Actually in igg4rd we have found in human a special t cell with character of both cd4 and cd 8 called as cd4ctl they selects sets of cytokines like il1 beta, ifn gamma , and tgf beta _ which explain obliteratirave phlebitis due to endothelial proliferation by il1 and ifn and also they secrets 3 enzymes such as grayzyme perforins and granyolysin which cause local tissue appotosis > to clear this apostolic material macrophage cames but due to precens of tgf beta this macrophage conver to M 2 phenotype Anti-Inflammatory or fibrotic And here APC is b cell not DC so byproduct is igg4
So t + b + plasma cell involved so lymphoplamacytic infiltrate , b cell act as APC but it also got support of il4/ 5 by thf not th2 ( another exception ) in influence of il4 igg4 , and ig e formed and under influence of il5 eosinophilia can ouccer So if u block B cell 1st step u can control d dis so rituxi rocks
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Correction: I have mistaken said pseudotumor cerebri in place of pseudoorbital tumor in the second image
Thank you for detailed and informative video
CD4+ is not cytotoxic.
that is CD8+...
CD4+ is helper T cell
Actually in igg4rd we have found in human a special t cell with character of both cd4 and cd 8 called as cd4ctl they selects sets of cytokines like il1 beta, ifn gamma , and tgf beta _ which explain obliteratirave phlebitis due to endothelial proliferation by il1 and ifn and also they secrets 3 enzymes such as grayzyme perforins and granyolysin which cause local tissue appotosis > to clear this apostolic material macrophage cames but due to precens of tgf beta this macrophage conver to M 2 phenotype Anti-Inflammatory or fibrotic
And here APC is b cell not DC so byproduct is igg4
So t + b + plasma cell involved so lymphoplamacytic infiltrate , b cell act as APC but it also got support of il4/ 5 by thf not th2 ( another exception ) in influence of il4 igg4 , and ig e formed and under influence of il5 eosinophilia can ouccer
So if u block
B cell 1st step u can control d dis so rituxi rocks
👏👍thank you💐
If Igg4 count is 2.15 g/l pls advice
Do lecture on scorpion sting , unknown pesticides come consumption management, and more clinically based lecture please
You posted after many days…………..