Pregabalin (Lyrica): What You Need To Know
ฝัง
- เผยแพร่เมื่อ 11 พ.ค. 2017
- Pregabalin (Lyrica) is a medication in the gabapentinoid class. It has anticonvulsant, anxiolytic, and analgesic properties. As such, it's used for epilepsy, neuropathic pain, anxiety, and other conditions.
Despite being a GABA derivative, it doesn't appear to be operating through a GABA-related mechanism.
The substance is also used recreationally due to its euphoric, anxiolytic, and pro-social effects.
Overview Page (Including References): thedrugclassroom.com/video/pr...
Reddit discussion: / pregabalin_lyrica
Pregabalin = Lyrica; (S)-3-isobutyl-GABA
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Special thanks to Benjamin/BronzeManul ( / snowkayt ) for helping with the legality info.
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Timestamps
Effects (medical) - 00:23
Effects (non-medical & recreational) - 04:38
Pharmacology & Chemistry - 08:19
How It's Used - 11:34
History - 12:24
Legal Status - 16:44
Safety - 16:54
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Do you gonna make a video about lean?
The Drug Classroom Can you make a video on Cylobenzaprine?
The Drug Classroom hello can you do a video on abilify ? Just started using it love your videos :) would love to see one on abilify
lyrica is very helpful against anxiety, but for best results it should be combined with Lorazepam.
The Drug Classroom pregabalina 75mg. traduciral castellano
Thank you for the detailed information. Your deep dive into Lyrica is impressive. I feel more confident about taking the drug with a full understanding of the benefits and side effects.
I couldn't remember if my name was Lindy when I was at my girlfriend's front door and called out it's Lindy I was confusion about my name and had to ask my girlfriend if my name was Lindy, memory loss and forgetful and this was a couple of years ago and still I have a bad memory.stops the brain or prevents the brain renewing the connections and new connections, There is a article on lyrica and the brain and preventing new connections and renewing connections.i still have nerve pain but I will not take Lyrica ever again.
❤💕💖💝💜👣
@@lindyoneill8779 may I ask the amount of dosage you were taking and for how long? Also, were you on any other medication before or while on Lyrica?
merncat75 I was on 75mg 2 x a day,so 150mg daily, years before I was prescribed lyrica I’ve been on antidepressants since November the year of September 11 planes ,twin towers,I stopped living and just exist ever since. Cipramil 2x20mg once at night ,muralax (oxazepam 30mg) 0-2 a day extreme anxiety and ptsd and it’s the only way I can find me or bring me back when I disassociate from me(it’s very complex)lol, and I was also on anti inflammatory medication for my lower back,that was (BRUFEN 200mg) 1 a day. I think I started taking that about maybe 5 months before I started on lyrica then I found out brufen was linked to heart attacks so I stopped taking them,I don’t think I was on brufen when I started lyrica,I’ve been reading the comments and I read antidepressants and lyrica are not good together,I know it was lyrica that made my memory all messed up and my eye sight blurry and I don’t know if this feeling of ice going down my back and the back of my legs and the feeling of being burnt mostly the size of a smoke burning me but sometimes it can be the size of my hand burning like a flame oh and electric shocks i feel at least 2-3 times a week,this could be because the nerve damage I have is from my neck and daily migraines and nerve damage around my elbow. I hope this helps.🙏💞Sorry I don’t think I said how long I was on lyrica to be honest I don’t know or remember exactly how long I was on it but I know it was less than a year.
Be prepared to take it forever...😢😢
Dam this drug had me eating barbecue sauce with crumpets and Netflix has never been so good 😆 🤣 😂
😂🤣😃
@@larryphillipsjr.1607 its mad how good that actually tasted 😋👌😍
if you would only know how stupid your comment is. people are struggling with epilepsy attacks, this is not joke. your stupid comments keep for yourself and your dearest. this pills have different results on different patients, it is so sensitive matter.
@@zorzobukumica628 Dude chill out, that only happens to people with Epilepsy or at a strong high dose like 900mg which can cause a seizure.
@@zorzobukumica628 but it's true 👍
Have been taking it for about 7-8 years for pinched nerve in my spine.. - It was horrible pain.. - Was prescribed Lyrica and the pain stopped.. - After 6 months of intense pain, I was ‘cured’.. - Had to adjust it a bit, am taking 225mg a day.. - Not only did it stop the pain in my spine,, it also stopped all migraines I was having for years.. - Was having at least two migraines a week, but when I started taking Lyrica, they simply disappeared..
Taper this drug if you’re stopping. Believe me the positive effects disappear and tolerance shoots ip fast, stopping cold turkey causes terrible mental and physical effects, I’d compare it to benzo and opioid like withdrawals combined!
I have myalgia 😢
Lyrica is okay for the first few months then all aspects of it go away, and it's torture to come off/ extreme weight gain is also a serious issue.
are you talking about recreational use or therapeutic? If recreatoinally then you shouldn't take it more than 1 time a week maybe 2 at the very max cause otherwise the tolerance increases.
