How Long Will Treatment Trials Take? And Why is Research so Hard? | With Prof. Carmen Scheibenbogen

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  • เผยแพร่เมื่อ 24 ธ.ค. 2024

ความคิดเห็น • 150

  • @charramsayroberts
    @charramsayroberts ปีที่แล้ว +19

    Thank you Gez for this series! It’s good to know that there are still people out there working on help for us! I feel like I’ve spent a ton of money this year proving what my symptoms aren’t.

  • @Gusski84
    @Gusski84 ปีที่แล้ว +24

    Thanks for putting this excellent three part series together Gez, such a refreshing contribution to the conversation... although it is indeed scary to think the timelines for LC/ME/CFS studies continue to be so protracted.

  • @smartgrandma
    @smartgrandma ปีที่แล้ว +8

    I have had ME/CFS for the past 30 years (ICC criteria), POTS, Fibromyalgia (since early childhood), Hashimotos Disease, Chronic Lyme disease (since the early 1980's), and Long Covid (from my 1st episode of getting Covid in 2020. I am 68 years old and have not been able to find a doctor that has any knowledge of any of this where I live in Spring Hill, Florida USA. So, it's not just a matter of when will there be any meds to treat Long Covid, ME/CFS, POTS, PEM etc., I don't have access to any doctors who is willing to educate themselves and be willing to take me on as a patient. Medical care is so horrendous here and the for profit hospitals are absolutely horrid.....not caring about their patients, nor their employees who are miserable....only caring about the almighty dollar. So this is all apart of the ugly picture for everyone in my shoes. I have been housebound and recliner/bedbound for over 9 years. Each time that I go to a medical appointment now (especially to an ER and hospital admittance) I become permanently worse. I have no doctor to turn to for help. This isn't living. It's merely existing and is a living death. I am only holding on by my fingernails in the hope that I will get some compassion and help someday.

    • @RUNDMC1
      @RUNDMC1  ปีที่แล้ว +1

      I am so sorry to hear all this :(

    • @renaissance5300
      @renaissance5300 8 หลายเดือนก่อน

      I also have lyme and long hauler I will be contact my old lyme dr again as he shut down for covid I take many supplements which have helped will be looking into a dr in ct usa who helps chronicly ill people I hope you will find a cure for this horror I hope you will find yourself running walking and feeling joy again in your life! god bless i will pray for you

    • @bizonc
      @bizonc 2 หลายเดือนก่อน

      I hear you. It’s impossible to find a doctor not ignorant of the disease. They don’t even try to understand it. I would love to have a doctor in Oregon that I can work with.

  • @ThePoppy74
    @ThePoppy74 ปีที่แล้ว +4

    AXA1125:
    Leucine - 1.00 gram
    Isoleucine: 0.50 gram
    Valine: 0.50 gram
    Arginine: 1.81 grams
    Glutamine: 2.00 grams
    N-Acetyl-Cysteine: 0.15 gram
    The first three can be found as BCAA in the correct ratio.

    • @RUNDMC1
      @RUNDMC1  ปีที่แล้ว +2

      Helpful - thank you!

    • @ThePoppy74
      @ThePoppy74 ปีที่แล้ว

      Struggling to edit the above post for some reason. Subjects were given two x 33.9g doses of AXA1225 daily in the trials.

    • @Benq140
      @Benq140 ปีที่แล้ว

      @@ThePoppy74 So howmuch BCAA does the 33.9g doses of AXA1225 equate to? (of the first three ingredients of course)

  • @brookem706
    @brookem706 ปีที่แล้ว +9

    Thank you so much great video as usual. Isn’t there any way we can find to help push trials along? So frustrating!

  • @bassbaboon6589
    @bassbaboon6589 ปีที่แล้ว +6

    Having been hit really hard by Long Covid since my spell in intensive care with Covid in March 2020, I asked my doctor a couple of weeks ago if there had been any developments in reserach to assist with my lack of proper lung function and significant loss of cognitive funtion, he simply said, "No, long covid isn't a sexy subject anymore and the medical world has moved on." That's nice then.

