlisatajirikenyana4519
      @yudelleanlisatajirikenyana4519 5 ปีที่แล้ว +29

      Honey Bee 😂😂😂 that's a great teacher

    • @jasonsage1417
      @jasonsage1417 5 ปีที่แล้ว +65

      I had a science teacher start our origins, universe life etc with: don’t believe everything they tell you, remember many think a supreme being, god, caused creation, others do not... in any case we don’t know how or why the universe came into being let alone having physics perfect for star formation, nuclear reactions, time, matter, all of it. That said... shall we begin.... first there was nothing, then there was a universe... any questions? Right... ok.. and we opened our books to chapter one. The Big Bang. Haha and the lesson commenced. I thought he was clever and wise and he was a great teacher. He also gave us real experiments, not cheesy ones. More dangerous chemicals and dissection, less baking soda and vinegar. Haha... break out the scalpels and Bunson burners baby.. whoops. Bang. Teacher my test tube is no more! You ok? Yeah. Had your eye wear on? Yeah. Ok... do it again but this time don’t skip step three in the directions... sorry Mr. Moss. Haha he was cool.

    • @renees1021
      @renees1021 5 ปีที่แล้ว +64

      The FDA also recommends not being the first to take new drugs; I'd suspect only people desperate for money (poor/poverty) would/will volunteer.

    • @darianbarber3763
      @darianbarber3763 5 ปีที่แล้ว +31

      @@renees1021 I don't think they normally end this badly due to prior testing on animals but yea this is also a very plausible outcome.

  • @graceaxisa4213
    @graceaxisa4213 ปีที่แล้ว +520

    Totally irrelevant, but the dramatization of this event was first class. As a cancer survivor, I am so grateful to anyone who participates in trials. Including the medical staff who take part. I am sorry that these men went through this horrific experience and I am grateful that, despite the dire consequences, new protocols relating to trials have been adopted. Seeing David with his young family was a huge relief ❤️

    • @sylviaking8866
      @sylviaking8866 ปีที่แล้ว +19

      My twin sister nearly died from Covid. The dramatization in this show is similar to what she went through. People next to her who did not make it were wheeled away. She said it was the worst experience of her life. Thank God she survived.

    • @graceaxisa4213
      @graceaxisa4213 ปีที่แล้ว +9

      @@sylviaking8866 oh my goodness, how traumatic for her. I hope she is fully recovered now.

    • @billyballsup2685
      @billyballsup2685 8 หลายเดือนก่อน

      There's not enough money to be made giving you a cancer wonder drug. Probably been around hidden for years. Pharmaceutical is a business. It's all about money not your good health.

  • @TheMutantCreeper
    @TheMutantCreeper ปีที่แล้ว +259

    I wish we could have had Ryan in the interview. I completely understand that he wouldn’t want to since he went through so much. I just wish we could understand what his life was afterwards.

    • @Monkey-fc9nc
      @Monkey-fc9nc 9 หลายเดือนก่อน +32

      He probably can't due to settling litigation out of court.

    • @kirin1230
      @kirin1230 8 หลายเดือนก่อน +16

      I wouldn't want my life broadcasted online either... but I wish him the best

    • @tshs1663
      @tshs1663 8 หลายเดือนก่อน +5

      ryan died actually

    • @Patricksbenzowithdrawal
      @Patricksbenzowithdrawal 7 หลายเดือนก่อน

      @@tshs1663 according to who?? Simple google search says absolutely nothing about him dying. He nearly died during his 4 months in hospital but he is very much alive after this horrific experience

    • @Mangafan47
      @Mangafan47 7 หลายเดือนก่อน +8

      @@tshs1663 source? I googled it, but couldn't find anything regarding him dying.

  • @amtf7251
    @amtf7251 5 ปีที่แล้ว +1579

    Everybody’s screaming in pain and the other dude’s just sitting there

    • @michellemuskeyn329
      @michellemuskeyn329 4 ปีที่แล้ว +39

      He’s soooo lucky 🍀!

    • @lorenzolatino7023
      @lorenzolatino7023 4 ปีที่แล้ว +5

      @@Timeless80 Haha, I was about to say that.

    • @dangerousbuterax6891
      @dangerousbuterax6891 4 ปีที่แล้ว +51

      i would’ve hated to be him. imagine everyone around you screaming in pain... terrifying

    • @LF-lv4ov
      @LF-lv4ov 4 ปีที่แล้ว +80

      @@dangerousbuterax6891 i'd rather be him than the ones that actually took the drug

    • @mlim6927
      @mlim6927 4 ปีที่แล้ว +9

      @@LF-lv4ov same he's lucky

  • @AppleYou
    @AppleYou 4 ปีที่แล้ว +1481

    Part 1: company brings patients to trial. Part 2: patients bring company to trial.

  • @kellymurphy6667
    @kellymurphy6667 ปีที่แล้ว +436

    This is astounding. I'm 24 years in remission from Leukaemia and two years of gruelling chemotherapy treatment I endured from 16 - 18. I imagine at some point each one of the toxins in the specific chemo cocktail I received were one trialled by participants equally as brave as these hero's. And I can say I wouldn't have envied what they put themselves through in doing so either! But I'm beyond grateful they did! Even given the long term ramifications I'll be dealing with from here on in, I wouldn't forsake that for the experience I had knowing what it is to be in love and the pure joy I eventually experienced in giving birth to two gorgeous and extremely precious daughters.

    • @tiredanddepressed
      @tiredanddepressed 10 หลายเดือนก่อน

      It's crazy when you think about the fact that healthy people took chemotherapy drugs first to see if it was safe. Knowingly taking the equivalent of a bomb going off in your system since it'll destroy everything in sight is wild

    • @lissakaye610
      @lissakaye610 8 หลายเดือนก่อน +10

      Success stories like you are exactly why I work in research. Every single cancer therapy and Alzheimer’s drug trial I hope not so see any observations or toxicity. It is always very sad when something doesn’t work as intended.

    • @PhoenIXPhantasies
      @PhoenIXPhantasies 7 หลายเดือนก่อน

      Not brave but stupid. Usually people in need of money.
      Your life is worth so much more than money!

    • @nickidaisydandelion4044
      @nickidaisydandelion4044 4 หลายเดือนก่อน

      No to pharma.

    • @MiVidaBellisima
      @MiVidaBellisima 3 หลายเดือนก่อน +1

      Congrats to you, and I hope you live to see 103 😊

  • @evelynenders3144
    @evelynenders3144 2 หลายเดือนก่อน +9

    'It had been successfully tested on monkeys'... Those poor animals cannot say that they are in pain. The whole farmaceutic scam disgusts me.

  • @StrawberryNinjaNibbles
    @StrawberryNinjaNibbles 4 ปีที่แล้ว +3577

    Get this casting director a raise. All these actors look so much like the real people while also being able to actually act

    • @lennysmileyface
      @lennysmileyface 4 ปีที่แล้ว +140

      I swear some of them are the actual people. Number 2 was definitely the same guy.

    • @GnosticSeeker369
      @GnosticSeeker369 4 ปีที่แล้ว +28

      It’s epic bro
      Best I’ve seen

    • @StrawberryNinjaNibbles
      @StrawberryNinjaNibbles 4 ปีที่แล้ว +65

      Robert Gardea im aware what a re-enactment is... hence why I said props to casting director

    • @nicoleyandle9978
      @nicoleyandle9978 4 ปีที่แล้ว +13

      StrawberryNinja Nibbles #mansplaining at its worst-🙄🙄

    • @nicoleyandle9978
      @nicoleyandle9978 4 ปีที่แล้ว +25

      StrawberryNinja Nibbles omg you’re right. Without thinking about it, I unconsciously found myself thinking, how did they have video of these people when it was happening Lolol duh

  • @gugumasango1802
    @gugumasango1802 5 ปีที่แล้ว +3307

    Doctor: How we doing David?
    David: Screams with agony and discomfort

    • @FabTasticBoi
      @FabTasticBoi 5 ปีที่แล้ว +169

      Me when my mom wakes me up for school

    • @old-yd2kp
      @old-yd2kp 5 ปีที่แล้ว +49

      flamingwolfgaming 101 disrspectful but true

    • @Insomniyuh
      @Insomniyuh 5 ปีที่แล้ว +6


    • @FabTasticBoi
      @FabTasticBoi 5 ปีที่แล้ว +10

      My bad

    • @sqwertt8605
      @sqwertt8605 5 ปีที่แล้ว +33

      Doctor : seams ok to me

  • @mambutuomalley2260
    @mambutuomalley2260 8 หลายเดือนก่อน +8

    "I was really down... the worst down" - That's such a chilling phrase.

