IgA nephropathy - causes, symptoms, diagnosis, treatment, pathology
ฝัง
- เผยแพร่เมื่อ 26 ส.ค. 2020
- What is IgA nephropathy? IgA nephropathy, sometimes called Berger disease, is a type of nephritic syndrome where abnormal IgA antibody is formed, which results in immune complex deposition in the glomerular mesangium, leading to kidney disease.
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I'm currently studying IgAN for my Med-Surge clinical. This helps so much!
Thanks for the feedback, Nicole! 😊
Very good explanation for immunological lesson
Excellent intro ty!
Very nicely explained 👍❤✨ Well Done Osmosis 😊😇
thank you 👍🏻
Thank you!!!!
JazakAllah kher
Thank u for video
Renal failure is an end-condition and not progressive disease as you explained here. Explain Balkan neuphropathy with that basic of understanding blocks
Thanks for letting us know about this. We'll have our team, review the information presented in this video. 😊
I was diagnosed with this about 10 years......I was not prescribed any medication of any kind.....still healthy....but everytime i get a fever my urine turns dark red....then it goes with the fever. I have muscle cramps sometimes mainly in neck and shoulders and whenever i eat meat my throat dries up with some mucus at the back of my throat forcing me to cough many times and my urine will foam up with all the excess protein discharged through my urine. ........Other than this, creatine and other things are kept normal. The doctor just asked me to take plenty of water. So getting a fever once or twice... maybe 4 times a year won't be that bad I think...so Works for me. Bear in mind this all started 11-12 years back..where everything except creatine was shocking....now I just stay hydrated and tries to resist eating "too" much meat.
How is your iga now? Is still stable?
How are you now!?
Which doctor you went
Hlo can u share ur some dm’s
Hi , I am 32yrs old and have been diagnosed with same issue and I am under treatment from 2.5yrs but in the past six months creatinine value increased from 1.9 to 2.4. Earlier it was coming around 1.7-1.9. I am taking medicines mainly for BP as prescribed by my doctor.
Can u please share me untill what value of creatinine it is safe?
Thats was helpful thank you
Glad it helped, Malak! 😊
I had a biopsy done due to proteinuria. I had no hematuria at any point. I actually saw my primary doctor for a range of odd symptoms, and had just recovered from PEs, and she sent me to nephro. The biopsy found very mild IgA nephropathy, like the video said, and the doctor said it could almost be considered an incidental finding, if they weren't already doing a kidney biopsy lol. I'm 27 years old. I just started taking an ACE inhibitor but other than that I just have to have annual urine testing to make sure nothing's getting worse.
I have the same problem. Do you know what caused it?
I'm 26 by the way
I also have IgA nephropathy and my nephrologist told me to take ACE inhibitor and Dapagliflozin.
Budesonide tablet
ACE inhibitors
Omega 3
Thankyou good information
Glad you liked it, Princy! 🙌🏼
Great video. Thank you for breaking it all down. More please lol
Most welcome! 🥰
@@osmosisWhat’s the prognosis for someone with glomerular disease? Not good, right? Does it depend at all on what specific type of glomerular disease? I have GN due to an autoimmune disease. I feel I am on borrowed time.
In which case of iga nephropathy.. Solu Medrol drug is used?
Excellent video 🎉
Thank you! Cheers! 🙌🏼
Perfect
Tq
As a someone with celiac disease, if you stabilize your Iga, can cross food reactivity ( Ige reaction), re trigger the iga in the kidney ?
Great video thanks. After I tested +ive for IGAN I was put straight onto 60mg Prednisolone and 10mg Ramipril as my GFR was in rapid decline. Kidneys lasted for 4 years before 7 years dialysis then a transplant at 31. Reason I believe I got IGA was through a bronchial infection at 19 years old. Unlucky but now my GFR is 89, Creatinine 100 and Albumin 39. Potassium fluctuates depending on diet anything from 4 to 6. Phosphate is a steady 0.8 but my HB goes up to 170+ then I have to have some blood drained. Blood Calcium is about 2.5 because my PTH is around 500 but my bone density scan is normal. I have calcification in my fistula due to high blood calcium.
The illest I became pre transplant, highest figures were a staggering potassium 9.1 where my body became paralysed, the only muscles left working were my tongue & heart. Phosphate 3.7 and Creatinine 1200. Thankfully I'm fit and well for now!
I was affected by tuberculosis in my right lung 4 years ago. From that time I feel pain both side of my back and flank where kidneys are located. Now this pain has been slightly increased but I tested my urine almost 10 individual times but till now nothing found. My protein ratio is in normal range but slightly high. And it is increasing slowly month by month. But didn't cross the border line yet. No other symptoms is seen yet without pain and foamy urine??? I don't know what should I do. Am I going to CKD slowly???