@@endriu55 sounds like gabapentin with the tolerance going way up in only a few days
@Kentish Rebel Interesting, I’m having those issues and the Dr said it’s not the lyrica Now I’m wondering if he knows anything at all.
@Kentish Rebel damn.. glad u feel ok now
@Kentish Rebel I HOPE 🤞 you’re feeling well, I’m so sorry all those Drs. have left you to suffer. It’s the exact way I feel were I live. As if I’m not good enough or they have something better to do. You deserve to be treat fairly, I’m sure you’re a good person with much to offer. You’re not alone. I’ve got your back (for what it’s worth) and will do what I can from where I’m at.
Lol I took 1200mgs and I started eating yogurt with tostitos chips I had the munchies and I cleaned my whole room and I felt very confident and good. Music sounds awesome too
U know that brother I got Spotify at the ready 😆🤣😂
gabapentinoids are hands down the best type of drugs. Nothing compares whatsoever to me and I've tried virtually everything.
@@marksmanmerc1 better than cocaine with xanax?
@@apfelsaft160 Last longer, completely functional while also feeling great, minimal side effects and instead of a comedown you usually get an afterglow the next day. Maybe my physiology is weird idk, but they're so far the only drugs I've found where the pros outweigh any cons. But if you're into being completely shitfaced(blacking out, can't even talk right, etc.) you'd probably not like them.
@@apfelsaft160 Only real downside that I've only noticed specifically and only with gabapentin is that occasionally some weird suicidal thoughts creep into you're head if you stop after a couple week long binge. Not serious ones just unusual ones.
I made a little change to the TDC website pages. From here on out, particularly for pharmaceuticals, I'm including short "conflict of interest" sections for each paper I talk about. I'll mention if the study was sponsored by a pharmaceutical company or if the authors have some form of connection to a company.
Company-sponsored papers can obviously be useful and are often entirely fine. But the potential for bias exists, so it's worth pointing it out.
A bigger issue is ultimately publication bias and there's not much I can do to address that issue. So, I'll do what I can in terms of highlighting possible conflicts.
Brain synapses? What exactly do you mean?
@Paul Allen what do you mean? Like addiction?
@Paul Allen What do u mean ?
I have general anxiety and social anxiety and at 150mg a day (seems low doesn't it) it really helps my anxiety, by reducing physical symptoms (and panic attacks) and making me more confident around people and relaxed and also helps me sleep (used to have horrible insomnia with around 4 hours or less sleep)
After 2 years of suffering from severe anxiety and depression and being on propanalol 80mg and duloxitine 60mg I am now trying this medicine at 600mg a day.I can say it’s brought back the person I use to be,Get me out of bed and I’m so happy now.
Just DO NOT attempt to abuse this medication as I can see the abuse potential and I know people who have took large doses with no prescription to feel good and high .
This video says exactly what effects I got and is great information.👍
ااا
Youre getting high on that medicine as well. It just helps you cope with your problem. Taking a pill is never a fix all eventually youll havw to learn to manage without it. Withdraw from this medication sounds awful from what i have read and that is another thing youll have to take into consideration.
Thats so good to hear. When I first started on Lyrica it cost nearly 600$ but it helped more than anything else so it was worth it. Now Pfizer sends it to me monthly for no cost and I am also on 600mg a day.
@Barribudda ́ loser
Barribudda ́ take 900mg for every single day for one months and you’ll be the one whining bud
It has been shown in some studies that Lyrica can cause both atrial fibulation and congestive heart failure. A family member just went through this. That fluid retained can also collect around the lungs and cause congestive heart, which it did in our case. Of course the dr.'s didn't agree with my suspicions so I searched and found some legit study cases, printed them out and gave to the dr.s.
I love how asshole doctors always think that they always in every situation know better even when what they're talking about isn't in their area of expertise
Good on you, doctors being submissive to a persons concerns without knowing the truth is so wrong.
Ok I'm 33 and had 5 Af attacks and now have af. It seems to come on when using benzos. Now I'm getting prepared to do an opiate withdrawal and had planned on using pregabs to help with the withdrawals. Now this is the first I've heard anyone else mention atrial fibrillation so it's got my attention. I've got emphysema, no right pulmonary artery and AF. I need to get off opiates to save my life. I'd planned on using either gabapentin or pregablin and some benzos, just whatever will help me succeed once and for all, 🤔
Dan Curry it sucks how well gabapentinoids help opiate withdrawal because they block your brains ability to create new synapses, thus making you just as as likely to be an addict. The best way by far is cold turkey, if you have the strength. Get ahold of some shrooms if you need motivation, overkill is the only way you can hurt yourself so don't go over 3 grams. They definitively help mental illness and it's a shame about their reputation.
@@digforbritain6225 Hope you're doing better man.
It's good that it works for some people. But remember, when you're on the max dosage for a few months or years and the doc cuts you off, you will wish that you're dead.
Randy Bobandy
It's not working, bcuz something else is being damaged. Your getting something for that pain but that something is going to give you a new pain somewhere else .lol
Hence the sticker the pharmacist puts on box: do not stop taking abruptly. In Australia.
