Telomeres, Telomerase, and their Function
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Instructor: Dave Carlson
DNA Replication - Telomeres
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I can't believe I only discovered your channel during my last-minute cramming. I wish I had found it earlier - will definitely be coming back throughout the rest of my degree!
This is one of the best video so far! Explanation is clear and straight to the point
You are a real teacher who can make things easily understandable
This is the most explanatory video I've seen on this topic, THANKS.
sir thank you so much for saving my life through med school!!
Thank you, this video was the most clear explanation I have encountered.
This videos are so amazing yet they are old, they make everything that I missed in my class so simple and easy to remember, thank you Dr Dave
You're very welcome!
Brilliant vid! Very clear and ez to undertand. Thank you
Helped me with MCAT. Now helping me through med school :)
thank you very much for the help on my bio final you handsome doctor man
Thank you Mr. for explaining this :)
A very nice presentation
WOW BETTER THAN MY PROFESSOR BY A MILLION
I bet you can also explain CARS!
Very well explained sir
Fantastic
Thank you
Thank you for a great video!
Just so people understand, telomeres do not filled the space the primer is/was, it extends the leading strand to allow the template to be extended as to not lose the information at the end of the replicated strand. In other words, the 3' overhand is extended further, not compensated for on the replicated side.
but what exactly extending does? Who fills up the space?
@@Rana-cz2dl telomerase adds to the overhang making it longer so then when its sufficiently long, primase can come in and add a primer and DNA Pol can make the last okazaki fragment.
@@josphellihsilak4588 that makes a lot of sense!! You explained much better than my professors!! Thank you so much mate :)
@@Rana-cz2dl I'm glad. Its certainly one of the more ambiguous aspects of replication. Best of luck to you!
Good very good
Good
Very fantastic
Thank you so much 😀
U soo good
Is it possible to shorten the telomeres technologically?
Sir what is the difrance between telomere and telocentric?
doesn't the DNA polymerase 1 fill in the RNA primers with new Dna nucleotides so why would the primer not be replicated
Thankss
You're welcome!
How is the Primer of the Leading strand replaced by DNA-Polymerase as there is no 3‘-OH to attach to either??
I think the removal of Primer only occurs on the Lagging, not in the Leading, right?
Dear, the leading strand also has RNA primer
Many videos suggest that... But truly, a 3' overhang should be in both the strands... As both of them are using RNA primers...
@@distantmelodies7719 The DNA polymerase is able to add a nucleotide on the hydroxyl end of the leading strand , and this is impossible with the lagging strand as the 5 end of lagging strand,
CAN YOU EXPLAIN THE END REPLICATION PROBLEM?
Can someone please tell me the name of this man
I don't think the telomeres shorten on both the leading and lagging strand, it is only a problem for the lagging strand?
Yes , because fragment okazaki , replication occur piece piece , while in leading replication occur in straight line without cut
Amazing explanation! Thank you! I'm still confused as to whether telomeres are on the template strand or daughter strand?
they are at the end of both strands, next to the 3' ends
@@melodiebridges8530 I thought DNA Pol 1 replaced the DNA. What is the correlation between telomerase and DNA pol 1? Does it not completely replace the DNA?
Why telomere become shorter and cell don't divide?
Due to end replication problem..
howz your health mate..i hope you are doing fine
Thank you!
Merci
I thought that the RNA primer bases were then replaced with DNA bases by DNA polyermase 1? So why do they disappear?
RNA primer is there only to start over the replication of template strand then it will be removed after replication by exonucleases which they said dispapper.
This video has a good animation. Unfortunately no sound over.
th-cam.com/video/5emqrkIvlTY/w-d-xo.html
Watching this video and you can see How the science and genetics simple, interesting and easy to study unlike our DOCTORs in college,✨You feel that they are trying hard to make it more difficul✨t🤦 ...
