قناتك كنز أنا محظوظ لأني وجدتها ،بالاضافة إلى ذالك لقد درست عليك في مادة الانيميا وامتحنتها وقد صادفت سؤال لم يستطيع اغلب الطلاب حله الا انا حللته لأنك ذكرته في الشرح شكراً جزيلاً لك
I'm on my third year of being a pre-med student and whenever I can't absorb the information on the books anymore, I just go to your channel. More like I like how you approach the lessons! Just wanna say thanks!
My wife and I lost our just turned 2 year old son 7 months ago to Aml. He had MLL gene rearrangement or subtype KMT2A or 11q23. He had a translocation between chromosomes 6 and 11, t(6;11). He received cytarabine, daunorubicin, etoposide, gemtuzumab ozagamicin then mitoxNtrone and cytarabine. He relapsed after the second chemo which signified refractory Aml which had a poor prognosis. Decitabine with mylotarg was then used. He died shortly after from within 4 months of treatment. Some side effects he had were bloody nausea and diahrea. Horrible bloody mouth sores. He was in pain all over. His right eye was covered by a leukemia pool that ended up bleeding.He had a lot of liquid in his lungs which they thought was pnemonia. He ultimately died from a brain bleed within 24 hours caused we think by the chemo.
Oh! I am so happy for u. I am an elder sister. I have a younger sister. She has some weird symptoms. Idk what doest it mean. 1) light headed 2) tired & weakness 3) coughs and flu 4) nose bleed 1 time (gum bleeds) just a little bit 5) today she has a unbearable pain on her teeth,ear & arms. But I said my mom about it & she doesn’t care about it. She wanted to say I am much hypochondriac. Basically I am so much obsessed with my sister. Maybe I love her a lot
Have you considered "intracellular" glutathione therapy? There is a whey protein that has a precursor that raises glutathione inside the cell. That glutathione is now able to promote "monoclonal expansion" of T-cells (cd4/cd8) which places cancer cells into "negative feedback inhibition." It works amazingly will in leukemias and many other cancers.
keep going sir :)) this is so helpful, and like I spent 20 hours trying to understand this yesterday but you made it so clear for me in less than 15 mins .. awesome content too .
Hi I’m a retired HemOnc RN who has recently beenndiagnosed with LCH, aka: Langerhans Cell Histiocytosis Can you address a segment to this chameleon like disease? TIA
one question tho, why doesn't it matter where wo do the biopsy? if the clonal cells haven't metastisized yet, they should be limited to one bone and only one bone no?
@@maryjohns7968 no she only began showing “mild” symptoms maybe 3 months(?) prior to diagnosis. At the time of diagnosis however her condition was bad. Very high relentless fever, very pale, weight loss, no energy, bruises everywhere… I’ve never seen a disease like this.
I have a question, in acute leukemias, there are high number of blasts but does that translate to a high total white count? or leukopenia? and in chronic leukemia, I assume that it would be leucocytosis?
In acute leukemias there is neutropenia but WBC count is high due to blasts(as they enter blood stream).And in chronic leukemias there would be leukocytosis.
I wish I could better understand what is going on with me. They found out I had MDS for years that was masked by me having colitis for years. Some of the same in CBC tests are the same. Then suddenly after my colon was removed I came down with AML. All bone marrow biopsy showed I had MDS that progressed to AML. Lone of the mutations were bad. Chemo bought me all the way to cytogentic remission last Sept. Things went great until an adrenal test when I had to stop anything steroid for 5 full days. I started feeling sick, it didn't do away. In hospital the bone marrow showed my AML back with one catch. I have isolated 20q12. Percentage of bone marrow is 86%. Red cells, platelets, and B cells are low. Everything else is normal. Whites are slightly low but not dangerous. Doctors have never seen this. Nothing is documented. They gave me 6 to 8 weeks to live. Now that is up in the air when CBC just before giving me blood showed my platelets went from 30 to 70, Now the doctor doesn't know what will happen other than it will kill me. blast levels in marrow are 20%. Peripheral bone smear marrow smear show 5%. Blasts in blood 0.5%. Blasts in marrow are atypical with slight left shift. What is the world is this and how long do you think I will have to live.
