This was thought to be a Resident Evil clone but when people actually played it they immediately changed their minds. This game is a masterpiece in nearly every aspect; story, gameplay, music score, and horror. This game is especially terrifying, specifically the character Eve and her gruesome transformations.
PE2 was very similar to Resident Evil. It's actually a good game but it feels far less ethereal than PE1 did. PE1 had a unique vibe & I agree it is a masterpiece. PE2 just felt like generic horror. As good as it was.
Of all the rip off remakes and reboots flooding the gaming libraries, THIS is NEEDED! Or even a sequel?!? This was one of my all time favorite games... That theater scene tho!!!
I've never played the game but i know from my uni classes that we only get mitochondrias dna from our mothers chromosomes, so that might explain why the entity is named Eve
Seems like it. Also while it is usually inherited maternally, it isn’t really tied to chromosome, it just happened that females are usually the one capable of passing it. The way it happened is also bizarre, in almost all case the mtDNA from fathers voluntarily “destroy themselves” in presence with the mother’s mtDNA. The reason i used usually and almost all above is because there are some cases where it can be passed paternally or even biparentally (heteroplasmy).
@@anonymouswhite7957 Biological mechanism to better integrate the fetus with the mother's cellular rhythms? Epigenetically it's important to assimilate for fetus survival. The microbes of the body have trouble integrating themselves in foreign bodies because they are not cultured the same way (i.e. lifestyle, difference in intake of prebiotics (i.e. fiber)) the mother doesn't usually take up the same eating patterns as the father so this could create a hostile environment for the foreign father mtDNA.
Love that you support and help people with emulation of older games. Preserving old games for history is more important than some monolithic companies unused copyright they keep locked in a vault.
I remember getting goosebumps watching this parasite eve video on an old ps1 demo disc and getting scared seeing that rat mutate. Also that bumping opera song that played. Fantastic
Parasite Eve is one of those games I played as a child around the same time as Resident Evil 3 and the first Silent Hill on PS1. It's one of those weird but brilliant games that simply doesn't get made anymore. I think I'll dust off the old PS3 and download it from the Store along with the second one. Great work as always, Max. 🤟🏻
@@josedorsaith5261 Indeed, I still remember how lucky I felt finding an import of the OST to PE1 at a local Comic and Anime shop back in 99. The rough days before Amazon delivery :P
I remember when this game came out. I rented it when I was 10 and never made it past the piano lady. It was way too scary. Glad somebody is explaining the game I missed out on. I found it odd that you chose Mitochondria to describe the game in one word. I was thinking along the lines of the game's tone and how it made me feel. I never thought to use something like the game's subject or antagonist to sum something up. You have a very interesting way of thinking.
Mitochondria really is an ever-present element in the game, to the point that it becomes a little funny how much it is mentioned from chapter 2 onward.
I prefer the term, "liberation" since Eve's entire goal with Aya was to awaken her and have her join her side. Aya's human instinct overwhelmed her alignment, it's something Eve could not understand since she wasn't one.
Love you for covering this, parasite eve has a very special place in my heart. I had pe2 disk and played it on my Ps2 as a kid every single day it's a big part of my childhood. I hope this great series comes back one day
Was always shitty at Math and Science in school as well. Realized later in life that it was more to do with how I was taught and who was teaching me. You released this literally 24 hours after I ordered an AP Chemistry and Physics workbook. Synchronicity?
Glad to see you covering Parasite Eve, I didn't know about the game back when the PS1 was in its heyday but came across it on the PSN store for the PS3. 1&2 were really fun games and I even have the 1st games OST on CD. I really wish that they'd revive this series just like I want Dino Crisis to be revived.
Games from '90s are unlike anything we get now .They are remarkable. This was truly a golden era for jrpg games and not only. Those werethe days when production of games was simpler and yet, developers could let themselves for more unrestrained creative freedom. And they were doing it with actual care rather than having to fulfill specific requirements.and and market expecations.
Kick ass video max! This actually reminded me of a book a read called biology of transcendence by Joseph Chilton Pearce. He tries to make the best scientific argument he can that our neural biology and development show its intent was enlightenment but our day to day gets in the way.
Never finished the first Parasite Eve, but the other two are other story. Like to see how scientifically factual the first game get its (besides the artistic freedom regards the mitochondria 'powers'). Love to see more videos on the subject, Max man. Great work!
The sequel is part of the first game.. Its just everyone was so lazy with completing or understanding it, Thats its all you can say - ''Other game'' etc.
Even though it wasn't a subject you had a lot of experience with, you really pooled your resources and the results were really cool to see. I seeing people take weird concepts like mitochondrial combustion and figuring out how realistic they are.
.. Fantasy and reality are only two sides of the same coin. What happened to be made into reality was done on purpose, While what was left as the dark-underside to it being fantasy.. Thats never completely 'Impossible' from also being made and included in reality, While reality being undone and shelved into fantasy.. That can happen too under the right, Most-unfortunate circumstances. Its happened before in small, But gruesome ways to entire cultures..
That lesson helped me understand why the mitochondria acted as it does throughout the series! 👍 I thought it was some misnomer or something due to my thinking that the cell would have nuclei should have been at the center of the plot rather than the mitochondria. This video has been enlightening, like most of your videos. Thank you! 💕
One of my favorite sagas ever. It mixes emotions and science perfectly. Also, what changes would you people have made to the second game ? I already have ideas for whoever is interested.
The second game was fine compared to the nothingness that came after it, So what are you TALKING about? Pe2 set up a brilliant opening for a sequel(s) where MORE than just Aya would have developed parasite-powers, Which would inevitably bring the wrath of those who WOULDNT have powers on them out of fear or worse, Thus creating some kind of civil-war. But barely any people noticed that, Madigan being the most outstanding suggestive but subtle-clue as to this having been something in aya's world's future.