@@kmferdoush1381 Foamy urine is an indicator of proteinurea which means protein is present in the urine. I'm not a Dr but if I were you I'd seek medical attn. Let me know what happens, good luck.
@@markyyyyyyyy321 I went to doctor specially nephrologist so many times. They don't care about foamy urine. They only see the report and if they find everything in normal range then they don't care about my pain and foamy urine. They prescribed me baclofen and other pain killer for the pain. I took baclofen for some days but nothing changed. Did you felt pain in your kidney, lower abdomen and groin area when you attacked by IGA???
@@kmferdoush1381 Baclofen? I think that's an agent used to relax muscles used in patients with spasticity.
When I felt the CKD in my kidneys I felt twinging pain in the kidneys both sides that's all really.
@@markyyyyyyyy321 I feel sudden shooting pain in my kidney area. Sometimes dull ache in my flank area.
Do not stay on immunosuppressant for a long time. It's not safe. Lots of bad side effects that put me on other meds. If it doesn't work after 8 weeks taper off that poisen.
Thank you.🤍
Most welcome, Zahraa! 😊
I had this and started dialysis when I was 21 years young. I actually urinated a solid dark red stream once in the emergency room.
How r u now?
@@tisveu3912 very good now! I deal with mental health issues since then due to what was considered trauma, but I exercise daily which helps tremendously!
@@shawnstover917 glad your doing good. Dont forget to smoke a little refer for the stress. Cheers!
@@shawnstover917 how does exercise affect your kidneys? Isn’t it too much stress on the kidneys?
@@alhambrabiker1476 I've been transplanted for 13 years so it's no problem exercising today. You do have to be care lifting weights and becoming dehydrated. I typically walk 3 miles per day and lift light weights. I believe exercising right after transplant is not good due to the possibility of the incision coming apart but simple exercise with little or no weights is good initially. The doctors have a better idea of when you can get back into more exercises, which is probably 3 months after transplant.
Finally FDA' approved drug Tarpeyo for iga
The therapies are not listed completely. In the meantime, Forxiga is used to prevent the progression of the disease.
Yes forxiga works for me. IGA NEPHROPATHY, too. Very good! I’m stage 3B ckd patient
@@evelynaustria5227How fast has you progression been?
I feel pain in my sides make urine analysis and appear hematuria and proteinurea and high blood pressure and im not hypertensive patient
Make urine albumin creatinine ratio 75 mg im take tritace 5mg
After 15 days
My urine albumincreatinine become normal 5
I want to ask if this iga or no
Thanks
Is burger disease vasculitis and IgA nephropathy same thing ?
No iga is Bergers with a E not a U
Buerger is thrombotic vasculitis
Sorry but this is a video with a lot of missing information.
There was a 5 year long clinical study about using immune supressiva for IgA and the study got the result hat immune supressiva does not help, especially if you show symptoms. It can help if you are without symptons and stop the disease. But the video left out a major information - if you get the symptons it is already to late because more than half of the ability of your kidneys to clean your blood is gone. At that time you can only slow the disease down.
The problem is the common "gold" standard to test for kidney problems, that in my opinion is more of a known rusty standard. They test your creatinine, but the problem is this test got a blind area where your kidneys are already failing but creatinine is still ok. That blind area is known and covers the rate of 99.9% functional kidneys to about 50% functional kidneys. The second problem is that creatinine depends on your behavior. When you had a protein rich day the day before your test the creatinine could be high and if you had little protein it could be low. But only if half of the kidneys ability to clean is gone, only then creatinine is really going up, you get high blood pressure, blood and/or protein in your urine, gout, etc. and the symptom of high blood pressure will destroy more of the kidneys ability to clean your blood if you don't do anything aginst it. That is why you get ACE inhibitors and ARB's - it is just fighting the symptoms.
A way to diagnose a kidney disease would be another blood parameter called Cystatin C and an urine Albumin test that is normally not tested. If you already got diabetes, a heart disease, high blood pressure etc. it is a recommendation to test for it because of the higher risk of getting a kidney disease (for example diabetes induced kidney disease) because of that. But even then some docs do not test for it. The test for Cystatin C should be standard for everyone, because if that where the case nephropathies could be detected when your kidneys are still working good enough not to show symptoms. The only cause I think why they do not test for it are the costs. A Cystatin C test costs 5 times more than a creatinine test and is in many times not an insurance payed service if you don't have already a disease with a nephropathy risk. To include that in the complete blood count like the creatinine test would make the complete blood count more expensive for the insurances.
An information in the video that is a little wrong is the diagnosis - the only way what kind of nephropathy you got can only be diagnosed with a biopsy and even then they only identify the disease by the kind of damage it did. But that biopsy is important because you need different drugs depending on the cause for your nephropathy. A drug that helps with a diabetes kidneys can make an IgAN worse. Blood test, urine tests etc. only show that your kidneys got a problem but not why. That is only possible with a biopsy.