If continuous cell division exposes the folate deficiency Anemia than there should B12 deficiency Anemia and Iron deficiency Anemia too right ?? Or is there any other mechanisms in it, plz explain if you know
@@MedicosisPerfectionalis At 8:17 you were explaining about Lab in Acute lukemia. Due to rapid cell turnover nd continuous cell division, sometimes there can be Folate deficiency causing Macrocytic Anemia......so my question is B12 or Iron deficiency Anemia can also occur right ? Bcuz those things are important in cell division or is there something else causing only folate deficiency Anemia.... hope you got my question 😅
actually, how its become thrombocytopenia when ALL occurs? i thought it only influence lymphopoiesis lineage so it will never disrupt any platelet count.. please explain me doc :(
Hi! i am studying in (Medical Laboratory Technology 4years program) currently i am in 2nd year Hematology is include in my subjects, next month my annual exam will be start i watch the Leukemia videos there are a lot concepts are missing which i need i need your help
This is a very good explanation. It is my assessment that your presentation covers the symptomology of the disease process and current medical practices to correct the symptoms. I am intrigued to understand the actual disease process occurring in/at the bone marrow level. Some questions I have are what hormone cascades/signaling hormones are involved in the negative feedback loop of the bone marrow. Is there pathology in the negative feedback loop? What is actually occurring in the marrow to produce these immature blast cells? We understand the presentation of the disease well but with is the pathology as it relates to the bone marrow? Heavy metal deposition causing ROS and altering mitochondrial function? Are “forever chemical” depositing in the marrow and cause risk for cellular disfunction. Perhaps a severe acute stress response or chronic stress due to interpersonal relationships, or work could leave someone particularly vulnerable to relapse? I have so many questions. Blood cancers don’t start a tumor growths/mass development. What is occurring in the marrow? Is there tumor development in the marrow of dysfunctional marrow cells? Does the diseased marrow spread to other marrow containing bones?
Great content, as always! I need some advice: I have a SafePal wallet with USDT, and I have the seed phrase. (behave today finger ski upon boy assault summer exhaust beauty stereo over). How can I transfer them to Binance?
It's very difficult to differentiate between them based on the physical exam alone, we almost always need a bone marrow biopsy, peripheral smear, immunohistochemistry and flow cytometry. Based on age, ALL patients are usually (not always) younger. ALL is associated with Down syndrome, so you will see clinical features of Down's. AML-M3 subtypes has some specific characteristics such as DIC, AML-M5 has oral mucosa involvement.
oh gosh!!! really like your presentation!! It's interesting & funny at some points! Thank you so much ^^ Btw, may I know which software/app did you use to write these notes??
hello, first i would like to say thankyou for your amazing videos. second i would like to ask regarding wbc count, i dont understand how it can be increased wbc or decreased
Thank you Very much that was very helpful!!! I’m just abit confused about whether WBCs are raised or low in acute leukaemia? If they are raised then why are they more susceptible to infections?
WBCs could be any number in case of leukemia...They could be less than 10,000, more than 100,000 or anything in between. The reason why there could be infections is that these WBCs are malfunctioning, even though they might have a high number. Number and function are 2 different things!
there is squeaky weird noises in the background when I play this. strange.. nevertheless great vid as always!!! Thank you so much Medicosis i love you!
📝 Download Notes: www.medicosisperfectionalis.com/
Thank u very much. I get 18from 20 in med exam of hematology🎉
amazing
The link doesn't work 🙂
Love the dry humor and super casual attitude
Thank you 😊
Fr.His channel is gold for my small attention span.
قناتك كنز أنا محظوظ لأني وجدتها ،بالاضافة إلى ذالك لقد درست عليك في مادة الانيميا وامتحنتها وقد صادفت سؤال لم يستطيع اغلب الطلاب حله الا انا حللته لأنك ذكرته في الشرح شكراً جزيلاً لك
😊😊🙏🙏🙏
You are changing the history of medicine, dude!
