Homocysteine, MTHFR, and Glutathione and health, cv disease, dementia - FORD BREWER MD MPH
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- เผยแพร่เมื่อ 5 ก.ย. 2024
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ABOUT DR. BREWER:
Dr. Brewer started as an Emergency Doctor. After seeing too many preventable heart attacks, he went to Johns Hopkins to learn Preventive Medicine. While there, he went on the run the post-graduate training program (residency) in Preventive Medicine. From there, he made a career of practicing and managing preventive medicine and primary care clinics. His later role in this area was Chief Medical Officer for Premise, which has close to 1,000 primary care/prevention clinics. He was also the Chief Medical Officer for MDLIVE, the second largest telemedicine company. More recently, he founded PrevMed, a heart attack and stroke prevention clinic.
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Plz Doc , what is reduced B vitamins, why ? Because b vitamins seem it make be aggressive , but with out any i sleep , a lot, Thank You, and have a good day/ night.
Thanks, John.That's helpful to know about the potential sleep impact.
@John Lorscheider what about nutritional yeast (nom fortified), it has the natural folate.
@John Lorscheider Thanks, I did and they assured it's natural folate, nothing syntectic added.
@@PrevMedHealth It looks like the reply here is now gone. I was wondering as well: what are the 'reduced' B vitamins? The only results I found after searching online for reduced b vitamins were studies that didn't go into explaining which are the Reduced B vitamins. Thanks... I'm a poor methylater as well. My SNP results were about as bad as it can get when it comes to methylation..!
Try Nutritional yeast all your B vitamins 😏
Thanks for the great work you're doing for us all. We appreciate your service to humanity.
Thanks for sharing this information. I appreciate your showing the studies and reviewing the findings.
My neurologist after seeing him for a few years decided recently to have my homocysteine levels checked and it was high. He recommended that I take folic acid. My levels began reducing and is now normal. I am taking B complex vitamins and 4.5 milligrams of folic acid.
Can you please share the brand of folic acid?
Great analysis.
Organ meat. Beef liver. Beef kidney. That's where the B vitamins and folate really are. That's what we stopped eating about 50 years ago.
Thanks for sharing that.
When clams n liver aint brought up by a hospital employee
They aint getting my money
Exactly, right..that's how I manage my MTHFR-C677T heterozygous polymorphism. I am totally asymptomatic. I also take TMG supplements along with methylated B complex vitamins and consume green leafy vegetables like kale and arugula.. I also have a whole avocado a day😊...stay away from Folic acid.
This trials that reduced hcys without outcome had on average hcys below 15mcg which is still in the normal range. Furthermore it was done in patient populations with smokers, hypertension, diabetes, known cvd issues.. all with elevated risk for clotting. They were also on anticoagulants and most of them on statins which also has anticoagulant properties. I found 5 of those studies and they all had such problematic setup. None of them controlled for genetic predisposition either.
Can injectable glutathione be given subq or does it sting badly?😮
TMG - Trimethylglycine. Reduces homocysteine. Don't over do it or mood changes.
The vitamins especially folic acid in foods are synthetic and if you have the MTHFR genetic mutation like moi.....(insert miss piggy hair flip).....the synthetic versions build up in your system because the body can't process it or use it anyway. I switched my diet between keto and paleo just a broken version of them but still lots of greens and good foods in general and yes it's made a big difference but i also supplement A LOT. This video is great i'm studying the relation to PMDD, MTHFR and the close relationship to hormones and the brain. I feel like a cure isn't far away.
Thank you very much!
Interesting! Thankyou. nurse here who has worked in longevity research & been in several research clinical trial cases. Wondering if Higher doses of Vit K-2 & D-3 can help solve this problem in anyway along with sun & light therapies. ?? 🤔 thanks.
Hi Dr Brewer, could use a little direction. My husband was just tested for the MTHFR and is positive for both variants. We are on a plant-based diet so he was taking 2000 mcg of methelcobalamin B12 per day. Recent testing shows 1105 for the B12 and 23 for folate. I want to start him on the thorn methelated vitamins you recommended. But should we wait until the levels go down will that be too much or is it better to get him on the methylated vitamins ASAP? I'm so glad I follow your videos because now I know why my husband has increased inflammation. He has severe CAD and diabetes.. Thank you so much for all your videos!