I’ve been learning about my own illness for a while now. Not every doctor stinks but the overall healthcare of many places aren’t the best. Therefore by the time results show up on tests.. the damage is done. Not enough doctors know the depths of pathology. Which is a problem that leads to disregarding patients and misdiagnosis. Now I have mitral & tricuspid regurgitation. Leukemia & I’ve had a thalamic stroke. I’m only 23. The majority of it was triggered from anorexia nervousa. I’ve known these are the illnesses I’ve had. They’re now just finding out about my heart & brain. They use terms like POTS as an umbrella term when they don’t know what is wrong. It’s similar to technology. There’s a signal flow. Troubleshooting is a must and when they don’t do enough of it.. if you don’t fix the original problem it is bound to create more. Pharmaceutical & insurance companies have major flaws. Not every med is useless but if you can’t figure out a way to naturally have your body heal itself.. you’re asking for more symptoms. It’s a bandaid that should only be short term. Another form of pain management but not the best science we could use. Biotechnology is advancing with the new organ machines they have. So they can keep them longer before a transplant. Which I think is amazing. FDA just passed the one for the heart and is still looking into the liver boxes. Biotechnology needs to progress when it comes to scanning for illnesses. Take this from someone that is going to become a statistic based on horrible medical treatment. Well, lack of treatment too. You cannot catch an illness with basic tests. Not everyone’s body is a mold for medical science. Imagine how much scientists & doctors are missing based on the lack of proper tests. Our body fluctuates as it is trying to maintain survival. Acts like a Chameleon. So you’ll feel the symptoms/damage long before they stop telling you it’s all in your head. The levels look fine because the body is making up for them. Meanwhile it is being exhausted & overtime damaged. Then that’s when you see it on tests. For instance, the only way I was diagnosed with POTS & mitral/ tricuspid regurgitation is by one or two tests. If they didn’t do those tests they wouldn’t have caught it. Check all boxes is what I’m saying. I was only diagnosed with POTS from a tilt table and a brain scan. For my heart it was only the echo. Nothing else showed those results. X- rays as we know aren’t as in depth and are terrible for trying to scan for deeper medical issues. But many places rely on them and send people out the door with a robbed quality of life. Leaving them to go from doctor to doctor as they get sicker. Many doctors have been intimidated by what I know. But I’d rather know the truth and try to give myself the peace that they couldn’t give me. I just wanted help. I love healthcare workers but this system sucks. Some of the people shouldn’t even be in healthcare. They found out about all the things wrong with my body and there’s such a back up in trying to get treatment cause of covid., that I’ve accepted where I’m at. Nauseous everyday ., to double vision and pressure in my head. My heart just makes me tired all the time. Coughing blood. Yeah I went to the ER., they’re as basic as you’ll get. Hinted at cancer and sent me home. Been having fevers off and on. I already know I’m a dead person walking. We are all going to die but the least they could have done was pain management. I’m going to some specialists soon but I can’t wait. It’s getting worse. I’ve already had so many NDES. The chronic ill community needs help and more awareness. The sick should be educated but not doing the jobs of doctors & scientists. We’re already busy being sick. I don’t want to read constantly about it to find out that I’m the only one helping myself. I’m the one that needs help. I think I finally found some promising doctors but it’s taken me years to learn all this and search. Years I could have been up & around instead of bedridden. This quarantine is nothing new for the chronic ill community. We have all the time in the world to learn & to correct. So when someone tells you they don’t feel good. The least you could do is believe them. Your patients are the ones with the upper hand. They’re usually the ones that know exactly what it feels like. Respect works both ways. A coat shouldn’t mean that you oppress sick people. You’re supposed to be the greatest listeners & learners. The body is a system. Specializing is a must but if you don’t understand how it interacts with the body as a whole you’ll miss the picture. That’s why there’s teams of people. I have come across wonderful doctors but very few. They’re truly lifesavers. Emotionally & physically it’s scary to be sick. Pointing the finger at the patients doesn’t solve what prohibits them to make healthy changes. There’s already enough shame to go around. Why do you think addicts have a hard time in feeling worthy? If they were able to fix the deeper problems at hand as opposed to the surface level ones.. we could really help people. Until then., if you’ve never been through it, don’t know much about it.. do not speak or practice on it. Things aren’t perfect but these are peoples lives.
