Behavioural Genomics
Behavioural Genomics
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วีดีโอ

Do you have the warrior or the worrier gene? Effect of mutation in the COMT gene on personality.
มุมมอง 6K11 หลายเดือนก่อน
Do you perform at your best under pressure? Or do you prefer to environments where you have time think? A little of both? This gene may influence how you respond to stimulation.
Twin and Adoption Studies - Nature and Nurture in Personality and Behaviour
มุมมอง 3.6K2 ปีที่แล้ว
The cause of individual differences in behaviour and personality is one of the most hotly debated subjects in the history of psychology. This video gives and overview of the history and impact of twin and adoption studies and what they tell us about the source of individual differences in behaviour and personality.
Polygenic Scores - Genome-Wide Association Studies Explained Simply Part 5
มุมมอง 4.1K4 ปีที่แล้ว
One of the uses of Genome-Wide Association Studies is the development of polygenic scores. This video describes how they are produced, what they can tell us and how they are used.
Linear and Logistic Regression - Genome-Wide Association Studies (GWAS) Explained Simply Part 4
มุมมอง 7K4 ปีที่แล้ว
In this video we discuss how to find associations between continuous and dichotomous traits and genetic variants.
P-values and Multiple Testing - Genome-Wide Association Studies (GWAS) Explained Simply Part 3
มุมมอง 4.5K4 ปีที่แล้ว
Part 3 of this series on Genome-Wide Association Studies. Here we look at P-Values and the issue of multiple testing. I'm looking for a job btw, so if you know anyone who is hiring bioinformaticians/statisticians please drop me an email at paulcraig545@gmail.com And of course, if you have any questions or suggestions for future videos please leave a comment below.
Linkage Disequilibrium - Genome-Wide Association Studies (GWAS) Explained Simply Part 2
มุมมอง 9K4 ปีที่แล้ว
Part two if this video series on Genome-Wide Association Studies (GWAS). Here we look at linkage disequilibrium and the advantages and challenges it poses to detecting genetic variants associated with complex traits such as predispositions to certain behaviours. Read this video as a blog post: behaviouralgenomics.blogspot.com/2020/05/genome-wide-association-studies-part-2.html Article which exp...
Genetic Variation and Traits - Genome-Wide Association Studies (GWAS) Explained Simply Part 1
มุมมอง 3.6K4 ปีที่แล้ว
This video explains how genome wide association studies are used to identify genetic variants associated with different biological and behavioural traits.
Introduction to Behavioural Genomics
มุมมอง 8804 ปีที่แล้ว
Short introduction to the field of behavioural genomics. You can view the contents of this video as an article here: behaviouralgenomics.blogspot.com/2020/05/introduction-to-behavioural-genomics.html

ความคิดเห็น

  • @maxfeliz140
    @maxfeliz140 2 หลายเดือนก่อน

    Where do you test for this?

  • @anjangowdas2541
    @anjangowdas2541 2 หลายเดือนก่อน

    Awesome and insightful video.👏

  • @فيصلمنصورالنامي
    @فيصلمنصورالنامي 2 หลายเดือนก่อน

    What is the test that determines the genes of the warrior?

  • @AvoniasStratigis
    @AvoniasStratigis 2 หลายเดือนก่อน

    On a side note, isn't it somewhat unhelpful to put personality connotations to this as hero vs philosopher. I mean afterall at the end of the day it is about stimulation, and I am sure a lot of famous philosophers could've been both (worriers and warriers and in between). I think Philosophy, if going by the card sorting analogy, requires both kind of people.

  • @morwickchesterham3875
    @morwickchesterham3875 3 หลายเดือนก่อน

    I'm not going to lie... your pronunciation of 'warrior' and 'worrier'... a bit confusing...

  • @RealityCheck1
    @RealityCheck1 3 หลายเดือนก่อน

    I have the warrior gene 2x more according to promethease. I was a soldier in Iraq for several years & while I hate disorganized leadership, I prefered to be in the frontline bec I have a feeling that the job wilk get done quicker than somebody who is scared & lazy. I love martial arts & combat sports. I don't mind a messy room & have more success in business than in the classroom.

  • @Willem969
    @Willem969 4 หลายเดือนก่อน

    If you think you have the warrior gene cause you're lazy, you don't

  • @Voidapparate
    @Voidapparate 4 หลายเดือนก่อน

    Wouldn't epistatic effects create a non "Gaussian distribution" of complex traits in populations? Not to mention they'd be the easiest to drive into fixation.