  • @tracy1394
    @tracy1394 8 หลายเดือนก่อน +41

    I was in labor with my first baby and the pain was absolutely horrible. My husband said that I tried to get out of bed and leave. I truly believed that if I could just leave the room that I would be pain free.

    • @Strawberrymerit
      @Strawberrymerit 3 หลายเดือนก่อน

      Wording is a bit off

    • @skylarstarr3973
      @skylarstarr3973 2 หลายเดือนก่อน +5

      I tried this too. 😂 Funny now but at the time I was in so much pain and I was so scared. I told my husband I just needed to get out of the room and out of the hospital then I'd be ok. He was compassionate but also amused and said something like "but what about the baby? If you leave you still have to give birth." 😂 I don't know, man.

  • @soapz.
    @soapz. 4 ปีที่แล้ว +1729

    everyone: throwing up, screaming
    that one dude sitting: alright ima head out

    • @soapz.
      @soapz. 4 ปีที่แล้ว +5

      Megan Khadka it’s like... i didn’t know that

    • @anncommanda2060
      @anncommanda2060 4 ปีที่แล้ว +31

      He was a control/ placebo

    • @lulumce6281
      @lulumce6281 4 ปีที่แล้ว +4

      When was that? Just so I can skip a sis is scared of sick

    • @zhipeizhou5582
      @zhipeizhou5582 4 ปีที่แล้ว +1

      B lasagna

    • @counter_cris6371
      @counter_cris6371 4 ปีที่แล้ว +1

      anna commanda what does that mean?

  • @preciousj6931
    @preciousj6931 4 ปีที่แล้ว +1041

    Those 2 men won a LOTTERY called PLACEBO

    • @tatendamurena3498
      @tatendamurena3498 4 ปีที่แล้ว +7

      precious lol

    • @orchdork775
      @orchdork775 4 ปีที่แล้ว +67

      @@sunandmoon139 That's not actually what it is. It's when a person experiences a decrease in symptom severity, because they believe they are receiving medication. The placebo effect does not cure illnesses, it just helps to relieve symptoms.

    • @orchdork775
      @orchdork775 4 ปีที่แล้ว +23

      @@sunandmoon139 It has to do with believing that you are receiving a treatment that will make you feel better. I reccomend that you look up some examples and/or articles about it on google, as it's actually quite fascinating. There is also the nocebo effect, which is when a person believes a treatment will have negative side effects, so they end up experiencing those side effects simply because they expected to experience them. There have been trials done where one group of people is give sugar pills (though the trial participants were told it was real medication) and were not warned of any potential side effects, while the second group received the same placebo pills, but were told a list of potential side effects they might experience. The people in the second group reported experiencing those side effects at a much higher rate than people in the first group. By believing they might feel unwell, the trial participants actually caused themselves to feel sick. It really goes to show how much your mindset can effect you. This even manifests psychologically as well.
      For example, if you believe that you won't ever succeed, chances are you will have a lessened ability to perform tasks, low motivation, and little dedication. One of the biggest effects would be that you stop trying, and that you never actually put 100% into something. I mean, why bother putting your all into something if you are sure you will fail?? Alternatively, if you believe that you could be very successful, you would likely take way more opportunities, work harder and put more effort into things, have high motivation, and be very dedicated. These changes in behaivor have a serious effect on your life, and could actually cause someone to fail at things simply because they are convinced they aren't capable of succeeding.
      This is called fortune telling in psychology, if I remember correctly. I'm very guilty of doing this myself, actually. It's harder than it sounds to let go of all the negative beliefs one has about themselves and start believing in themselves all of the sudden. It's really hard, and at this point I actually fortune tell about fortune telling. I know that I do it a lot, so I end up doing it even more simply because I expect myself to. It's maddening 😂😭

    • @zangetsuu
      @zangetsuu 4 ปีที่แล้ว +5

      @@sunandmoon139 it has nothing to do with religion if that's what you're asking, although those words can be used in a spiritual context. if that's not what you meant ignore me haha

    • @filmmade6214
      @filmmade6214 4 ปีที่แล้ว +1

      Comment war

  • @toni4729
    @toni4729 ปีที่แล้ว +58

    I can't help crying for Ryan. What a life for a young man..

    • @user-kz4ke8mg4r
      @user-kz4ke8mg4r 3 หลายเดือนก่อน +1

      What about the victims in the world's largest and latest drug trial? 😉💉

  • @patsysolatzzo2962
    @patsysolatzzo2962 8 หลายเดือนก่อน +92

    While nobody deserves the outcome of this particular medical trial, it’s an incredibly brave and selfless act to anyone who needs medicine and even to the lives that are forced into trials like animals. It’s scary but to think of all of the lives and families this event has saved. I’m so sorry to everyone involved but the gratitude I have for such people is incredible.

    • @niamphdollieofficial
      @niamphdollieofficial 5 หลายเดือนก่อน +4

      I'm sure they instantly regretted it lol

  • @bonniera3819
    @bonniera3819 4 ปีที่แล้ว +1945

    They all must have some form of PTSD from going through that

    • @ava-tb3cw
      @ava-tb3cw 4 ปีที่แล้ว +100

      With a phobia of medication, needles and that i suppose

    • @bonniera3819
      @bonniera3819 4 ปีที่แล้ว +123

      Well they nearly died that's pretty traumatic in itself

    • @robertbunton6394
      @robertbunton6394 4 ปีที่แล้ว +7

      Yea thats for sure

    • @taunjabrockway6760
      @taunjabrockway6760 4 ปีที่แล้ว +52

      Well then, they now should be advocates for banning all animal testing since they know the horrors.. but they had it WAAAY better than the animals that are still being tortured

    • @cailumwolf1616
      @cailumwolf1616 4 ปีที่แล้ว +6

      Taunja Brockway but if animal testing had happend it would be different

  • @AugustBreak
    @AugustBreak 6 ปีที่แล้ว +16445

    It’s truly strange watching British documentaries as an American. American documentaries are so loud with constant motion and nonstop drama. I appreciate watching something that takes its time to tell the story without the need for embellishment.

    • @therealgamingderps9608
      @therealgamingderps9608 5 ปีที่แล้ว +478

      I mean this was quite intense too.

    • @unknownartist6898
      @unknownartist6898 5 ปีที่แล้ว +52

      August Break Same

    • @livelaughForte
      @livelaughForte 5 ปีที่แล้ว +542

      It isn't that it's British. They just didn't really need to be flashy because of the content... People fighting for their lives... pretty hardcore as is

    • @AugustBreak
      @AugustBreak 5 ปีที่แล้ว +186

      L L there’s a balance that a lot of documentaries and reality shows strike. This one hits right on the mark.

    • @elisesatter1473
      @elisesatter1473 5 ปีที่แล้ว +23

      August Break omg ikr!

  • @LostVindication
    @LostVindication 9 หลายเดือนก่อน +67

    I was once in the hospital for some testing and they tried me on a new medication. I instantly had a bad reaction and the whole situation was super traumatic and to this day I am afraid to try new meds. Lot of the first symptoms these men described I went though but no where near as bad. I was in the hospital afterwards for almost 2 week and it took me almost 4 months to fully recover. This breaks my heart.

    • @lucygoosie7726
      @lucygoosie7726 7 หลายเดือนก่อน +5

      I once had an anaphylactic reaction to an antibiotic, now I’m terrified of taking any medication. I have a lot of allergies and I’ve had reactions to multiple different meds, but that was the scariest. Trauma is not something to take lightly, it can be debilitating.

    • @venda.havelka
      @venda.havelka 5 หลายเดือนก่อน

      When I was sick with rather severe tonsillitis, I've had Doumox (amoxiciline) administered and got a terrible rash all over my body in some 24 hours after first dose. It scared my GP so much she got our national drug administration involved and it eventually sparked a Europe wide investigation by EMA on the drug (mainly because rash was not on the list of known side effects at the time). My rash got better in like a week and I eventually recovered from the tonsillitis just to be completely astonished by all the internetional fuss I caused. I still have amoxiciline allergy written in big red letters on my folder in the GP's pacient registry to this day...