Every time I see a video of Parasite Eve 1 I CLICK ON TIME. It's a game my cousins played and it scared me of the cutscenes because I was a kid, but I always wanted to know what was going on. As an adult, I finished 4 times and 2 of them were with the Chrysler Building. Every time I see about the game somewhere I go after it to find out if still exists something that I don't know about it or if the much desired REMAKE can exist!
My brother got this game as a gift from a pawnshop my parents had visited. He wasn’t really into horror so I ended up playing it the most. Almost made it to the end as a kid, but never could quite beat it. Went back a year ago and played through it twice. One playthrough for the default ending and the other for the true ending. My young self would have been happy.
you have no clue how happy i am to find this video. this was my very first playstation game (didn’t have many consoles growing up, got a ps1 at age 18, i’m 24 now) and this game, THIS beautiful piece of art, is all i talked about for two years straight. i’m SO happy i can relive this again
Super amazing game, one of my favorite games actually. The best way to do science fiction is to stay as close to real science as you can. The book and movie where great and I think they did a great job making a westernized continuation of the story. It always makes me happy seeing this game get love. Thanks for the vid mayne ^_^
My all-time favorite game without audio. When you finish the game you get to keep your most powerful weapons/armors and start the game over with them! The game has serious replay value!! Needs a remake.
I loved this game. I even read Sena's novel, which I didn't love so much, but I guess it was alright. So of course I had to watch this video, very interesting as usual. 😁
@@emmanuel_disla Nice. ;3 Probably confused it with the manga, Which ive heard is untranslated. But thats awesome, Ive always been curious about the written portions of this franchise.
This raises a question that I hope you can answer Max, how far can biology go? Can there every be a creature that, through their own pure biology, perform action that one would describe as magical?
Roanoke is awesome for the biology angle...one vid he did had the concept that if a multi cells become cancerous so had the ability to live as single cell but work together as a blob to reconstruct biomass was interesting to me he had the concept of how it could reform neural pathways
before I finish watching this, I would like to thank Max for this wonderful analysis of the game. This is so far the most unique analysis of the game, talking about transcending human... hmmm we're in the right track for Max Derrat Analysis.
Hey Max! There's a couple of indie games by the same developer that are worth checking out! The developer is called orange~ & the games are called "Fear & Hunger" & "Fear & Hunger 2: Termina". The second one just came out recently!
Great research, oxygen is therefore vital because it is used as the final receptor of the H+ ions, otherwise acidity would disrupt the mitochondria. I believe that is the basis of Prana, and much of the philosophies that deal with this "breath of life", it is a constant race to quench the inner fire in our cells.
This game introduced me to so many scientific oddities, like the aforementioned spontaneous combustion. I loved this game as a 12 year old who loved science, philosophy, and imaginative storytelling as this game touched on all those aspects. Thank you Max for playing this game and analyzing it.
One of the first videos I watched from you. I adore Parasite Eve and wish I got it on PS1/PS2 originally. SE really really needs to make an ‘HD Remaster’ ‘HD Port’ for newer consoles, like most of their 90’s RPG Library.
The Turing Test is also pretty grounded when it comes to its scientific foundations. Though, a study of molecular genetics and organic chemistry might be needed to fully enjoy how far they take it. Great video
The reason why parasite Eve has such a science field to it is cause it based off(sequel too) a book written by an author who studied in a similar file of science (I don't remember the exact field). He later became an author in which he used his science background to come up with really cool ideas. Definitely give the original book a read it amazing.
It transcends science, Suggesting at the end of medium like the movie, Or book, Or the games that theres something each are lacking, Both the mitochondria and the humans, And thats inevitable that theyre both going to encounter it in the future. Something supernatural that enhances each of the organisms..
Hey Max, how are you doing? I really wanted to see your take on the whole Godwyn the Golden lore. His mutation after death (the fish tail, the weird head) and the whole concept of "the one who lives in death" might be a good subject for a video.
I remember playing this game when i was like, 7 or 8. Years later in grade 8, learning about parts of the cell, i was blown away to learn that not only is the mitochondria real, its the powerhouse of the cell
The universe definitely has to hold some form of tangible thought invoking process because I literally just said to myself maybe two weeks ago “Parasite eve was honestly the coolest scientific blend of survival horror. If they remade or produced a third one now, it’d probably be crazy as hell.”
I was going to recommend Roanoke. Instead I shall recommend Grimbeard for his musical knowledge. Also, a book called Blood Music. Not about vampires but rather about a scientist who teaches blood to think.
The book was wild so how the first game plays off it is pretty nice. Its pseudoscience but its all grounded in the real world save for melting people all over the place and levitating without legs.
Although it does take a leap in belief in regards to how the science works, the idea of your very cells rebelling against you was always fascinating and terrifying! Imagine a creature that could control what your body does on a molecular level. Unless you have some sort of defence you would slowly loose your mind as your body twisted to the will of that creature. I think that’s why the police station attack and the mutation of Shiva always stuck with me. The animal wasn’t automatically under EVE’s control and struggled to get away from the young boy before completely mutating. Plus the scene was fantastic for PS1 graphics!
