The Complement System | The most COMPREHENSIVE Explanation

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  • เผยแพร่เมื่อ 3 ก.พ. 2025

ความคิดเห็น • 315

  • @MedicosisPerfectionalis
    @MedicosisPerfectionalis  3 ปีที่แล้ว +10

    💊🦠 Antibiotics Course: www.medicosisperfectionalis.com/products/courses/antibiotics/

    • @phonytexts2
      @phonytexts2 2 ปีที่แล้ว +2

      says it's deleted

    • @ashleelarsen2233
      @ashleelarsen2233 ปีที่แล้ว

      ​​@@phonytexts2 sweet! 6:30 ho!y sh!t no I can't bear compliments!!!!!

    • @ashleelarsen2233
      @ashleelarsen2233 ปีที่แล้ว

      Thank you sir!

    • @Julie.SandhuMD
      @Julie.SandhuMD ปีที่แล้ว

      ALMOST 1 MILLION SUBs !!! YeY

  • @jaru5836
    @jaru5836 3 ปีที่แล้ว +145

    if you see a medical student saying im going to study and YET find him smiling while staring his phone or laptop..
    .its not always tiktok videos he has been simply Welcomed to the famous world of medicosis perfictionalis❤️

  • @kairi419
    @kairi419 3 ปีที่แล้ว +124

    Sir, can I just say that you're carrying me to finish my Medical Laboratory Studies. I'm so thankful mate. You're really helping me achieving a dream here.

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  3 ปีที่แล้ว +12

      My pleasure 😇
      This what I love to hear!
      Good luck 🍀

    • @libertieaguiba1935
      @libertieaguiba1935 2 ปีที่แล้ว +4

      Omg. That’s literally why I’m watching this video haha. My board is coming up soon

    • @meganevans2003
      @meganevans2003 ปีที่แล้ว +1

      Same!!

    • @kellyfoegen7534
      @kellyfoegen7534 9 หลายเดือนก่อน

      I just found this, but same!❤

    • @UnknownPerson-xz2ps
      @UnknownPerson-xz2ps 8 หลายเดือนก่อน

      Can you update me about your degree like how it's going?

  • @MedicosisPerfectionalis
    @MedicosisPerfectionalis  2 ปีที่แล้ว +100

    Note: C2a is the old name, now they call it C2b (it’s still the same protein).

    • @mariyamqazi9829
      @mariyamqazi9829 ปีที่แล้ว +1

      Got it!

    • @joelleandaya350
      @joelleandaya350 ปีที่แล้ว +19

      This one answered my question while watching the video because, in our book, C2a is used. Thanks for the clarification

    • @catherinemundondi4654
      @catherinemundondi4654 ปีที่แล้ว +1

      C2a didn't change the functions is unknown thts why c2b is mostly considered.

    • @rahmanabisha9931
      @rahmanabisha9931 5 หลายเดือนก่อน

      Ig u should pin this

  • @sergiuerdei5739
    @sergiuerdei5739 7 หลายเดือนก่อน +16

    this video is actually worth more than an entire semester of Immunology lectures!! thank you

  • @rajalaxmi2443
    @rajalaxmi2443 5 หลายเดือนก่อน +13

    I have my exams tomorrow and it's an important long question that might come as 10 marks. Its a very big deal!!!! I literally used to just memorize without understanding anything and forget afterwards. Thank you so so much for this video. I wish you were a veterinary field professor 😭🙏🏻crisp clear concepts!!!

  • @aimeemcelvogue9290
    @aimeemcelvogue9290 2 ปีที่แล้ว +66

    Some of your metaphors have me laughing in the middle of the library- and during exam season too! Thank you for making everything super digestible!