  • @jamieclarke321
    @jamieclarke321 4 หลายเดือนก่อน

    Warrior/ worrier isn’t the greatest phrase to follow with a Scottish presenter

  • @linhkieu1347
    @linhkieu1347 4 หลายเดือนก่อน

    great explaination

  • @MichaTheLight
    @MichaTheLight 5 หลายเดือนก่อน

    Y theory is that Europe's rise is also given due the relative balance of warrior and worrier with a light dominance of worrier

    • @behaviouralgenomics438
      @behaviouralgenomics438 5 หลายเดือนก่อน

      @@MichaTheLight I'd advise against speculating anything which could be interpreted as genetic superiority of one group of people over another. I think it is more likely that the geographic factors which led to Europe's economic success also created an environment which selects for the worrier variant.

    • @MichaTheLight
      @MichaTheLight 4 หลายเดือนก่อน

      @@behaviouralgenomics438 Why must always the woke reflex come by just an argument. I didn't even say superiority. I didn't even say it would be true and I didn't even say it could be the sole reason.

    • @behaviouralgenomics438
      @behaviouralgenomics438 4 หลายเดือนก่อน

      @@MichaTheLight I know you didn't say superiority which is why I said "could be interpreted as...". No woke moralising intended. In any case that wouldn't explain why Europeans have this ratio to begin with so it would again push the problem back to environment.

    • @MichaTheLight
      @MichaTheLight 4 หลายเดือนก่อน

      @@behaviouralgenomics438 okay a misunderstanding. I was sometimes judged for just bringing an argument forward which wasn't connected to any political stuff. I think it's both environment forms ppl but ppl also form environment.I studied Anthropology and it was taboo to make rational arguments based on genetics I'am aware that the national or ethnic character is produced by the combination of many genes. There are constantly tiny changes which amount to evolution over long time spans.

  • @aclaros100
    @aclaros100 5 หลายเดือนก่อน

    I'm just erect

  • @BioCodeDiaries
    @BioCodeDiaries 5 หลายเดือนก่อน

    Great presentation! I appreciate how clearly and concisely you covered the topic. Thank you for sharing it.

  • @birutenaruseviciene3509
    @birutenaruseviciene3509 5 หลายเดือนก่อน

    Very interesting😊

  • @WorthlessWinner
    @WorthlessWinner 5 หลายเดือนก่อน

    I find the assumption of additive dominating a bit strange. Whenever I studied specific genes whose mechanism of action is known (e.g. that protect plants from drought) their effect is massively dependent on other genes and the environment. I fear that scientists assume interactions don't matter because it'd be almost impossible to study this if they did, so it's convenient to pretend they don't matter.

    • @behaviouralgenomics438
      @behaviouralgenomics438 5 หลายเดือนก่อน

      For polygenic traits it is simply not feasible to do so. Especially when you are dealing with associated SNPs and not a known causal mechanism.

    • @WorthlessWinner
      @WorthlessWinner 5 หลายเดือนก่อน

      @@behaviouralgenomics438 - agreed. But I suspect knowing that it can't be tested, has led scientists to want it to not matter that it can't be tested. I read a paper ages ago (sadly forget the title) about how the desire for things to be mathematically or empirically tractable leads scientists astray sometimes. I hope additive influence dominants though, i want it to be testable !

  • @AmabilePezetedb
    @AmabilePezetedb 6 หลายเดือนก่อน

    I'm a homozygous worrier and I feel like I have more "patience" with monotonous and mundane activities. I can even feel a slight pleasure in doing repetitive activities, how crazy is that! Even though I'm homozygous, I feel like I can react well to mild or moderate stress situations. However, at the same time I have had Post Traumatic Stress at work, I have anxiety and depression. I take the antidepressant venlafaxine and it has helped me a lot with my anxiety, my psychiatrist said that it regulates Dopamine.

  • @aic-gz3rz
    @aic-gz3rz 7 หลายเดือนก่อน

    Had a pretty hard time distinguishing if you were saying worrier vs warrior while I was listening at work. I'll have to watch it again with subtitles. Best presentation of the subject I've seen on TH-cam yet.

    • @behaviouralgenomics438
      @behaviouralgenomics438 7 หลายเดือนก่อน

      @@aic-gz3rz It's one of the downsides with a Scottish accent. That and "purple burglar alarm"

  • @zaryltopchubaeva8515
    @zaryltopchubaeva8515 8 หลายเดือนก่อน

    I think worrier has more dopamine

  • @szabiszekely00
    @szabiszekely00 9 หลายเดือนก่อน

    Fighter & Entrepreneur here. I only feel good whenever I do something hard, stressful or entertaining. I also tend to have ADHD symptoms. Didn't know genetics played such a big role. Awesome video.

