The Drug Trial That Went Horribly Wrong
ฝัง
- เผยแพร่เมื่อ 10 เม.ย. 2018
- On Monday 13 March 2006, eight healthy young men took part in a clinical trial of an experimental drug known as TGN1412. The drug was intended to treat leukaemia and had already been successfully tested on monkeys but never on humans.
It should have been a routine clinical trial but it soon spiralled into one of the most infamous medical emergencies in recent British history.
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It’s truly strange watching British documentaries as an American. American documentaries are so loud with constant motion and nonstop drama. I appreciate watching something that takes its time to tell the story without the need for embellishment.
I mean this was quite intense too.
August Break Same
It isn't that it's British. They just didn't really need to be flashy because of the content... People fighting for their lives... pretty hardcore as is
L L there’s a balance that a lot of documentaries and reality shows strike. This one hits right on the mark.
August Break omg ikr!
I can’t imagine being the person who received the fake medicine, and having to sit there, listening to all this wondering if you are next.
Wait I don't get this where do they say that they were given the fake drug?
two people recieve something completely else while the others recieve the drugs. But no one knows who got what but the doctor/nurse. i believe its explained in the beginning of the video.
neither the docs nor the nurses knew, only the one who packaged them.
at 8:03
ah thats right, thanks.
I'm being treated for ovarian cancer. I cannot express my gratitude to the people who have risked their life to try to save mine
@@india1422 me too and I’m so thankful to the people and animals that helped keep me going. My very best wishes to you.
@@india1422 my thoughts and prayers🙏🏼🩷
I have been receiving a type of monoclonal antibody infusion every 4 weeks for the last 10 years to treat an autoimmune disease. This medication saved my life and allows me to continue surviving. The people who are willing to submit themselves to clinical trials like this are part of the reason I’m still alive, and I have so much respect for them.
True but 😅😅😅😅
My son has a number of symptoms that are autoimmune in nature rendering him at 35 unable to work and using a cane but some days unable to leave the bed. He has been given possible bur never firm diagnosis for everything from MS to Parkinsons to Meneirs to heavy metal intoxication as he shows signs of all. One of the neurologists who seemed most hopeful finding neuropathy and all the signs of his own immune system attacking his digestive and nervous systoms suggested a drug to him which was described as a chemo drug originally for cancer patients but has shown to aid patients such as he. God i wish we coyld speak to you to somehow find out if you have a similar set of issues. If so much comfort it would be while making this very important and heart wrenching decision
I also have an autoimmune disease. I am taking Telfast and Montelukast daily. If I stop, my throat gets tight and itches all over the body. I live with misery and doctors couldn't help me.
There probably not so happy
Maybe try prolonged water only fast around 10 days? Prolonged fast is the only thing that treats and cure autoimmune diseases. And then carnivore diet.
I still remember how my 6th year biology teacher warned us to never volunteer to be a guinea pig. Thank you sir.
See, I'm thankful I study chemistry, not biology or medicine. I can watch them do trials from another building, thanks.
Honey Bee 😂😂😂 that's a great teacher
I had a science teacher start our origins, universe life etc with: don’t believe everything they tell you, remember many think a supreme being, god, caused creation, others do not... in any case we don’t know how or why the universe came into being let alone having physics perfect for star formation, nuclear reactions, time, matter, all of it. That said... shall we begin.... first there was nothing, then there was a universe... any questions? Right... ok.. and we opened our books to chapter one. The Big Bang. Haha and the lesson commenced. I thought he was clever and wise and he was a great teacher. He also gave us real experiments, not cheesy ones. More dangerous chemicals and dissection, less baking soda and vinegar. Haha... break out the scalpels and Bunson burners baby.. whoops. Bang. Teacher my test tube is no more! You ok? Yeah. Had your eye wear on? Yeah. Ok... do it again but this time don’t skip step three in the directions... sorry Mr. Moss. Haha he was cool.
The FDA also recommends not being the first to take new drugs; I'd suspect only people desperate for money (poor/poverty) would/will volunteer.
@@renees1021 I don't think they normally end this badly due to prior testing on animals but yea this is also a very plausible outcome.
Patient “am I going to die?”
Doctor “the real question is am I going to prison?”
@Kimber 10MM wtf are you talking about
@Kimber 10MM don't you understand it's just a joke , if you don't understand, Okey let me tell you it's a human thing & you need to settle up in a zoo
That’s funny
😆
It's an experimental drug, he volunteered.
It is glanced over so quickly that Ryan lost his finger tips and got a part of his toes and foot amputated. Wow my heart goes out for him ♥️.
Considering he has sadly passed, I think this was the least of his problems. This entire trial was absolutely horrifically botched, whether by accident, on purpose, the medication simply didn’t work or otherwise
@@JoyfulNerd400 He died??!!
When? As a result of this trial?
@@BlackKiryuu he did end up passing away, yeah. His organs failed and as far as I’m aware his treatment failed in the end
@@JoyfulNerd400 Oh my God. I feel soo sorry for him!
Did his family get any help after his death? Like compensation for damage and what not?