Its EXTREMELY controversial in terms of of withdrawal, following discontinuation... Therefore, people have HORRIBLE withdrawal due to Dr.'s not 'believing in' w/d symptoms. MANY Patients go through HELL due to this controversial view on it, within the medical field. Something NEEDS to be done about that because abrupt use can cause reoccurring seizures and the dreadful 'glutamate storm' which is arguably cause irreversible damage on the brain... WAYYY more long term research needed for this drug. WAYYYY to easily and inconsiderably prescribed. That being said... Some find extreme benefits and minimal negative side effects, IF/when the drug us discontinued... Theirs a game of Russian-roulette for ya'! Sounds desirable...
At 300mg/day for almost 2 years and I stop from 300 to 0 no problems without withdrawal...
@@vapor4denyou say that
People who like recreational drugs really sleep on pregabalin. It is probably one of the best medications to use for recreational use, it can be addictive but compared to benzo's, opiods and even alcohol it is alot harder to get addicted. The high is best described as the euphoria and sociability that mdma gives first time users, and the anxiety reduction and relaxation associated with benzos like diazapam. This is a great substance and the only thing someone needs to be careful with is mixing it will alcohol, I have had full blackouts mixing it with large amounts of alcohol even when taking it at medical doses
always a pleasure to listen to you and you speek in easy to understand terms some of the tables you talked about in you're videos my doctor has been able to try these meds as I haven't had to go on listening to the the way they work and I always end up with the right meds,my doctor said that I. should be a doctor cause I understand what he is talking about,and that makes it easier to get me on the right meds,thanks again, keep up the good work
Brilliant. I am on pregabalin in England where it became a control drug on April 1st. This was a great run through of all aspects. Thanks.
No fkin way lol…
'more effective than placebo' lol.. I'd say.
if you take it the once, yeah.
if you take it every day, i have doubts how much better than palecbo it is.
I'm on lyrica I was unaware how popular they are
@@Noah-wv4td There is a lot to be said about psychosomatic effects. I'd rather leave the conclusions based on results and hard knowledge.
@@Noah-wv4td for that matter trip balls
Wish there was more information on how to cope with the confusion and euphoria (more happy, just, a really good day, things that make you angry, are very short). I'm trying to get used to it as it's prescribed for pain (which it does really help for that).
I've been following this channel for a while now, after having tried some of these drugs, what is described here is so accurate, that it is perfect for those who are interested in trying any of these drugs, who wants some truthful information about them first.
i have been taking it for 4 years now (not continuously, only when i need it), as recreation use. and it is really helpful, it keeps me motivated and helps me get things done quickly and more efficiently.
How much dose do you take?
@@AndT101 150-300.. occasionally
@@omarxawneh I took 225mg once. I just got uncomfortably dizzy and slept for 14 hours. Idk how it helps you recreationally at that dose.
@@AndT101 lol.. just lower ur dose.. not all bodies are the same
@@AndT101 bruh I started out on 25
I get severe sciatica at least once a year or more from a herniated disc and the pain lasts months.
I get prescribed lyrica, it's works well and I can move with minimal pain but I do get many side effects. It makes me eat more, I want to drink alcohol when I usually don't, I feel dizzy and it makes me think and act differently. I do like talking to friends on it though and I can string a sentence better than when I'm pain free and soba, it kinda enhances cognitive ability. If I had the choice I wouldn't take it but the pain I experience is extreme and debilitating. I do feel drugged up on it. I usually take 150mg a day but somtimes do 300mg.
Thank you, you do great work and your research is very helpful to others
Sorry, I was prescribed Lyrica at one time for mixed connective tissue disorder (lupus, fibromyalgia, schleroderma etc) and lost 4 days of my life to one starter dose pill. I don't remember anything but my mother said I became very belligerent and refused to allow her to take me to the hospital. We're still not sure why it did this but I will never even touch the stuff ever again.
My son was prescribed this crap for leg pain. He took it for 2 weeks and it made him go crazy for a month. I would steer clear of this drug !!
I had several episodes of amnesia. Used lyrica sporadically, had a half hour of amnesia, then a couple years later I lost an entire day. Don’t remember much. After many tests, it was decided the lyrica was the most likely cause.
I'm a introvert. When i take over 900mg lyrica i turn into an extrovert.
YES. lol
Be Careful that's scary high !
Are you alive still? Just wondering
Agree there brother 🙌 👍 👌 🙏 💯
Same haha motormouthing like a mf 😂
I currently live in Thailand and recently went to one of the government hospitals to get consultation for back surgery. Before I left America two and a half years ago a neurologist said I need back surgery to fix the L4, L5, & S1 but I opted out, out of fear, Hind site...LOL! Well with all the doctors and test I went through here in Thailand and although all the other doctors cleared me for surgery the spine surgeon here said that he did not recommend surgery due to my age (70) and medical history (heart disease) and prescribed Brillion 50mg three time daily which helped with the lower back and sciatica pain to a degree but did not stop the pain. I have been on Brillion 50mg for about two months now and thinking about increasing my dosage ever so slightly to see if I can improve its effects. I think this video was very informative and really mirrored the comments made by the spine surgeon here on its effects.
easily the best drug info / harm reduction channel on youtube by far!
i hope in the near future you do a video on MXP / Methoxphenidine
Thank u Seth. Wow the amount Northwestern got from this drug! I've been on it for fibromyalgia for a number of years, and among the various prescriptions I've had or have, this is the one that seems to help the most, with the fewest negative cognitive effects - and that's a big deal for me. As a professor I don't know if I could continue working if I had to rely only on opioids and/or benzos. I do think it's begun contributing to vision problems over time but that could be just normal aging.