  • @sadfatdragon9529
    @sadfatdragon9529 9 หลายเดือนก่อน +56

    What honestly surprised me is that it seems like the people running the trails didn't have a plan for if things go horribly wrong.

    • @anglophils645
      @anglophils645 หลายเดือนก่อน +9

      They do now. And you must remember, nothing like this had ever happened before, during all the decades of drug trials. And this drug had already been tested on animals, with no adverse effects, at much higher doses.

    • @ID_Scarlet
      @ID_Scarlet 16 วันที่ผ่านมา

      Also these trials were preformed in presence of medical staff but even with that you cannot predict what immediate and also longterm side effects can occur.

  • @ROA1988
    @ROA1988 4 ปีที่แล้ว +483

    It makes me mad to think that the medication was administered 10 mins apart, rather than 90 mins apart. This could have only been one.

    • @birthdayplant
      @birthdayplant 4 ปีที่แล้ว +18

      'Berto O. A. you never know if another person will react the same way to the medication if only one person got the trial. that’s why there’s usually more than one person getting tested

    • @StanslaMichael
      @StanslaMichael 4 ปีที่แล้ว +4

      They just wanted to know who got the placebo.

    • @janeyd5280
      @janeyd5280 4 ปีที่แล้ว +21

      @@birthdayplant it was never appropriately thought out and therefore that was negligence in a big way.

    • @caseywinchester7639
      @caseywinchester7639 4 ปีที่แล้ว +5

      niyah and yet they all reacted the same way

    • @charliebrazier2863
      @charliebrazier2863 4 ปีที่แล้ว +7

      niyah yeah and If it went that bad on one person then they wouldn’t do it on another however if one person was fine

  • @floofytown
    @floofytown 5 ปีที่แล้ว +2444

    This reenactment is SO WELL DONE. Holy crap.

    • @lalala-vk7ex
      @lalala-vk7ex 5 ปีที่แล้ว +47

      Ikr!! I had to go back to the beginning of the video to find where it said it was reenactment I was like damnn

    • @susanfoley8360
      @susanfoley8360 5 ปีที่แล้ว +76

      They found actors who look incredibly like the real people involved.

    • @alexanderplatzberlin3940
      @alexanderplatzberlin3940 5 ปีที่แล้ว +36

      Yes. I totally forgot that it wasn´t real while watching … :D

    • @sleepyidiot2010
      @sleepyidiot2010 4 ปีที่แล้ว +8

      Susan Foley are all of them actors? I straight up thought one of them (the placebo guy watching everything go down) was the actual person

    • @xposed11
      @xposed11 4 ปีที่แล้ว +6

      You believe this? They gave clinical trial medication, as a test...to humans with nothing to actually cure.. it was meant to cure leukemia....which these random people did not have

  • @daddydancer1555
    @daddydancer1555 8 หลายเดือนก่อน +21

    Poor guys i hope they have managed to deal with the PTSD from this event. This is not something you can get over easily.

    • @KyleEvra
      @KyleEvra 8 หลายเดือนก่อน

      I don't blame them from being very weary about man made medicine.

  • @Courtneyemily91
    @Courtneyemily91 5 หลายเดือนก่อน +8

    I’d be freaking out as soon as the first guy started to have some severe effects. Omg…

  • @eddstudd
    @eddstudd 4 ปีที่แล้ว +1872

    This should be a Netflix documentary

    • @raiden961
      @raiden961 4 ปีที่แล้ว +17

      It should be that would be amazing

    • @rph_redacted
      @rph_redacted 4 ปีที่แล้ว +15

      This could be on House MD or the good doctor

    • @9852323
      @9852323 4 ปีที่แล้ว +34

      It’s better on TH-cam.

    • @makarti2158
      @makarti2158 4 ปีที่แล้ว +26

      Nah, TH-cam's where it's at.

    • @missy_vicky469
      @missy_vicky469 4 ปีที่แล้ว +5

      There is a indie style horror movie made based on this, wouldn’t recommend it.

  • @HP-cn4sd
    @HP-cn4sd 5 ปีที่แล้ว +3481

    Omg. Kid was 19 and saving up for driving lessons and now he has no fingers

    • @dylanp7817
      @dylanp7817 5 ปีที่แล้ว +44

      Gavin Haase 47:09

    • @shyshy8788
      @shyshy8788 5 ปีที่แล้ว +156

      He lost all his toes and parts of fingers. The tips

    • @nickhiggins1091
      @nickhiggins1091 5 ปีที่แล้ว +141

      He can still drive. My mother had crippling arthritis, and could not hold the steering wheel, just guide it with her palms, and turned with her elbows. He only lost the tips. Not the whole fingers. Yes, it is a tragedy he suffered. So did my mother. She still made do. Reiterate, he CAN still drive.

    • @ninjasneaks1472
      @ninjasneaks1472 5 ปีที่แล้ว +70

      I mean he could still drive? But they didnt specifically say what exactly happen to ryan..

    • @shyshy8788
      @shyshy8788 5 ปีที่แล้ว +94

      @@nickhiggins1091 doesn't sound safe at all. That's why in your driving test you have two hands on the wheel. Not your elbows

  • @LynetteTheRogue
    @LynetteTheRogue ปีที่แล้ว +37

    I'm surprised that they didn't have more doctors overseeing this trial considering how fast it all went sideways. You think they would be more prepared for that with it considering it was an experimental drug trial

    • @potocatepetl
      @potocatepetl 7 หลายเดือนก่อน +5

      Oh, you'd be surprised how low the requirements for trials are.... I wish I didn't know as much as I've learned in the last 5 years. One can only hope to have the luck of being and staying healthy.

    • @jenniferfriesen7691
      @jenniferfriesen7691 5 หลายเดือนก่อน +3

      The NIH didn’t even know they were doing this trial until the hospital called for help!

  • @user-jg6bu3hc8f
    @user-jg6bu3hc8f ปีที่แล้ว +61

    The actor who played as the Doctor really had me stressed out as well, he did a great job. Everyone did

  • @ravenryder6241
    @ravenryder6241 5 ปีที่แล้ว +5097

    For those of you making fun of the doctor for asking if they're okay, it's actually a very good practice. First of all, he's making sure they're still responsive. Second of all, he's trying to keep them calm. If you saw someone crack their skull open, you wouldn't start shouting "OMG ARE YOU OKAY!? OH MY GOD HE'S GONNA DIE THAT'S A LOT OF BLOOD" no, you'd say "It's going to be okay, you'll be fine."
    Just so you know

    • @toddhoward5749
      @toddhoward5749 5 ปีที่แล้ว +117

      lmao some doctor (well, nurse) screamed "OH MY GOD THAT'S A LOT OF BLOOD!!!" when I threw it up once, thought I was gonna die

    • @ravenryder6241
      @ravenryder6241 5 ปีที่แล้ว +33

      Index III is OUT my point exactly

    • @Caperhere
      @Caperhere 5 ปีที่แล้ว +19

      Raven Ryder I don’t know why Parexel claimed to have no knowledge of their responses, but the pharma doctor read in the literature supplied by Parexel that their reactions were thought to happen rarely.

    • @Wiplash12345
      @Wiplash12345 5 ปีที่แล้ว +8

      *aRe YoU oKaY*

    • @jsesheadphonesset6963
      @jsesheadphonesset6963 5 ปีที่แล้ว +7

      (OMG YOUR DEAD i mean) its fine ur gonna be okay:)

  • @julianbell9161
    @julianbell9161 5 ปีที่แล้ว +1567

    The worst part was how quickly they dosed everyone. They first guy is in a cold sweat and writhing in pain, and while this is going on they are dosing the guys in the other room.

    • @kristie-leecorney7388
      @kristie-leecorney7388 5 ปีที่แล้ว +15

      Julian Bell Mark R what was this drug trial for ?
      what the heck was the drug trial for because all those people were 100% healthy and had nothing to cure ,
      So do you think , is it really a cure they were looking for
      or is it a way to make people sick to cut down the population , the government plan ?