Thank you so much 😊
th-cam.com/video/4TmGXQjPIEM/w-d-xo.html
❤️💙🤍💜
Is that really a compliment?
@@heybruvv2733 Sure!
I'm on my third year of being a pre-med student and whenever I can't absorb the information on the books anymore, I just go to your channel. More like I like how you approach the lessons! Just wanna say thanks!
Some people just have the gift of getting through and communicating well. You have that gift. Thankful for videos like these!!!
Thank you 🙏
I watched most of your hematology videos, awesome fun and simple way of explaining things that are over-complicated by books! Thank you !
Cool...I am happy to help 😊
Even after 5 years you are my teacher thank you
Thank you!
My wife and I lost our just turned 2 year old son 7 months ago to Aml. He had MLL gene rearrangement or subtype KMT2A or 11q23. He had a translocation between chromosomes 6 and 11, t(6;11). He received cytarabine, daunorubicin, etoposide, gemtuzumab ozagamicin then mitoxNtrone and cytarabine. He relapsed after the second chemo which signified refractory Aml which had a poor prognosis. Decitabine with mylotarg was then used. He died shortly after from within 4 months of treatment. Some side effects he had were bloody nausea and diahrea. Horrible bloody mouth sores. He was in pain all over. His right eye was covered by a leukemia pool that ended up bleeding.He had a lot of liquid in his lungs which they thought was pnemonia. He ultimately died from a brain bleed within 24 hours caused we think by the chemo.
Oh!
I am so happy for u.
I am an elder sister. I have a younger sister. She has some weird symptoms. Idk what doest it mean.
1) light headed
2) tired & weakness
3) coughs and flu
4) nose bleed 1 time (gum bleeds)
just a little bit
5) today she has a unbearable pain on her teeth,ear & arms.
But I said my mom about it & she doesn’t care about it. She wanted to say I am much hypochondriac.
Basically I am so much obsessed with my sister. Maybe I love her a lot
On my second relapse of ALL, now I finally understand what’s happening. Great video
Thank you!
I wish you a speedy recovery!
I hope everything goes well this time around. Stay strong 💕
You got this. What hospital are you going to?
My son has been diagnosed recently , my heart goes out to you . Horrible illness and aggressive treatments. Stay strong .
Have you considered "intracellular" glutathione therapy? There is a whey protein that has a precursor that raises glutathione inside the cell. That glutathione is now able to promote "monoclonal expansion" of T-cells (cd4/cd8) which places cancer cells into "negative feedback inhibition." It works amazingly will in leukemias and many other cancers.
Thanks dude 🙏🙏🙏
Thank you for your support!
well, this is the first time i comment on a video on youtube, you're amazing! thank you so much, and keep going sir.
My pleasure 😇
keep going sir :)) this is so helpful, and like I spent 20 hours trying to understand this yesterday but you made it so clear for me in less than 15 mins .. awesome content too .
So happy that I was able to help...How did you find my videos?
th-cam.com/video/BO_dU1KtFhE/w-d-xo.html
It’s amazing how you explain this you make it easy to understand
📝 Download my handwritten notes: www.medicosisperfectionalis.com/
So simple to understand
Your way of explaining things is great .. finally found the best u tuber for pathology lecture ..keep it up bro
Thank you for your time and effort
I've never seen an explanation like this before❤
You're very welcome!
You know what is attractive, its your voice😁😁
Thank you ☺️
You are literally amazing thank you so much I'm studying my lab module right now !🙂
Excellent...Thanks a lot!
I honestly like the way you make life easier
Thank you ☺️
1:07 Hey! Don't neutrophiles stem from the same cells that make up monocytes, rather than other granulocytes?
youre the best teacher ever!!!
Thank you!