@@JoyfulNerd400 Bullshit. A fast Google search leads to a Facebook post from January 2021 saying that Ryan "recently graduated with a First in BSc Economic & Social Policy", and from there one can find a "Birkbeck Events Blog" that states that in 2012 he had a son, in 2016 he started his part-time BSc Economic and Social Policy degree, and that in November (2020) he graduated, winning the prize for the best final year Economics and Social Policy student. Also, judging by you saying "the medication simply didn’t work" and "his treatment failed in the end", you don't even understand what a drug trial is (none of the volunteers needed the drug!). Please avoid saying ignorant and stupid things, everyone reading your comments could end being dumber as a result.
They knew about the headache and pain and still injected the last patients. It's hard to comprehend.
Really? In 2024, it's still hard to believe? Wow.
@@kris2455 Yeah, you would think they would test one person, and see how they reacted, before continuing.
@@MaryDeanDotCom SAFE AND EFFECTIVE. I mean it's only killed millions....
@@jennifermarlow. this wasnt in 2024
@@nanofivee I think they mean that we have lived through how the world reacted to co.v.id. Nothing will suprise me anylonger when it comes to butched up medical treatment after that.
I've got to stop reading comments while watching documentaries. The amount of times I have to rewind is absurd.
into the mystic comment section is better than the vid
@@ethank5681 there would be no comments without the video
Keep doing the same lmao
thanks for the reminder, i wouldve gone 10 minutes deeper without this comment
I was thinking the same... lol
Who else watched this, and immediately decided to never participate in a clinical trial? 🤯🧐
I heard about this at the time it happened and then decided the same. Your life and health isn't worth playing Russian roulette with. Even if nothing like this happens to you, you don't know what unknown long term effects might be caused.
Sarah Vela I have participated In one! Nothing happened to me thank goodness lol
Where did you participate in your study at ?
@Poppy Mystique I'm in a study right now in the states at a place called PRA Health Sciences in Lenexa, Kansas City, Kansas
My study right now is 5 days for $3,000 us
I had considered cosmetic trials, but after this there is no amount of money in the world that could make me want to participate. Just to risky for me.
This is astounding. I'm 24 years in remission from Leukaemia and two years of gruelling chemotherapy treatment I endured from 16 - 18. I imagine at some point each one of the toxins in the specific chemo cocktail I received were one trialled by participants equally as brave as these hero's. And I can say I wouldn't have envied what they put themselves through in doing so either! But I'm beyond grateful they did! Even given the long term ramifications I'll be dealing with from here on in, I wouldn't forsake that for the experience I had knowing what it is to be in love and the pure joy I eventually experienced in giving birth to two gorgeous and extremely precious daughters.
It's crazy when you think about the fact that healthy people took chemotherapy drugs first to see if it was safe. Knowingly taking the equivalent of a bomb going off in your system since it'll destroy everything in sight is wild
Success stories like you are exactly why I work in research. Every single cancer therapy and Alzheimer’s drug trial I hope not so see any observations or toxicity. It is always very sad when something doesn’t work as intended.
Not brave but stupid. Usually people in need of money.
Your life is worth so much more than money!
No to pharma.
Congrats to you, and I hope you live to see 103 😊
As a healthcare professional that works in a hospital, this is an absolute nightmare all the way around. Everyone lost in this one
Everyone else:
*screaming in pain*
That one dude:
*mom come pick me up im scared*
mmm
That guy would be me
@Saint Beelzebub 😭😭😭
「 Cinderblock 」 😂
Hahahahs
Get this casting director a raise. All these actors look so much like the real people while also being able to actually act
I swear some of them are the actual people. Number 2 was definitely the same guy.
It’s epic bro
Best I’ve seen
Robert Gardea im aware what a re-enactment is... hence why I said props to casting director
StrawberryNinja Nibbles #mansplaining at its worst-🙄🙄
StrawberryNinja Nibbles omg you’re right. Without thinking about it, I unconsciously found myself thinking, how did they have video of these people when it was happening Lolol duh
I can't help crying for Ryan. What a life for a young man..
@user-kz4ke8mg4r F-off. Its just not relevant to the comment and makes your point weaker by just making you seem like a troll. I assume thats the point tho right?
Why is someone else's reaction to watching this video not relevant? And who are you to judge? Why is YOUR opinion more valid than anyone elses?
Grow up snowflake, the moral high ground does not belong to your generation...so relax.
The foul language is completely unnecessary, and if anyone is a troll, I'm afraid it is you my friend
What honestly surprised me is that it seems like the people running the trails didn't have a plan for if things go horribly wrong.
They do now. And you must remember, nothing like this had ever happened before, during all the decades of drug trials. And this drug had already been tested on animals, with no adverse effects, at much higher doses.
Also these trials were preformed in presence of medical staff but even with that you cannot predict what immediate and also longterm side effects can occur.
@@anglophils645I work in clinical research, and for a drug like this, with its proposed mechanism of action, it really is crazy to me that there was no major emergency protocol for this, because this side effect was not entirely unpredictable even if the pharmacology isn’t fully understood. there’s a reason they settled.