Sal hi I notice your black and white fern are you from NZ?, has PGN been avalible here for years?
I've been taking lyrica for anxiety for about 9-10 years. The only good thing it has done for me is to lessen the amounts of panic attacks I have, and the intensity of the attacks. But the body just wants more and more with time, to keep the good effects. I take 150mg now. I have gained a lot of weight, I'm tired and I can't think clearly.. theres like a heavy fog in my brain.
I'm gonna go down in strength very soon and phase it out of my system slowly, because it's very addictive. In my country it's classed as a narcotic now. Withdrawals here I come..
Come off slowly mate, l was on 300mg per day (150 x 2)..after watching this l now realise this wasn't a large dosage.. it helped ptsd & anxiety somewhat..lve got pinched nerves in my neck, it didn't help with this tho.
Anyway, reducing your dose, try not to cut down by greater than 30% decreases.. My anxiety flared ridiculously as did my insomnia...l read a fair bit online in forums, not a gd idea, they're never positive places.
But l took about 14 mths to rid myself of taking it slowly..none for over a year now.. so good luck with it mate..it has gd results..but definitely wasn't for me.
Im on it since 2 years and gained almost 30 Kilos. But my doc have me the okay to Go Higher and lower with the dosage If needed im on 150mg now from 450 mg a few weeks ago. Right now im better with my rls but there are Times i need more Medication. Its a good Medication If you dont abuse it (in my country thats a big Problem) but the weight gain is too much for me even though im Tracking my cal intake im keep gaining weight 😩
@@inciMoawad I mean.. it has helped me a little bit with my anxiety. But my weight gain has crushed the little bit of self-esteem that I had. Right now I'm down at 25mg per day.. so almost off it.
loving how detailed and balanced your review is, super useful for anyone who might be using/prescribed/used/ or even have a family member using - great work, how long does it take to gather all the info you use?
A most excellent breakdown that just earned a subscription, well done very informative.
As someone who's used high levels of gabapentin [3200mg daily/7000+mg recreationally] I can tell you that withdrawal from gabapentin is longer lasting as far as sleep disruption and intense night sweats. I've abused lyrica as well at levels as high as 3000+mg per day and although withdrawals are much worse [flu-like symptoms], they will only last 3-4 days. The addiction potential is very low with lyrica. I'm sober now [from an intense bout with all drugs, but mainly benzodiazepines and amphetamines] and currently studying to be an addiction specialist, while continuing to take Lyrica at levels of 150mg TID. I often forget to dose and have only taken it as prescribed since getting sober. It also has greatly removed any craving, but mostly regarding the desire for alcohol/benzos which makes sense due to GABA activity (even though they differ on the site). I've been watching you since way back. Thanks TDC!
Since you seem to have plenty of experience with the same regimen of substances as myself, I've never been tempted to use my scripts in a purely recreational way. After getting off benzos (with all the fun "brain shocks") Gabapentin and hydros for over two years, my pain levels returned with a vengeance.
I'm now prescribed 150mg Lyrica tid, and 5mg oxy's, up to pid, along with both a muscle relaxant and anti-anxiety med.
I've experienced that feeling of euphoria a few times and am curious if that is the "high" so sought after when looking for alternative uses?
Also, I've noticed a definite flu-like response if I accidentally miss even a single dose of the Lyrica. Sinuses are a real problem when using these in tandem (at least for me), but I've never read in either the printed or online version of warnings and side effects about it.
Best Regards.
I used to take lyrica and tramadol together and then i was off them for years but due to pain I have been prescribed codeine, horrendous withdrawal and I can't seem to come off of it. In your opinion, would switching to lyrica help? I'm really at my wits end.
Can you please tell me how is your memory/cognitive functions?I am really curious...I am taking pregabalin for health reasons
Hi so one year ago i damaged my costal cartlidge in my third rib. I was diagnpsed wrong and only 2 weeks ago i had an mri which told me the problem. I stay in thailand and they have prescribed me with lyrica, arcoxia and cybalt. Lyrica makes me so sleepy. I wake up and my head feels heavy. Im constantly in pain due to the cartlidge growing back deformed.
It really helps me to fall asleep, obviously. The trouble is in the morning I simply cannot talk. I feel fine and youd never know id taken anything until I try to speak. Its as if my tongue goes numb.
Yo Seth! So this is kinda a tangent but it's still relevant to pregabalin. One of the primary active constituents in 'Valerian root' is something called valeric acid. Valeric acid is closely related to this class of drugs, as well as drugs like valproate (depakote). I've been taking about 500mg Valerian root 3 times a day and it's been helping with my bipolar disorder. Do you think there is some pharmacology going on there? Or is valeric acid just a precursor and I'm mostly experiencing placebo?