  • @miezuni
    @miezuni 2 ปีที่แล้ว +34

    whenever im cramming for an exam (it's not like i want/like to cram, our school sched is so tightly packed), i always watch your lecture videos, and im able to understand AND RETAIN the topic SOOOO quickly in my head! thank you so much!! you make studying medicine seem so easy c: and i love the puns too! haha

  • @chandramoulis.g7202
    @chandramoulis.g7202 3 ปีที่แล้ว +8

    Never understood properly during my college days, scrached my head many times, but now understood in just 5 minutes, wonderful presentation, hope I had a professor like you

  • @Sam-e1b
    @Sam-e1b 7 หลายเดือนก่อน

    This is BY FAR the BEST video on COMPLEMENT SYSTEM!!!!!!!! I have been scratching my head for the past 2 weeks confused with all the alphabets and numbers and now i feel like i figured it all out in just one video. Thanks a lot. Your explanation is top notch and your sense of humour makes watching a 27min video seems like 5 min.

  • @Dn3118-p9g
    @Dn3118-p9g 3 ปีที่แล้ว +11

    I’m taking an immunology test soon and a video by medicosis to get me through this scary lesson is just a life saver!! Thank you so soo much!

  • @fanoor2427
    @fanoor2427 3 ปีที่แล้ว +3

    Omg ! The past few days medicosis has been uploading videos that are in line with what I am currently doing at medical school! This is amazing!!

  • @lunshitang513
    @lunshitang513 3 ปีที่แล้ว +13

    You are such an amazing teacher!!! Could you please do more lectures on immunology? It’s a hard topic but you explain things so beautifully!

  • @Pathologykim
    @Pathologykim 5 หลายเดือนก่อน +2

    i have a huge respect to Dr. Najeeb i think he is one of the best teacher in the world. But for me, you Medicosis suits me better. Thank you so much

  • @MedicosisPerfectionalis
    @MedicosisPerfectionalis  ปีที่แล้ว +1

    Pathology Playlist: th-cam.com/play/PLYcLrRDaR8_ef4PE6gduEK-Gpx4lawX2t.html&si=T45GEAcahgX_TMtB

  • @aliahmedqasem1502
    @aliahmedqasem1502 2 ปีที่แล้ว +5

    iam travelling the whole world in your channel
    from anemia to blood indices to this
    the journey never ends

  • @NihadTabakhy
    @NihadTabakhy ปีที่แล้ว +1

    I swear this video was good and effective for me, especially since I have a final exam in the immune system, and I did not know how to study this lesson.
    Thank you for being here, Professor💕💕

  • @rayaabdullah363
    @rayaabdullah363 ปีที่แล้ว +3

    I was thinking why I, as a medical student, study this subject, but after listening to your explanation, I realized the importance of this subject to me as a medical student, thank you Doctor

  • @shuttleship
    @shuttleship 3 ปีที่แล้ว +12

    FINALLY you did it !! what an amazing video covering all horizons (even that bridge thingy) btw some books mention C3 convertase of classical as C4b2a why is that so ?

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  3 ปีที่แล้ว +7

      There is some disagreements on the nomenclature of the complement proteins between different books written in different points in time.

  • @OnlyJalenPhd
    @OnlyJalenPhd 10 หลายเดือนก่อน

    I’m not a doctor, and I understand that the video includes “a” and “b”.
    My labs just say low 3 and 4.
    Not being an MD, your presentation was well written, and easy to follow/understand.

  • @medicallaboratory4673
    @medicallaboratory4673 ปีที่แล้ว +1

    I was trying to study it within 3 days and I did not understand it. Now I understood it in just half an hour. You are truly amazing.❤

  • @lamialamia5755
    @lamialamia5755 2 ปีที่แล้ว +7

    you are a genius i like when you mention philospher in your presentation but what i liked the most how you putting us in the big picture first and how you connect all systems and subjects to make information usfule and having a sence you are an artiste god bless you

  • @pamelakihumuro3360
    @pamelakihumuro3360 ปีที่แล้ว +2

    I love Medicosis perfectionalis, it appreciates the ♥️ that I am, the bright colors and illustrations, this is my Science way😁🥰

  • @jinyoshida321
    @jinyoshida321 ปีที่แล้ว +2

    And here I am studying immunology, and guy really says do not go to sleep yet... just what I needed 😫

  • @shaikh.700
    @shaikh.700 ปีที่แล้ว +2

    The same energy.
    It reminds me of the time when I studied hematology with you. ❤ Thank you

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  ปีที่แล้ว +2

      You’re always welcome!
      I appreciate you!
      Would you please help me by sharing?

