Vladimir Grouza - Histological Validation of rPCA Myelin Water Fraction in Hypomyelinating Mice

Quantitative Magnetic Resonance Imaging Conference: Validation of Quantitative MRI techniques (November 29th-December 1st 2023)
Validation of qMRI measurements (part 2) - Short talk
Vladimir Grouza - Histological Validation of rPCA-derived Myelin Water Fraction Imaging in a Panel of Variably Hypomyelinating Mice
Biography: PhD Candidate at McGill University
Abstract: We investigated the application of blind source separation, robust principal component analysis (rPCA) for myelin water imaging in a panel of mice exhibiting varied hypomyelination profiles. rPCA-MWF exhibited sensitivity to myelin as evidenced by region of interest (ROI) analysis of several white matter tracts as a function of relative myelin basic protein (MBP) gene messenger RNA (mRNA). Immunohistochemical staining for MBP revealed a pronounced correspondence between rPCA-MWF and MBP density.
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Organizing Committee
Dr. Mallar Chakravarty (@mallarchkrvrty1)
Dr. Christine Lucas Tardif (@tardiftweets)
Dr. Christopher Rowley (@rowleycd)
Dr. Aurélie Bussy (@AurelieBussy)
Olivier Parent (@oparent41)
Sajjad Feizollah (@SajjadFeizollah)
Mark Nelson (@Mark_Cameron_)