I'll have to research valerian more to give a true answer, but from my current understanding the primary actives of valerian might be functioning in a manner that's more directly GABA-related, while pregabalin is based around calcium channels.
Clearly there's some kind of pharmacological action of the substances in valerian. It does have an effect on the body after all.
You could be experiencing placebo, but it might be a real effect.
There are several "valerian acids" in valerian root, while there are scant studies the action does seem to work partially in the section of the brain as benzodiazapenes..so GABA mediation is at work here. First Use a Standardized extract for right amount of Active components-usually 4:1 extract.sometimes a mix of powdered herb with the extract works well.Valproate or valproic acid works on the post synaptic actions of GABA so tends to be used in bi-polar disorders, and some scizo-affective disorders so probably has some dopamine blockade activity..there is no evidence for this with valerian root, though it works quite well as a mild anxiolytic-sleep aid.One Herb in Extract form is KAVA KAVA, this is one of the best Natural anti -anxiety herbs available. it's main components are Kava-Lactones, lactones are well known from other plants , but kava probably has its main mediation through at least in part the GABAa receptor, mediates sedation as well..iv'e gone on too long. but hope this adds to discussion. Seth B.
The Drug Classroom
Have you researched valerian root more yet?
Mixed this with Subutex (Buprenorphine) which I take daily. Man it's like having 20 pints physically you can't stand, walk properly but your anxiety is none existent and euophoria is bliss especially with the opiates like I said.
Brilliantly detailed description of the substance keep it up man!
I'm on 10 mg sub what you on? 🇬🇧
@@mattcurtis3019 I was on 16mg back then I've tapered down to 9.4mg slowly but surely I WILL get off this drug.
@@johnbambrough3189 some people r on it for life uknown I'm 43
i did this today
@@DavidOrz me too. 600mg/lyrica at 5am & 4mg/sub 6pm.
Once again thank u drug classroom for your insightful and informative videos! Keep up the good work!
absolutely great video, you are totally spot on i am impressed very comprehensive
Excellent and very informative video thank you very much for the information.
I love ur videos so interesting ur user name fits I feel like I'm in a class about drugs keep up the good work
Lyrica was a godsent for me. It took me off of any antidepressants, it took away most of my general anxiety, it took away my back pain and it keeps my depression very well in check.
I take 150mg/day but it is a medicine for me, however, i took it recreationally several times out of curiosity and i found out that a good recreational dose is around 600mg at once with mild or no tolerance at all. If you go over 600mg, the side effects like dizziness and drowsiness, impaired motion will be too intense to call it a nice experience so, yeah.To describe the high is very similar to mdma but without the energy and the visual enhancement just the cozy, loving and relaxed feeling with a really strong mental euphoria in the first hour. There is no comedown, it has a pleasent afterglow of general good mood that can last the other day too. Good to know is that pregabalin builds tolerance incredibly fast so basically every other reacreational dose will be significanly less intense so you might wanna use it rarely to enjoy it.
As i said i personally use it daily as medication at a common dose, worked very well for me. The only noticeble side effect in 3 years is weight gain so you might keep in check your diet because you will have increased appetite in time from pregabalin (you will get fat fast if you dont pay attention to it), otherwise nothing negative, i feel way less anxious overall, i'm more empathic (i know for sure that for me it has a mild but welcomed entactogenic effect even at a small common dose), and more relaxed in general both physically and mentally.
If you wanna quit it after a prelonged daily use DO NOT go cold turkey because you will experience bad withdrawal symptoms like headaches, unsettleness and bad migraines that can last for days. Please taper it down, gradually reduce the dosage until you finally quit, take weeks or even a month if necessary dont go cold turkey on it.
Thanks for the information my friend it’s very much appreciated 🙏🏼
how did you ask for doctor for this for anxiety / depression? I tried but they didnt give it to me.
@@DavidOrz just as that, i asked.
I took it one time and made chips and cheese then itook it out of the microwave and poured tons of whip cream on it and brought it to my dad and said" here. This is a new recipe I'm trying"
i never clicked so fast , i was waiting for this thank you ♡
Can it effect HR? Or cause any vasoconstriction? I found some awhile ago but I always thought it was kind of a shitty drug.. I had no idea it could help insomnia and RLS.. this may help me alot but I am a bit afraid to try it because of the high amount that has to be taken
It is a shitty drug.
How long do you need to take it before you feel the drugs effects?
Just watched a documentary on this stuff. I had no idea people were strung out on it
This drug helped me control my anxiety and get my life back on track I never felt addicted and chose to stop talking it as my life is in control.
is this habit forming to where it causes severe withdrawyl? i read this somewhere now i dont know if i want to go back on it.
There are so many 'i know from experience, NEVER TAKE (insert drug)' comments. Every person's body and brain are different, telling someone to never take a drug because you had a bad experience is just silly. I've been on clonazepam for seven years, and by not using it every day I am still taking the same 2mg dose as I did seven years ago. I have stopped using it for weeks at a time to test for withdrawals, and there were none.