    • @RUNDMC1
      @RUNDMC1  ปีที่แล้ว +1

      It’s also frustratingly accurate

  • @simonpkershaw
    @simonpkershaw ปีที่แล้ว +6

    Thank you Carmen, I’ve watched quite a few of your presentations, thanks for continueing to have an enquiring mind

  • @deethompson3592
    @deethompson3592 ปีที่แล้ว +27

    Thank you Gez for another informative podcast - I can highly recommend your book - its my long covid bible. I have to say, after 3yrs I personally have plateaued re all my long covid symptoms. I genuinely don't think i will ever improve on where I am and thats not being all doom n gloom its more a case of acceptance and forging a head with a new way of being in life.The more you fight this thing the more frustrated you'll become leading to stress causing unnecessary fatigue ... This is what happens to me - I have limited tolerance for stress so i just try and - Let it go 🎈

    • @Richexperience1
      @Richexperience1 ปีที่แล้ว +3

      3 years here also. I’m starting to make my way to your way of thinking. Been fighting to get back to where I was, but it causes stress and makes everything worse.

    • @deethompson3592
      @deethompson3592 ปีที่แล้ว +4

      @@Richexperience1 I couldn't agree more - it's horrendous isn't it and we have to genuinely mourn for our previous lives but it's the only way forward - Thank God for Gezs podcasts and this community 🙏❤

    • @softcat2004
      @softcat2004 ปีที่แล้ว +3

      I needed to hear this. I'm at 2.5y and accepting I need a wheelchair is the kind of positivity I need - not hoping I might make a full recovery some day, it's better to be happy and accepting of where you are now, not wishing away your life ❤

    • @CBEACH
      @CBEACH ปีที่แล้ว +1

      Have you tried ArtemiC Support th-cam.com/video/B2kRGUuk7Wk/w-d-xo.html
      Long Covid 30 day th-cam.com/video/B2kRGUuk7Wk/w-d-xo.html or
      Long- Covid 32 day combo treatment th-cam.com/video/CxibS0mPRO4/w-d-xo.html

    • @leannshort2211
      @leannshort2211 ปีที่แล้ว +1

      @@Richexperience1Same here also! 😔😭
      I am so horribly stressed over my condition. In my instance it’s MCAS and so I have food sensitivities/intolerances. Back and forth between low dose Prednisone and inhalers to help with my debilitating breathing issues now. Wake multiple times during the night to a feeling of an Elephant on my chest and breathing thru a tiny straw. Wheezing, hard to even take in a breath, so I guess that would be labored breathing. These are my worst symptoms. My husband and I were hiking mountains last year even tho I had already been sick with LC for over a year. I don’t know how I did it, but I’m definitely worse now even a year after that and can’t hike, can’t even go for walks anymore! 😭I’ve been sick now for 2.5 years. My husband recovered fully from Covid, I didn’t. He got a fever, I never did. I think that’s important to note also. Because I also have Chronic Lyme and I guess the bacteria hinder you from getting fevers so as your body is not able to kill it off! 😑

  • @beknight9399
    @beknight9399 ปีที่แล้ว +5

    Thank you again, Gez, Dr. Khan and Prof. Scheibenbogen.
    It would be nice to have an interview with Prof. Schieffer, University of Giessen/Marburg (Germany). He shows - in addition to Post-Covid - a lot of engagement to diagnose and treat Post-Vac sufferers. As cardiologist, he focusses RAAS. Very interesting.

  • @SuperKabookie
    @SuperKabookie ปีที่แล้ว +5

    I have a autoimmune disease and have had long Covid for the last seven months. I am desperate for help because it has taken away my cognitive abilities and gives me super anxiety as well. Numbness, weakness, and overall I just feel like I’m going to die. It’s awful and I hope treatment will become available sooon!

    • @RUNDMC1
      @RUNDMC1  ปีที่แล้ว

      I’m so sorry to hear this Cheri :(

  • @mrfunkyman6860
    @mrfunkyman6860 ปีที่แล้ว +5

    It's funny she mentioned an amino acid because amino acids are the only I found that helped my fatigue. When I forget to take them for a few days, the fatigue comes back, not quite as bad as it was when I first had it but it's still very debilitating. I use full spectrum amino acids.