Epipens at the least
me: oh man my knees hurt again
*watches documentary *
never mind i’m good
Joji Jo I love it 😂
Same
legit me
@@becky2322DM me, you look stunning :)
LMAO
It makes me mad to think that the medication was administered 10 mins apart, rather than 90 mins apart. This could have only been one.
'Berto O. A. you never know if another person will react the same way to the medication if only one person got the trial. that’s why there’s usually more than one person getting tested
They just wanted to know who got the placebo.
@@birthdayplant it was never appropriately thought out and therefore that was negligence in a big way.
niyah and yet they all reacted the same way
niyah yeah and If it went that bad on one person then they wouldn’t do it on another however if one person was fine
This is probably why clinical trials span a few months rather than a few days
Even the placebo dosing is done over a month these days.
Most of the medical trials that I've looked into ask for a commitment of 2-3 years, and specify that the patient can withdraw at any point. I've never looked into a First in Man study (now I understand that as a female, I don't generally qualify for that), though I do understand how vital that step is. Now I understand a bit better!
While nobody deserves the outcome of this particular medical trial, it’s an incredibly brave and selfless act to anyone who needs medicine and even to the lives that are forced into trials like animals. It’s scary but to think of all of the lives and families this event has saved. I’m so sorry to everyone involved but the gratitude I have for such people is incredible.
I'm sure they instantly regretted it lol
Everybody’s screaming in pain and the other dude’s just sitting there
He’s soooo lucky 🍀!
@@Timeless80 Haha, I was about to say that.
i would’ve hated to be him. imagine everyone around you screaming in pain... terrifying
@@dangerousbuterax6891 i'd rather be him than the ones that actually took the drug
@@LF-lv4ov same he's lucky
This reenactment is SO WELL DONE. Holy crap.
Ikr!! I had to go back to the beginning of the video to find where it said it was reenactment I was like damnn
They found actors who look incredibly like the real people involved.
Yes. I totally forgot that it wasn´t real while watching … :D
Susan Foley are all of them actors? I straight up thought one of them (the placebo guy watching everything go down) was the actual person
You believe this? They gave clinical trial medication, as a test...to humans with nothing to actually cure.. it was meant to cure leukemia....which these random people did not have
"I was really down... the worst down" - That's such a chilling phrase.
Poor guys i hope they have managed to deal with the PTSD from this event. This is not something you can get over easily.
Agreed.
I don't blame them from being very weary about man made medicine.
100% Correct!
For those of you making fun of the doctor for asking if they're okay, it's actually a very good practice. First of all, he's making sure they're still responsive. Second of all, he's trying to keep them calm. If you saw someone crack their skull open, you wouldn't start shouting "OMG ARE YOU OKAY!? OH MY GOD HE'S GONNA DIE THAT'S A LOT OF BLOOD" no, you'd say "It's going to be okay, you'll be fine."
Just so you know
lmao some doctor (well, nurse) screamed "OH MY GOD THAT'S A LOT OF BLOOD!!!" when I threw it up once, thought I was gonna die
Index III is OUT my point exactly
Raven Ryder I don’t know why Parexel claimed to have no knowledge of their responses, but the pharma doctor read in the literature supplied by Parexel that their reactions were thought to happen rarely.
*aRe YoU oKaY*
(OMG YOUR DEAD i mean) its fine ur gonna be okay:)
I noticed they never talked about the eighth man, I looked him up and he’s wheel chair bound and had his fingertips fall off too.
How unfortunate for all of them.
Wow
Thank you for looking that up for us all!
what did you look up to find it?
Nicole Slaughter ...It mentions what happens to him right there in the video.
any link or name of the man so i could search it pls :) its very scary docu really if i could i would wish for this to never happen :(
I met a guy in London in 1996 who lost all his hair from drug trials. Even then I couldn't believe any one would volunteer for this
Shame on drug company. One guys fingers and toes fell off. They infused 8 x faster than on monkeys. These people deserve big compensation and massive apology
The worst part was how quickly they dosed everyone. They first guy is in a cold sweat and writhing in pain, and while this is going on they are dosing the guys in the other room.
Julian Bell Mark R what was this drug trial for ?
what the heck was the drug trial for because all those people were 100% healthy and had nothing to cure ,
So do you think , is it really a cure they were looking for
or is it a way to make people sick to cut down the population , the government plan ?
They should have waited way longer for each person getting injected and they should have given a way smaller dose to check how they reacted to it
@@kristie-leecorney7388 lol
@@kristie-leecorney7388 can see that you didn't watch the documentary, so you'll come up with ingenious conspiracy theories. Get out.
Kristie-lee Corney This isn’t a conspiracy video. If the government wanted to cut down on the population they wouldn’t have tested the drug, they would have given it to the patient so they could die.
Part 1: company brings patients to trial. Part 2: patients bring company to trial.
If only it was that easy
And loose!
AppleYou Brilliant comment!
I'm sure the patients signed away any probability of liability
Uno reverse card
I've watched this so many times-- the reenactments, along with the survivor's stories are so compelling.😢
As someone with auto immune disease its heros like this that risk their lives that give me the medicine I need to survive.