Every person is different!!!
Clonazepam saved my life and I got myself of opiates 20yrs mate and now I'm on this (Arthritis and nerve damage in my spine yep it hurts) I am having horrific side effects to this new wonder pill and truly at a loss now what to do.
dothejordman 7 years on 2mg there is No way you did cold turkey with No side effect
@@JacobafJelling He said he doesn't take it every day
dothejordman I’ve been taking 30 mg clonazepam and 50 mg alprazolam every day for 20 years and I quit cold turkey and no effects!!
@@Aypher don't piss down my back and tell me its raining. We all know that is bullshit
For me this caused dizziness a bit but I felt super upbeat too.
lyrica was the only non opiod medication that allowed me to feel halfway decent and get a little sleep during withdrawal from opiate medications.
I use Lyrica for nerve pain in my leg and it definitely helps with that . When I don't take it and I fall asleep I wake up 30 minutes later like someones has been flashing a light in my face.
Are you still using it for nerve pain?
I've a question, I've taken 3x1500 mg total yesterday and a 1500mg today for recreational purposes, when I took the 1500mg today I didn't feel anything basically because tolerance, so I was wondering how long does it take for the tolerance to go away
George Ayman completely 10 days
George Ayman just do a little more bruh start low , add more
You categorized sedation as a negative effect.. Why is that? I find sedation provided by several downers, ie benzos, opioids, alcohol, etc to be quite pleasant, actually.
It can be positive or negative. That's why I sometimes include the same effect in both categories in a given video. Some people mostly dislike it and are only looking for other effects, while others enjoy the sedative quality of various drugs.
Yeah you dumb bitch
vinci vedi vici lex talionas nice
wyatt watterud 😂😂
I also find it positive
Been on it for 3 years it's a miracle for nerve damage
Ever tried to stop it? Wondering bc of withdrawals.
I can't find a consensus on whether this can be used as a kind of 'as needed' basis (like how a benzo could be since it's powerful and 'kicks in' so fast making you feel calm etc) or whether it's more like an SSRI which needs to kind of 'build up' in your system before you kind of 'feel' it. Like, if I was nervous about doing something, I could pop some xanax and my anxiety would maybe go. Is it the same for lyrica?
Zack Nope Nope it has a build up release so doc said the drug has to administrated daily in order for some results/relief, It's not like an aspirin remember we are talking about our nerves. A scientific mystery to modern medicine
@@cherroccoberry2250 hiya. I actually spoke to someone who takes this recreationally today, and he said that it DOES work immediately without it needing to 'build up' over the course of days/weeks. He said he takes like 500mg on an 'as needed' basis, and within a few hours he has zero anxiety
I took this for three days but my hands and feet became really numb. I couldn't feel them for all most a week after stoping the drug. Im back on my gabapentins for my seizures now and I am staying on it. I didnt like lyrica at all.
You are doing god's work seth
Roupization Lyrica is Gods best high lol
Yah right ☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️😱(+_+)
Your welcome , taking nbome everyday isn't easy but it does come with its side effects
I had a pinched nerve in my back and the pain even with percocet and vicodin was so great I was contemplating suicide, solely due to the pain. I am quite strong minded but I was about to give up hope getting relief. I took one Lyrica capsule from a blister pack and my pain was COMPLETELY GONE it was an answer to my prayers. This is the most amazing drug in the world if you have nerve pain. It made me crazy though I had extreme anxiety and pretty bad paranoia. I took it only until surgery, I didnt have any desire to abuse it.
How many mg was it?
Its weird how its perscribed for anxiety but causes it in some people
@@ThaGVPSon that's what I'm paranoid about. I have to say Gabapentin makes my anxiety melt away almost instantly but I haven't tried Lyrica yet.. I'm nervous but hopeful
Exact same situation, about five days using it, my pain was greatly reduced, and after 10 days there was no pain at all.
Does it make an difference to take the pregabalin powder with or without the capsule?
No
Lyrica as given me back my every day life back again. No more severe nerve pain in my back and hips, but I am on a low dose of 75 mgs per day. I had back surgery 2 years ago .
twitches do happen, I have noticed people self included will even drop objects during a twitch.....excellent for every other day use especially for wd from opiates.
Works great for my daughter's diabetic pain but we had to stop it due to the high cost of this medication in South Africa.
Hello I've been using pregabalin for the last 4 years and have never went to any withdrawal symptoms can anyone advise me on what to expect and is there any medication i could use to stem the withdrawal listen iim AFRAID i will collapse and what to expect DAMIEN thank you
Very informative video, thankyou
I take this medication to help me get through work.
I have Fibromyalgia, severe anxiety and panic disorder.. along with arthritis... i have refused medication since diagnosis. Since then I have really had times where Ive struggled so bad I couldn't get out of bed.... this medication was suggested and given to me, but I never filled the prescription, that was a few years ago.. I'm now Considering it... ugh
Lyrica works great for my anxiety. I contacted Pfizer and they actually send me the drug for free. It would have cost me 560$ a month.