U aint reading ingredients on your fake plant based foods
I think i might have bad homocystein levels cause started taking tmg also know as betain anhydrous and was amazed how much helped discovered this all by accident been having a lot physical pain cause cotocondritis imflamation of rib cage. Also bad bck and a constant nerve problems. But this tmg seems to help if take it when i eat i also have suspected ibd. So im concerned but no dr or any emergency room seems to care. In fact my local er had me labeled as over dramatic even tho my albumin level was really high and blood pressure was high and they could feel the huge lump in my neck said something about vagus nerve inflamation. Wish had dr like u
Thanks for sharing.
ERs are for emergencies, not these chronic health concerns. You need to discuss these issues with your pcp.
This is more complicated with homocisteine.There is link with non functional genes mtfh and mtrr and osteoporosis + neural tube defects which is affecting calcium deposition in inflamed vessels.These 3 are connected homocisteine ,calcium score and bone density.Active b9,active b12 + beetroot whith meat and high k2 with c and s k dependant proteins can help.
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Did my Homocysteine a few days back and result was elevated 10.6 Wish I knew what it was before I started the Keto diet 6 months ago to see if that had any impact on it. However I will do it again in three months to see if any movement. One of my supplements is K2 mk7 (not just for calcium, but K2 kills chemo resistant prostate cancer cells - not that I have this), but apparently that could impact calcification along with controlled Blood sugars. I have Alpha LA, NACystein, B complex in the fridge - so maybe start using them. And add more of the green veges. To see if I can make any noticeable impact on the levels.
Thanks. And good luck with it.
Have you re-tested yet?
Hi Dr. Brewer. I have blockage and calcium in carotid artery and coronary artery. I also have mthfr (c677T one copy) and osteopenia. 3 different medical professionals have told me not to take vitamin K2 as mthfr is a clotting disorder. None the less I'm eating 1 Tablespoon of Natto daily. Please advise on how to clear my arteries. I am 67 years old and want to live a long life without any cardiovascular events! P.S. I am taking methylfolate and B12, coq10, d2, magnesium, fish oil and am on a statin and low dose aspirin (every other day on both).
All of a sudden my Homocysteine is though the roof.... 25 And kidney function is dropped a lot since last blood work. Can low kidney function increase Homocysteine
First time on this site for me. Interesting discussion. However pkease Dr less with the cliché white lab coat. In reality lab coats should not be worn outside the lab for fear of outside contamination, both medical, chemical and biological sciences. Well done on the points made though
How do we know if we should use this glutothione supplement along with diet?
Amy can order a test for you.
Ford Brewer great thank you!! I’d like to know!
Simple... take a blood test
When we test for homocysteine could this really be indirect testing for glutathione deficiency? The real reason for elevated homcysteine could be the same conditions that lead to glutathione deficiency.
Do you know if glutathione suppositories are any good? Are they as effective as intravenous glutathione?
All i see is docs writing ✍️ scripts, billing them and their families then scheduling further medical procedures
Thats what i see
How do you treat below range low levels of homocysteine?
Why would you?
@@PrevMedHealth they showed below normal range as in too low...but I have it resolved now
I’m confused. You say you take ‘reduced b vitamins’ to improve homosysteine/methylation processes. An integrative doc advised me to supplement with b6 and b12 to lower my homosysteine levels. What do you mean by reduced levels? Thank you.
and B2?
Methylated
I watched your video hear your thoughts on Glutathione supplements.
Thanks. I have Glutathione on the list. But the list is a few months long now.
I would love to get this information but your delivery is very hard to watch. Plus I am looking for a conclusion!
I also dont think we give epogenetic information enough respect, i think there is a deep connection to our daily lives, how epogenetically we flourish or flouder in our environments and how it affects our bodies and reaction to our own inside exchange of chemical information.
It's a good point. Have you seen my videos on epigenetics?