Coming from a science (pharmacy) background, I love the content you make that addresses transcendence. Fun fact; Mitochondria used to be independent of single-celled organisms. That's why mitochondria have their own genetic code (mitochondrial RNA)
Yep Max mentioned it in the vid, also so does chloroplasts in autotrophs. The human body is much more of a mix and match than most people perceived. 40-80% of our DNA are viral DNA, 10-100 trillion microbiotes residing in and on our body, ecto and endoparasites, etc. They are also more influential than previously thought. One of the viral DNA called Arc are responsible for safe transfer synapse firing by instructing the construction of capsids (directly affect reward system and consciousness). Having a separate neurochemicals system in our gut, microbiote adhesion can also affect our CNS. Parasites aiding in human evolution (like toxoplasma that is theorized to help in human self domestication, by “pacifying” the population)
Love the video, but gotta point out: "The body is 75% water" --paper on screen at the same time stating 60%. Again, love the content, this was just too funny 😅🤣
That's telekinesis, Kyle! OK, I'm sure 1,000 people resisted the silly urge to type that haha but for real, PE needs a remaster, same combat system though, it was amazingly fun
Talk about deja vu. I was just flipping through an old EGM magazine which had a full page advert for Parasite Eve in it. This video came up on my feed and I wondered why it sounded familiar?!
In this universe they do. It looks like the mitochondria that inhabit the brains in this universe's women suffered an accelerated mutation that allowed them to cooperate on the body's mutation based in the brain's orders of survival.
@@-TriP- in a way they do. They are the responsibles for your brain's regulation and choose which parts are to be estimulated in order for you to respond to an experience. Not to mention how the body is directed of course.
Lab technician here: while PE obviously tries to make the magic in the game seem like it has a scientific basis, and while some of the technobabble is based on fact, most of it is utter bullshit. NONE of the effects manifested in the game are even theoretically possible just as simple re-engineering of existing flesh, and all the mutations seen in the game would be almost instantly fatal. An interesting bit of scientific lore though, is that this symbiosis of mitochondrial ancestors and our own evolutionary ancestor's cellular structures is what makes us animals: this is the factor more than anything else that defines an animal cell as an animal cell, and the rest is simply traits that emerges after this union. Additional bit of lore: in the same way mitochondria provide energy for animal cells, chloroplasts perform the same function for plants, and chloroplasts are also 'captured' organisms that became organelles for plant cells, and that's what makes them plants. In the ancient past, plants and animals were basically the same thing, until each Kingdom absorbed different powerhouses. Oh, lastly, if you want to tap me as a way to answer some questions Max, I'll help if I can.
not to be picky, but I wouldn't say "plants and animals were basically the same thing", more like "plants and animals didn't even make sense as separate categories" : p
@@user-sl6gn1ss8p Yeah, that's a fair nitpick; I often have trouble trying to guide the line between what a professional would know, and what a layman would grasp. I think it would be more accurate to say that back in the beginnings of life, before major categories of complex, multi-cellular life came around, the major differentiating factors were far more murky and at this point difficult to tell. It wasn't until you got profoundly different characteristics inherent to the Kingdoms, like mitochondria/chloroplasts for animals and plants, that things really started to take on separate categories. I think before that distinction most life could be categorized as either Protists or Eukaryotes, with maybe some Archaea depending on what period we're talking about. Fungi is basically what plants and animals would've become if they hadn't absorbed their own power plants elsewhere, and honestly the way I've always looked at it is that Fungi are 'failed' plants and animals that sortof stayed in the middle and just went far more slowly since they couldn't rely on the extra power.
@@LabTech41 oh, that sounds like an interesting way to look at the difference between animals, plants and fungi. I had never looked into how fungi get energy, but that's an interesting question, given the mitochondria and the chloroplast.
@@user-sl6gn1ss8p Well, think of it like a tradeoff: Fungi, pound for pound, produce and use far less energy than plants or animals, and as such their growth is far slower, but they fill a lot of niches between them and they're far more durable. Most people think of stuff like mushrooms as basically a plant, but there's also forms of fungi that have animal like qualities, such as slime molds; they straddle a lot of lines. They're immobile for the most part and have harder cell walls like plants do, but they actively digest matter to get their nutrients like animals do. Their primary value, their real niche, is that fungi are decomposers: their consumption of dead animal and plant matter, and returning it to the environment, is supremely important insofar as keeping ecological chains going, otherwise the entire biosphere would be choked with detritus and all the available material would be locked up in otherwise useless matter. It's all about interconnected webs of dependence, which is why the primary motivation of the Parasite Eve enemies makes no sense to me, because from the mitochondria's perspective it's gotten a free ride for little effort for the better part of a billion years: while the rest of the cell has done all the work. All the mitochondria's really responsible for is maintaining what's called the Kreb's Cycle, or the citric acid cycle as it's otherwise called. It's like having a roommate, but you pay all the rent, and all they have to do is cook dinner; why the fuck would the roomie resent that arrangement enough to kill the guy paying the rent?
The way you explain Mitochondria in this game and how it can mutate to the point of evolution, it's a lot like the X-Gene in the X-Men Comics as well as the Animated Series
Something I feel was sorely overlooked here are mitochondrial uncoupling agents. The mitochondria is more akin to the lungs than the muscle of your cell since they are the organelle utilizing oxygen. They utilize a series of chemical reactions with many intermediates with an overall chemical formula that overall is similar to a combustion reaction. The traditional combustion reaction uses the high electron attractive potential of oxygen such that combining it with electrons (forming water) unleashes energy. In your run of the mill combustion reaction that energy is just given off as heat and light. The mitochondria and the breakdown of glucose (and other molecules) act almost like a Rube Goldberg machine to collect that energy and pack it away in molecules (ATP) with high energy bonds, creating an energy currency for the rest of your body. The final stage before (the bulk of) ATP production involves setting up a vast difference in concentration of Hydrogen protons between two sides of a membrane within the mitochondria. An enzyme placed within that membrane then acts akin to a hydroelectric damn, allowing those protons to flow down their gradient (across the membrane) while using their movement to power the creation of ATP. The relevance to Parasite Eve is that heat can be produced very quickly when this membrane system is bypassed. Creating a hole in the membrane causes protons to spill out so quickly and in such great quantity that it generates massive amounts of heat within an organism. This is a naturally used mechanism among voles and other animals in specific fatty tissues called “brown fat”, allowing them to warm themselves. It is also utilized by infants with the molecule poking holes in the membrane called “thermogenin” coming from therm-related to heat and genin-meaning creation. There have been pharmacological agents created and tested to do the same thing. The idea is that if you can make your body waste energy this way you could force it to utilize your body’s energy stores resulting in weight loss. The problem was the people using it produced too much heat and nearly cooked themselves from the inside out. Forcing people’s mitochondria’s to do this would have been a far more realistic way of causing death with mitochondrial mechanisms in this game. Or Eve could have just made them stop producing ATP. This would have been like asphyxiating them since you primarily need lungs to get oxygen to your mitochondria anyway. Not sure I’d call this the most scientifically accurate game.