@@ItzBrittKneeBish ❤️
This is why I'm open to being involved in clinical trials! I have these conditions, and am interested in improving the care that other people with them can obtain. Like Subject #1, I understand that it's important to report anything even slightly out of the ordinary because information is vital! I wish these men hadn't suffered like this, and thank them for their sacrifice.
Doctor: How we doing David?
David: Screams with agony and discomfort
Me when my mom wakes me up for school
flamingwolfgaming 101 disrspectful but true
Ikr
@@old-yd2kp
My bad
Doctor : seams ok to me
everyone: throwing up, screaming
that one dude sitting: alright ima head out
Megan Khadka it’s like... i didn’t know that
He was a control/ placebo
When was that? Just so I can skip a sis is scared of sick
B lasagna
anna commanda what does that mean?
I'm surprised that they didn't have more doctors overseeing this trial considering how fast it all went sideways. You think they would be more prepared for that with it considering it was an experimental drug trial
Oh, you'd be surprised how low the requirements for trials are.... I wish I didn't know as much as I've learned in the last 5 years. One can only hope to have the luck of being and staying healthy.
The NIH didn’t even know they were doing this trial until the hospital called for help!
Can we take a moment and acknowledge how horrible it is that we must subject animals (macaques in this case) routinely to these horrible experiments, and after a life of horrendous isolation and suffering, these animals are simply discarded like garbage.
So what are they suppose to do to help people then give them a solution then
Yeah it's horrible but there's no other way.
Our lives aren't above animal lives.
Look up Dr hadwin / Animal free research charity it is possible
I agree. I watch the TV show about Monkey World in Dorset, UK (on TH-cam under Beyond Wildlife) where many of the primates came from laboratories and now get to live their lives at the sanctuary with other primates, the right food and the ability to go outside, play, etc. I noticed that the monkeys which appeared in the documentary were squirrel monkeys, but the narratives mention macaques.
They all must have some form of PTSD from going through that
With a phobia of medication, needles and that i suppose
Well they nearly died that's pretty traumatic in itself
Yea thats for sure
Well then, they now should be advocates for banning all animal testing since they know the horrors.. but they had it WAAAY better than the animals that are still being tortured
Taunja Brockway but if animal testing had happend it would be different
Omg. Kid was 19 and saving up for driving lessons and now he has no fingers
Gavin Haase 47:09
He lost all his toes and parts of fingers. The tips
He can still drive. My mother had crippling arthritis, and could not hold the steering wheel, just guide it with her palms, and turned with her elbows. He only lost the tips. Not the whole fingers. Yes, it is a tragedy he suffered. So did my mother. She still made do. Reiterate, he CAN still drive.
I mean he could still drive? But they didnt specifically say what exactly happen to ryan..
@@nickhiggins1091 doesn't sound safe at all. That's why in your driving test you have two hands on the wheel. Not your elbows
This is why I don't do trials. I did one and I had the symptoms of malaria. Never again.
Well, the entire world went trough a massive trial three-four years ago.
I was in labor with my first baby and the pain was absolutely horrible. My husband said that I tried to get out of bed and leave. I truly believed that if I could just leave the room that I would be pain free.
Wording is a bit off
I tried this too. 😂 Funny now but at the time I was in so much pain and I was so scared. I told my husband I just needed to get out of the room and out of the hospital then I'd be ok. He was compassionate but also amused and said something like "but what about the baby? If you leave you still have to give birth." 😂 I don't know, man.
Should of stood up to deliver baby.
"No one's gonna die right?"
"Well, we'll see"
well at least he was honest
That part made me laugh so hard
"We'll see... Well... I'mean I will see. In case you, ... you know."
followed by evil cartoon villain cackle lol
yeah doctors cannot affirm things they don't know or they might be charged with lies
Those 2 men won a LOTTERY called PLACEBO
precious lol
@@sunandmoon139 That's not actually what it is. It's when a person experiences a decrease in symptom severity, because they believe they are receiving medication. The placebo effect does not cure illnesses, it just helps to relieve symptoms.
@@sunandmoon139 It has to do with believing that you are receiving a treatment that will make you feel better. I reccomend that you look up some examples and/or articles about it on google, as it's actually quite fascinating. There is also the nocebo effect, which is when a person believes a treatment will have negative side effects, so they end up experiencing those side effects simply because they expected to experience them. There have been trials done where one group of people is give sugar pills (though the trial participants were told it was real medication) and were not warned of any potential side effects, while the second group received the same placebo pills, but were told a list of potential side effects they might experience. The people in the second group reported experiencing those side effects at a much higher rate than people in the first group. By believing they might feel unwell, the trial participants actually caused themselves to feel sick. It really goes to show how much your mindset can effect you. This even manifests psychologically as well.
For example, if you believe that you won't ever succeed, chances are you will have a lessened ability to perform tasks, low motivation, and little dedication. One of the biggest effects would be that you stop trying, and that you never actually put 100% into something. I mean, why bother putting your all into something if you are sure you will fail?? Alternatively, if you believe that you could be very successful, you would likely take way more opportunities, work harder and put more effort into things, have high motivation, and be very dedicated. These changes in behaivor have a serious effect on your life, and could actually cause someone to fail at things simply because they are convinced they aren't capable of succeeding.