    • @bageda3109
      @bageda3109 5 ปีที่แล้ว +145

      They should have waited way longer for each person getting injected and they should have given a way smaller dose to check how they reacted to it

    • @pepsimax48820
      @pepsimax48820 5 ปีที่แล้ว +13

      @@kristie-leecorney7388 lol

    • @Jellybellyirish
      @Jellybellyirish 5 ปีที่แล้ว +102

      @@kristie-leecorney7388 can see that you didn't watch the documentary, so you'll come up with ingenious conspiracy theories. Get out.

    • @saras.7928
      @saras.7928 5 ปีที่แล้ว +57

      Kristie-lee Corney This isn’t a conspiracy video. If the government wanted to cut down on the population they wouldn’t have tested the drug, they would have given it to the patient so they could die.

  • @philbarone4603
    @philbarone4603 3 หลายเดือนก่อน +11

    In the last few years I’ve discovered just how much doctors don’t know what they’re doing.

    • @vallivergano239
      @vallivergano239 2 หลายเดือนก่อน


    • @lebohangm7252
      @lebohangm7252 8 วันที่ผ่านมา

      Makes sense considering that they did not build humans and have to learn what humans are made of and how each organ plays a role in order to know how to treat each organ

    • @philbarone4603
      @philbarone4603 8 วันที่ผ่านมา

      @@lebohangm7252 well, I wish they didn’t use my body to experiment with. I’m done with western medicine with several exceptions.

  • @monkeynumbernine
    @monkeynumbernine ปีที่แล้ว +36

    It's insane that they didn't stop the dosing when they saw that it was going so wrong.

    • @circlingoverland4364
      @circlingoverland4364 8 หลายเดือนก่อน +4

      I'm sure they thought that the drug would be safe and effective

    • @lenitaa7938
      @lenitaa7938 7 หลายเดือนก่อน +5

      I think they gave the whole dose at once, fast, which was a mistake on their part!! It was too late to stop, as I understood it!

    • @leamesbah5343
      @leamesbah5343 10 วันที่ผ่านมา

      @@lenitaa7938 no they gave the drug with a perfusor which is slowly pumping the drug

  • @muffinman5741
    @muffinman5741 5 ปีที่แล้ว +826

    "No one's gonna die right?"
    "Well, we'll see"
    well at least he was honest

    • @TheMausymaus
      @TheMausymaus 5 ปีที่แล้ว +8

      That part made me laugh so hard

    • @Deezhan
      @Deezhan 5 ปีที่แล้ว +24

      "We'll see... Well... I'mean I will see. In case you, ... you know."

    • @katerickard2804
      @katerickard2804 5 ปีที่แล้ว +10

      followed by evil cartoon villain cackle lol

    • @O7ghostX
      @O7ghostX 4 ปีที่แล้ว +5

      yeah doctors cannot affirm things they don't know or they might be charged with lies

  • @nicoleslaughter7983
    @nicoleslaughter7983 4 ปีที่แล้ว +4091

    I noticed they never talked about the eighth man, I looked him up and he’s wheel chair bound and had his fingertips fall off too.
    How unfortunate for all of them.

    • @sarahmai5902
      @sarahmai5902 4 ปีที่แล้ว +85


    • @joyful_tanya
      @joyful_tanya 4 ปีที่แล้ว +358

      Thank you for looking that up for us all!

    • @janekeller3791
      @janekeller3791 4 ปีที่แล้ว +60

      what did you look up to find it?

    • @flowerfaerie8931
      @flowerfaerie8931 4 ปีที่แล้ว +164

      Nicole Slaughter ...It mentions what happens to him right there in the video.

    • @wiktoriagwozdowska5484
      @wiktoriagwozdowska5484 4 ปีที่แล้ว +34

      any link or name of the man so i could search it pls :) its very scary docu really if i could i would wish for this to never happen :(

  • @greenbrain8725
    @greenbrain8725 8 หลายเดือนก่อน +107

    Can we take a moment and acknowledge how horrible it is that we must subject animals (macaques in this case) routinely to these horrible experiments, and after a life of horrendous isolation and suffering, these animals are simply discarded like garbage.

    • @diannbajewicz8952
      @diannbajewicz8952 7 หลายเดือนก่อน +16

      So what are they suppose to do to help people then give them a solution then

    • @srccde
      @srccde 7 หลายเดือนก่อน +13

      Yeah it's horrible but there's no other way.

    • @crazyvida2091
      @crazyvida2091 6 หลายเดือนก่อน +21

      Our lives aren't above animal lives.

    • @user-br9br2dk4n
      @user-br9br2dk4n 6 หลายเดือนก่อน

      Look up Dr hadwin / Animal free research charity it is possible

    • @helenl44
      @helenl44 6 หลายเดือนก่อน +5

      I agree. I watch the TV show about Monkey World in Dorset, UK (on TH-cam under Beyond Wildlife) where many of the primates came from laboratories and now get to live their lives at the sanctuary with other primates, the right food and the ability to go outside, play, etc. I noticed that the monkeys which appeared in the documentary were squirrel monkeys, but the narratives mention macaques.

  • @Katsofin
    @Katsofin ปีที่แล้ว +52

    I have a close relative who has to take anti leukemia drugs, I am very thankful to those absolutely healthy people who take such risks and help the science to create safe medications

    • @edwardtrezza8129
      @edwardtrezza8129 ปีที่แล้ว +1

      Doctors not care about their patients

    • @chip736
      @chip736 ปีที่แล้ว +8

      @@edwardtrezza8129 if doctors don't care about their patients then how come they try their hardest to save their patients? But yes there are some bad doctors out there don't get me wrong, being a doctor is not for the weak.

    • @childofcascadia
      @childofcascadia 7 หลายเดือนก่อน

      Huh? You making a blanket statement like that leads me to believe you're an ignorant fool.

  • @sarahvela4354
    @sarahvela4354 4 ปีที่แล้ว +2713

    Who else watched this, and immediately decided to never participate in a clinical trial? 🤯🧐

    • @richardblackhound1246
      @richardblackhound1246 4 ปีที่แล้ว +92

      I heard about this at the time it happened and then decided the same. Your life and health isn't worth playing Russian roulette with. Even if nothing like this happens to you, you don't know what unknown long term effects might be caused.

    • @Ashley-on4ln
      @Ashley-on4ln 4 ปีที่แล้ว +38

      Sarah Vela I have participated In one! Nothing happened to me thank goodness lol

    • @Jaxon0098
      @Jaxon0098 4 ปีที่แล้ว +9

      Where did you participate in your study at ?

    • @Jaxon0098
      @Jaxon0098 4 ปีที่แล้ว +22

      @Poppy Mystique I'm in a study right now in the states at a place called PRA Health Sciences in Lenexa, Kansas City, Kansas
      My study right now is 5 days for $3,000 us

    • @sarahvela4354
      @sarahvela4354 4 ปีที่แล้ว +22

      I had considered cosmetic trials, but after this there is no amount of money in the world that could make me want to participate. Just to risky for me.

  • @liofotia
    @liofotia 5 ปีที่แล้ว +2074

    Doctor: How are we doing, David?
    David: *screams into the 5th dimension*

    • @normalhuman78-53
      @normalhuman78-53 5 ปีที่แล้ว +10

      heiress of stupidity more like weirdly cut moans

    • @u.s.n.retired1995
      @u.s.n.retired1995 5 ปีที่แล้ว +25

      I was thinking the same thing. The patient is clearly in distress and a great deal of it!!

    • @teknacious
      @teknacious 4 ปีที่แล้ว +8

      lmfao best comment

    • @breonawarren1507
      @breonawarren1507 4 ปีที่แล้ว +23

      Valincia Pruitt They ask anyways to make sure you can respond. Yeah you aren’t doing good but are you responsive?

    • @teariet.tekken-wolffenn5881
      @teariet.tekken-wolffenn5881 4 ปีที่แล้ว +2

      That's what I thought.

  • @kris2455
    @kris2455 4 หลายเดือนก่อน +5

    They knew about the headache and pain and still injected the last patients. It's hard to comprehend.

  • @autdelux
    @autdelux 7 หลายเดือนก่อน +10

    "there is no rulebook for such a case" makes me shiver

  • @possiblyelle
    @possiblyelle 3 ปีที่แล้ว +1302

    His fingertips fell off!! They weren't even amputated! Imagine just laying there watching your fingertips FALL OFF!!! I feel so bad for those men...

