Bone elongation - processes at the epiphyseal plate

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• Interstitial lengthening occurs in only certain bones, primarily those of the appendages.
• Such lengthening takes place at the epiphyseal plate, a layer of hyaline cartilage in the metaphysis of a growing bone.
1. Zone of resting cartilage.
• Consisting of a hyaline cartilage pad made of inactive chondrocytes, this zone anchors the plate to the epiphysis.
2. Zone of proliferating cartilage.
• The mitotic proliferation of chondrocytes in this zone pushes the resting cartilage outward, helping to lengthen the diaphysis.
3. Zone of hypertrophic.
• In this zone, chondrocytes are stimulated to mature and enlarge, helping to lengthen the diaphysis.
4. Zone of calcified cartilage.
• This thin zone of dying and dead cartilage cells cements the epiphyseal plate to the diaphysis and borders the creation of new bony matrix.
• Osteoclasts remove the calcified cartilage and make way for osteoblasts to build new spongy bone trabeculae.
• proliferation of chondrocytes increases cell number.
• The increased numbers of chondrocytes enlarge, moving the epiphysis away from the diaphysis. This increases the length of the bone.
• The larger amount of dying cartilage tissue is replaced with bone matrix thereby solidifying the resulting elongation.

[@Devil-qn4gm]

Thanks

[@nobhk]

Quick and Clear explanation thank you!

[@tahsenhossain3749]

Can i see my growth plates from normal knee x-ray?

[@homeworkclinic2119]

Absolutely, Growth plates are easy to spot on an X-ray because they're softer and contain less mineral, making them appear darker on an X-ray image than the rest of the bone.

[@PunisherBrutalHeadHunter]

For how long? Or will we always see the line .

[@Dietitian.Manahil.99]

What this less number of subscriptions?😑

[@homeworkclinic2119]

The channel is still new :)

[@binai6328]

They deserve more

[@sameerhinduja7357]

That's great informative video so how many years before we can finally manipulate adult growth plates?

[@aozp1451]

Liked. That is an interesting thought. However doing so, may only serve cosmetic or aesthetic purposes. Such purposes are secondary to the true purpose of medicine, which is to heal. Future research, in all likelihood, will be dedicated to treatment of fatal diseases.

[@sadatali455]

Wow that was amazing 😍

[@Cornbreadddd]

What a great, succinct explanation.

[@georgeglenbuenaflor8368]

thanks for the info! it helps ne a lot

[@PadsterX]

great video! one question: by good nutrition, exercise and sleep bones grow quicker, but does it also mean the ephiphyseal plate closes faster? are people suffering from malnutrition shorter because their bones didn't grow enough to close the ephiphyseal plate?

[@The_Man_Who_Sold_the_World.]

Good question

[@Sky_elf]

They don't grow quicker they grow more. By doing those lifestyle changes that you mentioned you can increase final height when the plate does close.

[@sincity5268]

I believe estrogen makes them close

[@johnmottram7895]

Great video!

[@naveramukhtar953]

Thanks.

[@concept_of_BiologyAS]

Thank you so much sir

[@alireza-yu2yd]

best

[@قلاستغفراللهالعظيم]

Thanks Doktor
What is the hormone responsible for the closure of growth centers in the human body?

[@homeworkclinic2119]

human growth hormone (HGH). Produced by the anterior portion of the pituitary gland, HGH accelerates protein synthesis, particularly in skeletal muscle and bones.

[@bertrand00956]

@@homeworkclinic2119 You didn't answer correctly. HGH is not the hormone responsible for the CLOSURE of the growth plate.
Actually, there isn't a "hormone" responsible for the closure of the growth plate. The growth plate closes by itself through ossification, once the rate of ossification and degenerescence of chondrocytes surpasses the regeneration of the proliferative layer.
While there are factor that can cause the growth plate to close prematurely/sooner, there isn't a single hormone or mediator that is responsible for growth plate closure alone ; it closes naturally with time, and the age at which it closes depends on numerous factors, mainly genetics, but also environmental.

[@bertrand00956]

@@homeworkclinic2119 Also, GH exerces an influence on bone growth through somatomedin (IGF-1 mainly). Just saying that GH has anabolic effects doesn't explain how bone elongation works.

[@قلاستغفراللهالعظيم]

But I became famous because women have higher estrogen points for this number of heights only, but men have estrogen, but necessarily for this men Eli as well??????​@@bertrand00956

[@قلاستغفراللهالعظيم]

@@bertrand00956ok I read that women's stock is higher than men's due to estrogen. Is this true?

[@MominsWorld]

thank you!

[@homeworkclinic2119]

Welcome!

[@theinvertedprotagonist]

In your opinion, can sleep deprivation and depression affect this process? Thus a kid won't achieve their maximum potential adult height.

[@homeworkclinic2119]

Sleep deprivation and depression are neuron-based conditions, they would have little to no effect on a person's height or growth potential.

[@theinvertedprotagonist]

@@homeworkclinic2119 This is interesting. I thought that we grow and our body produces growth hormone when we sleep?

[@homeworkclinic2119]

@@theinvertedprotagonist Height is carefully controlled by hormones that are secreted in minute amounts when your body is ready to grow. The pathway that leads to growth and depression aren't linked in even the slightest way. Being under extreme stress, however, can impact any biological process, but it's not a significant factor here.

[@brentporter986]

@@homeworkclinic2119 While it may be true there isn't much demonstrable evidence sleep has no affect on growth directly, you would be hard pressed to say it isn't linked in the slightest way. Someone under low sleep is by definition under high levels of stress. We cannot segment our understanding of human biology and medicine by simplysaying "that's a neuro problem so it isn't linked". Seems like a bit of an overreach.
Whichever the case, this was a brilliant video and very helpful! Thanks for your work.

[@homeworkclinic2119]

@@brentporter986 I agree because growth hormone is normally released during sleep. However, it's not a major factor here

[@prajwalravi4182]

Hey,I'm 20 n 5'7(dad-5'7--mom-5'3)
Will I grow or not??
Thanks

[@bingchilling9942]

Maybe a 1 mm but probably not

[@cesruhf2605]

sad

[@royalfrog3958]

@@cesruhf2605 how old are you. Are you taking eLs to prevent growth plate closure or have they already closed?

[@brolyui4484]

@@royalfrog3958 what is els

[@lefthanded5473]

How tall were you at 18?

[@brucechoi4727]

At what age do bones stop growing?

[@homeworkclinic2119]

When we are about 25 years old our bones stop growing larger, but they keep on building new bone cells to replace old cells.

[@harshitswami5256]

Homework Clinic when ( what age ) does epiphyseal plates / growth plates closes or solidifies ? If the answer is 25 , i assume people can grow taller till 25 ????

[@homeworkclinic2119]

@@harshitswami5256 The plates solidify completely by 25 for male adults, but earlier for females. Growth is 90% complete by your teens.

[@harshitswami5256]

Homework Clinic I am 17 years old male ( i will be 18 in this march ) . I am 5 '6 ( father 5'10, mother 5'0 ) . How many inches can i add more ??? Please help !

[@StudyForceOnline]

@@harshitswami5256 Are you certain your dad is 175 cm to 180 cm?

[@zoyajunaid6351]

thanks, my school teacher sucks

[@homeworkclinic2119]

welcome :)