Im in the exact same boat with an interest mostly in psychology, psychiatry, philosophy, etc. Human kind is very fascinatingly simple yet complex when it comes to actions and ideology. So its equally fascinating that someone else in the same boat is just as interested, if not moreso, in this little series :D
DNP a metabolic uncoupler, I think that compound could be worth looking into. Many people trying to lose weight cooked themselves alive taking the stuff, so I assume it acts upon the mitochondria.
All you require for a combustive reaction is oxygen, heat, and some kind of fuel. For instance, you can take a bag of fresh cut grass, seal it up, and then put it in a dry place. It will get hot inside from decomposing, and also as a result of that decomposition oxygen will be generated, and of course the grass itself will be the fuel. Many houses have burned down due to this, and even more garages and barns. This is just one of a plethora of examples where combustion can happen without any obvious triggers. It is not a requirement that combustion be existing to begin a combustion reaction. When heat, oxygen, and fuel exist in the same space, combustion can spontaneously occur.
NOT! but... Sena did write his PhD thesis on the basis of the relationship between mitochondria's inner workings and fats. The story itself takes the endosymbiotic theory as its main source. Of course, the main plots contains 1:1 the same scientific absurdities as RE - impossibly quick mutations, breaking the 2nd law of thermodynamics, etc.
In the case of the mitochondria causing spontaneous human combustion. Most humans wear clothes ( fuel source ) 85% of the day , every day , all year. We've been doing that for millions of years too.
15:22 Roanoke Games is amazing with biology & is really funny. Hope there’s a future collaboration 🥳
Do it!
Even the girl who helped with the video gets the rip off spam comments.😂
@@prouddegenerates9056 and I even reported the previous ones 😂
@@prouddegenerates9056 ...and even then many people are surprised by the Dead Internet concept lol
Would be an awesome colla to be sure!
This was thought to be a Resident Evil clone but when people actually played it they immediately changed their minds. This game is a masterpiece in nearly every aspect; story, gameplay, music score, and horror. This game is especially terrifying, specifically the character Eve and her gruesome transformations.
PE2 was very similar to Resident Evil. It's actually a good game but it feels far less ethereal than PE1 did. PE1 had a unique vibe & I agree it is a masterpiece. PE2 just felt like generic horror. As good as it was.
Funny how much the RE live action movies pulled from PE…
Lol absolutely nothing like RE .both one and 2 are just so not
@@BoozeAholic idk literally only the auto aim but that's it lol
the god awful fucking sequel was the resident evil clone.
Of all the rip off remakes and reboots flooding the gaming libraries, THIS is NEEDED! Or even a sequel?!? This was one of my all time favorite games... That theater scene tho!!!
You know there were two games? 🤨
@@MartiniBlankontherest Three.
The first game does deserve a remake or reboot... the other two, not so much.
@@Exile_Sky Two, there is no such thing as the third birthday. Fake game.
@@trissc6855 lol. Look, we can dislike that a thing existed.. like a certain LoZ game, but mistakes were made and it did exist.
Come to think of it.... I vaguely remember playing a sequel and being extremely disappointed... Geez,, it was like 20 years ago...
I've never played the game but i know from my uni classes that we only get mitochondrias dna from our mothers chromosomes, so that might explain why the entity is named Eve
Seems like it. Also while it is usually inherited maternally, it isn’t really tied to chromosome, it just happened that females are usually the one capable of passing it. The way it happened is also bizarre, in almost all case the mtDNA from fathers voluntarily “destroy themselves” in presence with the mother’s mtDNA.
The reason i used usually and almost all above is because there are some cases where it can be passed paternally or even biparentally (heteroplasmy).
@@anonymouswhite7957 Biological mechanism to better integrate the fetus with the mother's cellular rhythms? Epigenetically it's important to assimilate for fetus survival. The microbes of the body have trouble integrating themselves in foreign bodies because they are not cultured the same way (i.e. lifestyle, difference in intake of prebiotics (i.e. fiber)) the mother doesn't usually take up the same eating patterns as the father so this could create a hostile environment for the foreign father mtDNA.
Actually according to the book and movie it's because the mido originally created the first female
also mitochondria are thought to have been unicellular organisms that our primordial cells engulfed and made them work
That's just fantasy, I bet the creator is just studying biology and then making up something from that knowledge
Love that you support and help people with emulation of older games. Preserving old games for history is more important than some monolithic companies unused copyright they keep locked in a vault.
I remember getting goosebumps watching this parasite eve video on an old ps1 demo disc and getting scared seeing that rat mutate. Also that bumping opera song that played. Fantastic
Parasite Eve is one of those games I played as a child around the same time as Resident Evil 3 and the first Silent Hill on PS1. It's one of those weird but brilliant games that simply doesn't get made anymore. I think I'll dust off the old PS3 and download it from the Store along with the second one. Great work as always, Max. 🤟🏻
I did the same with SH2 (got leave ending) and now PE, (just left Soho) the holidays really bring out the gaming in me.