    • @possiblyelle
      @possiblyelle 3 ปีที่แล้ว +22

      @jorge rodi Ohhhhh I'm dumbbbb
      I got so freaked out!!

    • @logicss2893
      @logicss2893 3 ปีที่แล้ว +2


    • @kells8241
      @kells8241 3 ปีที่แล้ว +41

      @jorge rodi please use your inside voice

    • @jonnyb.animationstutorials7119
      @jonnyb.animationstutorials7119 3 ปีที่แล้ว +55

      Necrosis is the term for Dying tissue. This is why I think this was blood poisoning. Necrosis can occur when the blood isn't healthy enough to provide the flesh nutrition, and the cells in the tissue die.

    • @miriamllamas224
      @miriamllamas224 3 ปีที่แล้ว +14

      @jorge rodi Capital letters means you're shouting. So low your voice 🤗 and be caring.

  • @starthejar1419
    @starthejar1419 3 ปีที่แล้ว +1234

    Everyone: puking, screaming, dying
    That one guy: okay think imma head out ✌️

    • @harssamoanlal2947
      @harssamoanlal2947 3 ปีที่แล้ว +46

      @Jimo National ok boomer

    • @rickastleyisnevergonnagive5673
      @rickastleyisnevergonnagive5673 3 ปีที่แล้ว +15

      @Jimo National ok snow roach

    • @emip4669
      @emip4669 3 ปีที่แล้ว +9

      @Jimo National and this is a problem because...

    • @bettyjanemaynard2269
      @bettyjanemaynard2269 3 ปีที่แล้ว +1

      @@harssamoanlal2947 kip

    • @jaydon7819
      @jaydon7819 3 ปีที่แล้ว +2

      @Jimo National apespeak isn’t a real word either 💀 what a mong

  • @Kelli-br5px
    @Kelli-br5px 9 หลายเดือนก่อน +7

    Truly appreciate learning from this documentary more about drug trials and the way it was presented. Real Stories is certainly a favorite production company of mine when it comes to documentary filmmaking❤

  • @joe1071
    @joe1071 3 หลายเดือนก่อน +5

    As a healthcare professional that works in a hospital, this is an absolute nightmare all the way around. Everyone lost in this one

  • @patricknein9062
    @patricknein9062 4 ปีที่แล้ว +2449

    If this would have happened in America, they would have been stuck with the medical bill as well.

    • @AlucardRawks
      @AlucardRawks 3 ปีที่แล้ว +109

      @@Tyler-zw4kq just because a law suit is won doesn't mean they ever see the money

    • @hellaSwankkyToo
      @hellaSwankkyToo 3 ปีที่แล้ว +57

      big facts. good ole american health“care.”

    • @samsamthetrashcan
      @samsamthetrashcan 3 ปีที่แล้ว +5

      Lol accurate

    • @patricknein9062
      @patricknein9062 3 ปีที่แล้ว +64

      @AL Cats They absolutely would have. It's the American way. Oh and when you write a sentence calling people stupid, make sure it isn't two sentences crammed into one.

    • @susanjoynes6395
      @susanjoynes6395 3 ปีที่แล้ว +13

      @AL Cats I don't know . you tell us. How do you.

  • @tbjorn7374
    @tbjorn7374 4 ปีที่แล้ว +750

    My first Chemo infusion took over 13 hours to complete. These men were given a full infusion in 10 minutes...That is crazy!

    • @johnbasiglone1219
      @johnbasiglone1219 4 ปีที่แล้ว +113

      How are you doing? I hope you are doing well. I sincerely mean that.

    • @gg-sc6gy
      @gg-sc6gy 4 ปีที่แล้ว +129

      @@sabitrakhadka8397 wtf is wrong with you

    • @kungfreddie
      @kungfreddie 4 ปีที่แล้ว +27

      @@gg-sc6gy 1st time internetting?

    • @gg-sc6gy
      @gg-sc6gy 4 ปีที่แล้ว +21

      @@kungfreddie yeah i made it 29 years and never once did I discover it until today

    • @kungfreddie
      @kungfreddie 4 ปีที่แล้ว

      @@sabitrakhadka8397 swedish

  • @louisenaude4467
    @louisenaude4467 ปีที่แล้ว +47

    I'm sorry for what these men went through, but I am also grateful for them, they made it safer for those that were brave enough to come after them to also take part in clinical trials

    • @HisameArtwork
      @HisameArtwork ปีที่แล้ว +4

      I found it interesting that they didn't accept women because it was considered too risky.
      While I can appreciate the chivalry it does aparently lead to mis-dosing for women because they don't test stuff enough on women.

    • @NotSoSerious69420
      @NotSoSerious69420 ปีที่แล้ว +2

      @@HisameArtwork it’s also an immune system stimulating drug isn’t it? Women have stronger immune systems in some senses then men so it’s more risky to do first in human testing on women. Don’t think they often worry about it once it passes first in humans as it often moves to treating the people with the actual diseases soon after and someone with cancer is probably not as worried about side effects if it saves them.

    • @childofcascadia
      @childofcascadia 7 หลายเดือนก่อน +3

      Its because "average" is considered an around 160 lb 5'11 male to drug companies at the time this study took place.
      Its better now, people of different genders, sizes and genetic backgrounds take part.

  • @kimmead3683
    @kimmead3683 3 หลายเดือนก่อน +6

    This is why I don't do trials. I did one and I had the symptoms of malaria. Never again.

  • @user-ui8sp5th4g
    @user-ui8sp5th4g 4 ปีที่แล้ว +546

    Imagine being one of the ones that got the medicine and being right behind the guy showing the first symptoms. That would be terrifying. He starts screaming and you have to wait until it happens to you. Talk about a horror movie.

    • @MsT-xm8xz
      @MsT-xm8xz 4 ปีที่แล้ว


    • @ryanblack3285
      @ryanblack3285 4 ปีที่แล้ว +3

      I'd rip the IV out b4 it was my turn. Not worth 2k.

    • @ThatFuckinGame
      @ThatFuckinGame 3 ปีที่แล้ว

      @@ryanblack3285 apart of the 2k, you would get in a lot of legal trouble, you signed a contract. also by the time the first severe symtphoms showed up, the drug was already administered on everybody.

  • @anoukkroolvink1397
    @anoukkroolvink1397 4 ปีที่แล้ว +980

    They talk about how a lot of the man got back to “normal” but still one guy lost just fingers and a foot and his life was never the same

    • @desolationangel5136
      @desolationangel5136 4 ปีที่แล้ว +22

      You should also watch the thalidomide documentary on youtube. th-cam.com/video/6uizvsiaHyw/w-d-xo.html

    • @spvillano
      @spvillano 4 ปีที่แล้ว +94

      Not a one of them went back to normal, their immune systems are fouled up to this day.

    • @thedopeexperiment
      @thedopeexperiment 4 ปีที่แล้ว +35

      Yeah I wanna know more about Ryan.

    • @BS-dq1kz
      @BS-dq1kz 4 ปีที่แล้ว +20

      And his penis. So there’s that. Pretty significant if you ask me.

    • @thedopeexperiment
      @thedopeexperiment 4 ปีที่แล้ว +11

      @@BS-dq1kz is that true?what a shame & he was the youngest of the group, not that it would suck any less happening to any of the others.

  • @20PINKluvr
    @20PINKluvr 7 หลายเดือนก่อน +8

    This is probably why clinical trials span a few months rather than a few days

  • @india1422
    @india1422 3 หลายเดือนก่อน +4

    I'm a former nurse and i remember hearing about this at the time. As i remember it they essentially gave all the patients the drug basically ask at once

  • @EmilySimpson723
    @EmilySimpson723 3 ปีที่แล้ว +1236

    That moment when you realize only three of the eight people are in the documentary ...

    • @imjustchilling4477
      @imjustchilling4477 3 ปีที่แล้ว +18


    • @imjustchilling4477
      @imjustchilling4477 3 ปีที่แล้ว +9

      That... no

    • @secnytsecnyt2981
      @secnytsecnyt2981 3 ปีที่แล้ว +180

      I am fairly sure they all survived, though someone can correct me if I’m wrong. More likely, they couldn’t get in contact with the others, or they weren’t interested.