    • @taragunn9400
      @taragunn9400 ปีที่แล้ว +2

      Love amino acids. Mine focus on anxiety and heart palpitations. Taurine. But do your own research of course

  • @carolenmarch7445
    @carolenmarch7445 ปีที่แล้ว +9

    Thanks to this womderful academic and her team rhe gao narrows for finding meaningful diagnistic gruopings for LC , diagnostic testing and pitential drug treatments . You now just need ti send your primary cate physician this video . Huge thanks to Prof Scheibenbogen and Gez ! 😊

  • @luisevieten2035
    @luisevieten2035 ปีที่แล้ว +14

    There is one thing I dont understand or what makes me very bitter. For HIV so many Galas and concerts were performed to rais money why not for the Long Covid Me/cfs crowd?

    • @mbug7973
      @mbug7973 ปีที่แล้ว

      Because no one cares about us. Sad but true. Most doctors think we are simulants or psychos. I developed post-vac with me/CFS 2 years ago, and believe me, most doctors do not realize that this is actually an illness with physiological cause.

    • @jackholloway1
      @jackholloway1 ปีที่แล้ว +3

      It took years to be fair

    • @RUNDMC1
      @RUNDMC1  ปีที่แล้ว +18

      Because ME/CFS only kills you metaphorically.

    • @mbug7973
      @mbug7973 ปีที่แล้ว

      @@RUNDMC1 People die from ME/CFS! Either directly from it because they are in the very severe stadium and the body completely shuts down, or as a consequence of the increased risk of having a stroke, heart attack, cancer, etc. And let's not forget the many people that commit suicide because they can't cope anymore with the hell they are living in and the lack of medical support. You should have asked Carmen about that. Death from ME/CFS is a reality.

    • @AlbaLynxQueen
      @AlbaLynxQueen ปีที่แล้ว

      I think because there is a test for HIV, and LC and ME are always doubted to be "all in your head".

  • @nooryosef6916
    @nooryosef6916 ปีที่แล้ว +1

    I’m also from Germany, she said that before that we need like 2 years for research, but it was one year ago when she said it.

  • @vamtube1
    @vamtube1 ปีที่แล้ว +3

    Thanks Gez and Asad for this great interview series! I´m wondering if the increase in anti-b adrenergic receptors might be a compensatory effect of lower perfusion due to microclots. That would explain why symptoms return after a few months. Probably combining antibody immunoadsorption and triple anti-coagulant therapy would do the trick.

  • @jaynesierakowska3120
    @jaynesierakowska3120 ปีที่แล้ว +8

    Thank you for your videos. I struggled to hear what drugs the Professor said existed to help ME/CFS? I listened several times but couldnt make it out. Are you able to help please?

    • @llamazoo8724
      @llamazoo8724 ปีที่แล้ว +3

      I heard Mestanon, ivabradine, abilify & low dose naltrexone.

    • @jaynesierakowska3120
      @jaynesierakowska3120 ปีที่แล้ว

      @@llamazoo8724 Many thanks for that Llama.

    • @TheSelflessVibe
      @TheSelflessVibe ปีที่แล้ว

      ​@@llamazoo8724 low dose abilify

  • @luisevieten2035
    @luisevieten2035 ปีที่แล้ว +4

    An other question for Gez would be, what do you think of the FLCCC long Covid Suggestion for Treatments ?
    Greatings from Cologne !

    • @RUNDMC1
      @RUNDMC1  ปีที่แล้ว

      Thanks Luise!

  • @protocode_227
    @protocode_227 ปีที่แล้ว +4

    What's the article or paper in the german physician Journal, which is recommended to take to your doctor?

  • @hollyeverhart9348
    @hollyeverhart9348 ปีที่แล้ว +11

    Thanks Gez for you're continued hard work and all the people out here working hard to find a cure . Us people really appreciate it , it's refreshing to know there is at least people that understand what's going on and not blind sided to it like alot of these doctors are . I've been to numerous amounts of doctors I just gave up , is there anything over the counter we can buy to help reduce the inflammation in the throat and in the chest ? I've went to a low histamine diet hoping it helps some . ❤️❤️

    • @RUNDMC1
      @RUNDMC1  ปีที่แล้ว +3

      I’d try H1 and H2 antihistamines if you haven’t already?

    • @hollyeverhart9348
      @hollyeverhart9348 ปีที่แล้ว +1

      @Gez Medinger what antihistamines do you use ? I've tried Allegra D and pepcid but feels like Allegra D isn't working very well . Thank Gez I appreciate you so much ❤️

    • @geneticainferior2494
      @geneticainferior2494 ปีที่แล้ว +2

      ​@@hollyeverhart9348I had some improvement taking Hydroxyzine.