Do it
I been prescribed lyrica 150x2 a day for nearly 3 yrz.but try not to take everyday due to hearing all bad effects coming off it.ive had times on it like good xtc were ive had to lay on the bed floating away and other times my eyes just cant focus properly .it does kill the back pain which is prescribed to me for.
Help! I took lyrics at 75 mg for a month, two weeks after the start I noticed a decreased libido. Now I have not accepted the lyrics for 5 days and there is no libido.
I tried twice. She helped me quickly recover after a couple of days partying. Quickly acted and I fell asleep and saw very beautiful and bright with a lot of color shades, dreams!! And for three or four hours of sleep, I woke up and felt good, as if I had not been hanging out for days
same to me 3 hour sleep with it feels like 8 hour or more
WOW, you did an amazing job with giving such detailed information in this video.. I really appreciate it !!!
I'm interested in getting switched from gabbapentin to this but I just don't want to get too low of a starting dose. I'm on 2700mg now of neurontin TID. What is a equivalent pregabalin dose?
baclofen and gabapentin
Denmaki Saewsaq yea I’m on both those, if used in high enough doses you get some pretty unavoidable nodding going on
Is this a good non addicting alternative to benzos if you want muscle relaxation only?If not which drug has the least side effects for reducing muscle spasms without risking addiction?
It would not be a go-to drug for that use. Baclofen may be of use.
Hi seth awesome video! Question: Are you ever going to talk about drug politics, decriminalization, legalization, harm reduction programs, drug law enforcement, etc?
Certainly. I was actually speaking with someone about that recently and I think it'll be good to cover policy as well. It may be a little while, but that's an area I want to expand into.
Hi Seth. Great video mate!
I spent around 5 or 6 years on pregabalin whilst waiting for an operation on my neck. The surgeon now refuses to do the operation due to "ongoing other health problems". I asked him about this stuff that he had put me on all those years ago and was told, that, "It's ok, you can continue to have these prescribed each month at 300 mg x 2 per day".
I spoke to my GP and spent the first 3 months or so of this year, whittling the dosage down until I was finally free of the stuff.
Kids, if you wanna get off your face then there are plenty of less harmful things than this awful shite. Months after bein free of it, my head is still clouded to hell. I forget way more stuff than I even hope to remember. Which sounds ok until you start forgetting more important things in your life. Like how to get home!
I was always dropping shit like an old person. Totally messing with motor function. Didn’t find it helpful for pain at all.
Helped my pain but I was zombiefied
Thank you so much for this information
Can you take ppecabalin n zolpidem together
I took recently 300 mg of pregabalin from my mother's medications, It was a really good experience don't know why but I felt like I was on LSD but without the hallucinations just the colors were more powerful like I put a filter or something, I can say that pregabalin is a good one time try as a recreational drug because it can be really addictive.
Thats what I though yesterday, felt weirdly psychedelic/dissociative. Ive never tooken lsd before but it felt kinda trippy like 2cb
I find this quite common in 900mgs and above and greatly increased Opiate medications too
@@2koP7tooken? Wtf bro 😅
This drug worked well for me but it was the most intense withdrawal symptoms I've ever experienced.
I took pregaballin for 3 weeks for a spinal injury. I was on oxycotin for 3 weeks also and experienced a very limited withdrawal compared to pregabalin.
I'm now taking no pain meds
Mawk Grasper I’ve been on it for 11 years & in some ways it’s worse than opiate withdrawal if one tries quitting cold turkey. Withdraw symptoms are so bad that I try to keep at least half a month extra as a safety net in case of the “unknown” & I have to find a new doctor or something. It HAS improved my quality of life, I was suffering with severe nerve pain. I’m almost 53 & ok with the fact I’m gonna be on it for life. Anyone who decides to start taking this medication needs to talk with their dentist about dry mouth & a proactive plan to battle tooth decay.
Is it safe for kidney and liver?
Watched your Nos video, now im benige watching. Great content!
It worked really well for me to treat anxiety. But the withdrawal can be hell.
For how long have you used it and what dosage? How long did withdrawal last? Why did you stop taking it if it worked well? Thanks.
@@johnj6743 why you asking
Because he wants to know and so do i
I took one last night for the first time. What an awful experience.
Couldn’t sleep, restless, rash and gave me a headache. Its safe to say I won’t be taking it anytime soon.
Thank you
Thanks for the video. Did you skip opiate withdrawal part on purpose?
I didn't. It's mentioned in the video and is discussed in more detail on the linked TDC page.
From video: "For people who are dependent on drugs like alcohol, benzodiazepines, and opioids, pregabalin might be helpful. Some evidence suggests it can reduce withdrawal symptoms and even reduce craving."
Can you cover Temazepam?
I had agonising sciatic pain and pregabalin helped massively. The side effects were pretty bad but faded after a week.
No weight gain, but I sleep for much longer now (7-8 hours) than I did before.
Pain releif is a side effect as is phantom pain
Weight gain is a sideffect as is weight loss
It can fix anxiety and it can cause anxiety
It has no actual use its just a big bag of maybe
@@justinblake420 - clinical trials, and punctuation have their advantages.