You did not show how Telomerase finishes the end so that we will not lose it.
Sir one question plz
Unfortunately, several fundamental mistakes are made:
1) the way it's sketched, lagging strand synthesis seems to be continuous, while it is not
2) transcribed or replicated? (min 3:21)
3) replicative telomere shortening leads to cell proliferation arrest way long before the first gene can be lost (min 4:35)
4) telomerase does not fill in the overhang, on the contrary it extends it, as it needs a single stranded end to synthesise DNA from (min 6:57)
He is nice and all but he is oversimplifying and it's dangerous. Is the 3' overhang same as the the end replication problem? Does the end replication problem pertain to both the leading and lagging strands? How does the activity of the telomerase resolves the absence of the RNA primer on the parent or old strand?
And Sir pls don't ignore my question because it does not congratulate like most. Because in congratulations there is not much to be learned and there isn't much growth. I hope you open to criticism.
Sooooo the telo part means ..... recieving signals . ...... not ending .... recieving (telo) me(my) ra(light)se(signals) its a transciever to your body in the light.
That's an interesting way to think about it!
@@PremedHQ whats more interesting is the Thayliens. Now THAT would be much more complex an analogy for a breakdown of the wording process.
Ive also concluded that im an infinate telomerase. Used to say it as a mantra since i was 12 though i had no idea where i got the idea or notion or even what it meant at the time but i know now and yeah. I dont age. Its Its something about how the light of one's dreams interactions with the H5O2 in your Pineal gland creates a monoatomic gold filament your chromosome uses....
At least thats what im led to believe from the correlating science of today and what ive recently discovered on the interaction of structured water with contained light ...
Your pineal gland CREATES light when in REM sleep... this is due to the squeezing of DMT crystals in the pineal gland itself as a result of the Melatonin Serotonin process. Not many know this. Its better common knowledge though that the light of your dreams in an uninhibited pineal gland potentially creates the natural way to obtain everlasting life. ...booyaa
Or you could just chow down on a really high volume of monoatomic gold powder. That could work to.
The telomeres are MADE of gold by the way. At least the underlying dynamic scaffolding at least. The hydrogen/ carbon bonds in between as well are a factor but the scaffolding itself that recieves a signal..(broadcast from the hearts toroidal waveform patterns) that writes the genetic codes as its reproduced in a "bliss moment" (tingly feeling). I never took genetics. I just smoked DMT in the form of salvia and talked to the gatekeepers. They gave me the rundown. Its all true and all the science behind what i say is on you tube as well...i knew it but i checked as a result of what was told already by things not of this ... existence. Kinda neat right?
Well the oxidation of the genetic code eats at the telomeres. Take the oxidation OFF by syructuring your water ionically. H5O2 is god water.add sunlight to make golden water. Add intentionto structure it further based on the work if Dr Yamoto Masura and his water experiments. Water is the medium.
@@conraddevigne pass me the blunt dude..you seem lit and soooo litttt...
@@conraddevigne oh shut the fuck up with your blabbering bullshit.
In a certain harsh environment telomerase (sp guys?) stops functioning around age 33 because I will never let you see with your eyes what I have just seen open up before me. Its not because of anything you did its deliberate because I made a spelling error. please dont do that
Just FYI, the telomere sequences ARE NOT conserved across species.
Nobody said they are.
Some of the very first words are, “highly conserved across eukaryotes…”. The sequence is also incorrectly stated as “TTAAGG” even when it is correctly written on the white board.
Hw says TTAAGG but the sequence on the board is TTAGGG
ahh this video is scary.
yours voice is very slow sir
There is a great invention called "Playback speed" sir