Liver failure from copper (Wilson Disease)
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- เผยแพร่เมื่อ 15 ต.ค. 2024
- Wilson Disease is a rare genetic disease that can cause multiorgan failure. Liver transplantation can cure this disease! Let me know which GI/liver disease I should discuss next in my disease of the week series! #GI #Diseaseoftheweek
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Currently studying for boards right now and the amount of questions I have gotten on Wilson’s disease is surprising. They love this disease so much for some reason
It’s definitely a popular test question!
Good luck on the boards!!!!!
@@Doc_Schmidt i have the disease
"[...]eye exam by an ophthalmologist."
Dr. Glaucomflecken has entered the chat.
Fun fact from the veterinarian: The Bedlington terrier has an inherited coppar storage disease very similar to Wilson’s disease.
I was a recently a inpatient in the orthopaedic unit, and my roommate has Wilson’s disease. In addition to the neurological aspects of the disease, it had attacked her prosthetic hip and she was on her fourth artificial hip when I met her.
A copper deficiency can also cause major issues issues. A weird possible cause of copper deficiency is secondary to improper denture adhesive use. Some denture adhesives contain zinc which interrupts copper absorption. So if you ever have a patient with a copper deficiency then check and see if they have an ill fitting denture. If so, refer to a prosthodontist for assessment. That will fix the source of the zinc toxicity, but you will still need to manage the copper deficiency.
i have wilsons, luckily was diagnosed early on, i still face many dialy life issues but well i am luckily leading a fairly normal life , i really hope anyone else that is going through Wilson's takes care and has a good healthy life, swnding everyone the best of wishes
Pls give your insta id
I first learned about this on house MD :)
Seriously. I think it was the final diagnosis on at least 3 episodes.
I learned about a liver disease on House MD that turned out to be total bullshit and when I researched it online, the only place it was mentioned in any medical website was on House MD! It was so annoying.
It’s never lupus. 😂
Me too!!
My uncle had this and unfortunately died from it in his 30’s
Yeah same with my stepbrother
How long until they found out they had it
Yes, actually. I learned about it from House and Mystery Diagnosis.
First of all, yes we knew about it. All you have to do is watch House. Second of all, one of the clinicians at work complimented me for knowing how to correctly pronounce words like endoscopy so thanks.
Ok, so now I have to Google foods containing copper. Why didn't I know that was a thing?
This was on House, MD so I already knew about it lol
Nice
I remember this from that episode of Scrubs.
The More You Know...
🌈 🌟 (cue music)
Never heard about copper buildup before. A friend of mine is in the hospital now for problems with calcium levels after a thyroid removal, which I didn't know was possible either.
Minerals can cause lots of problems!
Sounds like they also removed, stunned, or damaged some of her parathyroids. There are 4 of them and they regulate calcium. They are located directly behind, and sometimes somewhat intertwined with, the thyroid gland.
Doctors should know more about scheurmans kyphosis I went for forty years without a diagnosis always tired and always having back pain
Well, after watching every episode of House, in which Wilson Disease was excluded first almost every time, now I finally know what it is!
So, are all metals poisonous, some just happen to be useful to the organism at lower doses? And are they all poisonous by the same mechanism? Because I know of heavy metal poisoning, but what I heard about aluminium poisoning doesn't seem that different, and that's a very light metal
I’m desperate for any information about this because I’m sure I have this but no one will help me
The trouble with Wilson's Disease literally no one wants to help you, I nearly died a very horrible death (I honestly wouldn't wish what I went through on my worst enemy) with all the typical symptoms and blood tests showing it and not one specialist or doctor helped me. I ended up having to buy my own chelators online to save my own life. I even now have a report from a genetic consultant that says I carry the two pathogenic genes for WD and yet still no one helps while I still live on a knife edge each day.
I hope you are doing well now?
@@masoomee No sadly I'm trying to get more formal help but it's an uphill struggle.
@@rebeccapadmore8528 Sorry to hear that. Get well soon!
I have wilsons too, I was luckily diagnosed early on, but I am here if you'd like to talk about it, I wish you the best In your recovery though ofcourse
Liver transplantation is not completely curative if other systemic complications have already occurred 🤔🤔🤔
Interesting fact-the Bedlington Terrier has an extremely high level of Wilson’s Disease. at one point it was around 65% of the breed.
So liver is responsible for copper metabolism? However, organ rejection with its lifelong struggles are a burden + finding a match.
Copper excretion* It’s excreted in bile
@@Doc_Schmidt thx. So only excreted? No other processes like that of Bilirubin?
what happens if the original eye color was copper like? does the color still show enough for doctors to tell?
You’d still be able to note a ring of different appearance. Can eyes even be copper colored naturally??
Actually, my eyes are copper-colored( hazel). Hopefully this will never be an issue!😮
@@Doc_Schmidt oh i see, cool! thank you for telling me! i was thinking of a reddish brown color that resembles copper color XD
Thanks doc
WWWHHHAAATTT!!!!
i can increase and decrease the font size and the brightness, i can even speed up the play back to above normal, but i cant slow it down to where i can catch up to what he is saying.
Slow down! I have Wilson's Disease.
Interesting 👍🏼
Not me being tested for this rn 😅
Hello
Hey
Kayser Fleischer rings
Doc you speak fast, We cannot understand , we are scared .
I'm going to look at people's eyes from now on with the intention of trying to detect that copper brownish ring around their iris! 😂😳😮
Last time I checked the mutation in my atp7b chromosome would still be there regardless of liver transplant. If a patient with Wilson’s came in (and person didn’t know and docs didn’t know) and got a new liver, it’d just be a fresh new liver for the Wilson’s to ruin. The root problem is still there. As of this comment there is some promising gene therapy trials on going
Also I disagree on looking for KF rings being the most definitive way to test for Wilson’s. A genetic test to see if one had the mutation on their atp7b chromosome would be the most definitive. Though while the KF rings do indicate Wilson’s disease. They only show up once there’s enough copper has built and has been deposited in the eyes and they also fade away with chelation therapy.
Oh man, I thought this was about police shootings.
No, that would be excessive lead buildup from having 50 Cent levels of bullets in your body.