@@motivatorsoftheheart0007 While I myself really focus on getting 300 Junk Weapon, and then, try to Challenge Chrysler Building. Wish me luck.
@@excelfate1602 Yeah, the 300 Junk weapon makes the game too easy.
Love that you’re covering one of my favorite games. I play this every holiday season to match the game’s timeline. ❤❤❤
The soundtrack alone is incredible
Same, I just left soho. Had to run back to the station to drop items then I'm off again.
@@josedorsaith5261 Indeed, I still remember how lucky I felt finding an import of the OST to PE1 at a local Comic and Anime shop back in 99.
The rough days before Amazon delivery :P
I remember when this game came out. I rented it when I was 10 and never made it past the piano lady. It was way too scary. Glad somebody is explaining the game I missed out on.
I found it odd that you chose Mitochondria to describe the game in one word. I was thinking along the lines of the game's tone and how it made me feel. I never thought to use something like the game's subject or antagonist to sum something up. You have a very interesting way of thinking.
Mitochondria really is an ever-present element in the game, to the point that it becomes a little funny how much it is mentioned from chapter 2 onward.
@@Rihcterwilker Ah, so it starts to feel like brainwashing via repeated words or phrases I'm guessing. 😂
I prefer the term, "liberation" since Eve's entire goal with Aya was to awaken her and have her join her side. Aya's human instinct overwhelmed her alignment, it's something Eve could not understand since she wasn't one.
Dude I remember getting this game as a kid and I couldnt get past the piano lady, *eve*. lolol
HAHAHAH "TIM THE TOOL" LMAO
A remake for Parasite Eve in Unreal 5 would be gorgeous!
Love you for covering this, parasite eve has a very special place in my heart. I had pe2 disk and played it on my Ps2 as a kid every single day it's a big part of my childhood. I hope this great series comes back one day
Me 2
I had the 1st one the 2nd one and 3rd birthday
I love them all
Was always shitty at Math and Science in school as well. Realized later in life that it was more to do with how I was taught and who was teaching me. You released this literally 24 hours after I ordered an AP Chemistry and Physics workbook. Synchronicity?
Before I’ve even start watching this, I want to say, I’m super excited to watch this, as this is one of my absolute favorite horror games
Glad to see you covering Parasite Eve, I didn't know about the game back when the PS1 was in its heyday but came across it on the PSN store for the PS3. 1&2 were really fun games and I even have the 1st games OST on CD. I really wish that they'd revive this series just like I want Dino Crisis to be revived.
hidden gem of a game that was ahead of its time. deserved much more recognition. they don't make em like they used to.
Games from '90s are unlike anything we get now .They are remarkable. This was truly a golden era for jrpg games and not only. Those werethe days when production of games was simpler and yet, developers could let themselves for more unrestrained creative freedom. And they were doing it with actual care rather than having to fulfill specific requirements.and and market expecations.
Kick ass video max! This actually reminded me of a book a read called biology of transcendence by Joseph Chilton Pearce. He tries to make the best scientific argument he can that our neural biology and development show its intent was enlightenment but our day to day gets in the way.
Never finished the first Parasite Eve, but the other two are other story. Like to see how scientifically factual the first game get its (besides the artistic freedom regards the mitochondria 'powers'). Love to see more videos on the subject, Max man. Great work!
The sequel is part of the first game.. Its just everyone was so lazy with completing or understanding it, Thats its all you can say - ''Other game'' etc.
Great video.
p.s. those Darkwood voting results looked quite nice, hope you make a video about it too. Love that game
Max I love Parasite Eve lore, and this is your best video ever. Happy Holidays!
Even though it wasn't a subject you had a lot of experience with, you really pooled your resources and the results were really cool to see. I seeing people take weird concepts like mitochondrial combustion and figuring out how realistic they are.
I'm so excited that you made an episode for this game 🥳 🎉
How is this video 4 minutes old and this comment 2 days
@@keyofdoornarutorscat Patreon supporters get it early.
Parasite Eve is one of my all time favorite video games. The soundtrack is amazing and I still listen to it after so many years.
I think the same way. What's funny to me now is how many facts have become false and how much fiction has become reality. Great Work as always man!!!
.. Fantasy and reality are only two sides of the same coin. What happened to be made into reality was done on purpose, While what was left as the dark-underside to it being fantasy.. Thats never completely 'Impossible' from also being made and included in reality, While reality being undone and shelved into fantasy.. That can happen too under the right, Most-unfortunate circumstances. Its happened before in small, But gruesome ways to entire cultures..
That lesson helped me understand why the mitochondria acted as it does throughout the series! 👍 I thought it was some misnomer or something due to my thinking that the cell would have nuclei should have been at the center of the plot rather than the mitochondria. This video has been enlightening, like most of your videos. Thank you! 💕
One of my favorite sagas ever. It mixes emotions and science perfectly.
Also, what changes would you people have made to the second game ? I already have ideas for whoever is interested.
I’m not interested. I like your name, and pfp
The second game was fine compared to the nothingness that came after it, So what are you TALKING about?
Pe2 set up a brilliant opening for a sequel(s) where MORE than just Aya would have developed parasite-powers, Which would inevitably bring the wrath of those who WOULDNT have powers on them out of fear or worse, Thus creating some kind of civil-war. But barely any people noticed that, Madigan being the most outstanding suggestive but subtle-clue as to this having been something in aya's world's future.
Every time I see a video of Parasite Eve 1 I CLICK ON TIME. It's a game my cousins played and it scared me of the cutscenes because I was a kid, but I always wanted to know what was going on. As an adult, I finished 4 times and 2 of them were with the Chrysler Building. Every time I see about the game somewhere I go after it to find out if still exists something that I don't know about it or if the much desired REMAKE can exist!
This is absolutely, without a doubt, one of the games of all time.