    • @RUNDMC1
      @RUNDMC1  ปีที่แล้ว +2

      @@hollyeverhart9348 I’m on fexofenadine and famotidine :)

    • @hollyeverhart9348
      @hollyeverhart9348 ปีที่แล้ว

      @@RUNDMC1 thank you so much ! ❤️❤️❤️❤️

  • @bell4textu973
    @bell4textu973 ปีที่แล้ว +6

    Well done Gez! ❤

  • @RachelEarp-j7d
    @RachelEarp-j7d ปีที่แล้ว +4

    Thanks again for another great mini-series. Great to meet you last weekend at Cheltenham Science Festival - a fantastic 'talk' raising awareness. And they say never meet your heros, but in this case it was that definitely wasn't the case. 😊

    • @RUNDMC1
      @RUNDMC1  ปีที่แล้ว +2

      Haha, that’s very kind of you Rachel! Was great to meet you too ☺️

    • @RachelEarp-j7d
      @RachelEarp-j7d ปีที่แล้ว +2

      @@RUNDMC1 Apologies for the 'gushing'! 🤣

    • @RUNDMC1
      @RUNDMC1  ปีที่แล้ว +2

      @@RachelEarp-j7d that’s alright, wouldn’t have described it as that! :)

    • @RachelEarp-j7d
      @RachelEarp-j7d ปีที่แล้ว +1

      😅

    • @barryjohn6101
      @barryjohn6101 ปีที่แล้ว

      There is already a treatment for long covid it's called self employment.

  • @baileystruss7319
    @baileystruss7319 ปีที่แล้ว +7

    Ashamed that we have to be our own guinea pigs. Im currently self trying low dose doxycycline at 25mg every other day. Since it can calm microglial over activation without affecting gut microbiome.

    • @nyrreal8764
      @nyrreal8764 ปีที่แล้ว +2

      I used 200mg two times a day. Only this helped me ...

    • @baileystruss7319
      @baileystruss7319 ปีที่แล้ว

      But thats an entirely different mechanism than what im trying to accomplish. Im not trying to kill bacteria.

    • @nyrreal8764
      @nyrreal8764 ปีที่แล้ว

      @@baileystruss7319 What are you trying? Thnx.

    • @baileystruss7319
      @baileystruss7319 ปีที่แล้ว +2

      ..Trying to reduce neuro inflammation. Specifically microglial immune over activation. There is some research that low dose doxy or mino can help.

    • @nyrreal8764
      @nyrreal8764 ปีที่แล้ว +1

      @@baileystruss7319 But 25mg is too low I think :/

  • @katemclachlan2508
    @katemclachlan2508 ปีที่แล้ว +1

    Ive had strong symptoms of bloodflow issue in hands and feet throughout with ‘covid-toe’ even in summer in hands and feet as well as me/cfs, OI, POTS, MCAS etc. Propanolol has helped. I just wonder whether propanolols influence on b2 adernergic receptors might have interrupted/interfered with the autoantibodies on these same receptors? I feel excited to maybe know the mechanism behind why this is helping rather than just being grateful it is.

  • @melanieolmsted6740
    @melanieolmsted6740 ปีที่แล้ว +1

    Very timely subject for me, oy!

  • @mikejalcock
    @mikejalcock ปีที่แล้ว +7

    Gez, I'm curious, how's your long covid recovery going?

    • @FirstnameLastname-pe5ib
      @FirstnameLastname-pe5ib ปีที่แล้ว +3

      Been 10 months. Overall, a lot better but still have slightly high inflammatory markers which lead to more aches & pains & seemingly higher risk of injury, despite being relatively young.

    • @RUNDMC1
      @RUNDMC1  ปีที่แล้ว +5

      Slower than I’d like

    • @digger663
      @digger663 ปีที่แล้ว +1

      ​@@RUNDMC1 what are your most troubling symptoms still if I can ask? Thx

    • @mitzyb11
      @mitzyb11 ปีที่แล้ว

      ​@@FirstnameLastname-pe5ibwhat symptoms do u still have

    • @mitzyb11
      @mitzyb11 ปีที่แล้ว

      ​@@RUNDMC1hi Gez, what symptoms do u still have

  • @BestCoachOnEarth
    @BestCoachOnEarth ปีที่แล้ว

    thx for your great work !
    Are there any news about enzymes like nattokinase, serrapeptase? I remember there should be a trial running.