This is called fortune telling in psychology, if I remember correctly. I'm very guilty of doing this myself, actually. It's harder than it sounds to let go of all the negative beliefs one has about themselves and start believing in themselves all of the sudden. It's really hard, and at this point I actually fortune tell about fortune telling. I know that I do it a lot, so I end up doing it even more simply because I expect myself to. It's maddening 😂😭
@@sunandmoon139 it has nothing to do with religion if that's what you're asking, although those words can be used in a spiritual context. if that's not what you meant ignore me haha
Comment war
I watched this when it first came out 6 yrs ago and let me tell you that i have never forgotten about it. It's truly haunting to think about what they went through.
As a mom whose daughter is making progress against pancreatic cancer we were originally told don’t bother with chemo, it won’t work, enjoy your last 7 months, thank you to all who sacrifice in hope to help others.
This should be a Netflix documentary
It should be that would be amazing
This could be on House MD or the good doctor
It’s better on TH-cam.
Nah, TH-cam's where it's at.
There is a indie style horror movie made based on this, wouldn’t recommend it.
Placebo guy: reading his book
Guy next to him: in horrible pain
Placebo guy: *chuckles I’m in danger*
Ralph wigam
The 6 men who received the actual drug all got compensation as they rightly deserved. However, the 2 men who didnt receive the drug in my opinion should also have been compensated (to a lesser extent). They had to sit in the room for hours while the other men deteriorated, they heard every scream, even moan of pain and would have been aware of what the doctors and nurses were saying all while wondering when/if it was going to happen to them. The mental turmoil that put on them will possibly leave them scared for life
I’d be freaking out as soon as the first guy started to have some severe effects. Omg…
They talk about how a lot of the man got back to “normal” but still one guy lost just fingers and a foot and his life was never the same
You should also watch the thalidomide documentary on youtube. th-cam.com/video/6uizvsiaHyw/w-d-xo.html
Not a one of them went back to normal, their immune systems are fouled up to this day.
Yeah I wanna know more about Ryan.
And his penis. So there’s that. Pretty significant if you ask me.
@@BS-dq1kz is that true?what a shame & he was the youngest of the group, not that it would suck any less happening to any of the others.
an hour long, slow-pace documentary, totally for free on youtube! this makes me very happy
Yus
ᴴᵃᶰˢ ᴮˡᵃᵃᵘʷ me tooo
There is hundreds of them on here they r amazing
What TH-cam was really made for
These poor guys were thrashing around, probably thinking they were going to die and no one had the common sense to put the side rails up????? WEIRD!!!! I know no one expected all of this to happen! And God knows we need to produce life saving medications but I really did feel for these young men! And I'm sure the staff was in great mental anguish watching them suffer and not really knowing how it was going to end. But, as an RN of 31 years, the first thing I would have done was put up the side rails as a very simple measure of protection for the volunteers.
I was one of the early people treated with skin grafts. I had 3rd and 2nd degree burns when i was little. Now I have no scars. I appreciate the human test subjects for what they have helped achieve.
Everyone: puking, screaming, dying
That one guy: okay think imma head out ✌️
@Jimo National ok boomer
@Jimo National ok snow roach
@Jimo National and this is a problem because...
@@harssamoanlal2947 kip
@Jimo National apespeak isn’t a real word either 💀 what a mong
That moment when you realize only three of the eight people are in the documentary ...
Nononoooo
That... no
I am fairly sure they all survived, though someone can correct me if I’m wrong. More likely, they couldn’t get in contact with the others, or they weren’t interested.
Lawsuits, NDA agreements.
Yes very strange. I wonder how the boy is doing who lost his fingertips and a few of his toes
It made me so happy at the end when I saw David with his children ❤
Thank you for posting ❤
This is the second time I watched this video, what a horrific trial these wonderful men went through, my daughter was diagnosed with leukemia at age 10 with other complications. Without brave people like these, my daughter would not be a alive today. This Was back in 2001. My sarah is doing well today. My only child. I owe it to brave people like the ones in this document. Thank you so very much from the bottom of my heart. Thank you. Mike, from Richmond, Virginia
That's great. But everyone that I know that had leukemia and was treated for it , died. They spent years of their life receiving agonizing treatment that was meant to save them, costing thousands. They would be in remission, like they were cured, then it returned, only to kill them quickly, since their immune system was gone. RIP: Aunt Marty, Steele, Carmen.
@@lorinagosso While that is the norm, there are a few exceptions. Perhaps her young age aided her recovery. Then again they say 25% of cancers get cured all by itself (not sure if it applies to leukemia though), but I guess most don't wanna play with those odds and go for the chemo route, despite it perhaps only buying them more time and only making their early death even more likely.
@@lorinagosso leukemia in a certain group age and the type of leukemia the person has determines the rates of their survival. Simply put the older you are the deadlier it gets, children have higher survival rates and longer remission. Sorry for your loss though, seeing a loved one succumb to illness makes you feel hopeless and it's a wound that never heals even after they pass.