It definitely is one of the games
One of the best two-games (Third is just mostly awful and doesnt matter)
"one of the games of all time" well duh
My brother got this game as a gift from a pawnshop my parents had visited. He wasn’t really into horror so I ended up playing it the most. Almost made it to the end as a kid, but never could quite beat it. Went back a year ago and played through it twice. One playthrough for the default ending and the other for the true ending. My young self would have been happy.
Happy that you're studying one of my favorite games (probably my second favorite), and happy you enjoyed it too.
I remember being stoked to learn about mitochondria after having played this
you have no clue how happy i am to find this video. this was my very first playstation game (didn’t have many consoles growing up, got a ps1 at age 18, i’m 24 now) and this game, THIS beautiful piece of art, is all i talked about for two years straight. i’m SO happy i can relive this again
Super amazing game, one of my favorite games actually. The best way to do science fiction is to stay as close to real science as you can. The book and movie where great and I think they did a great job making a westernized continuation of the story. It always makes me happy seeing this game get love. Thanks for the vid mayne ^_^
My all-time favorite game without audio. When you finish the game you get to keep your most powerful weapons/armors and start the game over with them! The game has serious replay value!! Needs a remake.
That was a great video and much worth the wait. But can we talk about that thumbnail? Like damn. That sir. That is a good thumbnail!
Another great video as always thank you
Thanks for the vid! I love retro game lore and deep dives.
Love the feel of your videos, always glad to visit.
I loved this game. I even read Sena's novel, which I didn't love so much, but I guess it was alright. So of course I had to watch this video, very interesting as usual. 😁
People don't seem to know that he (sena) owns the IP and is the reason no more PE games have been done.
Yeah the novel is just so dry
Was that novel in english? Id like to buy and read it if it is translated..?
@@DavidpuzzlerU9738 The name of the novel is also Parasite Eve in English, it has indeed been translated and you can find it on Amazon, for example.
@@emmanuel_disla Nice. ;3 Probably confused it with the manga, Which ive heard is untranslated.
But thats awesome, Ive always been curious about the written portions of this franchise.
This raises a question that I hope you can answer Max, how far can biology go?
Can there every be a creature that, through their own pure biology, perform action that one would describe as magical?
I don't remember the exact quote but any sufficient technology would be impossible to tell from magic.
Roanoke is awesome for the biology angle...one vid he did had the concept that if a multi cells become cancerous so had the ability to live as single cell but work together as a blob to reconstruct biomass was interesting to me he had the concept of how it could reform neural pathways
Loved this game. One of the few I played to completion back in the day. The music and sound effects were awesome.
before I finish watching this, I would like to thank Max for this wonderful analysis of the game. This is so far the most unique analysis of the game, talking about transcending human... hmmm we're in the right track for Max Derrat Analysis.
I’m so excited your covering this game !!
Hey Max! There's a couple of indie games by the same developer that are worth checking out! The developer is called orange~ & the games are called "Fear & Hunger" & "Fear & Hunger 2: Termina". The second one just came out recently!
Great research, oxygen is therefore vital because it is used as the final receptor of the H+ ions, otherwise acidity would disrupt the mitochondria.
I believe that is the basis of Prana, and much of the philosophies that deal with this "breath of life", it is a constant race to quench the inner fire in our cells.
This game introduced me to so many scientific oddities, like the aforementioned spontaneous combustion. I loved this game as a 12 year old who loved science, philosophy, and imaginative storytelling as this game touched on all those aspects. Thank you Max for playing this game and analyzing it.
Also, isn't it interesting how chlorophyll and mitochondria are so similarly structured?
Not sure if you always had that intro but it’s so fucking dope the dead aim save room theme is so awesome
Happy new yer Max. Stay Red!
Roanoke Games and Max Derrat working together would be awesome!
I’ve been studying endosymbiosis recently and am very happy I stumbled onto this video
PE has haunted my dreams and my soul since I was about 6 years old.
I’m 30 now.
Love all your content
This is the greatest Christmas video I've ever seen!!
One of the first videos I watched from you. I adore Parasite Eve and wish I got it on PS1/PS2 originally. SE really really needs to make an ‘HD Remaster’ ‘HD Port’ for newer consoles, like most of their 90’s RPG Library.
The Turing Test is also pretty grounded when it comes to its scientific foundations. Though, a study of molecular genetics and organic chemistry might be needed to fully enjoy how far they take it. Great video
The joke alone at 7:00 had me. Subscribed!!!
I love good videos about this game. I probably played it 30 times at least between NG and mostly NG+ since 1998
The reason why parasite Eve has such a science field to it is cause it based off(sequel too) a book written by an author who studied in a similar file of science (I don't remember the exact field). He later became an author in which he used his science background to come up with really cool ideas. Definitely give the original book a read it amazing.
It transcends science, Suggesting at the end of medium like the movie, Or book, Or the games that theres something each are lacking, Both the mitochondria and the humans, And thats inevitable that theyre both going to encounter it in the future. Something supernatural that enhances each of the organisms..
Hey Max, how are you doing? I really wanted to see your take on the whole Godwyn the Golden lore. His mutation after death (the fish tail, the weird head) and the whole concept of "the one who lives in death" might be a good subject for a video.
RE:Dead Aim intro music?! ❤️
I ADORE that game.
Coincidentally, Sphere Hunter's the only person I've seen properly cover how bonkers it is.
I remember playing this game when i was like, 7 or 8. Years later in grade 8, learning about parts of the cell, i was blown away to learn that not only is the mitochondria real, its the powerhouse of the cell
I wholeheartedly agree, you and Roanoke Gaming should collaborate on this!