    • @lorinagosso
      @lorinagosso 3 ปีที่แล้ว +96

      Lawsuits, NDA agreements.

    • @lovelovelovexo
      @lovelovelovexo 3 ปีที่แล้ว +82

      Yes very strange. I wonder how the boy is doing who lost his fingertips and a few of his toes

  • @jaydensmith920
    @jaydensmith920 4 ปีที่แล้ว +506

    This is like watching a horror movie but every detail actually happened

    • @LiterallyEly
      @LiterallyEly 3 ปีที่แล้ว

      Ikr, it makes it WAYYY scarier... obviously

    • @SolarBlyze
      @SolarBlyze 3 ปีที่แล้ว

      @@LiterallyEly honestly this scared me more than any horror movie ever has

  • @Courtneyemily91
    @Courtneyemily91 5 หลายเดือนก่อน +9

    The major issue was the drug being administered to every man within minutes of one another instead of adopting a wait and see approach, which you think would be standard initially in a first in man trial. Side note: David’s family is beautiful! So happy to see that.

    • @juditmlnr
      @juditmlnr 3 หลายเดือนก่อน

      While that's clearly the case, it seems they still have done everything according to protocol, haven't they? At least they say that in the documentary, so it may not have been standard at the time?

    • @Courtneyemily91
      @Courtneyemily91 3 หลายเดือนก่อน +2

      @@juditmlnr you would think it’d be common sense though. A drug that’s never been given to humans before and they’re rapidly dosing everyone before any side effects are able to take effect. Live and learn, I guess. I’m just glad it wasn’t at the expense of someone’s life.

  • @teddy2596
    @teddy2596 10 หลายเดือนก่อน +2

    Thank you for posting ❤

  • @email2336
    @email2336 4 ปีที่แล้ว +1719

    In the U.S the hospital would of have tried to charge you for your stay

    • @dr224
      @dr224 4 ปีที่แล้ว +46


    • @Thinkingisallowed
      @Thinkingisallowed 4 ปีที่แล้ว +75

      You are right, and they would have charged 3,000 a night.

    • @duck3819
      @duck3819 4 ปีที่แล้ว +121

      You just nearly died because of us...
      Give us $30,000

    • @justjadethings9630
      @justjadethings9630 4 ปีที่แล้ว +48

      @@duck3819 That is very accurate. My quack of an orthopedist gave me an unnecessary MRI, over my ankle being swollen and having pronation. It found bone bruising, JUST BONE BRUISING. It was a waste of 2hrs and $900

    • @aprilminder6851
      @aprilminder6851 4 ปีที่แล้ว +5

      donte ray damn right they would have

  • @pixl2524
    @pixl2524 2 ปีที่แล้ว +982

    David: literally dying
    The doctor: yooo what's good david

    • @apseudonym
      @apseudonym 2 ปีที่แล้ว +9

      😂😂😂 truly

    • @djangofreeman3153
      @djangofreeman3153 2 ปีที่แล้ว +7

      i laughed too loudly at this

    • @nancyhoward7005
      @nancyhoward7005 2 ปีที่แล้ว +3

      What is organ failer

    • @nancyhoward7005
      @nancyhoward7005 2 ปีที่แล้ว +1

      My husband's face swell up like this...allergic reaction to dye in hair color

    • @nancyhoward7005
      @nancyhoward7005 2 ปีที่แล้ว +4

      For all yall who do this kind of testing. Thankyou so so much. With out the test ....wow....

  • @IrishElf
    @IrishElf 8 หลายเดือนก่อน +10

    I am a New Zealander, struck me, as in saying that someone from my small country got affected by this. Also, this is absolutely horrific, stomach turning.

  • @elsarm178
    @elsarm178 7 หลายเดือนก่อน +12

    Once I took some medicine to treat heavy allergy, the name is Xyzall. I never felt so horrible, I became deaf for 1 week, had nose bleeding and I was paralyzed for 8 hours. I can’t imagine some people went though the medical trial with that crap, and why it is not discontinued. That was a very scary experience.

    • @potocatepetl
      @potocatepetl 7 หลายเดือนก่อน +2

      Did you check the articles they most likely published? Were all the side effects you had mentioned? Or are you aware of any other trials they did after yours? Having a trial doesn't automatically mean that the drug is put in a short term on the market. There might be a need for the drug or the method of administration to be changed... One needs a trial to find out how exactly a drug works on people and if and what is wrong...

    • @patrickmcpartland1398
      @patrickmcpartland1398 7 หลายเดือนก่อน +1

      ​@@potocatepetlno no no don't you see? It took some allergy medicine so he's an expert in pharmacology and clinical trials.

  • @Noodles03
    @Noodles03 5 ปีที่แล้ว +631

    I cant imagine being one of the people with the placebo... just watching and listening to everythung around you, always wondering if youre next and when its going to happen. It sounds so terrifying...

    • @trinitylivingston1286
      @trinitylivingston1286 5 ปีที่แล้ว +10

      Yeah and he was so young at the time so it really pulls at your heart for the poor boy.

    • @onistgaming5177
      @onistgaming5177 5 ปีที่แล้ว +1

      American roulette

    • @alex73217
      @alex73217 5 ปีที่แล้ว +7

      @Addicted 2This but also guilty though. Survivors guilt

    • @etherraichu
      @etherraichu 5 ปีที่แล้ว

      Nah. after they were the onlyone in the room it didn't happen to, Im guessing they figured out they had the placebo. But the first hour or so would've been rough, yea.

    • @edelleaa
      @edelleaa 5 ปีที่แล้ว +3

      I would feel so very guilty honestly

  • @Vanereall
    @Vanereall 3 ปีที่แล้ว +644

    It's crazy to think that they didn't have an emergency protocol in place. That doctor was scrambling to find any other doctor.

    • @seanshields86
      @seanshields86 2 ปีที่แล้ว +19

      That dr was probably just a pawn on a larger chess board.

    • @billmartins5545
      @billmartins5545 2 ปีที่แล้ว +3

      You can't plan for unexpected reactions

    • @donaldprice9230
      @donaldprice9230 2 ปีที่แล้ว +4

      Very poorly administered trial for sure. Why inject them all at once??? Pathetic!!!

    • @Abdi-libaax
      @Abdi-libaax 2 ปีที่แล้ว +4

      @@nasramohamed no he called for the other doctors because he didn't know what to do.

    • @cataniamommaitalia87
      @cataniamommaitalia87 ปีที่แล้ว

      They don't know what to be prepared for, that's why they're called drug trials.
      Unfortunately, too many people are still willing to inject untested drugs into their bodies with pharmaceutical companies having immunity from all outcomes

  • @Emy53
    @Emy53 8 หลายเดือนก่อน +11

    Had this been done on animals, they would have suffered more intensely because they can't speak and tell you what they are feeling.

    • @jennifermuse9154
      @jennifermuse9154 3 หลายเดือนก่อน

      So sad. Kills me to think about

    • @MachallaNaNaNa
      @MachallaNaNaNa หลายเดือนก่อน +1

      It was done on animals before the human trials. The animals didn't have this kind of reaction

    • @lilmissjoodypoody
      @lilmissjoodypoody หลายเดือนก่อน

      @@MachallaNaNaNawell, not the last batch before it went to human trials. To establish dosage, they would have kept pushing it higher until they elicited negative side responses to determine the maximum. That also informs them of what potential side effects and reactions they can expect. Unfortunately, many animals would have suffered to get to the human trials stage, not to mention all the ones that had such horrendous reactions that it never reached human trials. And even if they didn’t suffer direct side effects from the drug itself, they would have been caged and poked and prodded, with multiple blood extractions and perhaps biopsies as well as some animals euthanised in order to open them up to see the histological changes to their bodies as a result of the substance. They wouldn’t have been kept in humane habitats.
      It’s a huge problem with how we develop an understanding of disease and treatments. I don’t have the answers but I am well aware of the price of our health on other animals.

  • @janicemackie611
    @janicemackie611 ปีที่แล้ว +3

    You are a true inspiration to all….we tend to complain about a lot of petty things but your story truly awakens the senses to what’s important….so happy you got through it with the help of your wonderful family.