I’m so happy for you and Sarah. I hope she loves a long successful life!
Hi Michael the world also won a precious gift then : Sarah. Please send her a hug all the way from Brasil !! She isa brave and inspiring girl ❤️🙏🏻
Imagine being one of the ones that got the medicine and being right behind the guy showing the first symptoms. That would be terrifying. He starts screaming and you have to wait until it happens to you. Talk about a horror movie.
😩
I'd rip the IV out b4 it was my turn. Not worth 2k.
@@ryanblack3285 apart of the 2k, you would get in a lot of legal trouble, you signed a contract. also by the time the first severe symtphoms showed up, the drug was already administered on everybody.
I am a New Zealander, struck me, as in saying that someone from my small country got affected by this. Also, this is absolutely horrific, stomach turning.
The major issue was the drug being administered to every man within minutes of one another instead of adopting a wait and see approach, which you think would be standard initially in a first in man trial. Side note: David’s family is beautiful! So happy to see that.
While that's clearly the case, it seems they still have done everything according to protocol, haven't they? At least they say that in the documentary, so it may not have been standard at the time?
@@juditmlnr you would think it’d be common sense though. A drug that’s never been given to humans before and they’re rapidly dosing everyone before any side effects are able to take effect. Live and learn, I guess. I’m just glad it wasn’t at the expense of someone’s life.
@@juditmlnrI mean technically, yes, they did everything according to protocol - but the protocol is largely determined by the entity running the trial following some standard guidelines and requirements. personally, I think the biggest problem is that this kind of reaction should not have been so unforeseen (they even acknowledged cytokine storm as a possible side effect beforehand) that they didn’t prepare for it to happen in a first-in-human trial.
@@junk_DNA The doctors were not prepared for anything to go wrong. Common sense says you should be prepared for ANYTHING when testing an unknown drug!
His fingertips fell off!! They weren't even amputated! Imagine just laying there watching your fingertips FALL OFF!!! I feel so bad for those men...
@jorge rodi Ohhhhh I'm dumbbbb
I got so freaked out!!
Bruh
@jorge rodi please use your inside voice
Necrosis is the term for Dying tissue. This is why I think this was blood poisoning. Necrosis can occur when the blood isn't healthy enough to provide the flesh nutrition, and the cells in the tissue die.
@jorge rodi Capital letters means you're shouting. So low your voice 🤗 and be caring.
Doctor: How are we doing, David?
David: *screams into the 5th dimension*
heiress of stupidity more like weirdly cut moans
I was thinking the same thing. The patient is clearly in distress and a great deal of it!!
lmfao best comment
Valincia Pruitt They ask anyways to make sure you can respond. Yeah you aren’t doing good but are you responsive?
That's what I thought.
It sounds so similar to the first wave of COVID-19 patients.
Once I took some medicine to treat heavy allergy, the name is Xyzall. I never felt so horrible, I became deaf for 1 week, had nose bleeding and I was paralyzed for 8 hours. I can’t imagine some people went though the medical trial with that crap, and why it is not discontinued. That was a very scary experience.
Did you check the articles they most likely published? Were all the side effects you had mentioned? Or are you aware of any other trials they did after yours? Having a trial doesn't automatically mean that the drug is put in a short term on the market. There might be a need for the drug or the method of administration to be changed... One needs a trial to find out how exactly a drug works on people and if and what is wrong...
@@potocatepetlno no no don't you see? It took some allergy medicine so he's an expert in pharmacology and clinical trials.
That one guy just sitting there on the bed was horrified.
I feel terrible knowing the mass pain they were going through.
m3m3d_ I felt real sorry for him . He was just siting there and every one else was reacting to it. He was probably thinking that he was going to get it soon
I would feel guilty for Being tho One Who got the placebo
crumch
Are you him (Looking at your profile pic even though I know it's just Arin
the 2 (one in each room) who got the placebo will definately have long term mental issues from what they saw and heard..I hope they both got some great counseling...crap like that can mess your head up for life.
My first Chemo infusion took over 13 hours to complete. These men were given a full infusion in 10 minutes...That is crazy!
How are you doing? I hope you are doing well. I sincerely mean that.
@@sabitrakhadka8397 wtf is wrong with you
@@gg-sc6gy 1st time internetting?
@@kungfreddie yeah i made it 29 years and never once did I discover it until today
@@sabitrakhadka8397 swedish
I'm sorry for what these men went through, but I am also grateful for them, they made it safer for those that were brave enough to come after them to also take part in clinical trials
I found it interesting that they didn't accept women because it was considered too risky.
While I can appreciate the chivalry it does aparently lead to mis-dosing for women because they don't test stuff enough on women.
@@HisameArtwork it’s also an immune system stimulating drug isn’t it? Women have stronger immune systems in some senses then men so it’s more risky to do first in human testing on women. Don’t think they often worry about it once it passes first in humans as it often moves to treating the people with the actual diseases soon after and someone with cancer is probably not as worried about side effects if it saves them.
@HisameArtwork
Its because "average" is considered an around 160 lb 5'11 male to drug companies at the time this study took place.