The universe definitely has to hold some form of tangible thought invoking process because I literally just said to myself maybe two weeks ago “Parasite eve was honestly the coolest scientific blend of survival horror. If they remade or produced a third one now, it’d probably be crazy as hell.”
I was going to recommend Roanoke. Instead I shall recommend Grimbeard for his musical knowledge.
Also, a book called Blood Music. Not about vampires but rather about a scientist who teaches blood to think.
Good to see Grimbeard being mentioned! I love his music and humour with his video game reviews.
Love the RE Dead Aim save room theme for the Intro
The book was wild so how the first game plays off it is pretty nice. Its pseudoscience but its all grounded in the real world save for melting people all over the place and levitating without legs.
Although it does take a leap in belief in regards to how the science works, the idea of your very cells rebelling against you was always fascinating and terrifying! Imagine a creature that could control what your body does on a molecular level. Unless you have some sort of defence you would slowly loose your mind as your body twisted to the will of that creature. I think that’s why the police station attack and the mutation of Shiva always stuck with me. The animal wasn’t automatically under EVE’s control and struggled to get away from the young boy before completely mutating. Plus the scene was fantastic for PS1 graphics!
LESSS GOOO!!!!
(Just so you know, I suggested this before the poll :)
Coming from a science (pharmacy) background, I love the content you make that addresses transcendence.
Fun fact; Mitochondria used to be independent of single-celled organisms. That's why mitochondria have their own genetic code (mitochondrial RNA)
Yep Max mentioned it in the vid, also so does chloroplasts in autotrophs.
The human body is much more of a mix and match than most people perceived. 40-80% of our DNA are viral DNA, 10-100 trillion microbiotes residing in and on our body, ecto and endoparasites, etc.
They are also more influential than previously thought.
One of the viral DNA called Arc are responsible for safe transfer synapse firing by instructing the construction of capsids (directly affect reward system and consciousness). Having a separate neurochemicals system in our gut, microbiote adhesion can also affect our CNS. Parasites aiding in human evolution (like toxoplasma that is theorized to help in human self domestication, by “pacifying” the population)
Love the video, but gotta point out:
"The body is 75% water"
--paper on screen at the same time stating 60%.
Again, love the content, this was just too funny 😅🤣
That's telekinesis, Kyle! OK, I'm sure 1,000 people resisted the silly urge to type that haha but for real, PE needs a remaster, same combat system though, it was amazingly fun
Squrenix would need permission from the IP owner/ books author who doesn't appear to be interested in anymore adaptations.
"mitochondria, son"
- Steven Armstrong
"Mitochondria... The powerhouse of the cell!"
-Monsoon
Talk about deja vu.
I was just flipping through an old EGM magazine which had a full page advert for Parasite Eve in it. This video came up on my feed and I wondered why it sounded familiar?!
A very interesting concept, but somehow manages to end up going the same way the "We only use 10% of our brain" concept did.
I loved this game back in the 90s. It's the game I would most like to be rebooted. I thought I was the only one
Consciousness requires some kind of neural network, which mitochondria posses no faculty of. Nonetheless, the prospect would be terrifying.
In this universe they do. It looks like the mitochondria that inhabit the brains in this universe's women suffered an accelerated mutation that allowed them to cooperate on the body's mutation based in the brain's orders of survival.
what if all of the mitochondria within an organism are what forms this "neural network"?
@@-TriP- in a way they do. They are the responsibles for your brain's regulation and choose which parts are to be estimulated in order for you to respond to an experience. Not to mention how the body is directed of course.
A remake and a proper sequel of this game is much needed. This had a pretty big impact on me back in the day.
Yah!! Thank you for doing this one Max!!
I you want more collaboration ideas, try Burgerkrieg and Meme Analysis, you might get along well with both of them for different reasons.
Excellent video, thanks!
You and Roanoke Gaming doing a collab would be great. Your philosophical and scientific analysis with their scientific analysis would be great to see.
Lab technician here: while PE obviously tries to make the magic in the game seem like it has a scientific basis, and while some of the technobabble is based on fact, most of it is utter bullshit. NONE of the effects manifested in the game are even theoretically possible just as simple re-engineering of existing flesh, and all the mutations seen in the game would be almost instantly fatal.
An interesting bit of scientific lore though, is that this symbiosis of mitochondrial ancestors and our own evolutionary ancestor's cellular structures is what makes us animals: this is the factor more than anything else that defines an animal cell as an animal cell, and the rest is simply traits that emerges after this union.
Additional bit of lore: in the same way mitochondria provide energy for animal cells, chloroplasts perform the same function for plants, and chloroplasts are also 'captured' organisms that became organelles for plant cells, and that's what makes them plants. In the ancient past, plants and animals were basically the same thing, until each Kingdom absorbed different powerhouses.
Oh, lastly, if you want to tap me as a way to answer some questions Max, I'll help if I can.
not to be picky, but I wouldn't say "plants and animals were basically the same thing", more like "plants and animals didn't even make sense as separate categories" : p
@@user-sl6gn1ss8p Yeah, that's a fair nitpick; I often have trouble trying to guide the line between what a professional would know, and what a layman would grasp.
I think it would be more accurate to say that back in the beginnings of life, before major categories of complex, multi-cellular life came around, the major differentiating factors were far more murky and at this point difficult to tell. It wasn't until you got profoundly different characteristics inherent to the Kingdoms, like mitochondria/chloroplasts for animals and plants, that things really started to take on separate categories. I think before that distinction most life could be categorized as either Protists or Eukaryotes, with maybe some Archaea depending on what period we're talking about. Fungi is basically what plants and animals would've become if they hadn't absorbed their own power plants elsewhere, and honestly the way I've always looked at it is that Fungi are 'failed' plants and animals that sortof stayed in the middle and just went far more slowly since they couldn't rely on the extra power.