50 hematology 💉 *cases* - written by me - are NOW available on www.patreon.com/medicosis/
I told everyone
Be drunk and then study you will know medicine easily
You are donerrrreerrrr♥️
Hi
You the best,you taught easily and what’s necessary.Thank you God bless you.👌🏻🙏
I am honored:)
Oh I can't explain how these videos are amazing thank u♥️🌸
Thank you 🙏
Thanks a lot man
this helped a lot for my FINALS!
Glad it helped!
Thank you ,, your videos are so informative and cool .. this helped me in my study leave alot
My pleasure 😇
Hi
I’m a retired HemOnc RN who has recently beenndiagnosed with LCH, aka:
Langerhans Cell Histiocytosis
Can you address a segment to this chameleon like disease?
TIA
Thanks a lot for making my life easier!
My pleasure 😇
you're the best keep going🔥🔥🔥🔥
Appreciate it, brother!
thank you for this thorough video! excellent visuals!
Thank you so much 😊
Why does infection increase in leukemia (high WBC)? Due to dysfunction of WBC
"Crazy, useless, immature cancer cells" 😂
that ALL drawing at testicles at 7:33 is perfect 😂
one question tho, why doesn't it matter where wo do the biopsy? if the clonal cells haven't metastisized yet, they should be limited to one bone and only one bone no?
BEST explanation ever! Thank you so much!
My pleasure 😇
th-cam.com/video/4TmGXQjPIEM/w-d-xo.html
th-cam.com/video/BO_dU1KtFhE/w-d-xo.html
I had a friend get diagnosed with AML in November 2010 and pass away from it in January 2011. It is so rapid and aggressive.
Was it caught late?
@@maryjohns7968 no she only began showing “mild” symptoms maybe 3 months(?) prior to diagnosis. At the time of diagnosis however her condition was bad. Very high relentless fever, very pale, weight loss, no energy, bruises everywhere… I’ve never seen a disease like this.
you are the best. i cant believe u dont have many views yet.
Thanks a ton! You made my day! Please help me by sharing! Thanks in advance!
@@MedicosisPerfectionalis sure
Thank you so much!
Wow great overview. Very pleasant to watch too and informative. Thank you!!!
Amazing!
Thank you so much 😊
th-cam.com/video/4TmGXQjPIEM/w-d-xo.html
Thank you ❤
Hello! I'd like to thank you for this vedio .
I want to ask , do you allow to take a screenshot of the vedio?!
Thanks alot.
Thank you very much doctor
My pleasure 😇
Thank you for make it so simple
My pleasure...Best of luck to you!
th-cam.com/video/4TmGXQjPIEM/w-d-xo.html
Very nice explanation ....
Thank you 🙏
Friend diagnosed with AML and he is almost 61. Was low in ferritin for a while. Anemic. Pretty healthy guy.. except I guess not.
I have a question, in acute leukemias, there are high number of blasts but does that translate to a high total white count? or leukopenia?
and in chronic leukemia, I assume that it would be leucocytosis?
In acute leukemias there is neutropenia but WBC count is high due to blasts(as they enter blood stream).And in chronic leukemias there would be leukocytosis.
I wish I could better understand what is going on with me. They found out I had MDS for years that was masked by me having colitis for years. Some of the same in CBC tests are the same. Then suddenly after my colon was removed I came down with AML. All bone marrow biopsy showed I had MDS that progressed to AML. Lone of the mutations were bad. Chemo bought me all the way to cytogentic remission last Sept. Things went great until an adrenal test when I had to stop anything steroid for 5 full days. I started feeling sick, it didn't do away. In hospital the bone marrow showed my AML back with one catch. I have isolated 20q12. Percentage of bone marrow is 86%. Red cells, platelets, and B cells are low. Everything else is normal. Whites are slightly low but not dangerous. Doctors have never seen this. Nothing is documented. They gave me 6 to 8 weeks to live. Now that is up in the air when CBC just before giving me blood showed my platelets went from 30 to 70, Now the doctor doesn't know what will happen other than it will kill me. blast levels in marrow are 20%. Peripheral bone smear marrow smear show 5%. Blasts in blood 0.5%. Blasts in marrow are atypical with slight left shift. What is the world is this and how long do you think I will have to live.