  • @leopoldofregoli3817
    @leopoldofregoli3817 ปีที่แล้ว +2

    Speaking of Antihistamins, Gez are you still on those? What protocol are you actually following?

    • @RUNDMC1
      @RUNDMC1  ปีที่แล้ว +2

      Yes I’m still taking H1 and H2. No specific protocol

  • @kathleenbren1523
    @kathleenbren1523 ปีที่แล้ว

    Reminds when they first were able to use germ theory, microscopes to find the different causes of lung disease that were originally all under " consumption".

  • @cordyone
    @cordyone 11 หลายเดือนก่อน

    what was the amino acid trial she mentioned?

  • @GeorgeMonaghan
    @GeorgeMonaghan ปีที่แล้ว +35

    Amazing how quick it was to get a vaccine researched and into people's arms. If only we had waited and done all the normal checks!

    • @Biochemechanic
      @Biochemechanic ปีที่แล้ว

      Not quick at all. Research on that was started in the 1960s.

    • @GeorgeMonaghan
      @GeorgeMonaghan ปีที่แล้ว

      @@Biochemechanic MRNA was first experimented on in 1987 in what was described as a "molecular stew." Used in animals for some years now but not humans until Covid 19. It had been the hope of big pharma to find a "human" use for all the research and Covid 19 provided that opportunity. Those who refused the "vaccine" I think probably dodged a bullet.

    • @perpetualincomeearner8015
      @perpetualincomeearner8015 ปีที่แล้ว

      On Coronavirus tho?

    • @topchic7475
      @topchic7475 ปีที่แล้ว

      Yes! And with the premise that they were ‘saving lives’ !!! If only they were as keen now to throw billions of taxpayers hard earned cash into this research! Fundamentally to doing the same thing… save people’s lives!

    • @nelgoncalvesgoncalves3508
      @nelgoncalvesgoncalves3508 8 หลายเดือนก่อน +3

      For bigfarma quik vacines,quik money.......

  • @nyrreal8764
    @nyrreal8764 ปีที่แล้ว +2

    Is some video about reactivation latent infections/ viruses? I think is very important part of Long Covid. I know hundreds people and they have reactivated Lyme, EBV, CMV, chlamydia, HSV1/2 etc....

    • @radicr
      @radicr ปีที่แล้ว

      Yes, I have EBV reactivated but there is no treatment for that either. At least not here where I live

    • @barkingsquirrel7166
      @barkingsquirrel7166 ปีที่แล้ว

      What about acyclovir?

    • @nyrreal8764
      @nyrreal8764 ปีที่แล้ว

      @@barkingsquirrel7166 Did you try it?

    • @kateroyston9416
      @kateroyston9416 ปีที่แล้ว

      Are these symptoms recurring in “vaccinated” individuals?

    • @nyrreal8764
      @nyrreal8764 ปีที่แล้ว

      @@kateroyston9416 both. So yes.

  • @kapaul1584
    @kapaul1584 ปีที่แล้ว +1

    What drug are they trialing?

  • @epicchannel4724
    @epicchannel4724 ปีที่แล้ว +3

    So if antibodies are potentially a problem, could currently circulating less virulent versions still cause a higher negative effect by stimulating higher levels of those same antibodies?

    • @RUNDMC1
      @RUNDMC1  ปีที่แล้ว +3

      It’s autoimmunity that’s the issue - not the antibodies made to combat sars cov 2 infection

    • @epicchannel4724
      @epicchannel4724 ปีที่แล้ว +2

      @@RUNDMC1 I might be mistaken but don't a number of autoimmune conditions involve antibodies attacking the human body? Lupus for instance.

    • @RUNDMC1
      @RUNDMC1  ปีที่แล้ว +1

      @@epicchannel4724 that’s exactly what they do. Point being these are not the same antibodies created to tackle the initial infection (although lupus generally not infection triggered)

    • @epicchannel4724
      @epicchannel4724 ปีที่แล้ว +1

      @@RUNDMC1 I had believed that part of the problem was that the spike protein had areas that resemble human protein creating antibodies that attack those areas. I have read resemble that claims that it particularly had protein resemblance with protein found in female Uterus and placenta. You may remember the mass reports of women on mass reporting period problems.
      Also we have studies showing antibodies induced by synthetic spike causing MS. The WHO actually published those cases.