And one thing I missed in the therapy are the don'ts. Don't use self medication any more, for example aspirin is bad for your kidneys. BTW that is the case for all NSAIDs. Many over the counter medications uses ingredients that are bad for your kidneys, there is even a nephropathy caused by overuse of NSAID's. Don't use alcohol, tabac, caffeine etc. because it stresses your kidneys, drink two liters a day but not more than your doc allows. Try to eat healthy without ready to eat food (because many addons to convenience food like glutamate are not good for your kidneys) and with low protein (max about 1g/kg body weight according WHO). For example meat got about 25g protein per 100g meat. Ask the doc about your neded diet.
Hi is there any way i can reach to you ? i want to talk about something really important about my reports that i want to share with you. Please reply & this is so descriptive & helpful comment. I understood what you are actually telling us all and making sense. thank you
I think he mentioned biopsy for definitive diagnosis. Also you do realized this is pathophysiology and not a clinical video. Based on the length of the video, he was probably just hitting the main points. One would definitely use supplemental materials to accomplish in-dept understanding. The don’t you mentioned are good patient teaching point which only clinicians would know. The person doing the narration may not be a clinician.
Good points though. Good luck with your studies.
I wouldn’t say if you experience symptoms, it’s too late. I experienced blood in urine, swelling, and flank pain. They gave me a kidney biopsy which confirmed it. Because we/my doctor caught it before kidney damage, my kidney function is normal now. I was on immunosuppression, including cellcept and prednisone. It took about a year and a half to get control of it, but now I’m going to be on blood pressure medication to prevent strain on my kidney filters. I understand there is no cure, but it is under my impression with my doctor (who is one of the top nephrologists infections the world) that damage had not been done.
@@keeleya7654 hi, I’m in need of a great nephrologist, unfortunately mine is too far in advance and I need help. I got a kidney biopsy last week which confirms IGAn and it’s at a high level. Thank you!
@@ashleyzacahula5235 hi. I’m so sorry to hear that. :( I don’t know where you are, but there are Mayo Clinic’s across the US that have great nephrology specialists.
That’s what happened to me over two years ago
How are you doing now? Is it better or worse? I just got diagnosed with this
THERE IS SOME TREATMENT IN HOMEOPATHY I HAVE HEARED, IS IT TRUE?
Lecture pdf
Also a diet with very low salt is necessary. Less meet. More vegetable but not substitute meat bevause all ready meals contains to much salt.
Check each product in the supermarket for salt content.
You have this disease..?
I have IGA and the covid vaccine wrecked my kidneys.
You fundamentally misunderstand the process here. Everyone has IgA. It’s an antibody that is in every human’s system.
If you have IgA nephropathy, or IgA vasculitis, then you have that and the shot didn’t do anything to you, and that’s what attacked your kidneys.
@J.G. McBell didn't have iga until after the Vax. 2 weeks after the shot everything went bad. I have very good data to support it. You keep taking your shots.
why edema occurs mainly on face ?
Na++ retention or protein retention
Or due to transudate extravasation into tissues due to vasodailatation
Cbum should stop juicing it is dangerous
😥😨
Is igA nephropathy patient (Male), will be marry?
Hello, is there any cure for this plz, let me know this
Fast 2 days straight
No, put you can treat it with medication and a specific diet can slow the progression
@@ThatsWhy- hey i heard fasting is super healthy once a week. Do u think 3 days straight fasting can cure this?
Is IGA nephrotic syndrome curable???
No specific cure for Iga neprhopathy
I think pt will not get benefit from immune suppressant drug ...I think you should change the treatment part of this video ...otherwise people get wrong idea about this
I am treated with Prednisolone 5mg OD as part of immunosuppression treatment along with 540mg Mycophenelate Acid BDS and 1.5mg Tacrolimus BDS
@@markyyyyyyyy321 is there any possibility to get in touch trough some different platform different than YT comments please?
CBUM😔
Turkısh plase 😔
iyi misiniz.
durumlar nasıl tam olarak
Medical students, if you come here for IG-A Nephropathy and don't know what this bean shaped organs are, there is no hope for you.
*these
*these
Liars!!
I have IgA. Can I drink alcohol?
Try not to
Strictly no please
I was just diagnosed and I'm a craft cocktail bartender... I'm only stage 2 and was told as long as my labs are good here and there is ok... I mainly do straw tasting for new recipes... but just being able to do that got me out of my depression bc I love making new drinks... BUT Dr said in moderation... and not make cocktails a regular occurrence!
@@j.2438bro can we drink beer? I have also igA nephropathy😢
Can we marry i also have Iga nephropathy creatinine 1.6 ? mortality rate ?