How are you
May you be healed of this cancer!
If continuous cell division exposes the folate deficiency Anemia than there should B12 deficiency Anemia and Iron deficiency Anemia too right ?? Or is there any other mechanisms in it, plz explain if you know
Sorry, I didn’t understand the question...Can you phrase it in other words, please?
@@MedicosisPerfectionalis At 8:17 you were explaining about Lab in Acute lukemia. Due to rapid cell turnover nd continuous cell division, sometimes there can be Folate deficiency causing Macrocytic Anemia......so my question is B12 or Iron deficiency Anemia can also occur right ? Bcuz those things are important in cell division or is there something else causing only folate deficiency Anemia.... hope you got my question 😅
Yes! You’re absolutely correct! B12 deficiency will be the last to appear because the liver store it for years.
@@MedicosisPerfectionalis these things are easy to discuss on paper but in clinical diagnosis it must be hard to determine specific pathology 😐😓😕
Yup
excellent video....
great explanation..!!
Thanks a ton!
actually, how its become thrombocytopenia when ALL occurs? i thought it only influence lymphopoiesis lineage so it will never disrupt any platelet count.. please explain me doc :(
Hyper-production of WBC lineage will "crowd out" other cell lines such as platelets and RBCs leading to thrombocytopenia and anemia respectively.
THANK YOU 🙏 MORE POWER❣️GOOD LUCK 🍀
Hi! i am studying in (Medical Laboratory Technology 4years program) currently i am in 2nd year
Hematology is include in my subjects, next month my annual exam will be start
i watch the Leukemia videos
there are a lot concepts are missing which i need
i need your help
What an amazing effort..👏👏
Thank you 🙏
can you recap the video content? I need it for the upcoming lesson
This is a very good explanation. It is my assessment that your presentation covers the symptomology of the disease process and current medical practices to correct the symptoms.
I am intrigued to understand the actual disease process occurring in/at the bone marrow level. Some questions I have are what hormone cascades/signaling hormones are involved in the negative feedback loop of the bone marrow. Is there pathology in the negative feedback loop?
What is actually occurring in the marrow to produce these immature blast cells? We understand the presentation of the disease well but with is the pathology as it relates to the bone marrow? Heavy metal deposition causing ROS and altering mitochondrial function? Are “forever chemical” depositing in the marrow and cause risk for cellular disfunction. Perhaps a severe acute stress response or chronic stress due to interpersonal relationships, or work could leave someone particularly vulnerable to relapse? I have so many questions.
Blood cancers don’t start a tumor growths/mass development. What is occurring in the marrow? Is there tumor development in the marrow of dysfunctional marrow cells?
Does the diseased marrow spread to other marrow containing bones?
You are awesome🥺. Thank you so much
My pleasure 😇
Medicosis perfectionalis. 👏👏👏❤️❤️❤️❤️❤️
Thank you for your very good presentation.
best explaination so far
Thank you so much 😊
Can you please explain the mechanism of Dic in acute leukemia :")
Please watch my video titled: “DIC”.
Great content, as always! I need some advice: I have a SafePal wallet with USDT, and I have the seed phrase. (behave today finger ski upon boy assault summer exhaust beauty stereo over). How can I transfer them to Binance?
Thank you sir.
my teacher ileen😂 watches your video's No more headaches.
var caught😁
Thank you so much 😊
Hahaahah i can't breathe 😁
th-cam.com/video/4TmGXQjPIEM/w-d-xo.html
th-cam.com/video/BO_dU1KtFhE/w-d-xo.html
can you please just give me the definition of monoclonal?? you are the best ..
Monoclonal: Originating from one entity (from one cell)...Think of it as plants originating from a common root.