@@LabTech41 oh, that sounds like an interesting way to look at the difference between animals, plants and fungi. I had never looked into how fungi get energy, but that's an interesting question, given the mitochondria and the chloroplast.
@@user-sl6gn1ss8p Well, think of it like a tradeoff: Fungi, pound for pound, produce and use far less energy than plants or animals, and as such their growth is far slower, but they fill a lot of niches between them and they're far more durable.
Most people think of stuff like mushrooms as basically a plant, but there's also forms of fungi that have animal like qualities, such as slime molds; they straddle a lot of lines. They're immobile for the most part and have harder cell walls like plants do, but they actively digest matter to get their nutrients like animals do.
Their primary value, their real niche, is that fungi are decomposers: their consumption of dead animal and plant matter, and returning it to the environment, is supremely important insofar as keeping ecological chains going, otherwise the entire biosphere would be choked with detritus and all the available material would be locked up in otherwise useless matter.
It's all about interconnected webs of dependence, which is why the primary motivation of the Parasite Eve enemies makes no sense to me, because from the mitochondria's perspective it's gotten a free ride for little effort for the better part of a billion years: while the rest of the cell has done all the work. All the mitochondria's really responsible for is maintaining what's called the Kreb's Cycle, or the citric acid cycle as it's otherwise called. It's like having a roommate, but you pay all the rent, and all they have to do is cook dinner; why the fuck would the roomie resent that arrangement enough to kill the guy paying the rent?
I left a comment on Roanoke's gremlins video he did for Christmas about a potential collaboration. Would be awesome to see that video happen.
The way you explain Mitochondria in this game and how it can mutate to the point of evolution, it's a lot like the X-Gene in the X-Men Comics as well as the Animated Series
Congrats, you disproved my mitochondrial human combustion theory that I made when I was 13 years old
Something I feel was sorely overlooked here are mitochondrial uncoupling agents. The mitochondria is more akin to the lungs than the muscle of your cell since they are the organelle utilizing oxygen. They utilize a series of chemical reactions with many intermediates with an overall chemical formula that overall is similar to a combustion reaction. The traditional combustion reaction uses the high electron attractive potential of oxygen such that combining it with electrons (forming water) unleashes energy. In your run of the mill combustion reaction that energy is just given off as heat and light. The mitochondria and the breakdown of glucose (and other molecules) act almost like a Rube Goldberg machine to collect that energy and pack it away in molecules (ATP) with high energy bonds, creating an energy currency for the rest of your body. The final stage before (the bulk of) ATP production involves setting up a vast difference in concentration of Hydrogen protons between two sides of a membrane within the mitochondria. An enzyme placed within that membrane then acts akin to a hydroelectric damn, allowing those protons to flow down their gradient (across the membrane) while using their movement to power the creation of ATP. The relevance to Parasite Eve is that heat can be produced very quickly when this membrane system is bypassed. Creating a hole in the membrane causes protons to spill out so quickly and in such great quantity that it generates massive amounts of heat within an organism. This is a naturally used mechanism among voles and other animals in specific fatty tissues called “brown fat”, allowing them to warm themselves. It is also utilized by infants with the molecule poking holes in the membrane called “thermogenin” coming from therm-related to heat and genin-meaning creation. There have been pharmacological agents created and tested to do the same thing. The idea is that if you can make your body waste energy this way you could force it to utilize your body’s energy stores resulting in weight loss. The problem was the people using it produced too much heat and nearly cooked themselves from the inside out. Forcing people’s mitochondria’s to do this would have been a far more realistic way of causing death with mitochondrial mechanisms in this game. Or Eve could have just made them stop producing ATP. This would have been like asphyxiating them since you primarily need lungs to get oxygen to your mitochondria anyway. Not sure I’d call this the most scientifically accurate game.
You seem like the perfect person to do a philosophical analysis of DMT
MORE!! This was my FAVORITE game, at the time of release. I was 11 and a total Mon ster movie nerd.
You and Roanoke Gaming would be an awesome combo!
Im in the exact same boat with an interest mostly in psychology, psychiatry, philosophy, etc. Human kind is very fascinatingly simple yet complex when it comes to actions and ideology.
So its equally fascinating that someone else in the same boat is just as interested, if not moreso, in this little series :D
I like how the fact of people exploding in goo mass is more plausible than spontaneous combustion
DNP a metabolic uncoupler, I think that compound could be worth looking into. Many people trying to lose weight cooked themselves alive taking the stuff, so I assume it acts upon the mitochondria.
All you require for a combustive reaction is oxygen, heat, and some kind of fuel. For instance, you can take a bag of fresh cut grass, seal it up, and then put it in a dry place. It will get hot inside from decomposing, and also as a result of that decomposition oxygen will be generated, and of course the grass itself will be the fuel. Many houses have burned down due to this, and even more garages and barns. This is just one of a plethora of examples where combustion can happen without any obvious triggers. It is not a requirement that combustion be existing to begin a combustion reaction. When heat, oxygen, and fuel exist in the same space, combustion can spontaneously occur.
7:01 an iconic noise from an iconic man
Christmas 1997 in NYC. What a time. Beautiful year
NOT! but... Sena did write his PhD thesis on the basis of the relationship between mitochondria's inner workings and fats. The story itself takes the endosymbiotic theory as its main source. Of course, the main plots contains 1:1 the same scientific absurdities as RE - impossibly quick mutations, breaking the 2nd law of thermodynamics, etc.
I loved this game when it came out, I played it so many times. It truly made me love science.
My dude you start with RE dead aim safe room them ? I love you already
I would have never dreamed we'd reach the days when people need tutorials on how to emulate games.
In the case of the mitochondria causing spontaneous human combustion. Most humans wear clothes ( fuel source ) 85% of the day , every day , all year. We've been doing that for millions of years too.