  • @Joule_Frog
    @Joule_Frog 10 หลายเดือนก่อน

    i have the warrior variant of the gene and on my days off i never get anything i wanted to accomplish done just procrastinate endlessly but at work as a line cook when there is food orders streaming down the the floor from the printer i run circles around everyone like a tasmanian devil from loony toons

    • @Joule_Frog
      @Joule_Frog 10 หลายเดือนก่อน

      a interest contrast is there is one co-worker who def has the worrier variant and the pros is he never forgets anything that needs to be done throughout the day while ill miss things like making gravy as an example, nothing like that gets passed him. but when it gets busy he does shutdown and goes into a quiet support role like taking care of putting bread for a clubhouse into the toaster and filling up sauce cups for the next order coming up, its actually nice combo we got going on line when together

    • @LG-bi1sr
      @LG-bi1sr 5 หลายเดือนก่อน

      @@Joule_Frog This was my first thought as well; are the warriors procrastinators? I haven't tested yet, but I know for a fact that back in university I needed to delay tasks to build up pressure for me to get locked in before a deadline and perform well. It was like starting early writing didn't stimulate me enough.

    • @Squared_Table
      @Squared_Table 4 หลายเดือนก่อน

      @@LG-bi1srRaid. Sleep on a pile of corpses and riches. Exhaust resources. Raid.

  • @bobjenzen8735
    @bobjenzen8735 10 หลายเดือนก่อน

    I don’t relate to either of these. I was diagnosed with adhd pretty late in life, always had low executive function and was disorganized, got in trouble in school for being too talkative, typical adhd treats. However, I always excelled in more boring tasks. I did well in school and went to an Ivy League school, and have sucked at warrior tasks, like sports and anything physical

  • @sippxn
    @sippxn 10 หลายเดือนก่อน

    Incredibly informative video. I am a homozygous warrior, and it makes complete sense as I am simply unable to concentrate on mundane tasks such as assignments

  • @ghosternz6109
    @ghosternz6109 11 หลายเดือนก่อน

    Excellent presentation! Loved it. Based on the knowledge and expriences i have about myself, i am heterozygous. I love to move around and live in expanded steppes and mountains and do martial art and horseriding and sharpshooting, and at the same time i enjoy sitting and spending countless hours on math and physics as im studying physics and philosophy at uni. + i love scottish teachers they are the best teachers i ever had in my life, learned faster with them. Keep up the great work!

  • @Motionless_Puppet
    @Motionless_Puppet 11 หลายเดือนก่อน

    Thank you for sharing this!

  • @McD-j5r
    @McD-j5r 11 หลายเดือนก่อน

    I have both.

  • @williammdsilva
    @williammdsilva 11 หลายเดือนก่อน

    Very fair and thorough explanation!

  • @HDQuakelive
    @HDQuakelive 11 หลายเดือนก่อน

    It's a little confusing that warrior and worrier nearly sound identical haha. Need a different name for worrier.

  • @redsolaris1
    @redsolaris1 11 หลายเดือนก่อน

    How does gender fit into this? the pathologies table could easily map into a list of standard gender differences

    • @Dan-ud8hz
      @Dan-ud8hz 11 หลายเดือนก่อน

      Since this gene is not on the X or Y chromosome, sex and/or gender does not fit into this.

    • @behaviouralgenomics438
      @behaviouralgenomics438 11 หลายเดือนก่อน

      There is a large literature about the moderating effect of gender on the associations between COMT polymorphisms and behaviour. To include it would have made the video too long. Oestrogen also regulates prefrontal cortical dopamine so there is certainly an interaction between sex and COMT status.

  • @Dan-ud8hz
    @Dan-ud8hz 11 หลายเดือนก่อน

    “As mortals, we're ruled by conditions, not by ourselves.” ― Bodhidharma

    • @behaviouralgenomics438
      @behaviouralgenomics438 11 หลายเดือนก่อน

      That's a great quote.

    • @McD-j5r
      @McD-j5r 11 หลายเดือนก่อน

      We are ruled by conditions and by ourselves. We can also change conditions.

    • @fidelkva4810
      @fidelkva4810 5 หลายเดือนก่อน

      we are part of the conditions

    • @MrPathorock
      @MrPathorock 4 หลายเดือนก่อน

      LOL, total BS

  • @diannh2894
    @diannh2894 ปีที่แล้ว

    I was adopted. I ended up on drugs for ten years. My adopted family has zero history, and i had unconditional love. I swear there is something to this.