    • @shaikh.700
      @shaikh.700 ปีที่แล้ว

      @@MedicosisPerfectionalis
      Already shared with my fellow 💕

  • @darkconspiracy559
    @darkconspiracy559 22 วันที่ผ่านมา

    Thanks for the amazing video ! I just want to shortly note that in the formation of active C3 convertase after the cleavage of factor B by factor H, there is no C3a released. The released particle is called Ba and and the 9KDa C3a fragment is retained within the structure.

  • @nikendwisetyaningrum279
    @nikendwisetyaningrum279 10 หลายเดือนก่อน

    Sir, my lecturer never give this kind of way learning. Like its hard to connecting the dots from things he explained. But ur video really help a lot. Thanks sir❤

  • @kunkundajonan2470
    @kunkundajonan2470 10 หลายเดือนก่อน +2

    You need to make a video teaching us how you manage to memorize and integrate all this knowledge and some philosophical aspects

    • @Steven_Dunbar
      @Steven_Dunbar 4 หลายเดือนก่อน

      I'm sure they refresh their knowledge of the material during the preparation of the video.

  • @gracessecret4978
    @gracessecret4978 2 ปีที่แล้ว +3

    Sir you're such a life saver! love and respect from Algeria

  • @rajivgayen120
    @rajivgayen120 ปีที่แล้ว +1

    I can't believe you taught me the thing like bread and butter what I was unable to understand for past few months❤❤❤loved this video

  • @tebibamina9563
    @tebibamina9563 7 หลายเดือนก่อน +1

    you're, GENIUS DOCTOR!! I really loved how you explained it with a funny and simple way! you made me fall in love with the complement system ( haha not with William 😂) Thank you so much, I really appreciate your videos ❤❤

  • @ShabirAhmad-pp7yr
    @ShabirAhmad-pp7yr 2 ปีที่แล้ว +2

    Love your lectures and tone.Especially the tricks for remembring the stuff are awesome.....Love and respect from Pakistan🍀🍀🍀

  • @mayukhmitra8820
    @mayukhmitra8820 2 ปีที่แล้ว +1

    When C2 binds to C4b C2a remains forming C4b2a and Cb leaves as anaphylotoxin...Thanks for the lecture u r
    Lifesaver 🥰

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  2 ปีที่แล้ว +1

      C2a is the old name, now they call it C2b (it’s still the same complement protein though).

    • @mayukhmitra8820
      @mayukhmitra8820 10 หลายเดือนก่อน

      ​@@MedicosisPerfectionalis Oh thanks

  • @abdelrahmanmohamedmahmoud850
    @abdelrahmanmohamedmahmoud850 ปีที่แล้ว +1

    Many thanks from Egypt. Please, continue this work.

  • @lucytravis9333
    @lucytravis9333 2 ปีที่แล้ว +1

    this guy is so whacky but i am HERE for it. Really funny and thorough explanation. thank you medicosis, you might have saved me in this fridays exam!!

  • @khatijaafrojbristi
    @khatijaafrojbristi 5 หลายเดือนก่อน +1

    This is first time i comment on youtube. Just appetizing .I wish if you were our proffesor;

  • @ShirsJournal
    @ShirsJournal 8 หลายเดือนก่อน

    Thank you very much!!!❤ GOD is using you to help countless medical students

  • @manshaalagh23
    @manshaalagh23 2 หลายเดือนก่อน +1

    This is my first time visiting to your channel and your explanation as well as the content is really good now I will visit to your page more often :)

  • @AP-ei4jt
    @AP-ei4jt 3 ปีที่แล้ว +2

    I learned the C system before. Thanks for providing a different perspective!

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  3 ปีที่แล้ว

      My pleasure 😇

    • @AP-ei4jt
      @AP-ei4jt 3 ปีที่แล้ว

      @@MedicosisPerfectionalis I’m looking into C5b wrt to COVID and clotting in severe hospitalized patients. Amazing how everything ties together eventually.