@@justinblake420 Excellent Ted Talk
@@NapoleonGelignite Your comma is entirely redundant.
@@naughtymonkey1563 - fixed
Is this good for anxiety? I've just started Lexapro and I feel AWFUL, the anxiety went from about a 2 pre-medication to a 10 after taking it. Horrible reaction. 5 mg only as well
Nooòo please don't take it..all i do is walk on a dam boat and sleep..which isn't VERY helpful because clonazepam makes me sleep im over anxiety and pain farkkkkkk.
try clenezepam or zoplicone SSRIs cause me way to much depresion and even more anxiety its just doctors push them too much
Can this drug help with benzodiazepine detox?
muscle twitches and stuttering speech if taken with antidepressants... anyone else ,?
Pawsha Padfield yessss
Thats interesting, Pregabalin has also been said to have a strong possibility for adverse effects with other serotonergic drugs such as MDMA and its analogues and possibly certain serotonergic psychedelics. Its mechanisms of action are very diverse and quite mysterious at this point so mixing with such powerful medications could be risky and I certainly wouldn't advise it.
yes stress tics
Oh fuck . I'm watching this video because I just got prescribed pregabalin and mirtzapine
Yes I get muscle twitches!!
My mom’s on pregabalin for about 1;5 year now she takes 300 mg a day her stomach is so swollen ankle feet has anyone else exprerienced this ? I really worry
yes I'm.... what would we do
I've been on 300mg a day for over a year now, for nerve pain. Fuzzy head and forgetfulness are my only side affect. How's your mum doing these days?
THANKS TO THINKER'S well getting fat isn’t a serious problem compare to other I think ?
Alexander Atterbury thank you she’s fine but like balloon 🎈:D
Yes, it actually f**ks stomach up.
That... was a LOT of info. Thanks!
I've been using doses up to 1.5g several times (overdose of prescribed medicine). Pretty bad hangover was present day after and effects aren't much stronger.
I HATE Lyrica! Even at a very small dose I had hallucinations, nausea, dizziness, night mares, rapid weight gain (I hardly peed), itchiness under my skin, had trouble getting to sleep, and my hair started falling out by the hand full! Withdrawal was horrendous!
i hope you told you physician
Great! Now do one on Phenylpiracetam.
My squirrel said this stuff is kinda legit when you snort it...
Damn squirrel.
Does it affect central pain syndrome?
Edit: yes it has. Imma ask my doc to prescribe it to me.
Insomnia was the biggest issue for me in withdrawal
I love lyrica . for my diabetic nerve pain
lyricas price is off the chain
yeah...600 per month for mine...I will stick to my methadone for pain.
that's why they sold you to it. you should be taking methadone . absolutely NO high ,no nerve pain and no permanent destruction of your kidneys and liver. oh and the permanent nerve damage. i took it for 3 months and for the last three years i can't grip anything. i can hold it tight and it will slip out like a wet ice cube. my arms ,hands legs and feet ,still feel covered in plastic and it never stopped that nerve pain . how long have you taken it? how many time have you needed an increase? soon it will not work and it is so toxic you can't take it any more and you will need to come off it and that's when you will have total mental breakdown . lyrica is trash. methadone is cheap. no patent. never need increases.never crave it . except for pain. NO HIGH.
Oh, I am SO glad you said that! I just started it for the same exact thing. Neurapathy really sucks. I started at 75mg twice a day. Where are you at for effective use?
@@@andrewturner421 here is now a Generic version much cheaper !
At what dose is it best recommended for generalised anxiety?
150-450 mg/d (sometimes up to 600 mg), starting low and working up from there. The dose is split, e.g. 75 mg twice per day to start and adjusting as needed.
This may sound like a dumb question, but does this drug have any potential to treat addiction? (Opiates)
Yes it does it works wonders for opiet withdrawals
I can absolutely confirm this ,too..............and its not a dumb question, Ive been "taught" that the only remedy to Opioids are Opioids,which I did believe until I found PGN
Yes, but it feel a lot better than Opioids.
AKZPT#74 I completely agree..been there and tramadol is my long term solution..I don't have cravings, depression or anxiety..also, if I miss a dose or dont take any, no need to panic cause I don't get sick! Its what works for me..
Be careful with tramadol, if you miss a few doses because it not only binds to a subset of opioid receptors, it also works on Serotonin- so "serotonin-syndrome" can happen & is not Fun.
This is great drug for anxiety! But much like benzo would not recommend for Longterm use (years) on 450mg a day atm, yes it has abuse potential but not worth it if you’re taking it for a general reason.
Yeah tollerance builds up crazy fast. Even though I dont get the same euphoria it still helps my anxiety immensely.
If I take a recreational dose, once the high kicks in my speech gets slurred. It hard to talk fast and form sentences, I took 900mg and I was very confident and social with no anxiety. But it pissed me off because me speech was fucked
300 mg should be enough, just wait 2-3 hours before dosing. And never drink alcohol with it.
good quality content / delivery... a credit to the WWW