  • @cristianserious
    @cristianserious ปีที่แล้ว

    So at the moment is a big problem with getting everyone in a matrix of a diagnostic for proper treatment. Multiple mechanism give the same disorder but different treatment.

  • @maryscarpa229
    @maryscarpa229 9 หลายเดือนก่อน

    My worse symptom is nausea and vomiting I take anti nausea med other symptoms like headaches heart palpitations which have slowed down dizziness and fatigue I have to pace because if I do to much when I feel a little better I end up crashing with all symptoms any suggestions for the nausea.?

  • @bluescrew3124
    @bluescrew3124 ปีที่แล้ว +2

    Thank you

  • @EnockEzra
    @EnockEzra ปีที่แล้ว

    This gives me a tiny iota of hope. Also thanks to everyone involved, from myself, personally. Sad I've been so unwell, that I am way behind on this channel.

  • @hal511bm
    @hal511bm ปีที่แล้ว

    Hello and good day. If a disease worse than HIV/AIDS were to come along how would it compare to COVID/Variants please ?

  • @multiversomental6893
    @multiversomental6893 ปีที่แล้ว

    So basically AXA1125 could be ready in about a year or some more? I was hoping the timeline was gonna be faster 😢

    • @RUNDMC1
      @RUNDMC1  ปีที่แล้ว +2

      You can make your own version of the amino acids combination - just look up the specific ones and quantities used. It’s definitely been discussed on twitter

    • @multiversomental6893
      @multiversomental6893 ปีที่แล้ว

      Oh ok I will try. I mean if the studies so far show that it works, it is worth trying

    • @multiversomental6893
      @multiversomental6893 ปีที่แล้ว

      I didnt find the thread on twitter but I will look up de composition of axa1125

  • @BB-pn2qv
    @BB-pn2qv ปีที่แล้ว

    Hope soon

  • @andtheflyinglizard
    @andtheflyinglizard ปีที่แล้ว

    thank you Gez

  • @jackf8450
    @jackf8450 ปีที่แล้ว +1

    She said a lot of people are recovering. Feel like it's half at most.

    • @RUNDMC1
      @RUNDMC1  ปีที่แล้ว +2

      When there’s 150 million people worldwide with LC, half is a lot!

    • @Turtledove2009
      @Turtledove2009 ปีที่แล้ว

      @@RUNDMC1 Insane to imagine that number, eh?

    • @LostNspace94
      @LostNspace94 ปีที่แล้ว

      @@RUNDMC1 Yeah but what about RELAPSING from re-infection? Randomly relapse not reported or recorded? How do you determine true recovery?

  • @josemontilla-p5s
    @josemontilla-p5s ปีที่แล้ว

    What do you do when you are so severe you can't risk visiting the doctor ?
    To them, there is a real risk of triggering such a brutal crash that, it would not just worsen symptoms, but lower their energy envelope permanently... literally, for the rest of their lives!

  • @rp011051
    @rp011051 ปีที่แล้ว

    if the politicians donot take the lead and remain captured by the pharma industry, pray for the people who will continue to suffer from long covd.

  • @agathahofmann6977
    @agathahofmann6977 ปีที่แล้ว

    oxazepam and physical therapy

  • @timoluetk
    @timoluetk ปีที่แล้ว

    Push!

  • @eltercalpar
    @eltercalpar ปีที่แล้ว +1

    IVM

  • @christopherfields6704
    @christopherfields6704 ปีที่แล้ว

    🤘 Promo*SM

  • @michaelshoemaker8440
    @michaelshoemaker8440 ปีที่แล้ว +5

    Nothing new same old same old

  • @LostNspace94
    @LostNspace94 ปีที่แล้ว

    In other words, very little to nothing is being done. And pharmaceutical corporations are not interested in pursuing due to the lack of profit revenue & investment pay off.
    Long story short. We will continue to suffer with no legitimate help.
    Thanks for the videos though, you all are good people.

    • @CBEACH
      @CBEACH ปีที่แล้ว

      I had a strong case of Longcovid with fatigue😂 but after using the ArtemiC Rescue and Support combo treatment it has completely gone away.