  • @zaaarabd6391
    @zaaarabd6391 ปีที่แล้ว +2

    You are an amazing teacher ❤️.. love your videos and how you describe them with so much ease and with such beautiful examples which we can remember

  • @pamelawu2834
    @pamelawu2834 3 ปีที่แล้ว +2

    Awesome content!! Was wondering if I could add another topic on your never ending list of request - a video on haemophagocytic lymphohistiocytosis? Appreciate all the learning you are facilitating here!

  • @dennisjecool
    @dennisjecool 17 ชั่วโมงที่ผ่านมา

    You are great in explaining in a fun way, resembles this game ImmunoWars in which they also very nicely add humor to immune cell gamification

  • @nirwansendraperiera2043
    @nirwansendraperiera2043 ปีที่แล้ว +1

    Now it makes perfect sense 👌 🤩🤩🤩love from Philippines 🇵🇭 💕

  • @-Cece
    @-Cece 3 ปีที่แล้ว +3

    I like your voice and delivery style!

  • @azamahanita4109
    @azamahanita4109 ปีที่แล้ว +3

    Best channel ever 👌

  • @Kalaimaniuniprep
    @Kalaimaniuniprep 14 วันที่ผ่านมา

    Thankyou sir! Your videos are the bestest ones! ❤❤❤

  • @jenneferannestavas4751
    @jenneferannestavas4751 9 หลายเดือนก่อน +1

    I just noticed you now but iIlike you already, it helps me more.

  • @BUNANE-w7g
    @BUNANE-w7g 4 วันที่ผ่านมา

    This is good video with high simplicity, thanks much🙏

  • @yasminaisyaputri
    @yasminaisyaputri 2 ปีที่แล้ว +2

    How do you make it so easy to understand?!?!? Thank you it's so helpful !

  • @zahraatahseen9061
    @zahraatahseen9061 3 หลายเดือนก่อน +1

    Thank you ❤
    When I can find pdf for this subject?

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  3 หลายเดือนก่อน +1

      On my website: www.medicosisperfectionalis.com/

    • @zahraatahseen9061
      @zahraatahseen9061 3 หลายเดือนก่อน

      @@MedicosisPerfectionalis thank very much

  • @pamelakihumuro3360
    @pamelakihumuro3360 ปีที่แล้ว +1

    Guys, we have the Best Teacher Ever.
    😁🤣🤣 I know he didn't just say that, she gone men, she gone
    🤩🤩OH YES HE DID,
    OH YES HE DID!!

  • @EzehChidinma-yo2mg
    @EzehChidinma-yo2mg 5 หลายเดือนก่อน +1

    The side puns😂😂
    Thank you so much for such an amazing video ❤

  • @vishwakhatri3890
    @vishwakhatri3890 2 ปีที่แล้ว +2

    OMG! I LOVE THIS CHANNEL!!!

  • @humairaemma3701
    @humairaemma3701 2 ปีที่แล้ว +1

    you made me so adaptive to your videos i dont Understand any pther person's explanation!!! can u make videos on gynae obs more for post grad?

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  2 ปีที่แล้ว

      Thank you so much!
      I am currently working on a complete Ob.Gyn HighYields course that will be uploaded to my website at the end of February 2023:
      www.medicosisperfectionalis.com/

    • @humairaemma3701
      @humairaemma3701 2 ปีที่แล้ว

      @@MedicosisPerfectionalis omg thanks!

  • @prashanth-py9jc
    @prashanth-py9jc 3 ปีที่แล้ว +2

    Super always I will see all ur videos thank u so much for great videos

  • @silvere.9265
    @silvere.9265 ปีที่แล้ว +1

    Thank you for making my life easier….and that MAC and Attack..😂😂😂

  • @theafricanesther5795
    @theafricanesther5795 ปีที่แล้ว +1

    Another brilliant video. Thank you for teaching me.

  • @Harryy123
    @Harryy123 ปีที่แล้ว +1

    Medicine makes perfect sense here !

  • @nomidiaaitbaziz7886
    @nomidiaaitbaziz7886 ปีที่แล้ว +1

    never thought immunology could be that cool !

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  ปีที่แล้ว

      Thank you so much, Nomidia!
      I appreciate you!
      Would you please help me by sharing?