    • @behaviouralgenomics438
      @behaviouralgenomics438 ปีที่แล้ว

      Thank you for your personal perspective on this topic

    • @proudatheist2042
      @proudatheist2042 7 หลายเดือนก่อน

      I am sorry for your trials and I hope things are better for you now. You may enjoy reading The Neuroscience of Addiction and Blueprint How DNA Makes Us Who We Are. The common thread of both texts is that genetics build more of our basis than many people are comfortable admitting. The second book states that genes are probabilistic, not deterministic. However, such probabilistic genes can push people towards certain behaviors and outcomes.

    • @sidharthv
      @sidharthv 2 หลายเดือนก่อน

      My biological parents unconditionally love me and have zero history with drugs. But I've struggled with it. I attribute it to my dumb choices instead of my genetics.

  • @mwanganamubita9617
    @mwanganamubita9617 ปีที่แล้ว

    Wow! Just exactly what I was looking for! Thanks for the very clear explanation.

  • @jennifergardner6313
    @jennifergardner6313 2 ปีที่แล้ว

    🌻

  • @MeWatchingYouTubeVideos
    @MeWatchingYouTubeVideos 2 ปีที่แล้ว

    👍👍👍

  • @danielabaracaldo2066
    @danielabaracaldo2066 2 ปีที่แล้ว

    THANK YOU THANK YOU

  • @PalfraDK
    @PalfraDK 2 ปีที่แล้ว

    5e-8 is lenient if you say it's 3.3mio independent common SNPs.. should be p-values less than 1.5e-8 if so.. what is the explanation for this? It's even more lenient if you consider how many researchers are using the same UK biobank data to tests probably thousands of different hypothesis...

  • @charlesonukak2632
    @charlesonukak2632 2 ปีที่แล้ว

    Beautifully introduced. Thanks

  • @blenderwang5061
    @blenderwang5061 2 ปีที่แล้ว

    Thank you! Great video.

  • @BioCodeDiaries
    @BioCodeDiaries 2 ปีที่แล้ว

    Great video...concepts are introduced and explained with amazing clarity..thank you

  • @krices1
    @krices1 2 ปีที่แล้ว

    That’s a very helpful, clear and interesting video, thank you! It should be shared with psychology undergrads at the very least!

  • @WorthlessWinner
    @WorthlessWinner 2 ปีที่แล้ว

    A good summary. The university of Minnesota course on this has a really good explanation of the logic behind twin studies if you haven't seen it. I wish heritabiliy was easier to interpret.

  • @qing4249
    @qing4249 2 ปีที่แล้ว

    Perfectly explained! Thank you!!

  • @youssefabdelmonem419
    @youssefabdelmonem419 2 ปีที่แล้ว

    Extremely helpful! Thank you!

  • @gsye981
    @gsye981 2 ปีที่แล้ว

    Very nice introduction!

  • @cristianatisca5987
    @cristianatisca5987 3 ปีที่แล้ว

    Excellent video.

  • @hodaabouzeid3312
    @hodaabouzeid3312 3 ปีที่แล้ว

    Amazing explanation.. hope you can do more videos

  • @aleksandrachybowska9819
    @aleksandrachybowska9819 3 ปีที่แล้ว

    This is great! Thank you so much for preparing this video. I found it extremely helpful :o)

  • @samurai1470
    @samurai1470 3 ปีที่แล้ว

    Phenomenal video!!! Thank you for drawing the connection between linkage disequilibrium and haplotypes. The absence of this connection increases confusion when texts explain LD blocks (haplotypes) that ARE associated with diseased alleles. It’s easy to question “just because two alleles are linked doesn’t mean a diseased allele is nearby, right?”, but the fact that linkage disequilibrium creates haplotypes/LD Blocks makes this much more reasonable to understand how these haplotypes can indicate diseased states. Having this said, without actually genotyping the intervening exons and introns… how can we say for certainty the haplotype is pure to the reference and isn’t experiencing an alternative mutation?

  • @sahanabaskar715
    @sahanabaskar715 3 ปีที่แล้ว

    Thank you so much. The video was clear and precise and helped me understand the concepts 🔥

  • @Bio-be1wm
    @Bio-be1wm 3 ปีที่แล้ว

    can you do walk through of GWAS analysis using plink or and R?

  • @hagayladany3278
    @hagayladany3278 3 ปีที่แล้ว

    Very good, I like your accent.