Its better now, people of different genders, sizes and genetic backgrounds take part.
Imagine how the monkeys felt when they were injected with this drug
They were straight 😂😅
Not the same reaction, apparently...
TH-cam, I don’t think an add for a drug trial study is the best thing to run during this video. Like seriously, I don’t think people will want to take part in a study after watching this.
Pilar Tromacek 😂😂😂😂😂
2 months later and I got the add too!
ye THIS TOTALLY HAPPENED...
Yea TH-cam has no humanity or morality left. Google is probably run by Skynet
XD still gonna, because someone got to be the one to do it
ME, thinking I'm going to only watch 5 minutes of this and end up watching the whole thing!
Sammmme girl
This really does intrigue me .
God Is So Merciful .. Amen .
No amount of $$$$$ ... Is worth playing the , maybe , or , maybe not day !!! Which is a memory of , I'm alive !
Same! 😬
I have a huge respect and appreciation for the people who raise their hand up for the clinical trial. I hope they stay healthy.
I was once in the hospital for some testing and they tried me on a new medication. I instantly had a bad reaction and the whole situation was super traumatic and to this day I am afraid to try new meds. Lot of the first symptoms these men described I went though but no where near as bad. I was in the hospital afterwards for almost 2 week and it took me almost 4 months to fully recover. This breaks my heart.
I once had an anaphylactic reaction to an antibiotic, now I’m terrified of taking any medication. I have a lot of allergies and I’ve had reactions to multiple different meds, but that was the scariest. Trauma is not something to take lightly, it can be debilitating.
When I was sick with rather severe tonsillitis, I've had Doumox (amoxiciline) administered and got a terrible rash all over my body in some 24 hours after first dose. It scared my GP so much she got our national drug administration involved and it eventually sparked a Europe wide investigation by EMA on the drug (mainly because rash was not on the list of known side effects at the time). My rash got better in like a week and I eventually recovered from the tonsillitis just to be completely astonished by all the internetional fuss I caused. I still have amoxiciline allergy written in big red letters on my folder in the GP's pacient registry to this day...
This is like watching a horror movie but every detail actually happened
Ikr, it makes it WAYYY scarier... obviously
@@LiterallyEly honestly this scared me more than any horror movie ever has
I cant imagine being one of the people with the placebo... just watching and listening to everythung around you, always wondering if youre next and when its going to happen. It sounds so terrifying...
Yeah and he was so young at the time so it really pulls at your heart for the poor boy.
American roulette
@Addicted 2This but also guilty though. Survivors guilt
Nah. after they were the onlyone in the room it didn't happen to, Im guessing they figured out they had the placebo. But the first hour or so would've been rough, yea.
I would feel so very guilty honestly
as beeing a doctor myself, i can only congratulate to the doctor on charge how well he manged the situation!! congrats!!! ashes on my head. i couldn't have managed it better. dr from switzerland
Back when i went to rehab and like 1000 meetings, i started getting alot accomplished being sober, AA said i was doing too much for myself, to be humble, and focus more on recovery and less on achievements, to put recovery first .
I got sober to make my life better and they didnt like how quickly my life was becoming better, my house manager got extremely upset with me when i skipped a meeting to spend time with my oldest son, he said put recovery first , that was close to the end of me going to meetings, my kids always come first
If this would have happened in America, they would have been stuck with the medical bill as well.
@@Tyler-zw4kq just because a law suit is won doesn't mean they ever see the money
big facts. good ole american health“care.”
Lol accurate
@AL Cats They absolutely would have. It's the American way. Oh and when you write a sentence calling people stupid, make sure it isn't two sentences crammed into one.
@AL Cats I don't know . you tell us. How do you.
I'm a former nurse and i remember hearing about this at the time. As i remember it they essentially gave all the patients the drug basically ask at once
No placebo?
@@imho2278 Watch the documentary. It's worth your time.
Safety standards was seriously lacking. Immediate stop after the first reaction. Every patient should have started in ICU wirh more Doctors present.
documentary: shows up in my recommended
me: aight ok guess i’m staying up another hour
claudia There is no sleep when there is TH-cam 😆
It is nice when the algorithm works.
Me rn
claudia same!!
claudia 4:42 here
It's crazy to think that they didn't have an emergency protocol in place. That doctor was scrambling to find any other doctor.
That dr was probably just a pawn on a larger chess board.
You can't plan for unexpected reactions
Very poorly administered trial for sure. Why inject them all at once??? Pathetic!!!
@@nasramohamed no he called for the other doctors because he didn't know what to do.
@@Abdi-libaax read the comment before replying the obvious jeez
That one guy who got the placebo looking at everyone else…
👁️👄👁️
Chilling documentary. Very well done.
David: literally dying
The doctor: yooo what's good david
😂😂😂 truly
i laughed too loudly at this
What is organ failer
My husband's face swell up like this...allergic reaction to dye in hair color
For all yall who do this kind of testing. Thankyou so so much. With out the test ....wow....