  • @DoaaHazem-gf7ez
    @DoaaHazem-gf7ez ปีที่แล้ว +1

    Thanks a lot for ur video ur explanation is awesome it helps me a lot to understand

  • @aarthi6089
    @aarthi6089 ปีที่แล้ว

    you’re saving my grades. thankyou so muchhhhhh

  • @coldencostumes2396
    @coldencostumes2396 ปีที่แล้ว +1

    Thanks for the most beautiful and excellent explanation

  • @adnanzia9167
    @adnanzia9167 2 หลายเดือนก่อน

    Medicosis amazing video for medical students, you made me understand this in minutes and remember it more easily. you have micro lessons?

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  2 หลายเดือนก่อน

      Yes! I have 2 Microbiology Playlists:
      - Detailed: th-cam.com/play/PLYcLrRDaR8_ftu9ms-ytDewlhJxYNuIYo.html&si=oQonoxJxTrjYhpdG
      - Quick Review: th-cam.com/play/PLYcLrRDaR8_cITmrZHvCQdjsc-e0kM0_U.html&si=4-5XLHkq_H9u9TMj

    • @adnanzia9167
      @adnanzia9167 2 หลายเดือนก่อน

      @MedicosisPerfectionalis Hi, do you have material on viruses? Also is your material suitable for students doing NBME exams at medical school? Also noticed your premium videos, how do i see sample content?

  • @Jackoline6
    @Jackoline6 2 ปีที่แล้ว +3

    Sir I think the C3 convertase in lectin and classical pathway is C4b2a, not C4b2b. Thank you for the great video btw!

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  2 ปีที่แล้ว +2

      C2a is the old name, now they call it C2b (it’s still the same protein).

  • @amnae.l
    @amnae.l หลายเดือนก่อน

    Thank you for making my day sir!

  • @hamidrezaashayeri7783
    @hamidrezaashayeri7783 2 ปีที่แล้ว +3

    Excellent video
    Only a small mistake: C3 convertase components in classic and lectin pathway are: C4b2a
    NOT C4b2b

    • @BaderWesteros
      @BaderWesteros 2 ปีที่แล้ว

      It was named c4b2a until scientists decided to change to c4b2b for “consistency” reasons

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  2 ปีที่แล้ว +1

      C2a is the old name, now they call it C2b (it’s still the same complement protein though).

  • @pigolamanastia1475
    @pigolamanastia1475 ปีที่แล้ว +1

    great explanation🙌🙌👏👏👏

  • @queennmo
    @queennmo ปีที่แล้ว +2

    Is the humor for me😂😂😂😂❤

  • @RUQAYAHABDULAZIZ
    @RUQAYAHABDULAZIZ 2 ปีที่แล้ว +1

    how the 2nd exposure we use classical pathway who requires an antigen-antibody complex and in the 2nd exposure there is no antigen antibody complex ?

  • @wafaaibrahim2490
    @wafaaibrahim2490 ปีที่แล้ว +1

    So useful .. so interisting

  • @darshankhatri2683
    @darshankhatri2683 ปีที่แล้ว +1

    Best explanation of the complement system

  • @nardjesrazika7861
    @nardjesrazika7861 ปีที่แล้ว +1

    Here's a menomic : when you said " we CALL it complement because it complements the immune system " the word CALL is for the 3 pathways : Classical, Alternative & Lectin

  • @sahartahlawy4609
    @sahartahlawy4609 2 ปีที่แล้ว +1

    You are an amazing person....Thanks very much

  • @norahassan8455
    @norahassan8455 ปีที่แล้ว +1

    You’re amazing.thank you so much :)❤

  • @rimsellami5593
    @rimsellami5593 2 ปีที่แล้ว +1

    Simply, Thank you.

  • @DANNYCHISENGA
    @DANNYCHISENGA 6 หลายเดือนก่อน +1

    You are the reason why I don't attend lectures 🙂🙂🙂🙂🥰

  • @1rrrrrrrrrrr544f
    @1rrrrrrrrrrr544f 3 หลายเดือนก่อน +1

    Thank you so much 💓

  • @tijjanialhmodu9580
    @tijjanialhmodu9580 2 ปีที่แล้ว

    You made this easy to understand thank you 🙏

  • @DrIA-
    @DrIA- ปีที่แล้ว +1

    12:44 C5b it’s a part of the MAC and the MAC will attack , I love it 😂

  • @jojocool6027
    @jojocool6027 2 ปีที่แล้ว +1

    That was so helpful thank you❤️

  • @dge.
    @dge. 3 ปีที่แล้ว +1

    Have been waiting for this!