@@PrevMedHealth No i haven't but i'd love to watch
I was told to check my glutathione levels after having been poisoned by Levaquin...I am glutathione deficient and my levels are in the 400
@John Lorscheider GLUTATHIONE
Test Code
90379X
CPT Code(s)
82978
Preferred Specimen(s)
10 mL (1 mL minimum) Whole blood collected in an ACD
(yellow-top) tube
Transport temperature: Refrigerated
Transport Container: ACD (yellow-top) tube
Minimum Volume
1 mL
Specimen Stability
Room temperature: Unacceptable
Refrigerated (cold packs): 21 days
Frozen: Unacceptable
Methodology
Kinetic
Performing Laboratory
Cambridge Biomedical
Setup Days
Set up: Varies; Report available: 3 days
Report Available
3 days
Reference Range(s)
544-1228 uM
Clinical Significance
Glutathione is a tripeptide formed by a peptide linkage between the amine group of cysteine linked to glycine and the carboxyl group of the glutamate side-chain. It is an abundant cellular reducing agent, whose major biological function is mitigating oxidative damage to biological macromolecules. Glutathione is also important in the metabolism and excretion of xenobiotic compounds. Glutathione is consumed to maintain cells in a reduced
condition. Consequently, glutathione levels in patient samples are expected to be diminished in disease states where oxygen reactive species are involved, such as rheumatoid arthritis and atherosclerosis. Low glutathione levels have been linked to reduced dopamine production in neurons, which suggests a relationship to dopamine based neurological disorders such as Parkinson’s disease. High levels of glutathione have been linked to chemotherapy resistance in cancer treatments.
@John Lorscheider thirdly.... clearly nobody knows anything about fluoroquinolone antibiotics or there wouldn't have been 800 million dollars in lawsuits in 2016.... for Levaquin alone ...
I'm not saying you don't... Most have no... clue....
Just a bunch of perfect-life problem-belittler's that have never had anything bad happen to them in their entire life.... Those are the people I run into all the time....
This isn't reality....
You want to know what I think's happening....
I think maybe those mitochondria in our cells came from bacteria after all.... Since fluoroquinolone Target's the DNA of bacteria... It may be targeting the mitochondria .... Maybe they have a similar signature... I don't know... But clearly neither does anybody else.... I don't know if a single person that's been healed of this...
This is going to take like $50,000 worth of stem-cell IVs.... It's that much damage....
Mostly what fluoroquinolones are doing to people besides the neurological damage that they do... They cause destruction of collagen throughout your entire body.... Your eyes(retinal detachment)... Your heart(aortic aneurysm)... Your tendons(tendon rupture tendinitis tendinopathies)....
Half-life's don't matter.... Many people have become disabled after taking three pills.... Many of these symptoms began to manifest only months afterward...
This isn't about half life's ....
It's more like being run over by a car.... The damage caused by being run over by a car doesn't decay over time.... It might decay some... but this is not a decay function.
I’m so sorry to hear this has happened to you. In my years as CMO - at MDLIVE especially- slowing the docs down on levaquin was one of my recurring headaches.
@@PrevMedHealth not your fault . I just want to fix it .... So just running tons of labs ... What can I improve ... Then do all those things.... It's too bad I didn't know all of this when I was healthy .
Trying Testosterone replacement therapy but honestly , the FDA needs to issue a recovery protocol at this point and advise to use things like anavar and deca ... Uphill battle given the stigma against anabolics .... But just like medical marijuana.... There are legitimate and VERY important uses for both . . In both cases people are depressed and totally out of options.... You gotta let them try ... Keep trying something.... Or they give up .
@@PrevMedHealth the thing is this ... My kid is 2 going on 3 .... I don't want him to ever figure out his dad isn't normal .... And that he has some problem that nobody understands...
I have this gene mutation, I take daily nutritional yeast (unfortified), and on the label it says Folate which I believe it's the natural form, so in this case it's OK to eat since it's not the syntectic form? Would natural folate bypass the MTHFR ? Or I should completely stop taking the yeast? Thanks, love your videos.
Folate could still be folic acid. You have to take methylated vitamins.
@@andrijaandelic6969 No? Thought Folic Acid was syntectic, folate is natural.
@@whitewidow69 Unfortunately, that's not the case all the time. The food industry uses them back and forth so a lot of foods and vitamins that say folate will be or convert into folic acid. You have to look for methylated vitamins. Check Naturelo Whole Food Vitamins or Seeking Health. They are made with MTHFR in mind and contain methylated vitamins if you look at the label. Folate will have this in the parenthesis (methyltetrahydrofolic acid). Try Naturelo, we have used it and it was great! Just make sure to get the whole food version and not the other.
@@andrijaandelic6969 Thanks for your answer but as s said natural folate it's supposed OK, I'm not questioning if the food industry is telling the truth if it's natural folate or not. My question was if with natural folate was OK. If you're saying that natural folate it's a risk then people can't eat green vegetables which is ridiculous. The whole video talks about Folic Acid, not the naturally occurring folate.
sounds like you had a cold doing this video
Dis doctor must have been vaxed the way he sniffs.