The saddest patient death I've ever dealt with was a man who had an unexpected allergic reaction to a psoriasis medication we were testing. He was a healthy guy in his early 50s. No one had any reason to believe he wouldn't be going home to his family the next day with some Christmas shopping money in his pocket. It was really a huge shock to everyone, especially his wife and kids.
I wish I wouldn't have read this.. Now I'm sad....I could only imagine how the wife and kids felt..
That is something you should understand taking any drug, isn't it? Let alone the one that was never tested on humans, no one knows whether it is safe and that's exactly the risk they are paid for.. If it was safe (and none of the drugs are just cause of the personal reactions anyway) there wouldn't be a need in testing it..
The people are lured by money like the 50 years old man that sadly lost his life. When you are 50 YO with family of your own, it’s not advised to take a trial test. Unfortunately he probably needed the money.
This is the devils medicine now learn natural medicine.
Just him? its a lot worse than you think be hind closed doors .
They should’ve never let that man go get food. They should’ve had him in a bed checking and making sure he wasn’t going to be sick.
At that point they could tell which two had received the placebo, though of course he could have been suffering from what he had just seen the others endure. You're very perceptive to consider him that way.
Thank you for sharing.
The placebo boys can count their lucky stars
Vehicle/control gang.
Black people can count their lucky stars….not 1 Black person experimented on.👊🏾
@@yamindapage1963 what does that have to do with anything? Further more that isn’t true 😂
@@yamindapage1963 🙄
I knew a guy in our 20s who signed up for clinical drug trials all the time for cash - never did anything else for a living. He also never wore anything but pajamas and flip flops.
patients: puking, fainting, screaming in pain
doctors: *Don't stop administrating the drug*
Mhm
😥
doctors: its working its working..infuse more drug
Ahhhh, the benefits of knowing more in the name of science
Ya what's that?
You are a true inspiration to all….we tend to complain about a lot of petty things but your story truly awakens the senses to what’s important….so happy you got through it with the help of your wonderful family.
bro when he said "well we'll see"
Patient: No one is going to die right?
Doctor: Who's your favorite Avenger? Just wondering..
Patient: I prefer DC
Doctor: yeah im just gonna give you another dose
😂😂
I don't feel so good doctor
I like how these reply’s are taking the joke in so many different ways
HA
The acting in this reconstruction is incredible !!
Alana this isn’t a act this is real I hope you know that!!
@@alexischang5929 yeah it is. These are actors they don't even look like the actual people?
Alexis Chang I know the story is real but the reconstruction of the events isn’t real!
Glad these gents are here to tell us their stories. I havent watched it all yet....
I feel so bad for all the patients involved. It had to be terrifying not knowing what is happening to you or possibly going to happen due to the placebo. I hope they all received mental care for their well being. You all are courageous. We salute you for your efforts to help people get healthier. Thank you.
To those who are interested, the reason was finally found.
Fair warning: I'm neither a chemist nor a physician, so I cannot guarantee I summed it up correctly. Also, before you jump to any conclusion or think "It sounds obvious that it was bound to go wrong", I suggest looking into the reports on your own, to understand the complexity of in vivo chemistry.
TGN1412 was designed to bind to the CD28 antigen of T lymphocyte cells.
Those T lymphocyte come in two sub-types: "Regulatory T cells", and "Memory T cells".
TGN1412 was designed/intended to stimulate the Regulatory T cells, which are the same in humans as in the monkeys.
However, the Memory T cells have that CD28 antigen as well for humans, but not in the monkeys.
And those cells started to emit a high amount of cytokines when activated by TGN1412.
This widespread sudden and overpaced emission of cytokines is what is called cytokine storm, and the cytokines attack and kill cells. This is what is called and happens in an inflammation. In a normal functioning immune system, this should happen in direct proximity of an infected cell to kill that cell (and only a few others as collateral damage, which are easily replaced in a healthy person). But here it happened in the whole body at once, basically attacking all cells everywhere at the same time.
THANK YOU SO MUCH, it makes perfect sense to me now. Your comment is the only one in here that had the science behind what happened.
Wow a overlook that had devestating result,altho making a new drug is never easy so small things are bound to be missed from time to time
And isn't it ironic that the covid virus that's going around now does the same exact thing in some people, causes a cytokine storm? The monocolona antibodies since then has been perfected and is currently being used in people with covid-19 successfully. The drug is known as regeneron.
Now they use 0.1% less of the drug at 40 times slower rate of infusion then they did in that trial. So basically it was a bad calculation on their part.
Can we call it a Drug induced sepsis
As a cancer treatment patient I understand the importance of drugs being administered at a slow rate.
I hope you get well and go into remission forever.
Hope you are doing better
It's basically poisonous nuclear waste they're dumping in people's bodies.
Cladrabine 7 day IV infusion slow I know it
That's because you don't know the great physician, the lord god almighty.Amen.
Here in the United States this ordeal would’ve been covered up by the government from the police through the hospital officials it’s happened many times before.
Praying for wisdom and guidance for future trials. Well done documentary.
Watching this in lockdown, quarantine coronavirus.
Same here😐
Yeah
yup 4/2/20
So what,everyone is in lockdown.
me too