  • @necipfazlay4059
    @necipfazlay4059 2 ปีที่แล้ว

    10:50 That WAS beautiful. Love your videos, maybe I should like them too..

  • @MoonLight-kt3mb
    @MoonLight-kt3mb 2 ปีที่แล้ว +1

    I enjoy your videos medicosis 😂😂

  • @johnbarghout5605
    @johnbarghout5605 ปีที่แล้ว

    Why C1 Esterase is an inhibitor?
    DO you mean that if it is present so the first step in inhibited?

  • @Snehalyf
    @Snehalyf ปีที่แล้ว

    i wanna see your face. u r just a best medical teacher for me

  • @ddsylvia5654
    @ddsylvia5654 2 ปีที่แล้ว +1

    You guys are good, you make me laugh while learning

  • @soniagrindstaff2416
    @soniagrindstaff2416 3 ปีที่แล้ว +2

    Love your videos 🌼 😁

  • @anivietv279
    @anivietv279 3 หลายเดือนก่อน

    How complement proteins recognise which is pathogen and which is our own cell ?

  • @sarahahmad4147
    @sarahahmad4147 ปีที่แล้ว +1

    thanks for sharing your nice information

  • @rasha1026
    @rasha1026 2 ปีที่แล้ว +1

    thankuuuu for that breakdown!

  • @KidistYosef-i3f
    @KidistYosef-i3f ปีที่แล้ว

    I have a question on the part that say bridge between innate and adaptive for first and second exposure looks same which one need antigen antibody complex

  • @zainabudakheel2462
    @zainabudakheel2462 3 หลายเดือนก่อน

    I think that C3 convertase consists of C42= C4b and C2a??

  • @Dkdc-jw3uk
    @Dkdc-jw3uk 2 หลายเดือนก่อน

    Where can I find the inflammatory mediator video?

  • @salomezhozhadze9071
    @salomezhozhadze9071 ปีที่แล้ว

    what is the video of you called about inflammatory mediators? i cant find it
    thank you for you work tho! im preparinf for an exam

  • @ahmedfahmi1927
    @ahmedfahmi1927 3 ปีที่แล้ว +1

    Thank you very much from Egypt , could you tell me a book or any source that may help to identify the best investigation for internal medicine diseases ?. We know all investigations for each disease but we can't identify the best investigation .

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  3 ปีที่แล้ว +3

      Thank you 🙏, Ahmed!
      I don’t think you can learn this skill in a book. What you want belongs to “mundane knowledge” (based on trial and error, personal experience, clinical skills,…etc), and not something that can be taught in a theoretical book, at least in my opinion.
      This is analogous to
      a young car mechanic asking another mechanic: “what book do you recommend so that I can recognize the best way to diagnose a car issue.” To which the mechanic answers: “only experience can teach you that.”
      So the best thing I can say is: “find a good doctor and shadow him…observe carefully…and take meticulous handwritten notes.”

  • @rayahrababah9183
    @rayahrababah9183 3 ปีที่แล้ว +2

    Thx very good ❤️‍🔥❤️‍🔥❤️‍🔥

  • @lynaberr2704
    @lynaberr2704 ปีที่แล้ว +1

    Thanks I was really not in the mood for another huge lecture to do, talking about the little spice ( jokes u made xD )

  • @swami6444
    @swami6444 ปีที่แล้ว +1

    Great👍👏😊

  • @athithibenny3674
    @athithibenny3674 ปีที่แล้ว

    Does a always leave the cascade ? In my textbook in some places b leaves and a stays altering the convertase formula iyk what I mean 😕

  • @timeless1908
    @timeless1908 ปีที่แล้ว

    why do you have that there is no antigen antibody complex under second exposure? I thought that was supposed to be for the first exposure.

    • @narmin9529
      @narmin9529 ปีที่แล้ว

      i think there is a mistake in slides