Based on physical examination that include age etc
How can u differentiate
AML & ALL
It's very difficult to differentiate between them based on the physical exam alone, we almost always need a bone marrow biopsy, peripheral smear, immunohistochemistry and flow cytometry. Based on age, ALL patients are usually (not always) younger. ALL is associated with Down syndrome, so you will see clinical features of Down's. AML-M3 subtypes has some specific characteristics such as DIC, AML-M5 has oral mucosa involvement.
oh gosh!!! really like your presentation!! It's interesting & funny at some points! Thank you so much ^^
Btw, may I know which software/app did you use to write these notes??
when lukemia metastasize into the lymphnodes will it be called lymphoma?
Yes
O my God dude! You are awesome!!!!!! 😃😍
Thank you 😊
Your absolutely the best I like ur videossss
Thank you so much 😊
Can you please help me by sharing?
Medicosis Perfectionalis yeah sure I’ll, any other thing u want me help u in?
That’s more than enough...Thank you so much!
Now, do you want any help from me?
Fantastic videos sir. Thank you for these. Really really helpful. ♥️♥️♥️♥️♥️♥️
Awesome 👏
th-cam.com/video/BO_dU1KtFhE/w-d-xo.html
hello, first i would like to say thankyou for your amazing videos. second i would like to ask regarding wbc count, i dont understand how it can be increased wbc or decreased
Cancer doesn't follow rules!
Amazing explanation👌thank you so much
My pleasure 😇
I have a question, why is the WBC count can be low in AML (
Not always!
We can’t rule out a leukemia based on the WBC count alone.
Medicosis Perfectionalis Okay now its clear to me! You are the best! ;)
Thank you so much 😊
The auer rods in AML are in the cytoplasm right?
Yup 👍
@medicosis perfectionalis
Thank you for this amazing illustration ;keep on 👌👏
and thank you for your kind words!
Your videos are fantastic, thanks 💜
My pleasure 😇
th-cam.com/video/4TmGXQjPIEM/w-d-xo.html
Very helpfull👌
Glad to hear that!
Thank you so much for these videos!
th-cam.com/video/4TmGXQjPIEM/w-d-xo.html
informative video. Loved it
Thank you so much 😊
Hi, I have a question, even if I'm awake or I don't always get enough sleep, can I have leukemia?
Leukemia cannot be ruled out or ruled in based on your sleep status alone!
Bro do a picture lecture of aml classification I got confused
can AML spread to lymph node and cause lymphadenopathy?
Thank you very much for all amazing infos. Can you please make more lecture about immunohematology ( blood bank) please!
Thank you Very much that was very helpful!!! I’m just abit confused about whether WBCs are raised or low in acute leukaemia?
If they are raised then why are they more susceptible to infections?
WBCs could be any number in case of leukemia...They could be less than 10,000, more than 100,000 or anything in between.
The reason why there could be infections is that these WBCs are malfunctioning, even though they might have a high number.
Number and function are 2 different things!
@@MedicosisPerfectionalis perfect this makes sense thank you !!
My pleasure 😇
there is squeaky weird noises in the background when I play this. strange.. nevertheless great vid as always!!! Thank you so much Medicosis i love you!
Thank you so much for your honest feedback!
you are great thank u so much
You are very welcome! Thank you for watching!
This was really good
Thank you 😊
That was so helpful
Thanks 😊
Simplified greatly
Thanks!
Thank you, sincerely.
My pleasure 😇
Thank you 👌👍
My pleasure 😇
ThanQ man ,l luv u💜
you are the best,,, keep going
Thank you 🙏
very good video
Thank you so much 😊
Can you please help me by sharing?
@@MedicosisPerfectionalis i shared your videos to all my classmates !!
awesomeeee explanation
FINALLY MEDICINE MAKES SENSE 👌🙌😅
Great 👍
You are amazing
Thank you 😊
Hey! What does monoclonal mean?
Originating from one cell only (or one ☝️ type of cells).
@@MedicosisPerfectionalis Thanks!
My pleasure 😇
Thanks!
You’re very welcome 😊
Every time I study these topics I end with forgetting them all in the early morning hope this time is different
Thank you alot