  • @m3m3d_
    @m3m3d_ 5 ปีที่แล้ว +379

    That one guy just sitting there on the bed was horrified.
    I feel terrible knowing the mass pain they were going through.

    • @scarlettellison3090
      @scarlettellison3090 5 ปีที่แล้ว +13

      m3m3d_ I felt real sorry for him . He was just siting there and every one else was reacting to it. He was probably thinking that he was going to get it soon

    • @mariekekito3998
      @mariekekito3998 5 ปีที่แล้ว +7

      I would feel guilty for Being tho One Who got the placebo

    • @tryblight
      @tryblight 5 ปีที่แล้ว


    • @soiboi1564
      @soiboi1564 5 ปีที่แล้ว

      Are you him (Looking at your profile pic even though I know it's just Arin

    • @jeaniejbutler4911
      @jeaniejbutler4911 4 ปีที่แล้ว +1

      the 2 (one in each room) who got the placebo will definately have long term mental issues from what they saw and heard..I hope they both got some great counseling...crap like that can mess your head up for life.

  • @pharmacyman6415
    @pharmacyman6415 4 ปีที่แล้ว +474

    Placebo guy: reading his book
    Guy next to him: in horrible pain
    Placebo guy: *chuckles I’m in danger*

  • @ginettemelody1035
    @ginettemelody1035 ปีที่แล้ว +1

    Thank you for sharing.

  • @c.w.6644
    @c.w.6644 9 หลายเดือนก่อน +9

    as beeing a doctor myself, i can only congratulate to the doctor on charge how well he manged the situation!! congrats!!! ashes on my head. i couldn't have managed it better. dr from switzerland

  • @NFSHeld
    @NFSHeld 2 ปีที่แล้ว +3280

    To those who are interested, the reason was finally found.
    Fair warning: I'm neither a chemist nor a physician, so I cannot guarantee I summed it up correctly. Also, before you jump to any conclusion or think "It sounds obvious that it was bound to go wrong", I suggest looking into the reports on your own, to understand the complexity of in vivo chemistry.
    TGN1412 was designed to bind to the CD28 antigen of T lymphocyte cells.
    Those T lymphocyte come in two sub-types: "Regulatory T cells", and "Memory T cells".
    TGN1412 was designed/intended to stimulate the Regulatory T cells, which are the same in humans as in the monkeys.
    However, the Memory T cells have that CD28 antigen as well for humans, but not in the monkeys.
    And those cells started to emit a high amount of cytokines when activated by TGN1412.
    This widespread sudden and overpaced emission of cytokines is what is called cytokine storm, and the cytokines attack and kill cells. This is what is called and happens in an inflammation. In a normal functioning immune system, this should happen in direct proximity of an infected cell to kill that cell (and only a few others as collateral damage, which are easily replaced in a healthy person). But here it happened in the whole body at once, basically attacking all cells everywhere at the same time.

    • @lentilneeds
      @lentilneeds 2 ปีที่แล้ว +406

      THANK YOU SO MUCH, it makes perfect sense to me now. Your comment is the only one in here that had the science behind what happened.

    • @boogiesparr
      @boogiesparr 2 ปีที่แล้ว +113

      Wow a overlook that had devestating result,altho making a new drug is never easy so small things are bound to be missed from time to time

    • @tcaldwell1782
      @tcaldwell1782 2 ปีที่แล้ว +185

      And isn't it ironic that the covid virus that's going around now does the same exact thing in some people, causes a cytokine storm? The monocolona antibodies since then has been perfected and is currently being used in people with covid-19 successfully. The drug is known as regeneron.

    • @tcaldwell1782
      @tcaldwell1782 2 ปีที่แล้ว +165

      Now they use 0.1% less of the drug at 40 times slower rate of infusion then they did in that trial. So basically it was a bad calculation on their part.

    • @Matetas-gv8lj
      @Matetas-gv8lj 2 ปีที่แล้ว +45

      Can we call it a Drug induced sepsis

  • @j.t.1215
    @j.t.1215 4 หลายเดือนก่อน +3

    Chilling documentary. Very well done.

  • @treeyellow4627
    @treeyellow4627 8 หลายเดือนก่อน +4

    Safety standards was seriously lacking. Immediate stop after the first reaction. Every patient should have started in ICU wirh more Doctors present.

  • @cn8299
    @cn8299 4 ปีที่แล้ว +1768

    Patient: No one is going to die right?
    Doctor: Who's your favorite Avenger? Just wondering..

  • @zainabxoxox5094
    @zainabxoxox5094 3 ปีที่แล้ว +1762

    can we just give these men a round of appaluse for what they have endured that must have been really traumatising especially the guy that lost his fingers and had his foot amputated

    • @sums9596
      @sums9596 3 ปีที่แล้ว +1


    • @williamarmstrong1017
      @williamarmstrong1017 3 ปีที่แล้ว +13

      For their Stupidity for taking a few bucks?

    • @cica8427
      @cica8427 3 ปีที่แล้ว +71

      @@williamarmstrong1017 I assure you, they would not go if they would be well informed. And what they do now with vaccine is pretty much the same! And they not have to pay for it.

    • @williamarmstrong1017
      @williamarmstrong1017 3 ปีที่แล้ว +9

      @@cica8427 For a elegal mrna vaccine?

    • @RK-su4hs
      @RK-su4hs 3 ปีที่แล้ว +1

      @@cica8427 💯

  • @SarahFinnCaparoo
    @SarahFinnCaparoo ปีที่แล้ว +1

    Very interesting! Thanks for this story 🙂

  • @ssears5678
    @ssears5678 ปีที่แล้ว +8

    I was it a trial at MD Anderson in Houston, Texas, and that trial saved my life💖

    • @jdlamb4212
      @jdlamb4212 ปีที่แล้ว +2

      My dad was also saved by an MD Anderson trial. Later I got to thank them by working on their cyber security.

  • @gem.8042
    @gem.8042 4 ปีที่แล้ว +924


    • @FaithandNova
      @FaithandNova 4 ปีที่แล้ว +46

      They do, even the woman who played his wife

    • @colourmycosplay
      @colourmycosplay 4 ปีที่แล้ว +23

      That's a first

    • @noahz7968
      @noahz7968 4 ปีที่แล้ว +2

      theREALmurtibing r/iAmVerySmart

    • @perrytheplatypus1323
      @perrytheplatypus1323 4 ปีที่แล้ว +2

      @@FaithandNova r/wooooooosh

    • @amirgill3006
      @amirgill3006 4 ปีที่แล้ว +3

      Thought I was the only one that noticed

  • @kandeejohnson
    @kandeejohnson 3 ปีที่แล้ว +6896

    ME, thinking I'm going to only watch 5 minutes of this and end up watching the whole thing!

    • @kylieskaggs1444
      @kylieskaggs1444 3 ปีที่แล้ว +42

      Sammmme girl

    • @dorametasimpson4985
      @dorametasimpson4985 3 ปีที่แล้ว +27

      This really does intrigue me .

    • @dorametasimpson4985
      @dorametasimpson4985 3 ปีที่แล้ว +22

      God Is So Merciful .. Amen .

    • @dorametasimpson4985
      @dorametasimpson4985 3 ปีที่แล้ว +20

      No amount of $$$$$ ... Is worth playing the , maybe , or , maybe not day !!! Which is a memory of , I'm alive !

    • @reyno6826
      @reyno6826 3 ปีที่แล้ว +6

      Same! 😬

  • @piotrtarkowski8595
    @piotrtarkowski8595 ปีที่แล้ว +30

    Hearing first hand how much suffering does such testing cause makes me feel very sad for those animals who don’t even volunteer for it. That is not ok to torture others for our benefit, only because we can.

  • @cherylmailloux9647
    @cherylmailloux9647 9 หลายเดือนก่อน +5

    Animal testing is cruel too!! At least humans volunteer animals have NO CHOICE!!!

