IgG4-related disease: How to identify, diagnose and treat

Watch Prof. John Stone, Dr Emanuel Della Torre and Dr Arezou Khosroshahi share practical insights on the clinical presentation, classification and diagnostic criteria, and current and emerging treatment options for immunoglobulin G4-related disease (IgG4-RD); filmed at the American College of Rheumatology Convergence 2023.
Now on-demand here - touchimmunologyime.org/igg4-r...
This activity is funded by an independent medical education grant from Horizon Therapeutics and is jointly provided by USF Health and touchIME.

[@peterharrop4685]

Please could alleviate my concerns? Your excellent video causes me to ask the following questions. Is this relevant to the IgG-4 class shift after mRNA booster shots? Due to the indolent nature of IgG-4 related disease, could we, potentially ,slowly see a massive increase in this disease over the next few years? How long before anyone can say it is or is not a problem?

[@universaltruth2025]

th-cam.com/users/shortsNgs26OeSWfc?si=gZDvLpvOkLnoTdxp

[@universaltruth2025]

Look up Mero genomics.
Delete the gap in that name. My replies being deleted.

[@RuinThatDay]

@@universaltruth2025 good advice !

[@shahinarya]

Yes. I know a case of exactly that. Two weeks after the second double dose of a booster mRNA/Moderna (double because the patient was diabetic, hence CDC recommendation to double booster), the patient was hospitalized, and Type-1 Pancreatitis diagnosed.

[@renataromanowski7174]

Vielen Dank für das hochladen. Es sind wertvolle Informationen für mich 🙏

[@marcofranzosi8825]

Would it be possible to have the link to the slides presented?

[@charisacuster2775]

I need help getting Treatment with my igg4 and igg2 results. I have autoimmune. Constantly have sinus and ear infections seems like im always sick. Rheumatologist told me that she can't treat me. I need to see an immunologist. Cant find immunologist to treat the igg4.

[@minicraftslearnplay3509]

Hi 👋 how high is your igg4? Did you had biopsy

[@realness_rarity]

I’m in the uk and the ‘ igg4 specialist ‘ dr George Webster here won’t assist me as my blood results don’t show high igg4 levels but but histology does show igg4 albeit not over the diagnostic threshold but the storiform fibrosis pattern, the lymphocytic infiltrate and others is present - because of this he won’t help me .
Ive already had my left submandibular gland excised due to a mass last year, eus of pancreas as I had a mass, lesions and obliterated distal duct and now this week I’ve had an ultrasound of my neck and now my right submandibular gland has an igg4 mass according to my report
What do I do because I feel constantly unwell and the uk dr won’t help me he’s so fixated on the igg4 levels and that’s it

[@ArtificialArtifact]

Have you been vaccinated with a mRNA vaccine? If so;
1: Which one?
2: Did you take it before or after being naturally infected with Covid?
3: Have you had any boosters if so how many?
Studies are showing that vaccination before natural infection creates an igG4 spike, where it is dominant over all other igG subclasses for an extended period.

[@keeleykobobel5507]

Is this caused by mold toxicity? Strep? Staph ?

[@christinabehr8938]

Nobody knows yet, by what IGG4-RD is caused. In my case I would say stress and trauma - but there is no definite answer. But as not everyone who has to deal with mold in their appartment has IGG4-RD I would say it's more of a risk factor - if anything.

[@sharonlovely4653]

Jab

[@user-vy5rs1rh4n]

All of those potentially my understanding which is rudimentary, this is the body off switch to immune system, the way we develop tolerance to antigens