  • @michaelwhite7288
    @michaelwhite7288 3 ปีที่แล้ว +1920

    This is the second time I watched this video, what a horrific trial these wonderful men went through, my daughter was diagnosed with leukemia at age 10 with other complications. Without brave people like these, my daughter would not be a alive today. This Was back in 2001. My sarah is doing well today. My only child. I owe it to brave people like the ones in this document. Thank you so very much from the bottom of my heart. Thank you. Mike, from Richmond, Virginia

    • @lorinagosso
      @lorinagosso 3 ปีที่แล้ว +51

      That's great. But everyone that I know that had leukemia and was treated for it , died. They spent years of their life receiving agonizing treatment that was meant to save them, costing thousands. They would be in remission, like they were cured, then it returned, only to kill them quickly, since their immune system was gone. RIP: Aunt Marty, Steele, Carmen.

    • @finlandjourney6065
      @finlandjourney6065 3 ปีที่แล้ว +37

      @@lorinagosso While that is the norm, there are a few exceptions. Perhaps her young age aided her recovery. Then again they say 25% of cancers get cured all by itself (not sure if it applies to leukemia though), but I guess most don't wanna play with those odds and go for the chemo route, despite it perhaps only buying them more time and only making their early death even more likely.

    • @KhadaJhin04
      @KhadaJhin04 3 ปีที่แล้ว +43

      @@lorinagosso leukemia in a certain group age and the type of leukemia the person has determines the rates of their survival. Simply put the older you are the deadlier it gets, children have higher survival rates and longer remission. Sorry for your loss though, seeing a loved one succumb to illness makes you feel hopeless and it's a wound that never heals even after they pass.

    • @hanasarver3837
      @hanasarver3837 3 ปีที่แล้ว +27

      I’m so happy for you and Sarah. I hope she loves a long successful life!

    • @rachelvillarim3279
      @rachelvillarim3279 3 ปีที่แล้ว +21

      Hi Michael the world also won a precious gift then : Sarah. Please send her a hug all the way from Brasil !! She isa brave and inspiring girl ❤️🙏🏻

  • @scusemelaydeh
    @scusemelaydeh 4 ปีที่แล้ว +292

    The acting in this reconstruction is incredible !!

    • @alexischang5929
      @alexischang5929 4 ปีที่แล้ว +3

      Alana this isn’t a act this is real I hope you know that!!

    • @lisa-fo4ig
      @lisa-fo4ig 4 ปีที่แล้ว +5

      @@alexischang5929 yeah it is. These are actors they don't even look like the actual people?

    • @scusemelaydeh
      @scusemelaydeh 4 ปีที่แล้ว +14

      Alexis Chang I know the story is real but the reconstruction of the events isn’t real!

  • @kanemura93
    @kanemura93 3 หลายเดือนก่อน +4

    My mother told me about this when it actually happened and at the time I was too young to understand the whole thing. It sounded terrifying though. I'm happy to get to see this documentary now and find out about what she told me about.

  • @daisybuckley5846
    @daisybuckley5846 5 หลายเดือนก่อน +6

    I absolutely love a doco and I have to say this is one of the best I’ve ever seen. Absolutely terrifying experience for those involved but the changes to drug trials since have meant nothing like this should ever happen again 💗

  • @pilarlastname8053
    @pilarlastname8053 6 ปีที่แล้ว +274

    TH-cam, I don’t think an add for a drug trial study is the best thing to run during this video. Like seriously, I don’t think people will want to take part in a study after watching this.

    • @MsLouisVee
      @MsLouisVee 5 ปีที่แล้ว

      Pilar Tromacek 😂😂😂😂😂

    • @skeeter7932
      @skeeter7932 5 ปีที่แล้ว

      2 months later and I got the add too!

    • @maibster
      @maibster 5 ปีที่แล้ว


    • @netook8
      @netook8 5 ปีที่แล้ว +9

      Yea TH-cam has no humanity or morality left. Google is probably run by Skynet

    • @petavirus5558
      @petavirus5558 5 ปีที่แล้ว +1

      XD still gonna, because someone got to be the one to do it

  • @wompstopm123
    @wompstopm123 4 ปีที่แล้ว +413

    the 2 people who got injected with the placebo where so lucky

    • @maddietrafford1225
      @maddietrafford1225 4 ปีที่แล้ว +18

      How hard is it to know the word “were” exists?

    • @rcab673
      @rcab673 4 ปีที่แล้ว +31

      Maddie Trafford that was 2 months ago and people make mistakes

    • @themotivationauts2989
      @themotivationauts2989 4 ปีที่แล้ว +41

      @@maddietrafford1225 oh get a life

    • @livingmeme6983
      @livingmeme6983 4 ปีที่แล้ว

      DaisyV. Wolf хаха какво се случва

    • @aelphind4954
      @aelphind4954 4 ปีที่แล้ว +3

      eh not exactly they probably have survivors guilt

  • @theaterkitkat
    @theaterkitkat 8 หลายเดือนก่อน +19

    I’m 18 years old and have four autoimmune diseases, Lupus, ITP, APS and vasculitis.
    I receive infusions of Rituximab to keep my immune system in check.
    All I can say? I have great respect and appreciation for all the people who put themselves at risk for the process of creating these kinds of drugs and treatments!
    The meds I’m on, although highly unpleasant, are the reason I’m alive.
    Thank you to all of the trial participants and the scientists who are working on development of them!

    • @ReineDeLaSeine14
      @ReineDeLaSeine14 8 หลายเดือนก่อน +1

      Rituxan saved me. I hope you’re doing okay.

  • @HansonFan7383
    @HansonFan7383 2 หลายเดือนก่อน +1

    I've watched this so many times-- the reenactments, along with the survivor's stories are so compelling.😢

  • @asimb2455
    @asimb2455 4 ปีที่แล้ว +2219

    Watching this in lockdown, quarantine coronavirus.

    • @gw4534
      @gw4534 4 ปีที่แล้ว +18

      Same here😐

    • @-coolaid-4539
      @-coolaid-4539 4 ปีที่แล้ว +7


    • @johnoktavec
      @johnoktavec 4 ปีที่แล้ว +8

      yup 4/2/20

    • @jaffa3869
      @jaffa3869 4 ปีที่แล้ว +12

      So what,everyone is in lockdown.

    • @lizzgrim
      @lizzgrim 4 ปีที่แล้ว +4

      me too

  • @gracelinenfelser8663
    @gracelinenfelser8663 4 ปีที่แล้ว +515

    patients: puking, fainting, screaming in pain
    doctors: *Don't stop administrating the drug*

    • @JacyTheAngel
      @JacyTheAngel 4 ปีที่แล้ว +1


    • @Hazel4love
      @Hazel4love 4 ปีที่แล้ว +4


    • @jasonwishere3121
      @jasonwishere3121 4 ปีที่แล้ว +12

      doctors: its working its working..infuse more drug

    • @simonbarr9476
      @simonbarr9476 4 ปีที่แล้ว +6

      Ahhhh, the benefits of knowing more in the name of science

    • @whendis.roberts6817
      @whendis.roberts6817 4 ปีที่แล้ว +3

      Ya what's that?

  • @randallsmerna384
    @randallsmerna384 3 หลายเดือนก่อน +6

    Kinda strange that they didn't immediately put them on dialysis...

  • @ItzBrittKneeBish
    @ItzBrittKneeBish 4 หลายเดือนก่อน +3

    As someone with auto immune disease its heros like this that risk their lives that give me the medicine I need to survive.

  • @colesmith7509
    @colesmith7509 3 ปีที่แล้ว +1304

    The poor nurses. They couldn't have imagined this was possible, and they definitely felt partly responsible.

    • @finlandjourney6065
      @finlandjourney6065 3 ปีที่แล้ว +27

      The old nurses knew. They've seen all sort of things. That's why they tend not last too long in the profession, and thus are all the time replaced by younger better indoctrinated by big pharma teachers ones.

    • @nic00001
      @nic00001 3 ปีที่แล้ว +48

      @@finlandjourney6065 oh the lunacy

    • @ross1116
      @ross1116 3 ปีที่แล้ว +43

      They were in part responsible. They rushed the injections from how it was explained. The first man was showing bad reactions before the last couple were even injected.

    • @colesmith7509
      @colesmith7509 3 ปีที่แล้ว +57

      @@ross1116 I think it was the protocol they were forced to follow. I agree that they definitely should've stopped though

    • @meganbretbrunner2344
      @meganbretbrunner2344 3 ปีที่แล้ว +31

      It is a nurse's responsibility to advocate for their patient, they can in fact, intercept prescriptions, and refuse orders as long as it's in the best interest of the patient.